Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

M3K12_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Part of a non-canonical MAPK signaling pathway (PubMed). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed). May be an activator of the JNK/SAPK pathway. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in M3K12_HUMAN
GO:0019900 kinase binding 56.2500 4 yes
GO:0019901 protein kinase binding 56.2500 5 yes
GO:0005524 ATP binding 50.0000 5 yes
GO:0017076 purine nucleotide binding 50.0000 4 yes
GO:0030554 adenyl nucleotide binding 50.0000 5 yes
GO:0032555 purine ribonucleotide binding 50.0000 4 yes
GO:0032559 adenyl ribonucleotide binding 50.0000 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 50.0000 4 yes
GO:0004674 protein serine/threonine kinase activity 37.5000 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 37.5000 4 yes
GO:0016301 kinase activity 37.5000 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 37.5000 4 yes
GO:0019887 protein kinase regulator activity 37.5000 4 yes
GO:0106310 protein serine kinase activity 37.5000 4 yes
GO:0042803 protein homodimerization activity 31.2500 4 yes
GO:0003723 RNA binding 31.2500 4 no
GO:0019209 kinase activator activity 25.0000 4 yes
GO:0030295 protein kinase activator activity 25.0000 5 yes
GO:0046872 metal ion binding 25.0000 4 no
GO:0004706 JUN kinase kinase kinase activity 12.5000 6 yes
GO:0004709 MAP kinase kinase kinase activity 12.5000 5 yes
GO:0043539 protein serine/threonine kinase activator activity 12.5000 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in M3K12_HUMAN
GO:0048522 positive regulation of cellular process 87.5000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 87.5000 4 yes
GO:0060255 regulation of macromolecule metabolic process 87.5000 4 yes
GO:0080090 regulation of primary metabolic process 87.5000 4 yes
GO:0009893 positive regulation of metabolic process 81.2500 4 yes
GO:0031323 regulation of cellular metabolic process 81.2500 4 yes
GO:0010468 regulation of gene expression 75.0000 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 75.0000 5 yes
GO:0010646 regulation of cell communication 75.0000 4 yes
GO:0031325 positive regulation of cellular metabolic process 75.0000 5 yes
GO:0048584 positive regulation of response to stimulus 75.0000 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 75.0000 5 yes
GO:0009889 regulation of biosynthetic process 68.7500 4 yes
GO:0009966 regulation of signal transduction 68.7500 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 68.7500 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 68.7500 5 yes
GO:0031326 regulation of cellular biosynthetic process 68.7500 5 yes
GO:0048523 negative regulation of cellular process 68.7500 4 yes
GO:0051246 regulation of protein metabolic process 68.7500 5 yes
GO:1902531 regulation of intracellular signal transduction 68.7500 5 yes
GO:0009967 positive regulation of signal transduction 62.5000 5 yes
GO:0010647 positive regulation of cell communication 62.5000 5 yes
GO:0023056 positive regulation of signaling 62.5000 4 yes
GO:0031399 regulation of protein modification process 62.5000 6 yes
GO:0051247 positive regulation of protein metabolic process 62.5000 6 yes
GO:0001932 regulation of protein phosphorylation 56.2500 7 yes
GO:0009891 positive regulation of biosynthetic process 56.2500 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 56.2500 6 yes
GO:0010941 regulation of cell death 56.2500 4 yes
GO:0019220 regulation of phosphate metabolic process 56.2500 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 56.2500 6 yes
GO:0031401 positive regulation of protein modification process 56.2500 7 yes
GO:0042325 regulation of phosphorylation 56.2500 7 yes
GO:0042981 regulation of apoptotic process 56.2500 6 yes
GO:0043067 regulation of programmed cell death 56.2500 5 yes
GO:0043549 regulation of kinase activity 56.2500 5 yes
GO:0045859 regulation of protein kinase activity 56.2500 6 yes
GO:0051174 regulation of phosphorus metabolic process 56.2500 5 yes
GO:0051252 regulation of RNA metabolic process 56.2500 5 yes
GO:0051338 regulation of transferase activity 56.2500 4 yes
GO:1902533 positive regulation of intracellular signal transduction 56.2500 6 yes
GO:0080134 regulation of response to stress 56.2500 4 no
GO:0001934 positive regulation of protein phosphorylation 50.0000 8 yes
GO:0006355 regulation of DNA-templated transcription 50.0000 6 yes
GO:0010562 positive regulation of phosphorus metabolic process 50.0000 6 yes
GO:0036211 protein modification process 50.0000 4 yes
GO:0042327 positive regulation of phosphorylation 50.0000 8 yes
GO:0043412 macromolecule modification 50.0000 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 50.0000 6 yes
GO:0045937 positive regulation of phosphate metabolic process 50.0000 7 yes
GO:1903506 regulation of nucleic acid-templated transcription 50.0000 7 yes
GO:2001141 regulation of RNA biosynthetic process 50.0000 6 yes
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0006796 phosphate-containing compound metabolic process 43.7500 4 yes
GO:0033674 positive regulation of kinase activity 43.7500 6 yes
GO:0043066 negative regulation of apoptotic process 43.7500 7 yes
GO:0043069 negative regulation of programmed cell death 43.7500 6 yes
GO:0043085 positive regulation of catalytic activity 43.7500 4 yes
GO:0043408 regulation of MAPK cascade 43.7500 6 yes
GO:0045860 positive regulation of protein kinase activity 43.7500 7 yes
GO:0051347 positive regulation of transferase activity 43.7500 5 yes
GO:0060548 negative regulation of cell death 43.7500 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 43.7500 5 no
GO:0031324 negative regulation of cellular metabolic process 43.7500 5 no
GO:0051128 regulation of cellular component organization 43.7500 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 43.7500 5 no
GO:0006468 protein phosphorylation 37.5000 5 yes
GO:0016310 phosphorylation 37.5000 5 yes
GO:0043410 positive regulation of MAPK cascade 37.5000 7 yes
GO:0045893 positive regulation of DNA-templated transcription 37.5000 7 yes
GO:0051254 positive regulation of RNA metabolic process 37.5000 6 yes
GO:0071900 regulation of protein serine/threonine kinase activity 37.5000 7 yes
GO:1902680 positive regulation of RNA biosynthetic process 37.5000 7 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 37.5000 8 yes
GO:0009894 regulation of catabolic process 37.5000 4 no
GO:0030030 cell projection organization 37.5000 4 no
GO:0043405 regulation of MAP kinase activity 31.2500 8 yes
GO:0043506 regulation of JUN kinase activity 31.2500 9 yes
GO:0046777 protein autophosphorylation 31.2500 6 yes
GO:0071902 positive regulation of protein serine/threonine kinase activity 31.2500 8 yes
GO:0010648 negative regulation of cell communication 31.2500 5 no
GO:0023057 negative regulation of signaling 31.2500 4 no
GO:0031344 regulation of cell projection organization 31.2500 5 no
GO:0051130 positive regulation of cellular component organization 31.2500 5 no
GO:0071310 cellular response to organic substance 31.2500 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 31.2500 6 no
GO:0033043 regulation of organelle organization 31.2500 5 no
GO:0050776 regulation of immune response 31.2500 4 no
GO:0032101 regulation of response to external stimulus 31.2500 4 no
GO:0032990 cell part morphogenesis 31.2500 4 no
GO:0048812 neuron projection morphogenesis 31.2500 7 no
GO:0048858 cell projection morphogenesis 31.2500 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 31.2500 6 no
GO:0022607 cellular component assembly 31.2500 4 no
GO:0000165 MAPK cascade 25.0000 4 yes
GO:0007254 JNK cascade 25.0000 6 yes
GO:0018105 peptidyl-serine phosphorylation 25.0000 6 yes
GO:0018193 peptidyl-amino acid modification 25.0000 5 yes
GO:0018209 peptidyl-serine modification 25.0000 6 yes
GO:0031098 stress-activated protein kinase signaling cascade 25.0000 4 yes
GO:0043406 positive regulation of MAP kinase activity 25.0000 8 yes
GO:0043507 positive regulation of JUN kinase activity 25.0000 9 yes
GO:0043523 regulation of neuron apoptotic process 25.0000 6 yes
GO:0051403 stress-activated MAPK cascade 25.0000 5 yes
GO:1901214 regulation of neuron death 25.0000 5 yes
GO:0008104 protein localization 25.0000 4 no
GO:0010628 positive regulation of gene expression 25.0000 6 no
GO:0010975 regulation of neuron projection development 25.0000 7 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0006915 apoptotic process 25.0000 4 no
GO:0080135 regulation of cellular response to stress 25.0000 4 no
GO:0009895 negative regulation of catabolic process 25.0000 5 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0051493 regulation of cytoskeleton organization 25.0000 6 no
GO:0031329 regulation of cellular catabolic process 25.0000 5 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0002831 regulation of response to biotic stimulus 25.0000 4 no
GO:0031347 regulation of defense response 25.0000 5 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0045088 regulation of innate immune response 25.0000 5 no
GO:0006996 organelle organization 25.0000 4 no
GO:0044271 cellular nitrogen compound biosynthetic process 25.0000 4 no
GO:0051896 regulation of protein kinase B signaling 25.0000 6 no
GO:0018107 peptidyl-threonine phosphorylation 18.7500 6 yes
GO:0018210 peptidyl-threonine modification 18.7500 6 yes
GO:0043524 negative regulation of neuron apoptotic process 18.7500 7 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 18.7500 7 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 18.7500 8 yes
GO:1901215 negative regulation of neuron death 18.7500 6 yes
GO:2000671 regulation of motor neuron apoptotic process 12.5000 7 yes
GO:2000672 negative regulation of motor neuron apoptotic process 12.5000 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
M3K12_HUMAN [view entry] [view interactions] Low throughput yes yes
JIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
F10C1_HUMAN [view interactions] Low throughput no yes
EGFR_HUMAN [view interactions] Low throughput no no
MBIP1_HUMAN [view interactions] Low throughput no yes
MP2K7_HUMAN [view entry] [view interactions] Low throughput yes yes
MK06_HUMAN [view interactions] High throughput no yes
US6NL_HUMAN [view interactions] High throughput no yes
MTOR_HUMAN [view entry] [view interactions] High throughput yes yes
SYYC_HUMAN [view interactions] High throughput no yes
MOT1_HUMAN [view interactions] High throughput no no
KLF16_HUMAN [view interactions] High throughput no yes
CANB1_HUMAN [view entry] [view interactions] High throughput yes yes
PP2BA_HUMAN [view entry] [view interactions] High throughput yes yes
T22D1_HUMAN [view interactions] High throughput no no
FRIL_HUMAN [view interactions] High throughput no yes
RGS1_HUMAN [view interactions] High throughput no yes
RL18A_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
JIP2_HUMAN [view entry] [view interactions] High throughput yes no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
INT14_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
LYRIC_HUMAN [view entry] [view interactions] High throughput yes yes
MYCB2_HUMAN [view entry] [view interactions] Computational yes no
MK14_HUMAN [view interactions] Computational no yes
MK11_HUMAN [view interactions] Computational no yes
PAK1_HUMAN [view entry] [view interactions] Computational yes yes
PAK2_HUMAN [view entry] [view interactions] Computational yes no
MP2K4_HUMAN [view interactions] Computational no yes
SYTC_HUMAN [view interactions] Computational no yes