IF4A2_HUMAN
Evidence for PS localization
Functions
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in IF4A2_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 46.0317 | 4 | yes |
| GO:0043168 | anion binding | 26.9841 | 4 | yes |
| GO:0000166 | nucleotide binding | 22.2222 | 4 | yes |
| GO:0005524 | ATP binding | 22.2222 | 5 | yes |
| GO:0017076 | purine nucleotide binding | 22.2222 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 22.2222 | 6 | yes |
| GO:0032555 | purine ribonucleotide binding | 22.2222 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 22.2222 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.2222 | 4 | yes |
| GO:0043169 | cation binding | 22.2222 | 4 | no |
| GO:0046872 | metal ion binding | 22.2222 | 5 | no |
| GO:0003743 | translation initiation factor activity | 14.2857 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 14.2857 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 14.2857 | 4 | yes |
| GO:0016887 | ATP hydrolysis activity | 14.2857 | 7 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 14.2857 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in IF4A2_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 71.4286 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 69.8413 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 66.6667 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 65.0794 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 65.0794 | 5 | yes |
| GO:0080090 | regulation of primary metabolic process | 65.0794 | 4 | yes |
| GO:0010468 | regulation of gene expression | 63.4921 | 6 | yes |
| GO:0048523 | negative regulation of cellular process | 61.9048 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 60.3175 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 49.2063 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 47.6190 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 47.6190 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 47.6190 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 47.6190 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 46.0317 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 44.4444 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 44.4444 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 41.2698 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 41.2698 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 41.2698 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 38.0952 | 5 | no |
| GO:0022607 | cellular component assembly | 38.0952 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 36.5079 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 36.5079 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 36.5079 | 5 | no |
| GO:0010646 | regulation of cell communication | 34.9206 | 4 | no |
| GO:0010629 | negative regulation of gene expression | 34.9206 | 7 | no |
| GO:0051252 | regulation of RNA metabolic process | 34.9206 | 5 | no |
| GO:0043933 | protein-containing complex organization | 31.7460 | 4 | no |
| GO:0009966 | regulation of signal transduction | 31.7460 | 4 | no |
| GO:0010608 | post-transcriptional regulation of gene expression | 30.1587 | 7 | yes |
| GO:0006996 | organelle organization | 30.1587 | 4 | no |
| GO:0008104 | protein localization | 30.1587 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.1587 | 6 | no |
| GO:0006417 | regulation of translation | 28.5714 | 6 | yes |
| GO:0009894 | regulation of catabolic process | 26.9841 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 26.9841 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.9841 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 26.9841 | 6 | no |
| GO:0031399 | regulation of protein modification process | 25.3968 | 6 | no |
| GO:0051129 | negative regulation of cellular component organization | 25.3968 | 5 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 25.3968 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.3968 | 4 | no |
| GO:0071702 | organic substance transport | 23.8095 | 4 | no |
| GO:0032880 | regulation of protein localization | 23.8095 | 5 | no |
| GO:0060341 | regulation of cellular localization | 23.8095 | 4 | no |
| GO:0051726 | regulation of cell cycle | 23.8095 | 4 | no |
| GO:0033043 | regulation of organelle organization | 23.8095 | 5 | no |
| GO:0090304 | nucleic acid metabolic process | 23.8095 | 4 | no |
| GO:0071310 | cellular response to organic substance | 22.2222 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 22.2222 | 4 | no |
| GO:0051049 | regulation of transport | 22.2222 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.2222 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.2222 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.2222 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 22.2222 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.2222 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 22.2222 | 7 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 22.2222 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 20.6349 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.6349 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 20.6349 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.6349 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.6349 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.6349 | 5 | no |
| GO:0016070 | RNA metabolic process | 20.6349 | 5 | no |
| GO:0009059 | macromolecule biosynthetic process | 20.6349 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 20.6349 | 4 | no |
| GO:0006446 | regulation of translational initiation | 17.4603 | 7 | yes |
| GO:0051338 | regulation of transferase activity | 17.4603 | 4 | yes |
| GO:0043086 | negative regulation of catalytic activity | 12.6984 | 4 | yes |
| GO:0051348 | negative regulation of transferase activity | 11.1111 | 5 | yes |
| GO:0034097 | response to cytokine | 7.9365 | 4 | yes |
| GO:0071345 | cellular response to cytokine stimulus | 7.9365 | 5 | yes |
| GO:0002183 | cytoplasmic translational initiation | 6.3492 | 4 | yes |
| GO:1990823 | response to leukemia inhibitory factor | 4.7619 | 5 | yes |
| GO:1990830 | cellular response to leukemia inhibitory factor | 4.7619 | 6 | yes |
| GO:1900259 | regulation of RNA-dependent RNA polymerase activity | 3.1746 | 5 | yes |
| GO:1900260 | negative regulation of RNA-dependent RNA polymerase activity | 3.1746 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| IF4G2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IF4G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4G3_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3L_HUMAN | [view interactions] | High throughput | no | yes |
