Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LRP1_HUMAN

(Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. [View more on UniProt]

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Position Amino acid Mutation Disease Overlap with binding region
1245 Lys Arg Keratosispilarisatrophicans(KPA) -
ELM instance Name Type Start End Partner
ELMI001560 LIG_PTB_Apo_2 LIG 4467 4474 -
ELMI001562 LIG_PTB_Apo_2 LIG 4501 4508 -
ELMI001543 LIG_PTB_Phospho_1 LIG 4467 4473 -
ELMI001546 LIG_PTB_Phospho_1 LIG 4501 4507 -
ELMI004252 TRG_DiLeu_BaEn_1 TRG 4526 4531 -
ELMI001560 LIG_PTB_Apo_2 LIG 4467 4474 -
ELMI001562 LIG_PTB_Apo_2 LIG 4501 4508 -
ELMI001543 LIG_PTB_Phospho_1 LIG 4467 4473 -
ELMI001546 LIG_PTB_Phospho_1 LIG 4501 4507 -
ELMI004252 TRG_DiLeu_BaEn_1 TRG 4526 4531 -

Molecular function

Term Name % Distance from the top of the tree Annotated in LRP1_HUMAN
GO:0043169 cation binding 38.5965 4 yes
GO:0046872 metal ion binding 36.8421 5 yes
GO:0043168 anion binding 33.3333 4 no
GO:0000166 nucleotide binding 31.5789 4 no
GO:0017076 purine nucleotide binding 29.8246 5 no
GO:0032555 purine ribonucleotide binding 29.8246 4 no
GO:0035639 purine ribonucleoside triphosphate binding 29.8246 4 no
GO:0019900 kinase binding 24.5614 4 no
GO:0019901 protein kinase binding 22.8070 5 no
GO:0003723 RNA binding 21.0526 4 yes
GO:0005509 calcium ion binding 8.7719 6 yes
GO:0070325 lipoprotein particle receptor binding 7.0175 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in LRP1_HUMAN
GO:0048522 positive regulation of cellular process 64.9123 4 yes
GO:0060255 regulation of macromolecule metabolic process 64.9123 4 yes
GO:0010646 regulation of cell communication 63.1579 4 yes
GO:0048523 negative regulation of cellular process 59.6491 4 yes
GO:0080090 regulation of primary metabolic process 59.6491 4 yes
GO:0031323 regulation of cellular metabolic process 57.8947 4 yes
GO:0009966 regulation of signal transduction 54.3860 4 yes
GO:0009889 regulation of biosynthetic process 52.6316 4 yes
GO:0009893 positive regulation of metabolic process 50.8772 4 yes
GO:0010468 regulation of gene expression 50.8772 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 50.8772 5 yes
GO:0031326 regulation of cellular biosynthetic process 50.8772 5 yes
GO:0051128 regulation of cellular component organization 49.1228 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 45.6140 5 yes
GO:0051246 regulation of protein metabolic process 45.6140 5 yes
GO:0048584 positive regulation of response to stimulus 45.6140 4 no
GO:0009892 negative regulation of metabolic process 43.8596 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 43.8596 5 yes
GO:0010647 positive regulation of cell communication 43.8596 5 no
GO:0023056 positive regulation of signaling 43.8596 4 no
GO:1902531 regulation of intracellular signal transduction 42.1053 5 yes
GO:0006996 organelle organization 42.1053 4 no
GO:0051049 regulation of transport 40.3509 4 yes
GO:0009967 positive regulation of signal transduction 40.3509 5 no
GO:0031325 positive regulation of cellular metabolic process 38.5965 5 no
GO:0008104 protein localization 36.8421 4 yes
GO:0031324 negative regulation of cellular metabolic process 36.8421 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 36.8421 5 no
GO:0009891 positive regulation of biosynthetic process 35.0877 5 no
GO:0022607 cellular component assembly 35.0877 4 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 yes
GO:0071702 organic substance transport 33.3333 4 yes
GO:0071705 nitrogen compound transport 33.3333 4 yes
GO:0042981 regulation of apoptotic process 33.3333 5 no
GO:0043067 regulation of programmed cell death 33.3333 4 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0031328 positive regulation of cellular biosynthetic process 33.3333 6 no
GO:0009890 negative regulation of biosynthetic process 31.5789 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 31.5789 6 yes
GO:0010648 negative regulation of cell communication 31.5789 5 yes
GO:0023057 negative regulation of signaling 31.5789 4 yes
GO:0031327 negative regulation of cellular biosynthetic process 31.5789 6 yes
GO:0051130 positive regulation of cellular component organization 31.5789 5 yes
GO:1902533 positive regulation of intracellular signal transduction 31.5789 6 no
GO:0043933 protein-containing complex organization 31.5789 4 no
GO:0048585 negative regulation of response to stimulus 29.8246 4 yes
GO:0006355 regulation of DNA-templated transcription 29.8246 7 no
GO:2001141 regulation of RNA biosynthetic process 29.8246 6 no
GO:0031399 regulation of protein modification process 29.8246 6 no
GO:0009968 negative regulation of signal transduction 28.0702 5 yes
GO:0044087 regulation of cellular component biogenesis 28.0702 4 no
GO:0050804 modulation of chemical synaptic transmission 28.0702 5 no
GO:0099177 regulation of trans-synaptic signaling 28.0702 4 no
GO:0009894 regulation of catabolic process 26.3158 4 yes
GO:0051248 negative regulation of protein metabolic process 26.3158 6 yes
GO:0007010 cytoskeleton organization 24.5614 5 no
GO:0043066 negative regulation of apoptotic process 24.5614 6 no
GO:0043069 negative regulation of programmed cell death 24.5614 5 no
GO:0065003 protein-containing complex assembly 24.5614 5 no
GO:0015031 protein transport 22.8070 4 yes
GO:0051240 positive regulation of multicellular organismal process 22.8070 4 yes
GO:0071310 cellular response to organic substance 22.8070 4 yes
GO:0001932 regulation of protein phosphorylation 22.8070 7 no
GO:0010628 positive regulation of gene expression 22.8070 7 no
GO:0019220 regulation of phosphate metabolic process 22.8070 6 no
GO:0042127 regulation of cell population proliferation 22.8070 4 no
GO:0042325 regulation of phosphorylation 22.8070 7 no
GO:0043408 regulation of MAPK cascade 22.8070 6 no
GO:0051129 negative regulation of cellular component organization 22.8070 5 no
GO:0051174 regulation of phosphorus metabolic process 22.8070 5 no
GO:0010243 response to organonitrogen compound 21.0526 4 yes
GO:0010629 negative regulation of gene expression 21.0526 7 yes
GO:0030162 regulation of proteolysis 21.0526 6 yes
GO:0033043 regulation of organelle organization 21.0526 5 yes
GO:0051050 positive regulation of transport 21.0526 4 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 21.0526 5 no
GO:0031401 positive regulation of protein modification process 21.0526 7 no
GO:0036211 protein modification process 21.0526 4 no
GO:0043412 macromolecule modification 21.0526 4 no
GO:0044057 regulation of system process 21.0526 4 no
GO:0050890 cognition 21.0526 4 no
GO:0033365 protein localization to organelle 21.0526 5 no
GO:1902532 negative regulation of intracellular signal transduction 19.2982 6 yes
GO:0060341 regulation of cellular localization 17.5439 4 yes
GO:0060627 regulation of vesicle-mediated transport 17.5439 4 yes
GO:0009896 positive regulation of catabolic process 15.7895 5 yes
GO:0030100 regulation of endocytosis 15.7895 5 yes
GO:0030334 regulation of cell migration 15.7895 5 yes
GO:0032880 regulation of protein localization 15.7895 5 yes
GO:1901701 cellular response to oxygen-containing compound 15.7895 4 yes
GO:2000145 regulation of cell motility 15.7895 4 yes
GO:0042176 regulation of protein catabolic process 14.0351 5 yes
GO:0043086 negative regulation of catalytic activity 14.0351 4 yes
GO:0071417 cellular response to organonitrogen compound 14.0351 4 yes
GO:1901699 cellular response to nitrogen compound 14.0351 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 12.2807 4 yes
GO:0098657 import into cell 12.2807 4 yes
GO:0045732 positive regulation of protein catabolic process 10.5263 6 yes
GO:0051336 regulation of hydrolase activity 10.5263 4 yes
GO:0030111 regulation of Wnt signaling pathway 8.7719 5 yes
GO:0045807 positive regulation of endocytosis 8.7719 5 yes
GO:0045861 negative regulation of proteolysis 8.7719 7 yes
GO:0052547 regulation of peptidase activity 8.7719 5 yes
GO:1903829 positive regulation of protein localization 8.7719 5 yes
GO:0006898 receptor-mediated endocytosis 7.0175 4 yes
GO:0007034 vacuolar transport 7.0175 4 yes
GO:0007041 lysosomal transport 7.0175 5 yes
GO:0030336 negative regulation of cell migration 7.0175 6 yes
GO:0032092 positive regulation of protein binding 7.0175 5 yes
GO:0032368 regulation of lipid transport 7.0175 5 yes
GO:0040013 negative regulation of locomotion 7.0175 4 yes
GO:0043393 regulation of protein binding 7.0175 4 yes
GO:0051099 positive regulation of binding 7.0175 4 yes
GO:0051493 regulation of cytoskeleton organization 7.0175 6 yes
GO:1905952 regulation of lipid localization 7.0175 4 yes
GO:2000146 negative regulation of cell motility 7.0175 5 yes
GO:0003018 vascular process in circulatory system 5.2632 4 yes
GO:0030178 negative regulation of Wnt signaling pathway 5.2632 6 yes
GO:0048143 astrocyte activation 5.2632 4 yes
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 5.2632 5 yes
GO:1900221 regulation of amyloid-beta clearance 5.2632 4 yes
GO:1904645 response to amyloid-beta 5.2632 4 yes
GO:1904646 cellular response to amyloid-beta 5.2632 5 yes
GO:0002265 astrocyte activation involved in immune response 3.5088 4 yes
GO:0010466 negative regulation of peptidase activity 3.5088 6 yes
GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway 3.5088 5 yes
GO:0010874 regulation of cholesterol efflux 3.5088 8 yes
GO:0010875 positive regulation of cholesterol efflux 3.5088 8 yes
GO:0014910 regulation of smooth muscle cell migration 3.5088 6 yes
GO:0031623 receptor internalization 3.5088 5 yes
GO:0032370 positive regulation of lipid transport 3.5088 5 yes
GO:0032371 regulation of sterol transport 3.5088 6 yes
GO:0032373 positive regulation of sterol transport 3.5088 6 yes
GO:0032374 regulation of cholesterol transport 3.5088 7 yes
GO:0032376 positive regulation of cholesterol transport 3.5088 7 yes
GO:0032956 regulation of actin cytoskeleton organization 3.5088 5 yes
GO:0032970 regulation of actin filament-based process 3.5088 4 yes
GO:0048514 blood vessel morphogenesis 3.5088 4 yes
GO:0048844 artery morphogenesis 3.5088 5 yes
GO:0051346 negative regulation of hydrolase activity 3.5088 5 yes
GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 3.5088 6 yes
GO:1900223 positive regulation of amyloid-beta clearance 3.5088 5 yes
GO:1905475 regulation of protein localization to membrane 3.5088 6 yes
GO:1905477 positive regulation of protein localization to membrane 3.5088 6 yes
GO:1905954 positive regulation of lipid localization 3.5088 4 yes
GO:2000586 regulation of platelet-derived growth factor receptor-beta signaling pathway 3.5088 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TSP1_HUMAN [view interactions] Low throughput no no
PDGFB_HUMAN [view interactions] Low throughput no yes
DAB2_HUMAN [view interactions] Low throughput no yes
FA8_HUMAN [view interactions] Low throughput no yes
GULP1_HUMAN [view interactions] Low throughput no no
TPA_HUMAN [view entry] [view interactions] Low throughput yes no
FA9_HUMAN [view interactions] Low throughput no no
LIPL_HUMAN [view interactions] Low throughput no no
LIPC_HUMAN [view interactions] Low throughput no no
SNX17_HUMAN [view interactions] Low throughput no yes
NGF_HUMAN [view interactions] Low throughput no no
NTF3_HUMAN [view interactions] Low throughput no no
NTF4_HUMAN [view interactions] Low throughput no no
BDNF_HUMAN [view interactions] Low throughput no yes
CLUS_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
A2MG_HUMAN [view interactions] Low throughput no yes
KAT5_HUMAN [view interactions] Low throughput no yes
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
JIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DAB1_HUMAN [view interactions] Low throughput no yes
ALG3_HUMAN [view interactions] Low throughput no yes
NOTC3_HUMAN [view interactions] Low throughput no yes
JAG1_HUMAN [view interactions] Low throughput no no
TSP2_HUMAN [view interactions] Low throughput no yes
AMRP_HUMAN [view interactions] Low throughput no yes
APOE_HUMAN [view entry] [view interactions] Low throughput yes yes
APBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
C1QA_HUMAN [view entry] [view interactions] Low throughput yes no
MBL2_HUMAN [view interactions] Low throughput no no
FCN2_HUMAN [view interactions] Low throughput no no
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
LEPR_HUMAN [view interactions] Low throughput no no
HS90A_HUMAN [view entry] [view interactions] Low throughput yes yes
RIC8B_HUMAN [view interactions] Low throughput no yes
C2D1A_HUMAN [view entry] [view interactions] Low throughput yes yes
RU17_HUMAN [view interactions] Low throughput no yes
ANS1B_HUMAN [view entry] [view interactions] Low throughput yes yes
PCLI1_HUMAN [view interactions] Low throughput no no
HNRDL_HUMAN [view interactions] Low throughput no yes
MARE1_HUMAN [view entry] [view interactions] Low throughput yes yes
PAI1_HUMAN [view interactions] Low throughput no no
CALX_HUMAN [view entry] [view interactions] Low throughput yes yes
CALR_HUMAN [view entry] [view interactions] Low throughput yes yes
PDIA2_HUMAN [view interactions] Low throughput no no
MMP14_HUMAN [view interactions] Low throughput no yes
CALCR_HUMAN [view interactions] Low throughput no no
SHC1_HUMAN [view entry] [view interactions] Low throughput yes yes
MK_HUMAN [view interactions] Low throughput no no
UPAR_HUMAN [view interactions] Low throughput no yes
CHFR_HUMAN [view interactions] Low throughput no no
RANB9_HUMAN [view entry] [view interactions] Low throughput yes yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
CSN5_HUMAN [view interactions] Low throughput no yes
PTN11_HUMAN [view entry] [view interactions] Low throughput yes yes
ASPC1_HUMAN [view interactions] Low throughput no yes
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
TGFR1_HUMAN [view interactions] Low throughput no no
TRI67_HUMAN [view interactions] High throughput no no
ZDH15_HUMAN [view entry] [view interactions] High throughput yes yes
B3GN2_HUMAN [view interactions] High throughput no yes
LRP1B_HUMAN [view interactions] High throughput no yes
LYRIC_HUMAN [view entry] [view interactions] High throughput yes yes
HXK1_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC2_HUMAN [view entry] [view interactions] High throughput yes yes
A1AT_HUMAN [view interactions] High throughput no no
LIFR_HUMAN [view interactions] High throughput no no
MTP_HUMAN [view interactions] High throughput no no
NTRK2_HUMAN [view entry] [view interactions] High throughput yes yes
PTPR2_HUMAN [view interactions] High throughput no yes
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
STING_HUMAN [view interactions] High throughput no yes
KDM1A_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
JIP2_HUMAN [view entry] [view interactions] High throughput yes no
SKIL_HUMAN [view interactions] High throughput no yes
CAC1A_HUMAN [view entry] [view interactions] High throughput yes no
UBP3_HUMAN [view interactions] High throughput no no
ILK_HUMAN [view interactions] High throughput no no
NU155_HUMAN [view interactions] High throughput no yes
TYW3_HUMAN [view interactions] High throughput no yes
DIAP1_HUMAN [view interactions] High throughput no yes
ZFP41_HUMAN [view interactions] High throughput no no
NDKM_HUMAN [view interactions] High throughput no yes
GATB_HUMAN [view interactions] High throughput no yes
GFPT2_HUMAN [view interactions] High throughput no yes
TNKS1_HUMAN [view interactions] High throughput no yes
TBB4A_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
PYC_HUMAN [view entry] [view interactions] High throughput yes yes
ADT3_HUMAN [view entry] [view interactions] High throughput yes yes
ODBB_HUMAN [view interactions] High throughput no yes
SYHM_HUMAN [view entry] [view interactions] High throughput yes yes
NPC2_HUMAN [view interactions] High throughput no yes
RL23_HUMAN [view entry] [view interactions] High throughput yes yes
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4B_HUMAN [view interactions] High throughput no yes
FOXF2_HUMAN [view interactions] High throughput no no
NPRL3_HUMAN [view interactions] High throughput no yes
TBB3_HUMAN [view entry] [view interactions] High throughput yes yes
TBB2A_HUMAN [view entry] [view interactions] High throughput yes yes
TBB8_HUMAN [view interactions] High throughput no no
ERFE_HUMAN [view interactions] High throughput no no
KMCP1_HUMAN [view interactions] High throughput no no
KCD18_HUMAN [view interactions] High throughput no yes
SAMD1_HUMAN [view interactions] High throughput no no
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
HASP_HUMAN [view interactions] High throughput no yes
PTCD2_HUMAN [view interactions] High throughput no yes
SCMC3_HUMAN [view interactions] High throughput no yes
TBB2B_HUMAN [view entry] [view interactions] High throughput yes yes
TNKS2_HUMAN [view interactions] High throughput no no
MTG2_HUMAN [view interactions] High throughput no yes
PGES2_HUMAN [view interactions] High throughput no yes
NOCT_HUMAN [view interactions] High throughput no no
TCAF1_HUMAN [view interactions] High throughput no no
LOXL2_HUMAN [view interactions] High throughput no yes
ERAL1_HUMAN [view interactions] High throughput no yes
GCNT1_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
SYJ2B_HUMAN [view interactions] High throughput no no
TNFA_HUMAN [view interactions] High throughput no no
STA5B_HUMAN [view interactions] High throughput no yes
MELK_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
HSC20_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
INSR_HUMAN [view interactions] High throughput no yes
CD81_HUMAN [view interactions] High throughput no no
MET_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
FOXB1_HUMAN [view interactions] High throughput no no
RBM11_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
GIPC1_HUMAN [view entry] [view interactions] High throughput yes yes
CAPON_HUMAN [view entry] [view interactions] High throughput yes yes
SCN3A_HUMAN [view interactions] High throughput no yes
APBA2_HUMAN [view interactions] High throughput no yes
ITBP1_HUMAN [view interactions] High throughput no no
APC10_HUMAN [view interactions] High throughput no yes
FBX6_HUMAN [view interactions] High throughput no yes
CUBN_HUMAN [view interactions] High throughput no no
INT6_HUMAN [view interactions] High throughput no yes
SMOC1_HUMAN [view interactions] High throughput no no
CQ080_HUMAN [view interactions] High throughput no yes
LCOR_HUMAN [view interactions] High throughput no yes
SCMC2_HUMAN [view interactions] High throughput no yes
MTO1_HUMAN [view interactions] High throughput no yes
GLMP_HUMAN [view interactions] High throughput no no
S26A6_HUMAN [view interactions] High throughput no yes
GFPT1_HUMAN [view interactions] High throughput no no
PAPD1_HUMAN [view interactions] High throughput no yes
RUSD3_HUMAN [view interactions] High throughput no yes
SENP1_HUMAN [view entry] [view interactions] High throughput yes no
MP2K7_HUMAN [view entry] [view interactions] High throughput yes yes
RTEL1_HUMAN [view interactions] High throughput no no
LEG9_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
HNRPL_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
DUS10_HUMAN [view entry] [view interactions] High throughput yes yes
BRD1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
WDR76_HUMAN [view interactions] High throughput no no
FZR1_HUMAN [view interactions] High throughput no no
TROP_HUMAN [view interactions] High throughput no no
NXPH4_HUMAN [view interactions] High throughput no no
ADT2_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1C_HUMAN [view interactions] High throughput no yes
DD19B_HUMAN [view interactions] High throughput no yes
AN36B_HUMAN [view interactions] High throughput no no
PCSK5_HUMAN [view interactions] High throughput no yes
HXA4_HUMAN [view interactions] High throughput no yes
FOXF1_HUMAN [view interactions] High throughput no no
RB39B_HUMAN [view interactions] High throughput no no
TRM44_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes