Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

M3K12_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Part of a non-canonical MAPK signaling pathway (PubMed). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed). May be an activator of the JNK/SAPK pathway. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in M3K12_HUMAN
GO:0019900 kinase binding 50.0000 4 yes
GO:0019901 protein kinase binding 50.0000 5 yes
GO:0000166 nucleotide binding 43.7500 4 yes
GO:0005524 ATP binding 43.7500 5 yes
GO:0017076 purine nucleotide binding 43.7500 5 yes
GO:0030554 adenyl nucleotide binding 43.7500 6 yes
GO:0032555 purine ribonucleotide binding 43.7500 4 yes
GO:0032559 adenyl ribonucleotide binding 43.7500 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 43.7500 4 yes
GO:0043168 anion binding 43.7500 4 yes
GO:0003723 RNA binding 37.5000 4 no
GO:0019887 protein kinase regulator activity 31.2500 4 yes
GO:0042803 protein homodimerization activity 31.2500 4 yes
GO:0004674 protein serine/threonine kinase activity 25.0000 4 yes
GO:0016301 kinase activity 25.0000 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 25.0000 4 yes
GO:0106310 protein serine kinase activity 25.0000 4 yes
GO:0043169 cation binding 25.0000 4 no
GO:0046872 metal ion binding 25.0000 5 no
GO:0019209 kinase activator activity 18.7500 4 yes
GO:0030295 protein kinase activator activity 18.7500 5 yes
GO:0004706 JUN kinase kinase kinase activity 12.5000 6 yes
GO:0004709 MAP kinase kinase kinase activity 12.5000 5 yes
GO:0043539 protein serine/threonine kinase activator activity 12.5000 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in M3K12_HUMAN
GO:0009889 regulation of biosynthetic process 81.2500 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 81.2500 5 yes
GO:0031323 regulation of cellular metabolic process 81.2500 4 yes
GO:0031326 regulation of cellular biosynthetic process 81.2500 5 yes
GO:0048522 positive regulation of cellular process 81.2500 4 yes
GO:0048523 negative regulation of cellular process 81.2500 4 yes
GO:0060255 regulation of macromolecule metabolic process 81.2500 4 yes
GO:0080090 regulation of primary metabolic process 81.2500 4 yes
GO:0010468 regulation of gene expression 75.0000 6 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 75.0000 5 yes
GO:0048584 positive regulation of response to stimulus 75.0000 4 yes
GO:0009966 regulation of signal transduction 68.7500 4 yes
GO:0009967 positive regulation of signal transduction 68.7500 5 yes
GO:0010646 regulation of cell communication 68.7500 4 yes
GO:0010647 positive regulation of cell communication 68.7500 5 yes
GO:0023056 positive regulation of signaling 68.7500 4 yes
GO:0009893 positive regulation of metabolic process 62.5000 4 yes
GO:0031325 positive regulation of cellular metabolic process 62.5000 5 yes
GO:0042981 regulation of apoptotic process 62.5000 5 yes
GO:0043067 regulation of programmed cell death 62.5000 4 yes
GO:0051252 regulation of RNA metabolic process 62.5000 5 yes
GO:0006355 regulation of DNA-templated transcription 56.2500 7 yes
GO:0009891 positive regulation of biosynthetic process 56.2500 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 56.2500 6 yes
GO:0010604 positive regulation of macromolecule metabolic process 56.2500 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 56.2500 6 yes
GO:0051246 regulation of protein metabolic process 56.2500 5 yes
GO:0141124 intracellular signaling cassette 56.2500 4 yes
GO:1902531 regulation of intracellular signal transduction 56.2500 5 yes
GO:1902533 positive regulation of intracellular signal transduction 56.2500 6 yes
GO:2001141 regulation of RNA biosynthetic process 56.2500 6 yes
GO:0001932 regulation of protein phosphorylation 50.0000 7 yes
GO:0019220 regulation of phosphate metabolic process 50.0000 6 yes
GO:0031399 regulation of protein modification process 50.0000 6 yes
GO:0042325 regulation of phosphorylation 50.0000 7 yes
GO:0043066 negative regulation of apoptotic process 50.0000 6 yes
GO:0043069 negative regulation of programmed cell death 50.0000 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 50.0000 5 yes
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 yes
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0051247 positive regulation of protein metabolic process 43.7500 6 yes
GO:0051128 regulation of cellular component organization 43.7500 4 no
GO:0010605 negative regulation of macromolecule metabolic process 43.7500 5 no
GO:0031324 negative regulation of cellular metabolic process 43.7500 5 no
GO:0001934 positive regulation of protein phosphorylation 37.5000 8 yes
GO:0010562 positive regulation of phosphorus metabolic process 37.5000 6 yes
GO:0031401 positive regulation of protein modification process 37.5000 7 yes
GO:0042327 positive regulation of phosphorylation 37.5000 8 yes
GO:0043085 positive regulation of catalytic activity 37.5000 4 yes
GO:0043549 regulation of kinase activity 37.5000 5 yes
