Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LRP4_HUMAN

Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation . [View more on UniProt]

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Position Amino acid Mutation Disease Overlap with binding region
137 Asp Asn Cenani-Lenzsyndactylysyndrome(CLSS) -
160 Cys Tyr Cenani-Lenzsyndactylysyndrome(CLSS) -
449 Asp Asn Cenani-Lenzsyndactylysyndrome(CLSS) -
461 Thr Pro Cenani-Lenzsyndactylysyndrome(CLSS) -
473 Leu Phe Cenani-Lenzsyndactylysyndrome(CLSS) -
529 Asp Asn Cenani-Lenzsyndactylysyndrome(CLSS) -
1017 Cys Arg Cenani-Lenzsyndactylysyndrome(CLSS) -
1170 Arg Trp Sclerosteosis2(SOST2) -
1186 Trp Ser Sclerosteosis2(SOST2) -
1233 Glu Lys Myasthenicsyndrome,congenital,17(CMS17) -
1277 Arg His Myasthenicsyndrome,congenital,17(CMS17) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in LRP4_HUMAN
GO:0003723 RNA binding 43.4783 4 no
GO:0043168 anion binding 26.0870 4 no
GO:0000166 nucleotide binding 23.9130 4 no
GO:0017076 purine nucleotide binding 23.9130 5 no
GO:0032555 purine ribonucleotide binding 21.7391 4 no
GO:0035639 purine ribonucleoside triphosphate binding 21.7391 4 no
GO:0019900 kinase binding 17.3913 4 yes
GO:0043169 cation binding 15.2174 4 yes
GO:0046872 metal ion binding 15.2174 5 yes
GO:0019901 protein kinase binding 13.0435 5 yes
GO:0005509 calcium ion binding 8.6957 6 yes
GO:0042803 protein homodimerization activity 6.5217 4 yes
GO:0030971 receptor tyrosine kinase binding 4.3478 4 yes
GO:1990782 protein tyrosine kinase binding 4.3478 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in LRP4_HUMAN
GO:0060255 regulation of macromolecule metabolic process 54.3478 4 yes
GO:0080090 regulation of primary metabolic process 54.3478 4 yes
GO:0048522 positive regulation of cellular process 52.1739 4 yes
GO:0031323 regulation of cellular metabolic process 50.0000 4 yes
GO:0022607 cellular component assembly 43.4783 4 yes
GO:0048523 negative regulation of cellular process 41.3043 4 yes
GO:0051128 regulation of cellular component organization 41.3043 4 yes
GO:0051246 regulation of protein metabolic process 41.3043 5 yes
GO:0009893 positive regulation of metabolic process 39.1304 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 36.9565 5 yes
GO:0009889 regulation of biosynthetic process 36.9565 4 no
GO:0010468 regulation of gene expression 36.9565 6 no
GO:0010556 regulation of macromolecule biosynthetic process 36.9565 5 no
GO:0031326 regulation of cellular biosynthetic process 36.9565 5 no
GO:0009966 regulation of signal transduction 32.6087 4 yes
GO:0010646 regulation of cell communication 32.6087 4 yes
GO:0048584 positive regulation of response to stimulus 32.6087 4 yes
GO:0006996 organelle organization 32.6087 4 no
GO:0043933 protein-containing complex organization 32.6087 4 no
GO:0031325 positive regulation of cellular metabolic process 30.4348 5 yes
GO:0051247 positive regulation of protein metabolic process 30.4348 6 yes
GO:0008104 protein localization 30.4348 4 yes
GO:0009967 positive regulation of signal transduction 28.2609 5 yes
GO:0010647 positive regulation of cell communication 28.2609 5 yes
GO:0023056 positive regulation of signaling 28.2609 4 yes
GO:1902531 regulation of intracellular signal transduction 28.2609 5 yes
GO:0065003 protein-containing complex assembly 28.2609 5 no
GO:0009892 negative regulation of metabolic process 28.2609 4 no
GO:0010605 negative regulation of macromolecule metabolic process 28.2609 5 no
GO:0031399 regulation of protein modification process 26.0870 6 yes
GO:0051130 positive regulation of cellular component organization 26.0870 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.0870 5 no
GO:0031324 negative regulation of cellular metabolic process 26.0870 5 no
GO:0051252 regulation of RNA metabolic process 26.0870 5 no
GO:0019220 regulation of phosphate metabolic process 23.9130 6 yes
GO:0051174 regulation of phosphorus metabolic process 23.9130 5 yes
GO:0007010 cytoskeleton organization 23.9130 5 no
GO:0006355 regulation of DNA-templated transcription 23.9130 7 no
GO:2001141 regulation of RNA biosynthetic process 23.9130 6 no
GO:0009059 macromolecule biosynthetic process 23.9130 4 no
GO:1901566 organonitrogen compound biosynthetic process 23.9130 4 no
GO:0031344 regulation of cell projection organization 21.7391 5 yes
GO:0042325 regulation of phosphorylation 21.7391 7 yes
GO:1902533 positive regulation of intracellular signal transduction 21.7391 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 19.5652 4 yes
GO:0030030 cell projection organization 19.5652 4 yes
GO:0031401 positive regulation of protein modification process 19.5652 7 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 19.5652 6 yes
GO:2000026 regulation of multicellular organismal development 19.5652 4 yes
GO:0001932 regulation of protein phosphorylation 19.5652 7 yes
GO:0009968 negative regulation of signal transduction 17.3913 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 17.3913 6 yes
GO:0010648 negative regulation of cell communication 17.3913 5 yes
GO:0023057 negative regulation of signaling 17.3913 4 yes
GO:0042327 positive regulation of phosphorylation 17.3913 8 yes
GO:0045937 positive regulation of phosphate metabolic process 17.3913 7 yes
GO:0048585 negative regulation of response to stimulus 17.3913 4 yes
GO:0051241 negative regulation of multicellular organismal process 17.3913 4 yes
GO:0001934 positive regulation of protein phosphorylation 17.3913 8 yes
GO:0050807 regulation of synapse organization 15.2174 5 yes
GO:0051056 regulation of small GTPase mediated signal transduction 15.2174 6 yes
GO:0072657 protein localization to membrane 15.2174 4 yes
GO:0010975 regulation of neuron projection development 13.0435 7 yes
GO:0032880 regulation of protein localization 13.0435 5 yes
GO:0034330 cell junction organization 13.0435 4 yes
GO:0043113 receptor clustering 13.0435 5 yes
GO:0051129 negative regulation of cellular component organization 13.0435 5 yes
GO:0051960 regulation of nervous system development 13.0435 5 yes
GO:0060341 regulation of cellular localization 13.0435 4 yes
GO:0061024 membrane organization 13.0435 4 yes
GO:0016055 Wnt signaling pathway 10.8696 4 yes
GO:0045595 regulation of cell differentiation 10.8696 4 yes
GO:0051057 positive regulation of small GTPase mediated signal transduction 10.8696 7 yes
GO:0051093 negative regulation of developmental process 10.8696 4 yes
GO:1905475 regulation of protein localization to membrane 10.8696 6 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 10.8696 4 yes
GO:0034329 cell junction assembly 8.6957 5 yes
GO:0035020 regulation of Rac protein signal transduction 8.6957 7 yes
GO:0045596 negative regulation of cell differentiation 8.6957 5 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 8.6957 8 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 8.6957 9 yes
GO:0050767 regulation of neurogenesis 8.6957 6 yes
GO:0050770 regulation of axonogenesis 8.6957 5 yes
GO:0050808 synapse organization 8.6957 5 yes
GO:0060284 regulation of cell development 8.6957 5 yes
GO:0098657 import into cell 8.6957 4 yes
GO:0007528 neuromuscular junction development 8.6957 6 yes
GO:0010977 negative regulation of neuron projection development 6.5217 7 yes
GO:0030111 regulation of Wnt signaling pathway 6.5217 5 yes
GO:0031345 negative regulation of cell projection organization 6.5217 6 yes
GO:0035022 positive regulation of Rac protein signal transduction 6.5217 8 yes
GO:0048812 neuron projection morphogenesis 6.5217 5 yes
GO:0071340 skeletal muscle acetylcholine-gated channel clustering 6.5217 6 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 6.5217 4 yes
GO:1903829 positive regulation of protein localization 6.5217 5 yes
GO:1905477 positive regulation of protein localization to membrane 6.5217 6 yes
GO:0009953 dorsal/ventral pattern formation 4.3478 4 yes
GO:0009954 proximal/distal pattern formation 4.3478 4 yes
GO:0010721 negative regulation of cell development 4.3478 6 yes
GO:0022008 neurogenesis 4.3478 4 yes
GO:0030178 negative regulation of Wnt signaling pathway 4.3478 6 yes
GO:0030278 regulation of ossification 4.3478 4 yes
GO:0030279 negative regulation of ossification 4.3478 5 yes
GO:0042475 odontogenesis of dentin-containing tooth 4.3478 5 yes
GO:0042476 odontogenesis 4.3478 4 yes
GO:0042733 embryonic digit morphogenesis 4.3478 4 yes
GO:0048699 generation of neurons 4.3478 5 yes
GO:0048813 dendrite morphogenesis 4.3478 6 yes
GO:0050768 negative regulation of neurogenesis 4.3478 6 yes
GO:0050771 negative regulation of axonogenesis 4.3478 6 yes
GO:0051961 negative regulation of nervous system development 4.3478 5 yes
GO:0060173 limb development 4.3478 4 yes
GO:0060828 regulation of canonical Wnt signaling pathway 4.3478 6 yes
GO:0071709 membrane assembly 4.3478 5 yes
GO:0090090 negative regulation of canonical Wnt signaling pathway 4.3478 7 yes
GO:0097090 presynaptic membrane organization 4.3478 5 yes
GO:0097104 postsynaptic membrane assembly 4.3478 6 yes
GO:0097105 presynaptic membrane assembly 4.3478 6 yes
GO:1901629 regulation of presynaptic membrane organization 4.3478 6 yes
GO:1901631 positive regulation of presynaptic membrane organization 4.3478 6 yes
GO:1903909 regulation of receptor clustering 4.3478 7 yes
GO:1903911 positive regulation of receptor clustering 4.3478 7 yes
GO:1904393 regulation of skeletal muscle acetylcholine-gated channel clustering 4.3478 8 yes
GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering 4.3478 8 yes
GO:0001822 kidney development 4.3478 4 yes
GO:0001941 postsynaptic membrane organization 4.3478 5 yes
GO:0007416 synapse assembly 4.3478 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SOST_HUMAN [view interactions] Low throughput no no
AGRIN_HUMAN [view entry] [view interactions] Low throughput yes yes
PCLI1_HUMAN [view interactions] Low throughput no no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
LRP4_HUMAN [view entry] [view interactions] Low throughput yes yes
MUSK_HUMAN [view entry] [view interactions] Low throughput yes no
JIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
RANB9_HUMAN [view entry] [view interactions] Low throughput yes yes
CALX_HUMAN [view entry] [view interactions] Low throughput yes yes
AMRP_HUMAN [view interactions] Low throughput no yes
CCAR2_HUMAN [view interactions] Low throughput no yes
MESD_HUMAN [view interactions] Low throughput no yes
PDIA4_HUMAN [view interactions] Low throughput no yes
RPN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SDF2L_HUMAN [view interactions] Low throughput no yes
EXOS5_HUMAN [view interactions] High throughput no yes
ZN398_HUMAN [view interactions] High throughput no no
ZFP41_HUMAN [view interactions] High throughput no no
ZN408_HUMAN [view interactions] High throughput no no
TYW3_HUMAN [view interactions] High throughput no yes
FCGRN_HUMAN [view interactions] High throughput no yes
ZN331_HUMAN [view interactions] High throughput no no
Z354C_HUMAN [view interactions] High throughput no no
GDF10_HUMAN [view interactions] High throughput no yes
ZN816_HUMAN [view interactions] High throughput no yes
ZSC26_HUMAN [view interactions] High throughput no no
ZN621_HUMAN [view interactions] High throughput no no
BEND7_HUMAN [view interactions] High throughput no no
ZN563_HUMAN [view interactions] High throughput no no
ZN669_HUMAN [view interactions] High throughput no no
ZN556_HUMAN [view interactions] High throughput no no
ZN224_HUMAN [view interactions] High throughput no yes
ZN214_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
MX1_HUMAN [view interactions] High throughput no yes
MOB1A_HUMAN [view interactions] High throughput no yes
SHLB1_HUMAN [view interactions] High throughput no yes
ABCF1_HUMAN [view interactions] High throughput no yes
NHRF1_HUMAN [view interactions] High throughput no no
SERB1_HUMAN [view interactions] High throughput no yes
CDV3_HUMAN [view interactions] High throughput no no
VASP_HUMAN [view entry] [view interactions] High throughput yes yes
PAHX_HUMAN [view interactions] High throughput no yes
LYRIC_HUMAN [view entry] [view interactions] High throughput yes yes
3HAO_HUMAN [view interactions] High throughput no no
EIF3E_HUMAN [view entry] [view interactions] High throughput yes yes
ROA2_HUMAN [view entry] [view interactions] High throughput yes yes
RL22_HUMAN [view entry] [view interactions] High throughput yes no
EIF2A_HUMAN [view interactions] High throughput no yes
RL6_HUMAN [view entry] [view interactions] High throughput yes yes
SNX17_HUMAN [view interactions] High throughput no yes
EI2BE_HUMAN [view interactions] High throughput no yes
HNRH3_HUMAN [view interactions] High throughput no no
EIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
THUM1_HUMAN [view interactions] High throughput no yes
HMCS1_HUMAN [view interactions] High throughput no yes
CSRP1_HUMAN [view entry] [view interactions] High throughput yes yes
RL7A_HUMAN [view entry] [view interactions] High throughput yes no
PABP2_HUMAN [view interactions] High throughput no yes
NMT1_HUMAN [view interactions] High throughput no yes
IF5_HUMAN [view interactions] High throughput no yes
RL15_HUMAN [view entry] [view interactions] High throughput yes no
RPR1B_HUMAN [view interactions] High throughput no yes
ACBP_HUMAN [view interactions] High throughput no yes
DNJC3_HUMAN [view interactions] High throughput no yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
PSD11_HUMAN [view entry] [view interactions] High throughput yes yes
G6PD_HUMAN [view entry] [view interactions] High throughput yes no
RL27A_HUMAN [view entry] [view interactions] High throughput yes yes
RS8_HUMAN [view entry] [view interactions] High throughput yes no
EF1A1_HUMAN [view entry] [view interactions] High throughput yes yes
ERP29_HUMAN [view interactions] High throughput no yes
LMCD1_HUMAN [view interactions] High throughput no yes
PUR6_HUMAN [view entry] [view interactions] High throughput yes yes
IF4A2_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD4_HUMAN [view interactions] High throughput no yes
NDUAC_HUMAN [view entry] [view interactions] High throughput yes yes
SH3G1_HUMAN [view entry] [view interactions] High throughput yes no
PUM1_HUMAN [view interactions] High throughput no yes
RL8_HUMAN [view entry] [view interactions] High throughput yes yes
ST1B1_HUMAN [view interactions] High throughput no no
ROA3_HUMAN [view entry] [view interactions] High throughput yes yes
CHD4_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
PAK2_HUMAN [view entry] [view interactions] High throughput yes no
IF4H_HUMAN [view interactions] High throughput no yes
FUS_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPF_HUMAN [view interactions] High throughput no yes
DCXR_HUMAN [view interactions] High throughput no no
DYR1A_HUMAN [view interactions] High throughput no yes
LCOR_HUMAN [view interactions] High throughput no yes
DSCR9_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
ZBBX_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
SLX4I_HUMAN [view interactions] High throughput no yes
BRD1_HUMAN [view interactions] High throughput no yes
SP110_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
AN36B_HUMAN [view interactions] High throughput no no
SHPK_HUMAN [view interactions] High throughput no no
ZN383_HUMAN [view interactions] High throughput no yes
ZN248_HUMAN [view interactions] High throughput no yes
FNDC8_HUMAN [view interactions] High throughput no no
ZNF34_HUMAN [view interactions] High throughput no no
ZSC21_HUMAN [view interactions] High throughput no yes
F120A_HUMAN [view interactions] High throughput no yes
NET5_HUMAN [view interactions] High throughput no no
ZN584_HUMAN [view interactions] High throughput no no
CX066_HUMAN [view interactions] High throughput no no
SULF2_HUMAN [view interactions] High throughput no yes
IGSF5_HUMAN [view interactions] High throughput no no
ZN778_HUMAN [view interactions] High throughput no yes
ZN121_HUMAN [view interactions] High throughput no no
ACSM3_HUMAN [view interactions] High throughput no yes
FST_HUMAN [view interactions] High throughput no no
DB123_HUMAN [view interactions] High throughput no no
IGFL3_HUMAN [view interactions] High throughput no no
MAP10_HUMAN [view interactions] High throughput no no
FEZF1_HUMAN [view interactions] High throughput no yes
ZNF74_HUMAN [view interactions] High throughput no yes
EMX2_HUMAN [view interactions] High throughput no yes
ZNF17_HUMAN [view interactions] High throughput no no
RL10_HUMAN [view entry] [view interactions] High throughput yes yes
ZN707_HUMAN [view interactions] High throughput no yes
WDR20_HUMAN [view interactions] High throughput no no
ATS1_HUMAN [view interactions] High throughput no no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
TOP3B_HUMAN [view interactions] High throughput no no
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
TIM13_HUMAN [view interactions] High throughput no yes
THTR_HUMAN [view interactions] High throughput no yes
BPHL_HUMAN [view interactions] High throughput no no
LRP6_HUMAN [view interactions] High throughput no yes
LRP5_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LAMP3_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
WHRN_HUMAN [view interactions] High throughput no no
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes