Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IF4A2_HUMAN

ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in IF4A2_HUMAN
GO:0003723 RNA binding 50.0000 4 yes
GO:0017076 purine nucleotide binding 26.6667 4 yes
GO:0032555 purine ribonucleotide binding 25.0000 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 yes
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0030554 adenyl nucleotide binding 23.3333 5 yes
GO:0032559 adenyl ribonucleotide binding 21.6667 5 yes
GO:0005524 ATP binding 21.6667 5 yes
GO:0003743 translation initiation factor activity 16.6667 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 15.0000 6 yes
GO:0016462 pyrophosphatase activity 15.0000 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 15.0000 4 yes
GO:0016887 ATP hydrolysis activity 11.6667 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in IF4A2_HUMAN
GO:0060255 regulation of macromolecule metabolic process 71.6667 4 yes
GO:0031323 regulation of cellular metabolic process 70.0000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 68.3333 4 yes
GO:0080090 regulation of primary metabolic process 68.3333 4 yes
GO:0048523 negative regulation of cellular process 65.0000 4 yes
GO:0048522 positive regulation of cellular process 63.3333 4 no
GO:0010468 regulation of gene expression 61.6667 5 yes
GO:0009889 regulation of biosynthetic process 58.3333 4 yes
GO:0031326 regulation of cellular biosynthetic process 58.3333 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 56.6667 5 yes
GO:0009892 negative regulation of metabolic process 53.3333 4 yes
GO:0051246 regulation of protein metabolic process 53.3333 5 yes
GO:0009893 positive regulation of metabolic process 51.6667 4 no
GO:0010605 negative regulation of macromolecule metabolic process 50.0000 5 yes
GO:0031324 negative regulation of cellular metabolic process 48.3333 5 yes
GO:0031325 positive regulation of cellular metabolic process 48.3333 5 no
GO:0010604 positive regulation of macromolecule metabolic process 46.6667 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 45.0000 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 43.3333 5 no
GO:0051128 regulation of cellular component organization 40.0000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 38.3333 5 yes
GO:0010608 post-transcriptional regulation of gene expression 36.6667 6 yes
GO:2000112 regulation of cellular macromolecule biosynthetic process 36.6667 6 yes
GO:0022607 cellular component assembly 36.6667 4 no
GO:0034248 regulation of cellular amide metabolic process 35.0000 5 yes
GO:0051252 regulation of RNA metabolic process 35.0000 5 yes
GO:0006417 regulation of translation 33.3333 6 yes
GO:0010646 regulation of cell communication 33.3333 4 no
GO:0009891 positive regulation of biosynthetic process 31.6667 5 no
GO:0031328 positive regulation of cellular biosynthetic process 31.6667 6 no
GO:0009890 negative regulation of biosynthetic process 30.0000 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 30.0000 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 30.0000 6 yes
GO:0010629 negative regulation of gene expression 30.0000 6 no
GO:0009966 regulation of signal transduction 30.0000 4 no
GO:0051247 positive regulation of protein metabolic process 30.0000 6 no
GO:0010557 positive regulation of macromolecule biosynthetic process 30.0000 6 no
GO:0051248 negative regulation of protein metabolic process 28.3333 6 no
GO:0006996 organelle organization 28.3333 4 no
GO:0009894 regulation of catabolic process 26.6667 4 no
GO:0031329 regulation of cellular catabolic process 26.6667 5 no
GO:1903506 regulation of nucleic acid-templated transcription 25.0000 7 yes
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 yes
GO:0008104 protein localization 25.0000 4 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0051338 regulation of transferase activity 23.3333 4 yes
GO:0051726 regulation of cell cycle 23.3333 4 no
GO:0010648 negative regulation of cell communication 23.3333 5 no
GO:0023057 negative regulation of signaling 23.3333 4 no
GO:0042325 regulation of phosphorylation 23.3333 7 no
GO:0010941 regulation of cell death 23.3333 4 no
GO:0043412 macromolecule modification 23.3333 4 no
GO:0071310 cellular response to organic substance 23.3333 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.3333 6 no
GO:0043933 protein-containing complex organization 21.6667 4 no
GO:0009968 negative regulation of signal transduction 21.6667 5 no
GO:0048585 negative regulation of response to stimulus 21.6667 4 no
GO:0051129 negative regulation of cellular component organization 21.6667 5 no
GO:0051130 positive regulation of cellular component organization 21.6667 5 no
GO:0090304 nucleic acid metabolic process 21.6667 4 no
GO:0010628 positive regulation of gene expression 21.6667 6 no
GO:0006355 regulation of DNA-templated transcription 21.6667 6 no
GO:0006446 regulation of translational initiation 20.0000 7 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 16.6667 6 yes
GO:0051253 negative regulation of RNA metabolic process 15.0000 6 yes
GO:0043086 negative regulation of catalytic activity 13.3333 4 yes
GO:1902679 negative regulation of RNA biosynthetic process 11.6667 7 yes
GO:1903507 negative regulation of nucleic acid-templated transcription 11.6667 8 yes
GO:0051348 negative regulation of transferase activity 10.0000 5 yes
GO:0002183 cytoplasmic translational initiation 6.6667 4 yes
GO:1900259 regulation of RNA-directed 5-3 RNA polymerase activity 3.3333 5 yes
GO:1900260 negative regulation of RNA-directed 5-3 RNA polymerase activity 3.3333 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in IF4A2_HUMAN
DOID:440 neuromuscular disease 3.3333 5 no
DOID:574 peripheral nervous system disease 3.3333 3 no
DOID:870 neuropathy 3.3333 4 no
DOID:37 skin disease 3.3333 3 no
DOID:0080000 muscular disease 3.3333 3 no
DOID:423 myopathy 3.3333 5 no
DOID:66 muscle tissue disease 3.3333 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
IF4G1_HUMAN [view entry] [view interactions] Low throughput yes yes
IF4G2_HUMAN [view entry] [view interactions] Low throughput yes yes
NEK2_HUMAN [view interactions] High throughput no no
PFD1_HUMAN [view interactions] High throughput no yes
KITH_HUMAN [view interactions] High throughput no yes
HSPB2_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3H_HUMAN [view interactions] High throughput no yes
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
SH3G3_HUMAN [view entry] [view interactions] High throughput yes no
LRP4_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
IF4G3_HUMAN [view interactions] High throughput no yes
EIF3L_HUMAN [view interactions] High throughput no yes
PDCD4_HUMAN [view interactions] High throughput no yes
EIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
IF4E_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRS_HUMAN [view entry] [view interactions] High throughput yes no
GGYF2_HUMAN [view interactions] High throughput no yes
CD2B2_HUMAN [view interactions] High throughput no yes
EIF3M_HUMAN [view interactions] High throughput no yes
AK17A_HUMAN [view interactions] High throughput no no
SMG1_HUMAN [view interactions] High throughput no yes
DYH5_HUMAN [view interactions] High throughput no no
JIP4_HUMAN [view interactions] High throughput no yes
EIF3K_HUMAN [view interactions] High throughput no yes
VAC14_HUMAN [view entry] [view interactions] High throughput yes yes
ATRX_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3D_HUMAN [view interactions] High throughput no yes
PDIA1_HUMAN [view interactions] High throughput no yes
CMBL_HUMAN [view interactions] High throughput no no
HNRL2_HUMAN [view interactions] High throughput no yes
IBTK_HUMAN [view interactions] High throughput no yes
RS29_HUMAN [view interactions] High throughput no yes
SYTM_HUMAN [view interactions] High throughput no yes
EF1B_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1B_HUMAN [view entry] [view interactions] High throughput yes no
PPBI_HUMAN [view interactions] High throughput no no
PPBT_HUMAN [view interactions] High throughput no yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
PABP1_HUMAN [view entry] [view interactions] High throughput yes yes
GBG12_HUMAN [view entry] [view interactions] High throughput yes yes
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
CDC5L_HUMAN [view interactions] High throughput no yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
TX101_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
DPPA4_HUMAN [view interactions] High throughput no no
MOT9_HUMAN [view interactions] High throughput no no
TRI39_HUMAN [view interactions] High throughput no no
TRI36_HUMAN [view interactions] High throughput no no
ADIP_HUMAN [view interactions] High throughput no yes
IPO11_HUMAN [view interactions] High throughput no yes
IF4A2_HUMAN [view entry] [view interactions] High throughput yes yes
PIHD2_HUMAN [view interactions] High throughput no no
DDX24_HUMAN [view interactions] High throughput no yes
ICLN_HUMAN [view interactions] High throughput no yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
SMAD2_HUMAN [view interactions] High throughput no yes
DYRK2_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
MDFI_HUMAN [view interactions] High throughput no no
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
MCPH1_HUMAN [view interactions] High throughput no yes
ZN620_HUMAN [view interactions] High throughput no no
NKRF_HUMAN [view interactions] High throughput no no
RL26L_HUMAN [view interactions] High throughput no yes
IF4H_HUMAN [view interactions] High throughput no yes
DDX3X_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3F_HUMAN [view interactions] High throughput no yes
RPAP2_HUMAN [view interactions] High throughput no yes
CD4_HUMAN [view interactions] High throughput no no
TFE2_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CD81_HUMAN [view interactions] High throughput no no
PLCB1_HUMAN [view entry] [view interactions] High throughput yes yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
ROA1_HUMAN [view entry] [view interactions] High throughput yes yes
UNK_HUMAN [view interactions] High throughput no yes
CRY1_HUMAN [view interactions] High throughput no yes
CRY2_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
DUS28_HUMAN [view interactions] High throughput no yes
IF4A1_HUMAN [view interactions] High throughput no no
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
FBX7_HUMAN [view interactions] High throughput no yes
LAP2A_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
RUNX1_HUMAN [view interactions] High throughput no yes
SUZ12_HUMAN [view interactions] High throughput no no
NR2C2_HUMAN [view interactions] High throughput no yes
GLUC_HUMAN [view interactions] High throughput no no
AGRIN_HUMAN [view entry] [view interactions] High throughput yes yes
APEX1_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
TIP_HUMAN [view entry] [view interactions] High throughput yes yes
TIF1B_HUMAN [view interactions] High throughput no yes
PPIA_HUMAN [view entry] [view interactions] High throughput yes yes
MN1_HUMAN [view interactions] High throughput no yes
CDCA5_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
4EBP2_HUMAN [view entry] [view interactions] High throughput yes yes
4ET_HUMAN [view interactions] High throughput no yes
4EBP1_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3B_HUMAN [view interactions] High throughput no yes
EIF3C_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3I_HUMAN [view interactions] High throughput no yes
EIF3G_HUMAN [view interactions] High throughput no yes
EIF3E_HUMAN [view entry] [view interactions] High throughput yes yes
ANGE1_HUMAN [view interactions] High throughput no yes
SPOP_HUMAN [view interactions] High throughput no no
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
SPRTN_HUMAN [view interactions] High throughput no yes
HECD1_HUMAN [view interactions] High throughput no yes
BAG1_HUMAN [view interactions] High throughput no yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
CP51A_HUMAN [view interactions] High throughput no no
DDX6_HUMAN [view entry] [view interactions] High throughput yes yes
DRG1_HUMAN [view interactions] High throughput no yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
PSPC1_HUMAN [view interactions] High throughput no yes
RBM42_HUMAN [view interactions] High throughput no yes
RBM8A_HUMAN [view interactions] High throughput no yes
RS11_HUMAN [view entry] [view interactions] High throughput yes yes
RS16_HUMAN [view entry] [view interactions] High throughput yes yes
SRP09_HUMAN [view interactions] High throughput no no
OTUD4_HUMAN [view interactions] High throughput no yes
SUMO2_HUMAN [view interactions] High throughput no yes
DX39B_HUMAN [view interactions] High throughput no no
AIMP1_HUMAN [view interactions] High throughput no yes
CETN2_HUMAN [view interactions] High throughput no yes
RSSA_HUMAN [view entry] [view interactions] High throughput yes yes
IF4A3_HUMAN [view entry] [view interactions] High throughput yes yes
LAGE3_HUMAN [view interactions] High throughput no yes
ATX2_HUMAN [view interactions] High throughput no yes
IF4B_HUMAN [view entry] [view interactions] High throughput yes yes
PABP4_HUMAN [view entry] [view interactions] High throughput yes yes
PRC2A_HUMAN [view interactions] High throughput no yes
PRC2B_HUMAN [view interactions] High throughput no no
PRC2C_HUMAN [view interactions] High throughput no yes
TDRD3_HUMAN [view interactions] High throughput no yes
TOP3B_HUMAN [view interactions] High throughput no no
RENT1_HUMAN [view entry] [view interactions] High throughput yes yes
UBP10_HUMAN [view interactions] High throughput no yes
YTHD2_HUMAN [view interactions] High throughput no yes
TBB5_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
OPTN_HUMAN [view interactions] High throughput no yes
4EBP3_HUMAN [view interactions] Computational no yes
CNOT3_HUMAN [view interactions] Computational no yes
NOM1_HUMAN [view interactions] Computational no yes
EF1G_HUMAN [view entry] [view interactions] Computational yes yes
PAIP1_HUMAN [view interactions] Computational no yes
IF2G_HUMAN [view interactions] Computational no yes
IF2A_HUMAN [view entry] [view interactions] Computational yes yes
CNOT8_HUMAN [view interactions] Computational no yes
EF2_HUMAN [view entry] [view interactions] Computational yes yes
CNOT7_HUMAN [view interactions] Computational no no
PAN2_HUMAN [view interactions] Computational no no
CNO10_HUMAN [view interactions] Computational no yes
CNOT4_HUMAN [view interactions] Computational no yes
CNO11_HUMAN [view interactions] Computational no yes
IF4E2_HUMAN [view interactions] Computational no no
EIF1_HUMAN [view interactions] Computational no no
CNO6L_HUMAN [view interactions] Computational no no
CNOT9_HUMAN [view interactions] Computational no yes
IF2P_HUMAN [view interactions] Computational no yes
I4E1B_HUMAN [view interactions] Computational no no
PAN3_HUMAN [view interactions] Computational no yes
EF1A1_HUMAN [view entry] [view interactions] Computational yes yes
IF1AX_HUMAN [view interactions] Computational no yes
CNOT6_HUMAN [view interactions] Computational no yes
IF2B_HUMAN [view interactions] Computational no yes
PARN_HUMAN [view entry] [view interactions] Computational yes yes
IF5_HUMAN [view interactions] Computational no yes
TUT7_HUMAN [view interactions] Computational no yes
IF4E3_HUMAN [view interactions] Computational no no
TB182_HUMAN [view interactions] Computational no yes
CNOT1_HUMAN [view interactions] Computational no yes
CNOT2_HUMAN [view interactions] Computational no yes