LRP4_HUMAN
Evidence for PS localization
Functions
Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 137 | Asp | Asn | Cenani-Lenzsyndactylysyndrome(CLSS) | - |
| 160 | Cys | Tyr | Cenani-Lenzsyndactylysyndrome(CLSS) | - |
| 449 | Asp | Asn | Cenani-Lenzsyndactylysyndrome(CLSS) | - |
| 461 | Thr | Pro | Cenani-Lenzsyndactylysyndrome(CLSS) | - |
| 473 | Leu | Phe | Cenani-Lenzsyndactylysyndrome(CLSS) | - |
| 529 | Asp | Asn | Cenani-Lenzsyndactylysyndrome(CLSS) | - |
| 1017 | Cys | Arg | Cenani-Lenzsyndactylysyndrome(CLSS) | - |
| 1170 | Arg | Trp | Sclerosteosis2(SOST2) | - |
| 1186 | Trp | Ser | Sclerosteosis2(SOST2) | - |
| 1233 | Glu | Lys | Myasthenicsyndrome,congenital,17(CMS17) | - |
| 1277 | Arg | His | Myasthenicsyndrome,congenital,17(CMS17) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LRP4_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 45.4545 | 4 | no |
| GO:0019900 | kinase binding | 22.7273 | 4 | yes |
| GO:0019901 | protein kinase binding | 22.7273 | 5 | yes |
| GO:0017076 | purine nucleotide binding | 22.7273 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 22.7273 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.7273 | 4 | no |
| GO:0046872 | metal ion binding | 15.9091 | 4 | yes |
| GO:0005509 | calcium ion binding | 9.0909 | 5 | yes |
| GO:0030971 | receptor tyrosine kinase binding | 6.8182 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 6.8182 | 4 | yes |
| GO:1990782 | protein tyrosine kinase binding | 6.8182 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LRP4_HUMAN |
|---|---|---|---|---|
| GO:0051171 | regulation of nitrogen compound metabolic process | 56.8182 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 56.8182 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 56.8182 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 54.5455 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 47.7273 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 45.4545 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 40.9091 | 4 | yes |
| GO:0022607 | cellular component assembly | 40.9091 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 38.6364 | 5 | yes |
| GO:0010468 | regulation of gene expression | 38.6364 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 38.6364 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 38.6364 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 36.3636 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 36.3636 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 36.3636 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 34.0909 | 5 | no |
| GO:0010646 | regulation of cell communication | 34.0909 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 31.8182 | 6 | yes |
| GO:0008104 | protein localization | 31.8182 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 31.8182 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 29.5455 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.5455 | 5 | no |
| GO:0006996 | organelle organization | 29.5455 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 27.2727 | 5 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 27.2727 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.2727 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 27.2727 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 27.2727 | 6 | yes |
| GO:0031399 | regulation of protein modification process | 27.2727 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 27.2727 | 7 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0043933 | protein-containing complex organization | 25.0000 | 4 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 25.0000 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | no |
| GO:0006518 | peptide metabolic process | 22.7273 | 4 | no |
| GO:0043603 | cellular amide metabolic process | 22.7273 | 4 | no |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 22.7273 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 22.7273 | 4 | no |
| GO:0007010 | cytoskeleton organization | 22.7273 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 22.7273 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 22.7273 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.7273 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.7273 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 22.7273 | 7 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.7273 | 4 | yes |
| GO:0031401 | positive regulation of protein modification process | 22.7273 | 7 | yes |
| GO:0051130 | positive regulation of cellular component organization | 22.7273 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 20.4545 | 4 | yes |
| GO:0006412 | translation | 20.4545 | 4 | no |
| GO:0009059 | macromolecule biosynthetic process | 20.4545 | 4 | no |
| GO:0034645 | cellular macromolecule biosynthetic process | 20.4545 | 4 | no |
| GO:0043043 | peptide biosynthetic process | 20.4545 | 5 | no |
| GO:0043604 | amide biosynthetic process | 20.4545 | 5 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 20.4545 | 8 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.4545 | 6 | yes |
| GO:0031344 | regulation of cell projection organization | 20.4545 | 5 | yes |
| GO:0042327 | positive regulation of phosphorylation | 20.4545 | 8 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.4545 | 7 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 18.1818 | 6 | yes |
| GO:0072657 | protein localization to membrane | 15.9091 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 15.9091 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 15.9091 | 5 | yes |
| GO:0016192 | vesicle-mediated transport | 15.9091 | 4 | yes |
| GO:0023057 | negative regulation of signaling | 15.9091 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 15.9091 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 15.9091 | 4 | yes |
| GO:0051960 | regulation of nervous system development | 13.6364 | 5 | yes |
| GO:0061024 | membrane organization | 13.6364 | 4 | yes |
| GO:0010975 | regulation of neuron projection development | 13.6364 | 7 | yes |
| GO:0030030 | cell projection organization | 13.6364 | 4 | yes |
| GO:0034330 | cell junction organization | 13.6364 | 4 | yes |
| GO:0043113 | receptor clustering | 13.6364 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 13.6364 | 5 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 11.3636 | 4 | yes |
| GO:0060284 | regulation of cell development | 11.3636 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 11.3636 | 4 | yes |
| GO:1905475 | regulation of protein localization to membrane | 11.3636 | 6 | yes |
| GO:0032880 | regulation of protein localization | 11.3636 | 5 | yes |
| GO:0050770 | regulation of axonogenesis | 11.3636 | 5 | yes |
| GO:0050807 | regulation of synapse organization | 11.3636 | 5 | yes |
| GO:1903829 | positive regulation of protein localization | 9.0909 | 5 | yes |
| GO:1905114 | cell surface receptor signaling pathway involved in cell-cell signaling | 9.0909 | 4 | yes |
| GO:1905477 | positive regulation of protein localization to membrane | 9.0909 | 6 | yes |
| GO:0006897 | endocytosis | 9.0909 | 5 | yes |
| GO:0007528 | neuromuscular junction development | 9.0909 | 6 | yes |
| GO:0016055 | Wnt signaling pathway | 9.0909 | 5 | yes |
| GO:0034329 | cell junction assembly | 9.0909 | 5 | yes |
| GO:0045596 | negative regulation of cell differentiation | 9.0909 | 5 | yes |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 9.0909 | 8 | yes |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 9.0909 | 9 | yes |
| GO:0050767 | regulation of neurogenesis | 9.0909 | 6 | yes |
| GO:0050808 | synapse organization | 9.0909 | 5 | yes |
| GO:0051093 | negative regulation of developmental process | 9.0909 | 4 | yes |
| GO:0071340 | skeletal muscle acetylcholine-gated channel clustering | 6.8182 | 6 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 6.8182 | 6 | yes |
| GO:1903909 | regulation of receptor clustering | 6.8182 | 7 | yes |
| GO:1903911 | positive regulation of receptor clustering | 6.8182 | 7 | yes |
| GO:0010977 | negative regulation of neuron projection development | 6.8182 | 7 | yes |
| GO:0030111 | regulation of Wnt signaling pathway | 6.8182 | 5 | yes |
| GO:0031345 | negative regulation of cell projection organization | 6.8182 | 6 | yes |
| GO:0032990 | cell part morphogenesis | 6.8182 | 4 | yes |
| GO:0048812 | neuron projection morphogenesis | 6.8182 | 7 | yes |
| GO:0048858 | cell projection morphogenesis | 6.8182 | 5 | yes |
| GO:0051961 | negative regulation of nervous system development | 4.5455 | 5 | yes |
| GO:0060173 | limb development | 4.5455 | 4 | yes |
| GO:0060828 | regulation of canonical Wnt signaling pathway | 4.5455 | 6 | yes |
| GO:0071709 | membrane assembly | 4.5455 | 5 | yes |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway | 4.5455 | 7 | yes |
| GO:0097090 | presynaptic membrane organization | 4.5455 | 5 | yes |
| GO:0097104 | postsynaptic membrane assembly | 4.5455 | 6 | yes |
| GO:0097105 | presynaptic membrane assembly | 4.5455 | 6 | yes |
| GO:1901629 | regulation of presynaptic membrane organization | 4.5455 | 6 | yes |
| GO:1901631 | positive regulation of presynaptic membrane organization | 4.5455 | 6 | yes |
| GO:1904393 | regulation of skeletal muscle acetylcholine-gated channel clustering | 4.5455 | 8 | yes |
| GO:1904395 | positive regulation of skeletal muscle acetylcholine-gated channel clustering | 4.5455 | 8 | yes |
| GO:0001822 | kidney development | 4.5455 | 4 | yes |
| GO:0001941 | postsynaptic membrane organization | 4.5455 | 5 | yes |
| GO:0007416 | synapse assembly | 4.5455 | 6 | yes |
| GO:0009953 | dorsal/ventral pattern formation | 4.5455 | 4 | yes |
| GO:0009954 | proximal/distal pattern formation | 4.5455 | 4 | yes |
| GO:0010721 | negative regulation of cell development | 4.5455 | 6 | yes |
| GO:0022008 | neurogenesis | 4.5455 | 4 | yes |
| GO:0030178 | negative regulation of Wnt signaling pathway | 4.5455 | 6 | yes |
| GO:0030278 | regulation of ossification | 4.5455 | 4 | yes |
| GO:0030279 | negative regulation of ossification | 4.5455 | 5 | yes |
| GO:0042475 | odontogenesis of dentin-containing tooth | 4.5455 | 5 | yes |
| GO:0042476 | odontogenesis | 4.5455 | 4 | yes |
| GO:0042733 | embryonic digit morphogenesis | 4.5455 | 4 | yes |
| GO:0048699 | generation of neurons | 4.5455 | 5 | yes |
| GO:0048813 | dendrite morphogenesis | 4.5455 | 8 | yes |
| GO:0050768 | negative regulation of neurogenesis | 4.5455 | 6 | yes |
| GO:0050771 | negative regulation of axonogenesis | 4.5455 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in LRP4_HUMAN |
|---|---|---|---|---|
| DOID:3635 | congenital myasthenic syndrome | 6.8182 | 7 | yes |
| DOID:439 | neuromuscular junction disease | 6.8182 | 6 | yes |
| DOID:440 | neuromuscular disease | 6.8182 | 5 | yes |
| DOID:574 | peripheral nervous system disease | 6.8182 | 3 | yes |
| DOID:870 | neuropathy | 6.8182 | 4 | yes |
| DOID:0060251 | sclerosteosis | 4.5455 | 7 | yes |
| DOID:0060757 | sclerosteosis 2 | 4.5455 | 8 | yes |
| DOID:0080001 | bone disease | 4.5455 | 4 | yes |
| DOID:0080005 | bone remodeling disease | 4.5455 | 5 | yes |
| DOID:0080006 | bone development disease | 4.5455 | 5 | yes |
| DOID:0090015 | Cenani-Lenz syndactyly syndrome | 4.5455 | 7 | yes |
| DOID:0110674 | congenital myasthenic syndrome 17 | 4.5455 | 8 | yes |
| DOID:1934 | dysostosis | 4.5455 | 6 | yes |
| DOID:205 | hyperostosis | 4.5455 | 6 | yes |
| DOID:65 | connective tissue disease | 4.5455 | 3 | yes |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PCLI1_HUMAN | [view interactions] | Low throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRP4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MUSK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| JIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RANB9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MESD_HUMAN | [view interactions] | Low throughput | no | yes |
| SDF2L_HUMAN | [view interactions] | Low throughput | no | yes |
| RPN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PDIA4_HUMAN | [view interactions] | Low throughput | no | yes |
| CCAR2_HUMAN | [view interactions] | Low throughput | no | yes |
| AMRP_HUMAN | [view interactions] | Low throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SOST_HUMAN | [view interactions] | Low throughput | no | no |
| AGRIN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACBP_HUMAN | [view interactions] | High throughput | no | yes |
| ATX2_HUMAN | [view interactions] | High throughput | no | yes |
| RPR1B_HUMAN | [view interactions] | High throughput | no | yes |
| RL15_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IF5_HUMAN | [view interactions] | High throughput | no | yes |
| NMT1_HUMAN | [view interactions] | High throughput | no | yes |
| PABP2_HUMAN | [view interactions] | High throughput | no | yes |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMCS1_HUMAN | [view interactions] | High throughput | no | yes |
| 1A1L1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH3_HUMAN | [view interactions] | High throughput | no | no |
| EI2BE_HUMAN | [view interactions] | High throughput | no | yes |
| SNX17_HUMAN | [view interactions] | High throughput | no | yes |
| RL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 3HAO_HUMAN | [view interactions] | High throughput | no | no |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAHX_HUMAN | [view interactions] | High throughput | no | yes |
| CDV3_HUMAN | [view interactions] | High throughput | no | no |
| PAIRB_HUMAN | [view interactions] | High throughput | no | yes |
| NHRF1_HUMAN | [view interactions] | High throughput | no | no |
| ABCF1_HUMAN | [view interactions] | High throughput | no | yes |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| STA10_HUMAN | [view interactions] | High throughput | no | yes |
| MOB1A_HUMAN | [view interactions] | High throughput | no | yes |
| VASP_HUMAN | [view interactions] | High throughput | no | yes |
| ZBBX_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| SLX4I_HUMAN | [view interactions] | High throughput | no | yes |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| SP110_HUMAN | [view interactions] | High throughput | no | no |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| AN36B_HUMAN | [view interactions] | High throughput | no | no |
| SHPK_HUMAN | [view interactions] | High throughput | no | no |
| ZN383_HUMAN | [view interactions] | High throughput | no | yes |
| ZN248_HUMAN | [view interactions] | High throughput | no | yes |
| FNDC8_HUMAN | [view interactions] | High throughput | no | no |
| ZNF34_HUMAN | [view interactions] | High throughput | no | no |
| ZSC21_HUMAN | [view interactions] | High throughput | no | yes |
| F120A_HUMAN | [view interactions] | High throughput | no | yes |
| NET5_HUMAN | [view interactions] | High throughput | no | no |
| ZN584_HUMAN | [view interactions] | High throughput | no | no |
| CX066_HUMAN | [view interactions] | High throughput | no | no |
| SULF2_HUMAN | [view interactions] | High throughput | no | yes |
| IGSF5_HUMAN | [view interactions] | High throughput | no | no |
| ZN778_HUMAN | [view interactions] | High throughput | no | yes |
| ZN121_HUMAN | [view interactions] | High throughput | no | no |
| ACSM3_HUMAN | [view interactions] | High throughput | no | yes |
| FST_HUMAN | [view interactions] | High throughput | no | no |
| DB123_HUMAN | [view interactions] | High throughput | no | no |
| IGFL3_HUMAN | [view interactions] | High throughput | no | no |
| MAP10_HUMAN | [view interactions] | High throughput | no | no |
| FEZF1_HUMAN | [view interactions] | High throughput | no | yes |
| ZNF74_HUMAN | [view interactions] | High throughput | no | yes |
| EMX2_HUMAN | [view interactions] | High throughput | no | yes |
| ZNF17_HUMAN | [view interactions] | High throughput | no | no |
| RL10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN707_HUMAN | [view interactions] | High throughput | no | yes |
| WDR20_HUMAN | [view interactions] | High throughput | no | no |
| ATS1_HUMAN | [view interactions] | High throughput | no | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM13_HUMAN | [view interactions] | High throughput | no | yes |
| THTR_HUMAN | [view interactions] | High throughput | no | yes |
| BPHL_HUMAN | [view interactions] | High throughput | no | no |
| LRP6_HUMAN | [view interactions] | High throughput | no | yes |
| LRP5_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WHRN_HUMAN | [view interactions] | High throughput | no | no |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOS5_HUMAN | [view interactions] | High throughput | no | yes |
| ZN398_HUMAN | [view interactions] | High throughput | no | no |
| ZFP41_HUMAN | [view interactions] | High throughput | no | no |
| ZN408_HUMAN | [view interactions] | High throughput | no | no |
| TYW3_HUMAN | [view interactions] | High throughput | no | yes |
| FCGRN_HUMAN | [view interactions] | High throughput | no | yes |
| ZN331_HUMAN | [view interactions] | High throughput | no | no |
| Z354C_HUMAN | [view interactions] | High throughput | no | no |
| ZN816_HUMAN | [view interactions] | High throughput | no | yes |
| GDF10_HUMAN | [view interactions] | High throughput | no | yes |
| ZSC26_HUMAN | [view interactions] | High throughput | no | no |
| ZN621_HUMAN | [view interactions] | High throughput | no | no |
| BEND7_HUMAN | [view interactions] | High throughput | no | no |
| ZN556_HUMAN | [view interactions] | High throughput | no | no |
| ZN669_HUMAN | [view interactions] | High throughput | no | no |
| ZN563_HUMAN | [view interactions] | High throughput | no | no |
| ZN224_HUMAN | [view interactions] | High throughput | no | yes |
| ZN214_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MX1_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF2A_HUMAN | [view interactions] | High throughput | no | yes |
| DCXR_HUMAN | [view interactions] | High throughput | no | no |
| HNRPF_HUMAN | [view interactions] | High throughput | no | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4H_HUMAN | [view interactions] | High throughput | no | yes |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTPCR_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| ROA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP2_HUMAN | [view interactions] | High throughput | no | yes |
| ST1B1_HUMAN | [view interactions] | High throughput | no | no |
| RL8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUM1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD4_HUMAN | [view interactions] | High throughput | no | yes |
| IF4A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMCD1_HUMAN | [view interactions] | High throughput | no | yes |
| PLIN2_HUMAN | [view interactions] | High throughput | no | no |
| ERP29_HUMAN | [view interactions] | High throughput | no | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSD11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAPH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE192_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC3_HUMAN | [view interactions] | High throughput | no | yes |
| DOK7_HUMAN | [view interactions] | Computational | no | yes |