| PDCD4_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GGYF2_HUMAN | [view interactions] | High throughput | no | yes |
| CD2B2_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3M_HUMAN | [view interactions] | High throughput | no | yes |
| AK17A_HUMAN | [view interactions] | High throughput | no | no |
| SMG1_HUMAN | [view interactions] | High throughput | no | yes |
| DYH5_HUMAN | [view interactions] | High throughput | no | no |
| JIP4_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3K_HUMAN | [view interactions] | High throughput | no | yes |
| VAC14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATRX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3D_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| CMBL_HUMAN | [view interactions] | High throughput | no | no |
| HNRL2_HUMAN | [view interactions] | High throughput | no | yes |
| IBTK_HUMAN | [view interactions] | High throughput | no | yes |
| RS29_HUMAN | [view interactions] | High throughput | no | yes |
| SYTM_HUMAN | [view interactions] | High throughput | no | yes |
| EF1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PPBI_HUMAN | [view interactions] | High throughput | no | no |
| PPBT_HUMAN | [view interactions] | High throughput | no | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBG12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DPPA4_HUMAN | [view interactions] | High throughput | no | no |
| MOT9_HUMAN | [view interactions] | High throughput | no | no |
| TRI39_HUMAN | [view interactions] | High throughput | no | no |
| TRI36_HUMAN | [view interactions] | High throughput | no | no |
| ADIP_HUMAN | [view interactions] | High throughput | no | yes |
| IPO11_HUMAN | [view interactions] | High throughput | no | yes |
| IF4A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIHD2_HUMAN | [view interactions] | High throughput | no | no |
| DDX24_HUMAN | [view interactions] | High throughput | no | yes |
| ICLN_HUMAN | [view interactions] | High throughput | no | yes |
| FTCD_HUMAN | [view interactions] | High throughput | no | no |
| DSCR6_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| MDFI_HUMAN | [view interactions] | High throughput | no | no |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCPH1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN620_HUMAN | [view interactions] | High throughput | no | no |
| NKRF_HUMAN | [view interactions] | High throughput | no | no |
| RL26L_HUMAN | [view interactions] | High throughput | no | yes |
| IF4H_HUMAN | [view interactions] | High throughput | no | yes |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3F_HUMAN | [view interactions] | High throughput | no | yes |
| RPAP2_HUMAN | [view interactions] | High throughput | no | yes |
| CD4_HUMAN | [view interactions] | High throughput | no | no |
| TFE2_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| PLCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| CRY1_HUMAN | [view interactions] | High throughput | no | yes |
| CRY2_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| DUS28_HUMAN | [view interactions] | High throughput | no | yes |
| IF4A1_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| RUNX1_HUMAN | [view interactions] | High throughput | no | yes |
| SUZ12_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| GLUC_HUMAN | [view interactions] | High throughput | no | no |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MN1_HUMAN | [view interactions] | High throughput | no | yes |
| CDCA5_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| 4EBP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 4ET_HUMAN | [view interactions] | High throughput | no | yes |
| 4EBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3B_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3I_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3G_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANGE1_HUMAN | [view interactions] | High throughput | no | yes |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CP51A_HUMAN | [view interactions] | High throughput | no | no |
| DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DRG1_HUMAN | [view interactions] | High throughput | no | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM42_HUMAN | [view interactions] | High throughput | no | yes |
| RBM8A_HUMAN | [view interactions] | High throughput | no | yes |
| RS11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRP09_HUMAN | [view interactions] | High throughput | no | no |
| TRI31_HUMAN | [view interactions] | High throughput | no | no |
| PLD2_HUMAN | [view interactions] | High throughput | no | yes |
| PLD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLD4_HUMAN | [view interactions] | High throughput | no | yes |
| PLD5_HUMAN | [view interactions] | High throughput | no | no |
| PLD6_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RNF8_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| OTUL_HUMAN | [view interactions] | High throughput | no | yes |
| ANR35_HUMAN | [view interactions] | High throughput | no | no |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| AIMP1_HUMAN | [view interactions] | High throughput | no | yes |
| CETN2_HUMAN | [view interactions] | High throughput | no | yes |
| RSSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAGE3_HUMAN | [view interactions] | High throughput | no | yes |
| TOP1_HUMAN | [view interactions] | High throughput | no | yes |
| ATX2_HUMAN | [view interactions] | High throughput | no | yes |
| IF4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PABP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRC2A_HUMAN | [view interactions] | High throughput | no | yes |
| PRC2B_HUMAN | [view interactions] | High throughput | no | no |
| PRC2C_HUMAN | [view interactions] | High throughput | no | yes |
| TDRD3_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| RENT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP10_HUMAN | [view interactions] | High throughput | no | yes |
| YTHD2_HUMAN | [view interactions] | High throughput | no | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| NEK2_HUMAN | [view interactions] | High throughput | no | no |
| PFD1_HUMAN | [view interactions] | High throughput | no | yes |
| KITH_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3H_HUMAN | [view interactions] | High throughput | no | yes |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |