Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

JIP1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI001935 CLV_C14_Caspase3-7 CLV 95 99 -
ELMI001936 CLV_C14_Caspase3-7 CLV 405 409 -
ELMI003088 DOC_MAPK_JIP1_4 DOC 160 166 -
ELMI004048 LIG_KLC1_Yacidic_2 LIG 707 711 -
ELMI004482 LIG_LIR_Gen_1 LIG 334 342 -
ELMI001935 CLV_C14_Caspase3-7 CLV 95 99 -
ELMI001936 CLV_C14_Caspase3-7 CLV 405 409 -
ELMI003088 DOC_MAPK_JIP1_4 DOC 160 166 -
ELMI004048 LIG_KLC1_Yacidic_2 LIG 707 711 -
ELMI004482 LIG_LIR_Gen_1 LIG 334 342 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in JIP1_HUMAN
GO:0019900 kinase binding 50.0000 4 yes
GO:0019901 protein kinase binding 43.7500 5 yes
GO:0000166 nucleotide binding 40.6250 4 no
GO:0017076 purine nucleotide binding 40.6250 5 no
GO:0032555 purine ribonucleotide binding 40.6250 4 no
GO:0043168 anion binding 40.6250 4 no
GO:0035639 purine ribonucleoside triphosphate binding 37.5000 4 no
GO:0043169 cation binding 37.5000 4 no
GO:0046872 metal ion binding 37.5000 5 no
GO:0030554 adenyl nucleotide binding 31.2500 6 no
GO:0032559 adenyl ribonucleotide binding 31.2500 5 no
GO:0005524 ATP binding 28.1250 5 no
GO:0016301 kinase activity 28.1250 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 28.1250 4 no
GO:0019894 kinesin binding 18.7500 4 yes
GO:0019887 protein kinase regulator activity 15.6250 4 yes
GO:0005078 MAP-kinase scaffold activity 12.5000 4 yes
GO:0008432 JUN kinase binding 12.5000 6 yes
GO:0004860 protein kinase inhibitor activity 9.3750 5 yes
GO:0019210 kinase inhibitor activity 9.3750 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in JIP1_HUMAN
GO:0048522 positive regulation of cellular process 75.0000 4 yes
GO:0010646 regulation of cell communication 71.8750 4 yes
GO:0009966 regulation of signal transduction 62.5000 4 yes
GO:0031323 regulation of cellular metabolic process 62.5000 4 yes
GO:0048523 negative regulation of cellular process 62.5000 4 yes
GO:0060255 regulation of macromolecule metabolic process 62.5000 4 yes
GO:1902531 regulation of intracellular signal transduction 59.3750 5 yes
GO:0051246 regulation of protein metabolic process 56.2500 5 yes
GO:0080090 regulation of primary metabolic process 56.2500 4 yes
GO:0009889 regulation of biosynthetic process 53.1250 4 yes
GO:0010468 regulation of gene expression 53.1250 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 53.1250 5 yes
GO:0031326 regulation of cellular biosynthetic process 53.1250 5 yes
GO:0009893 positive regulation of metabolic process 53.1250 4 no
GO:0010604 positive regulation of macromolecule metabolic process 53.1250 5 no
GO:0010647 positive regulation of cell communication 50.0000 5 yes
GO:0019220 regulation of phosphate metabolic process 50.0000 6 yes
GO:0031399 regulation of protein modification process 50.0000 6 yes
GO:0042325 regulation of phosphorylation 50.0000 7 yes
GO:0048584 positive regulation of response to stimulus 50.0000 4 yes
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 yes
GO:0141124 intracellular signaling cassette 50.0000 4 yes
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0009967 positive regulation of signal transduction 46.8750 5 yes
GO:0023056 positive regulation of signaling 46.8750 4 yes
GO:1902533 positive regulation of intracellular signal transduction 46.8750 6 yes
GO:0031325 positive regulation of cellular metabolic process 46.8750 5 no
GO:0051247 positive regulation of protein metabolic process 46.8750 6 no
GO:0001932 regulation of protein phosphorylation 46.8750 7 yes
GO:0008104 protein localization 43.7500 4 no
GO:0042981 regulation of apoptotic process 40.6250 5 yes
GO:0043067 regulation of programmed cell death 40.6250 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 40.6250 6 no
GO:0042327 positive regulation of phosphorylation 40.6250 8 no
GO:0045937 positive regulation of phosphate metabolic process 40.6250 7 no
GO:0030030 cell projection organization 40.6250 4 no
GO:0060341 regulation of cellular localization 40.6250 4 no
GO:1901701 cellular response to oxygen-containing compound 40.6250 4 no
GO:0051049 regulation of transport 40.6250 4 no
GO:0043549 regulation of kinase activity 37.5000 5 yes
GO:0051338 regulation of transferase activity 37.5000 4 yes
GO:0001934 positive regulation of protein phosphorylation 37.5000 8 no
GO:0031401 positive regulation of protein modification process 37.5000 7 no
GO:0032880 regulation of protein localization 37.5000 5 no
GO:0071310 cellular response to organic substance 37.5000 4 no
GO:0006355 regulation of DNA-templated transcription 34.3750 7 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 34.3750 5 yes
GO:0043066 negative regulation of apoptotic process 34.3750 6 yes
GO:0043069 negative regulation of programmed cell death 34.3750 5 yes
GO:0043408 regulation of MAPK cascade 34.3750 6 yes
GO:0045859 regulation of protein kinase activity 34.3750 6 yes
GO:0051252 regulation of RNA metabolic process 34.3750 5 yes
GO:2001141 regulation of RNA biosynthetic process 34.3750 6 yes
GO:0043085 positive regulation of catalytic activity 34.3750 4 no
GO:0009892 negative regulation of metabolic process 31.2500 4 yes
GO:0009968 negative regulation of signal transduction 31.2500 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 31.2500 5 yes
GO:0010648 negative regulation of cell communication 31.2500 5 yes
GO:0023057 negative regulation of signaling 31.2500 4 yes
GO:0031324 negative regulation of cellular metabolic process 31.2500 5 yes
GO:0043410 positive regulation of MAPK cascade 31.2500 7 yes
GO:0048585 negative regulation of response to stimulus 31.2500 4 yes
GO:0006796 phosphate-containing compound metabolic process 31.2500 4 no
GO:0009891 positive regulation of biosynthetic process 31.2500 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 31.2500 6 no
GO:0031328 positive regulation of cellular biosynthetic process 31.2500 6 no
GO:0036211 protein modification process 31.2500 4 no
GO:0043412 macromolecule modification 31.2500 4 no
GO:0022607 cellular component assembly 31.2500 4 no
GO:0051130 positive regulation of cellular component organization 31.2500 5 no
GO:0098657 import into cell 31.2500 4 no
GO:1903829 positive regulation of protein localization 31.2500 5 no
GO:0042127 regulation of cell population proliferation 28.1250 4 yes
GO:0016310 phosphorylation 28.1250 5 no
GO:0033674 positive regulation of kinase activity 28.1250 6 no
GO:0051347 positive regulation of transferase activity 28.1250 5 no
GO:0022603 regulation of anatomical structure morphogenesis 28.1250 4 no
GO:0010243 response to organonitrogen compound 28.1250 4 no
GO:0015031 protein transport 28.1250 4 no
GO:0071702 organic substance transport 28.1250 4 no
GO:0071705 nitrogen compound transport 28.1250 4 no
GO:0051240 positive regulation of multicellular organismal process 28.1250 4 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 yes
GO:0045860 positive regulation of protein kinase activity 25.0000 7 no
GO:0006996 organelle organization 25.0000 4 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:0034330 cell junction organization 25.0000 4 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0071417 cellular response to organonitrogen compound 25.0000 4 no
GO:1901699 cellular response to nitrogen compound 25.0000 4 no
GO:0071363 cellular response to growth factor stimulus 25.0000 4 no
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:1902532 negative regulation of intracellular signal transduction 21.8750 6 yes
GO:0045893 positive regulation of DNA-templated transcription 21.8750 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.8750 5 no
GO:0051254 positive regulation of RNA metabolic process 21.8750 6 no
GO:1902680 positive regulation of RNA biosynthetic process 21.8750 7 no
GO:0007167 enzyme-linked receptor protein signaling pathway 21.8750 4 no
GO:0010975 regulation of neuron projection development 21.8750 7 no
GO:0031344 regulation of cell projection organization 21.8750 5 no
GO:0048812 neuron projection morphogenesis 21.8750 5 no
GO:0050807 regulation of synapse organization 21.8750 5 no
GO:0050808 synapse organization 21.8750 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.8750 6 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 21.8750 4 no
GO:1905475 regulation of protein localization to membrane 21.8750 6 no
GO:1905477 positive regulation of protein localization to membrane 21.8750 6 no
GO:2000026 regulation of multicellular organismal development 21.8750 4 no
GO:0080134 regulation of response to stress 21.8750 4 no
GO:0009890 negative regulation of biosynthetic process 21.8750 5 no
GO:0009894 regulation of catabolic process 21.8750 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.8750 6 no
GO:0030334 regulation of cell migration 21.8750 5 no
GO:0031327 negative regulation of cellular biosynthetic process 21.8750 6 no
GO:2000145 regulation of cell motility 21.8750 4 no
GO:0010628 positive regulation of gene expression 21.8750 7 no
GO:0070201 regulation of establishment of protein localization 21.8750 6 no
GO:0000165 MAPK cascade 21.8750 5 yes
GO:0007254 JNK cascade 18.7500 6 yes
GO:0031400 negative regulation of protein modification process 18.7500 7 yes
GO:0043086 negative regulation of catalytic activity 18.7500 4 yes
GO:0046328 regulation of JNK cascade 18.7500 7 yes
GO:0050865 regulation of cell activation 18.7500 4 yes
GO:0071900 regulation of protein serine/threonine kinase activity 18.7500 7 yes
GO:2001233 regulation of apoptotic signaling pathway 18.7500 5 yes
GO:2001234 negative regulation of apoptotic signaling pathway 18.7500 6 yes
GO:0002694 regulation of leukocyte activation 18.7500 4 yes
GO:0010563 negative regulation of phosphorus metabolic process 15.6250 6 yes
GO:0033673 negative regulation of kinase activity 15.6250 6 yes
GO:0042326 negative regulation of phosphorylation 15.6250 8 yes
GO:0043405 regulation of MAP kinase activity 15.6250 8 yes
GO:0045936 negative regulation of phosphate metabolic process 15.6250 7 yes
GO:0046330 positive regulation of JNK cascade 15.6250 8 yes
GO:0050863 regulation of T cell activation 15.6250 6 yes
GO:0051249 regulation of lymphocyte activation 15.6250 5 yes
GO:0051348 negative regulation of transferase activity 15.6250 5 yes
GO:2001242 regulation of intrinsic apoptotic signaling pathway 15.6250 6 yes
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 15.6250 7 yes
GO:0006469 negative regulation of protein kinase activity 12.5000 7 yes
GO:0043506 regulation of JUN kinase activity 12.5000 9 yes
GO:0001933 negative regulation of protein phosphorylation 12.5000 8 yes
GO:0032944 regulation of mononuclear cell proliferation 9.3750 6 yes
GO:0042129 regulation of T cell proliferation 9.3750 7 yes
GO:0050670 regulation of lymphocyte proliferation 9.3750 6 yes
GO:0070663 regulation of leukocyte proliferation 9.3750 5 yes
GO:0071901 negative regulation of protein serine/threonine kinase activity 9.3750 8 yes
GO:0043407 negative regulation of MAP kinase activity 6.2500 8 yes
GO:0043409 negative regulation of MAPK cascade 6.2500 7 yes
GO:0043508 negative regulation of JUN kinase activity 6.2500 9 yes
GO:0046329 negative regulation of JNK cascade 6.2500 8 yes
GO:0046634 regulation of alpha-beta T cell activation 6.2500 7 yes
GO:0046640 regulation of alpha-beta T cell proliferation 6.2500 8 yes
GO:2000564 regulation of CD8-positive, alpha-beta T cell proliferation 6.2500 9 yes
GO:2001185 regulation of CD8-positive, alpha-beta T cell activation 6.2500 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CALX_HUMAN [view entry] [view interactions] Low throughput yes yes
TIAM1_HUMAN [view entry] [view interactions] Low throughput yes yes
M3K11_HUMAN [view interactions] Low throughput no yes
MK09_HUMAN [view interactions] Low throughput no yes
DUS16_HUMAN [view interactions] Low throughput no yes
PAX2_HUMAN [view interactions] Low throughput no no
M3K13_HUMAN [view interactions] Low throughput no yes
SOCS3_HUMAN [view interactions] Low throughput no yes
MP2K3_HUMAN [view entry] [view interactions] Low throughput yes yes
JUN_HUMAN [view interactions] Low throughput no yes
PARK7_HUMAN [view entry] [view interactions] Low throughput yes yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
MTAP_HUMAN [view interactions] Low throughput no no
KLC1_HUMAN [view entry] [view interactions] Low throughput yes no
RAB10_HUMAN [view entry] [view interactions] Low throughput yes yes
MK10_HUMAN [view entry] [view interactions] Low throughput yes yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
LRP2_HUMAN [view interactions] Low throughput no no
LRP1_HUMAN [view entry] [view interactions] Low throughput yes yes
LRP8_HUMAN [view entry] [view interactions] Low throughput yes no
LRP1B_HUMAN [view interactions] Low throughput no yes
LRP4_HUMAN [view entry] [view interactions] Low throughput yes yes
JIP3_HUMAN [view entry] [view interactions] Low throughput yes yes
M3K12_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRK2_HUMAN [view interactions] Low throughput no yes
MK08_HUMAN [view interactions] Low throughput no yes
VRK2_HUMAN [view interactions] Low throughput no no
M3K7_HUMAN [view interactions] Low throughput no yes
MP2K7_HUMAN [view entry] [view interactions] Low throughput yes yes
AKT1_HUMAN [view entry] [view interactions] Low throughput yes yes
TAB1_HUMAN [view interactions] Low throughput no yes
JIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
FYN_HUMAN [view entry] [view interactions] High throughput yes no
VP26C_HUMAN [view interactions] High throughput no yes
RSPH1_HUMAN [view interactions] High throughput no no
M3K10_HUMAN [view interactions] High throughput no yes
JIP2_HUMAN [view entry] [view interactions] High throughput yes no
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
SETX_HUMAN [view interactions] High throughput no yes
ACK1_HUMAN [view entry] [view interactions] High throughput yes yes
SH3R3_HUMAN [view interactions] High throughput no yes
TBB8_HUMAN [view interactions] High throughput no no
KEAP1_HUMAN [view interactions] High throughput no yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
GNA13_HUMAN [view entry] [view interactions] High throughput yes yes
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
ITA6_HUMAN [view interactions] High throughput no yes
TSPO_HUMAN [view interactions] High throughput no yes
LNP_HUMAN [view interactions] High throughput no yes
ANK3_HUMAN [view entry] [view interactions] High throughput yes yes
HXC8_HUMAN [view interactions] High throughput no no
TBB3_HUMAN [view entry] [view interactions] High throughput yes yes
TTLL4_HUMAN [view interactions] High throughput no yes
SENP5_HUMAN [view entry] [view interactions] High throughput yes no
FEM1B_HUMAN [view interactions] High throughput no yes
ITB3_HUMAN [view entry] [view interactions] High throughput yes no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
RECQ5_HUMAN [view interactions] High throughput no no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no