GO:0045859 regulation of protein kinase activity 37.5000 6 yes
GO:0045893 positive regulation of DNA-templated transcription 37.5000 8 yes
GO:0045937 positive regulation of phosphate metabolic process 37.5000 7 yes
GO:0051254 positive regulation of RNA metabolic process 37.5000 6 yes
GO:0051338 regulation of transferase activity 37.5000 4 yes
GO:1902680 positive regulation of RNA biosynthetic process 37.5000 7 yes
GO:0008104 protein localization 37.5000 4 no
GO:0009894 regulation of catabolic process 37.5000 4 no
GO:0000165 MAPK cascade 31.2500 5 yes
GO:0006796 phosphate-containing compound metabolic process 31.2500 4 yes
GO:0007254 JNK cascade 31.2500 6 yes
GO:0033674 positive regulation of kinase activity 31.2500 6 yes
GO:0043408 regulation of MAPK cascade 31.2500 6 yes
GO:0043410 positive regulation of MAPK cascade 31.2500 7 yes
GO:0045860 positive regulation of protein kinase activity 31.2500 7 yes
GO:0051347 positive regulation of transferase activity 31.2500 5 yes
GO:0033365 protein localization to organelle 31.2500 5 no
GO:0051049 regulation of transport 31.2500 4 no
GO:0022607 cellular component assembly 31.2500 4 no
GO:0043933 protein-containing complex organization 31.2500 4 no
GO:0065003 protein-containing complex assembly 31.2500 5 no
GO:0016310 phosphorylation 25.0000 5 yes
GO:0036211 protein modification process 25.0000 4 yes
GO:0043405 regulation of MAP kinase activity 25.0000 8 yes
GO:0043412 macromolecule modification 25.0000 4 yes
GO:0043506 regulation of JUN kinase activity 25.0000 9 yes
GO:0071900 regulation of protein serine/threonine kinase activity 25.0000 7 yes
GO:0006886 intracellular protein transport 25.0000 4 no
GO:0015031 protein transport 25.0000 4 no
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0072594 establishment of protein localization to organelle 25.0000 4 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0031344 regulation of cell projection organization 25.0000 5 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.0000 6 no
GO:0006915 apoptotic process 25.0000 4 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0010628 positive regulation of gene expression 25.0000 7 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0009890 negative regulation of biosynthetic process 25.0000 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0031327 negative regulation of cellular biosynthetic process 25.0000 6 no
GO:0006468 protein phosphorylation 18.7500 5 yes
GO:0018105 peptidyl-serine phosphorylation 18.7500 6 yes
GO:0018193 peptidyl-amino acid modification 18.7500 5 yes
GO:0018209 peptidyl-serine modification 18.7500 6 yes
GO:0043406 positive regulation of MAP kinase activity 18.7500 8 yes
GO:0043507 positive regulation of JUN kinase activity 18.7500 9 yes
GO:0043523 regulation of neuron apoptotic process 18.7500 6 yes
GO:0046777 protein autophosphorylation 18.7500 6 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 18.7500 7 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 18.7500 8 yes
GO:0071902 positive regulation of protein serine/threonine kinase activity 18.7500 8 yes
GO:2000671 regulation of motor neuron apoptotic process 18.7500 7 yes
GO:0043524 negative regulation of neuron apoptotic process 12.5000 7 yes
GO:0043687 post-translational protein modification 12.5000 5 yes
GO:2000672 negative regulation of motor neuron apoptotic process 12.5000 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
M3K12_HUMAN [view entry] [view interactions] Low throughput yes yes
JIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
F10C1_HUMAN [view interactions] Low throughput no yes
EGFR_HUMAN [view interactions] Low throughput no no
MBIP1_HUMAN [view interactions] Low throughput no yes
MP2K7_HUMAN [view entry] [view interactions] Low throughput yes yes
FKBPL_HUMAN [view interactions] Low throughput no yes
FKBP4_HUMAN [view entry] [view interactions] Low throughput yes yes
FKBP8_HUMAN [view entry] [view interactions] Low throughput yes yes
MP2K4_HUMAN [view interactions] Low throughput no yes
MK06_HUMAN [view interactions] High throughput no yes
US6NL_HUMAN [view interactions] High throughput no yes
KLF16_HUMAN [view interactions] High throughput no yes
MOT1_HUMAN [view interactions] High throughput no no
SYYC_HUMAN [view interactions] High throughput no yes
MTOR_HUMAN [view entry] [view interactions] High throughput yes yes
PP2BA_HUMAN [view entry] [view interactions] High throughput yes yes
CANB1_HUMAN [view entry] [view interactions] High throughput yes yes
T22D1_HUMAN [view interactions] High throughput no no
FRIL_HUMAN [view interactions] High throughput no yes
RGS1_HUMAN [view interactions] High throughput no yes
RL18A_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
JIP2_HUMAN [view entry] [view interactions] High throughput yes no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
INT14_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
LYRIC_HUMAN [view entry] [view interactions] High throughput yes yes