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JIP1_HUMAN

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells. [View more on UniProt]

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ELM instance Name Type Start End Partner
ELMI001935 CLV_C14_Caspase3-7 CLV 95 99 -
ELMI001936 CLV_C14_Caspase3-7 CLV 405 409 -
ELMI003088 DOC_MAPK_JIP1_4 DOC 160 166 -
ELMI004048 LIG_KLC1_Yacidic_2 LIG 707 711 -
ELMI004482 LIG_LIR_Gen_1 LIG 334 342 -

Molecular function

Term Name % Distance from the top of the tree Annotated in JIP1_HUMAN
GO:0019900 kinase binding 45.1613 4 yes
GO:0017076 purine nucleotide binding 38.7097 4 no
GO:0032555 purine ribonucleotide binding 38.7097 4 no
GO:0019901 protein kinase binding 35.4839 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 35.4839 4 no
GO:0030554 adenyl nucleotide binding 29.0323 5 no
GO:0032559 adenyl ribonucleotide binding 29.0323 5 no
GO:0046872 metal ion binding 29.0323 4 no
GO:0005524 ATP binding 25.8065 5 no
GO:0016301 kinase activity 25.8065 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 25.8065 4 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 22.5806 4 no
GO:0019894 kinesin binding 16.1290 4 yes
GO:0005078 MAP-kinase scaffold activity 12.9032 4 yes
GO:0019887 protein kinase regulator activity 12.9032 4 yes
GO:0004860 protein kinase inhibitor activity 6.4516 5 yes
GO:0019210 kinase inhibitor activity 6.4516 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in JIP1_HUMAN
GO:0010646 regulation of cell communication 77.4194 4 yes
GO:0048522 positive regulation of cellular process 74.1935 4 yes
GO:0048523 negative regulation of cellular process 67.7419 4 yes
GO:0009966 regulation of signal transduction 64.5161 4 yes
GO:0060255 regulation of macromolecule metabolic process 64.5161 4 yes
GO:0031323 regulation of cellular metabolic process 58.0645 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 58.0645 4 yes
GO:0080090 regulation of primary metabolic process 58.0645 4 yes
GO:0010468 regulation of gene expression 54.8387 5 yes
GO:0051246 regulation of protein metabolic process 54.8387 5 yes
GO:0009893 positive regulation of metabolic process 51.6129 4 no
GO:0010604 positive regulation of macromolecule metabolic process 51.6129 5 no
GO:0019220 regulation of phosphate metabolic process 51.6129 6 yes
GO:0031399 regulation of protein modification process 51.6129 6 yes
GO:0042325 regulation of phosphorylation 51.6129 7 yes
GO:0051174 regulation of phosphorus metabolic process 51.6129 5 yes
GO:1902531 regulation of intracellular signal transduction 51.6129 5 yes
GO:0001932 regulation of protein phosphorylation 48.3871 7 yes
GO:0051049 regulation of transport 45.1613 4 no
GO:0051128 regulation of cellular component organization 45.1613 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 45.1613 5 no
GO:0051247 positive regulation of protein metabolic process 45.1613 6 no
GO:0010647 positive regulation of cell communication 45.1613 5 yes
GO:0010941 regulation of cell death 45.1613 4 yes
GO:0043085 positive regulation of catalytic activity 41.9355 4 no
GO:0060341 regulation of cellular localization 41.9355 4 no
GO:0071310 cellular response to organic substance 41.9355 4 no
GO:0030030 cell projection organization 41.9355 4 no
GO:0009889 regulation of biosynthetic process 41.9355 4 yes
GO:0009967 positive regulation of signal transduction 41.9355 5 yes
GO:0016192 vesicle-mediated transport 41.9355 4 yes
GO:0023056 positive regulation of signaling 41.9355 4 yes
GO:0031326 regulation of cellular biosynthetic process 41.9355 5 yes
GO:0048584 positive regulation of response to stimulus 41.9355 4 yes
GO:1903506 regulation of nucleic acid-templated transcription 38.7097 7 yes
GO:2001141 regulation of RNA biosynthetic process 38.7097 6 yes
GO:0008104 protein localization 38.7097 4 no
GO:0010562 positive regulation of phosphorus metabolic process 38.7097 6 no
GO:0031325 positive regulation of cellular metabolic process 38.7097 5 no
GO:0032880 regulation of protein localization 38.7097 5 no
GO:0042327 positive regulation of phosphorylation 38.7097 8 no
GO:0045937 positive regulation of phosphate metabolic process 38.7097 7 no
GO:1901701 cellular response to oxygen-containing compound 38.7097 4 no
GO:0006355 regulation of DNA-templated transcription 38.7097 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 38.7097 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 38.7097 5 yes
GO:0043549 regulation of kinase activity 38.7097 5 yes
GO:0051252 regulation of RNA metabolic process 38.7097 5 yes
GO:0051338 regulation of transferase activity 38.7097 4 yes
GO:1902533 positive regulation of intracellular signal transduction 38.7097 6 yes
GO:0001934 positive regulation of protein phosphorylation 35.4839 8 no
GO:0031401 positive regulation of protein modification process 35.4839 7 no
GO:1903829 positive regulation of protein localization 35.4839 5 no
GO:0009892 negative regulation of metabolic process 35.4839 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 35.4839 5 yes
GO:0010648 negative regulation of cell communication 35.4839 5 yes
GO:0023057 negative regulation of signaling 35.4839 4 yes
GO:0031324 negative regulation of cellular metabolic process 35.4839 5 yes
GO:0036211 protein modification process 35.4839 4 yes
GO:0042981 regulation of apoptotic process 35.4839 6 yes
GO:0043067 regulation of programmed cell death 35.4839 5 yes
GO:0043412 macromolecule modification 35.4839 4 yes
GO:0045859 regulation of protein kinase activity 35.4839 6 yes
GO:0048585 negative regulation of response to stimulus 35.4839 4 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 35.4839 5 yes
GO:0080134 regulation of response to stress 35.4839 4 yes
GO:0033674 positive regulation of kinase activity 32.2581 6 no
GO:0043269 regulation of ion transport 32.2581 5 no
GO:0051050 positive regulation of transport 32.2581 4 no
GO:0051336 regulation of hydrolase activity 32.2581 4 no
GO:0051347 positive regulation of transferase activity 32.2581 5 no
GO:0009968 negative regulation of signal transduction 32.2581 5 yes
GO:0060548 negative regulation of cell death 32.2581 5 yes
GO:0080135 regulation of cellular response to stress 32.2581 4 yes
GO:0015031 protein transport 29.0323 4 no
GO:0034762 regulation of transmembrane transport 29.0323 4 no
GO:0045860 positive regulation of protein kinase activity 29.0323 7 no
GO:0071702 organic substance transport 29.0323 4 no
GO:0071705 nitrogen compound transport 29.0323 4 no
GO:0022607 cellular component assembly 29.0323 4 no
GO:0051130 positive regulation of cellular component organization 29.0323 5 no
GO:0006796 phosphate-containing compound metabolic process 29.0323 4 yes
GO:0042127 regulation of cell population proliferation 29.0323 4 yes
GO:0043408 regulation of MAPK cascade 29.0323 6 yes
GO:0043410 positive regulation of MAPK cascade 29.0323 7 yes
GO:0051248 negative regulation of protein metabolic process 29.0323 6 yes
GO:0010243 response to organonitrogen compound 25.8065 4 no
GO:0031344 regulation of cell projection organization 25.8065 5 no
GO:0045595 regulation of cell differentiation 25.8065 4 no
GO:0070848 response to growth factor 25.8065 4 no
GO:0071363 cellular response to growth factor stimulus 25.8065 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.8065 6 no
GO:0022603 regulation of anatomical structure morphogenesis 25.8065 4 no
GO:0034765 regulation of ion transmembrane transport 25.8065 5 no
GO:0031175 neuron projection development 25.8065 6 no
GO:0120036 plasma membrane bounded cell projection organization 25.8065 5 no
GO:0006468 protein phosphorylation 25.8065 5 yes
GO:0016310 phosphorylation 25.8065 5 yes
GO:0031400 negative regulation of protein modification process 25.8065 7 yes
GO:0043066 negative regulation of apoptotic process 25.8065 7 yes
GO:0043069 negative regulation of programmed cell death 25.8065 6 yes
GO:0006996 organelle organization 22.5806 4 no
GO:0009891 positive regulation of biosynthetic process 22.5806 5 no
GO:0009894 regulation of catabolic process 22.5806 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.5806 6 no
GO:0010975 regulation of neuron projection development 22.5806 7 no
GO:0030334 regulation of cell migration 22.5806 5 no
GO:0031328 positive regulation of cellular biosynthetic process 22.5806 6 no
GO:0045893 positive regulation of DNA-templated transcription 22.5806 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 22.5806 6 no
GO:0051129 negative regulation of cellular component organization 22.5806 5 no
GO:0051240 positive regulation of multicellular organismal process 22.5806 4 no
GO:0051254 positive regulation of RNA metabolic process 22.5806 6 no
GO:0051345 positive regulation of hydrolase activity 22.5806 5 no
GO:0071417 cellular response to organonitrogen compound 22.5806 4 no
GO:1901214 regulation of neuron death 22.5806 5 no
GO:1901699 cellular response to nitrogen compound 22.5806 4 no
GO:1902680 positive regulation of RNA biosynthetic process 22.5806 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 22.5806 8 no
GO:1905475 regulation of protein localization to membrane 22.5806 6 no
GO:1905477 positive regulation of protein localization to membrane 22.5806 6 no
GO:2000145 regulation of cell motility 22.5806 4 no
GO:0006897 endocytosis 22.5806 5 no
GO:0032990 cell part morphogenesis 22.5806 4 no
GO:0034330 cell junction organization 22.5806 4 no
GO:0048812 neuron projection morphogenesis 22.5806 7 no
GO:0048858 cell projection morphogenesis 22.5806 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 22.5806 6 no
GO:1904062 regulation of cation transmembrane transport 22.5806 6 no
GO:0043933 protein-containing complex organization 22.5806 4 no
GO:0050804 modulation of chemical synaptic transmission 22.5806 5 no
GO:0070201 regulation of establishment of protein localization 22.5806 6 no
GO:0099177 regulation of trans-synaptic signaling 22.5806 4 no
GO:0010563 negative regulation of phosphorus metabolic process 22.5806 6 yes
GO:0043086 negative regulation of catalytic activity 22.5806 4 yes
GO:0045936 negative regulation of phosphate metabolic process 22.5806 7 yes
GO:0050865 regulation of cell activation 22.5806 4 yes
GO:0071900 regulation of protein serine/threonine kinase activity 22.5806 7 yes
GO:0002694 regulation of leukocyte activation 19.3548 4 yes
GO:0032872 regulation of stress-activated MAPK cascade 19.3548 6 yes
GO:0032874 positive regulation of stress-activated MAPK cascade 19.3548 7 yes
GO:0042326 negative regulation of phosphorylation 19.3548 8 yes
GO:0043405 regulation of MAP kinase activity 19.3548 8 yes
GO:0046328 regulation of JNK cascade 19.3548 7 yes
GO:0070302 regulation of stress-activated protein kinase signaling cascade 19.3548 5 yes
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 19.3548 6 yes
GO:2001233 regulation of apoptotic signaling pathway 16.1290 5 yes
GO:2001234 negative regulation of apoptotic signaling pathway 16.1290 6 yes
GO:0001933 negative regulation of protein phosphorylation 16.1290 8 yes
GO:0033673 negative regulation of kinase activity 16.1290 6 yes
GO:0046330 positive regulation of JNK cascade 16.1290 8 yes
GO:0050863 regulation of T cell activation 16.1290 6 yes
GO:0051249 regulation of lymphocyte activation 16.1290 5 yes
GO:0051348 negative regulation of transferase activity 16.1290 5 yes
GO:1902532 negative regulation of intracellular signal transduction 16.1290 6 yes
GO:2001242 regulation of intrinsic apoptotic signaling pathway 12.9032 6 yes
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 12.9032 7 yes
GO:0006469 negative regulation of protein kinase activity 12.9032 7 yes
GO:0043506 regulation of JUN kinase activity 12.9032 9 yes
GO:0032944 regulation of mononuclear cell proliferation 9.6774 6 yes
GO:0042129 regulation of T cell proliferation 9.6774 7 yes
GO:0050670 regulation of lymphocyte proliferation 9.6774 6 yes
GO:0070663 regulation of leukocyte proliferation 9.6774 5 yes
GO:0071901 negative regulation of protein serine/threonine kinase activity 9.6774 8 yes
GO:2000564 regulation of CD8-positive, alpha-beta T cell proliferation 6.4516 9 yes
GO:2001185 regulation of CD8-positive, alpha-beta T cell activation 6.4516 8 yes
GO:0007258 JUN phosphorylation 6.4516 6 yes
GO:0032873 negative regulation of stress-activated MAPK cascade 6.4516 7 yes
GO:0043407 negative regulation of MAP kinase activity 6.4516 8 yes
GO:0043409 negative regulation of MAPK cascade 6.4516 7 yes
GO:0043508 negative regulation of JUN kinase activity 6.4516 9 yes
GO:0046329 negative regulation of JNK cascade 6.4516 8 yes
GO:0046634 regulation of alpha-beta T cell activation 6.4516 7 yes
GO:0046640 regulation of alpha-beta T cell proliferation 6.4516 8 yes
GO:0070303 negative regulation of stress-activated protein kinase signaling cascade 6.4516 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in JIP1_HUMAN
DOID:0050686 organ system cancer 6.4516 3 no
DOID:331 central nervous system disease 6.4516 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KLC1_HUMAN [view entry] [view interactions] Low throughput yes no
RAB10_HUMAN [view entry] [view interactions] Low throughput yes yes
MK10_HUMAN [view entry] [view interactions] Low throughput yes yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
LRP2_HUMAN [view interactions] Low throughput no no
LRP1_HUMAN [view entry] [view interactions] Low throughput yes yes
LRP8_HUMAN [view entry] [view interactions] Low throughput yes no
LRP1B_HUMAN [view interactions] Low throughput no yes
LRP4_HUMAN [view entry] [view interactions] Low throughput yes yes
JIP3_HUMAN [view entry] [view interactions] Low throughput yes yes
M3K12_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRK2_HUMAN [view interactions] Low throughput no yes
MK08_HUMAN [view interactions] Low throughput no yes
VRK2_HUMAN [view interactions] Low throughput no no
M3K7_HUMAN [view interactions] Low throughput no yes
MP2K7_HUMAN [view entry] [view interactions] Low throughput yes yes
AKT1_HUMAN [view entry] [view interactions] Low throughput yes yes
TAB1_HUMAN [view interactions] Low throughput no yes
JIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
CALX_HUMAN [view entry] [view interactions] Low throughput yes yes
TIAM1_HUMAN [view entry] [view interactions] Low throughput yes yes
M3K11_HUMAN [view interactions] Low throughput no yes
MK09_HUMAN [view interactions] Low throughput no yes
DUS16_HUMAN [view interactions] Low throughput no yes
PAX2_HUMAN [view interactions] Low throughput no no
M3K13_HUMAN [view interactions] Low throughput no yes
SOCS3_HUMAN [view interactions] Low throughput no yes
MP2K3_HUMAN [view entry] [view interactions] Low throughput yes yes
JUN_HUMAN [view interactions] Low throughput no yes
PARK7_HUMAN [view entry] [view interactions] Low throughput yes yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
MTAP_HUMAN [view interactions] Low throughput no no
SH3R3_HUMAN [view interactions] High throughput no yes
TBB8_HUMAN [view interactions] High throughput no no
KEAP1_HUMAN [view interactions] High throughput no yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
GNA13_HUMAN [view entry] [view interactions] High throughput yes yes
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
ITA6_HUMAN [view interactions] High throughput no yes
TSPO_HUMAN [view interactions] High throughput no yes
FEM1B_HUMAN [view interactions] High throughput no yes
TTLL4_HUMAN [view interactions] High throughput no yes
TBB3_HUMAN [view entry] [view interactions] High throughput yes yes
HXC8_HUMAN [view interactions] High throughput no no
ANK3_HUMAN [view entry] [view interactions] High throughput yes yes
SENP5_HUMAN [view interactions] High throughput no no
ITB3_HUMAN [view entry] [view interactions] High throughput yes no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
RECQ5_HUMAN [view interactions] High throughput no no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
FYN_HUMAN [view entry] [view interactions] High throughput yes no
M3K10_HUMAN [view interactions] High throughput no yes
JIP2_HUMAN [view entry] [view interactions] High throughput yes no
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
SETX_HUMAN [view interactions] High throughput no yes
ACK1_HUMAN [view interactions] High throughput no yes
M4K1_HUMAN [view interactions] Computational no no
RIMB2_HUMAN [view entry] [view interactions] Computational yes no
RIMB1_HUMAN [view interactions] Computational no yes
JIP4_HUMAN [view interactions] Computational no yes
ARG28_HUMAN [view interactions] Computational no yes
KLC4_HUMAN [view interactions] Computational no yes