IF4A2_HUMAN
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in IF4A2_HUMAN |
---|---|---|---|---|
GO:0003723 | RNA binding | 50.0000 | 4 | yes |
GO:0017076 | purine nucleotide binding | 26.6667 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | yes |
GO:0019900 | kinase binding | 25.0000 | 4 | no |
GO:0019901 | protein kinase binding | 25.0000 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 23.3333 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 21.6667 | 5 | yes |
GO:0005524 | ATP binding | 21.6667 | 5 | yes |
GO:0003743 | translation initiation factor activity | 16.6667 | 4 | yes |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 15.0000 | 6 | yes |
GO:0016462 | pyrophosphatase activity | 15.0000 | 5 | yes |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 15.0000 | 4 | yes |
GO:0016887 | ATP hydrolysis activity | 11.6667 | 7 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in IF4A2_HUMAN |
---|---|---|---|---|
GO:0060255 | regulation of macromolecule metabolic process | 71.6667 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 70.0000 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 68.3333 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 68.3333 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 65.0000 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 63.3333 | 4 | no |
GO:0010468 | regulation of gene expression | 61.6667 | 5 | yes |
GO:0009889 | regulation of biosynthetic process | 58.3333 | 4 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 58.3333 | 5 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 56.6667 | 5 | yes |
GO:0009892 | negative regulation of metabolic process | 53.3333 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 53.3333 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 51.6667 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 50.0000 | 5 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 48.3333 | 5 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 48.3333 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 46.6667 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 45.0000 | 5 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 43.3333 | 5 | no |
GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 38.3333 | 5 | yes |
GO:0010608 | post-transcriptional regulation of gene expression | 36.6667 | 6 | yes |
GO:2000112 | regulation of cellular macromolecule biosynthetic process | 36.6667 | 6 | yes |
GO:0022607 | cellular component assembly | 36.6667 | 4 | no |
GO:0034248 | regulation of cellular amide metabolic process | 35.0000 | 5 | yes |
GO:0051252 | regulation of RNA metabolic process | 35.0000 | 5 | yes |
GO:0006417 | regulation of translation | 33.3333 | 6 | yes |
GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 31.6667 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 31.6667 | 6 | no |
GO:0009890 | negative regulation of biosynthetic process | 30.0000 | 5 | yes |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 30.0000 | 6 | yes |
GO:0031327 | negative regulation of cellular biosynthetic process | 30.0000 | 6 | yes |
GO:0010629 | negative regulation of gene expression | 30.0000 | 6 | no |
GO:0009966 | regulation of signal transduction | 30.0000 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 30.0000 | 6 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 30.0000 | 6 | no |
GO:0051248 | negative regulation of protein metabolic process | 28.3333 | 6 | no |
GO:0006996 | organelle organization | 28.3333 | 4 | no |
GO:0009894 | regulation of catabolic process | 26.6667 | 4 | no |
GO:0031329 | regulation of cellular catabolic process | 26.6667 | 5 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 25.0000 | 7 | yes |
GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | yes |
GO:0008104 | protein localization | 25.0000 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
GO:0051338 | regulation of transferase activity | 23.3333 | 4 | yes |
GO:0051726 | regulation of cell cycle | 23.3333 | 4 | no |
GO:0010648 | negative regulation of cell communication | 23.3333 | 5 | no |
GO:0023057 | negative regulation of signaling | 23.3333 | 4 | no |
GO:0042325 | regulation of phosphorylation | 23.3333 | 7 | no |
GO:0010941 | regulation of cell death | 23.3333 | 4 | no |
GO:0043412 | macromolecule modification | 23.3333 | 4 | no |
GO:0071310 | cellular response to organic substance | 23.3333 | 4 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 23.3333 | 6 | no |
GO:0043933 | protein-containing complex organization | 21.6667 | 4 | no |
GO:0009968 | negative regulation of signal transduction | 21.6667 | 5 | no |
GO:0048585 | negative regulation of response to stimulus | 21.6667 | 4 | no |
GO:0051129 | negative regulation of cellular component organization | 21.6667 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 21.6667 | 5 | no |
GO:0090304 | nucleic acid metabolic process | 21.6667 | 4 | no |
GO:0010628 | positive regulation of gene expression | 21.6667 | 6 | no |
GO:0006355 | regulation of DNA-templated transcription | 21.6667 | 6 | no |
GO:0006446 | regulation of translational initiation | 20.0000 | 7 | yes |
GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 16.6667 | 6 | yes |
GO:0051253 | negative regulation of RNA metabolic process | 15.0000 | 6 | yes |
GO:0043086 | negative regulation of catalytic activity | 13.3333 | 4 | yes |
GO:1902679 | negative regulation of RNA biosynthetic process | 11.6667 | 7 | yes |
GO:1903507 | negative regulation of nucleic acid-templated transcription | 11.6667 | 8 | yes |
GO:0051348 | negative regulation of transferase activity | 10.0000 | 5 | yes |
GO:0002183 | cytoplasmic translational initiation | 6.6667 | 4 | yes |
GO:1900259 | regulation of RNA-directed 5-3 RNA polymerase activity | 3.3333 | 5 | yes |
GO:1900260 | negative regulation of RNA-directed 5-3 RNA polymerase activity | 3.3333 | 6 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in IF4A2_HUMAN |
---|---|---|---|---|
DOID:440 | neuromuscular disease | 3.3333 | 5 | no |
DOID:574 | peripheral nervous system disease | 3.3333 | 3 | no |
DOID:870 | neuropathy | 3.3333 | 4 | no |
DOID:37 | skin disease | 3.3333 | 3 | no |
DOID:0080000 | muscular disease | 3.3333 | 3 | no |
DOID:423 | myopathy | 3.3333 | 5 | no |
DOID:66 | muscle tissue disease | 3.3333 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
IF4G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IF4G2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NEK2_HUMAN | [view interactions] | High throughput | no | no |
PFD1_HUMAN | [view interactions] | High throughput | no | yes |
KITH_HUMAN | [view interactions] | High throughput | no | yes |
HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EIF3H_HUMAN | [view interactions] | High throughput | no | yes |
XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LRP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IF4G3_HUMAN | [view interactions] | High throughput | no | yes |
EIF3L_HUMAN | [view interactions] | High throughput | no | yes |
PDCD4_HUMAN | [view interactions] | High throughput | no | yes |
EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IF4E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTPRS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GGYF2_HUMAN | [view interactions] | High throughput | no | yes |
CD2B2_HUMAN | [view interactions] | High throughput | no | yes |
EIF3M_HUMAN | [view interactions] | High throughput | no | yes |
AK17A_HUMAN | [view interactions] | High throughput | no | no |
SMG1_HUMAN | [view interactions] | High throughput | no | yes |
DYH5_HUMAN | [view interactions] | High throughput | no | no |
JIP4_HUMAN | [view interactions] | High throughput | no | yes |
EIF3K_HUMAN | [view interactions] | High throughput | no | yes |
VAC14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATRX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EIF3D_HUMAN | [view interactions] | High throughput | no | yes |
PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
CMBL_HUMAN | [view interactions] | High throughput | no | no |
HNRL2_HUMAN | [view interactions] | High throughput | no | yes |
IBTK_HUMAN | [view interactions] | High throughput | no | yes |
RS29_HUMAN | [view interactions] | High throughput | no | yes |
SYTM_HUMAN | [view interactions] | High throughput | no | yes |
EF1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PPBI_HUMAN | [view interactions] | High throughput | no | no |
PPBT_HUMAN | [view interactions] | High throughput | no | yes |
MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GBG12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TX101_HUMAN | [view interactions] | High throughput | no | no |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DPPA4_HUMAN | [view interactions] | High throughput | no | no |
MOT9_HUMAN | [view interactions] | High throughput | no | no |
TRI39_HUMAN | [view interactions] | High throughput | no | no |
TRI36_HUMAN | [view interactions] | High throughput | no | no |
ADIP_HUMAN | [view interactions] | High throughput | no | yes |
IPO11_HUMAN | [view interactions] | High throughput | no | yes |
IF4A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PIHD2_HUMAN | [view interactions] | High throughput | no | no |
DDX24_HUMAN | [view interactions] | High throughput | no | yes |
ICLN_HUMAN | [view interactions] | High throughput | no | yes |
GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
ECT2_HUMAN | [view interactions] | High throughput | no | no |
MDFI_HUMAN | [view interactions] | High throughput | no | no |
GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MCPH1_HUMAN | [view interactions] | High throughput | no | yes |
ZN620_HUMAN | [view interactions] | High throughput | no | no |
NKRF_HUMAN | [view interactions] | High throughput | no | no |
RL26L_HUMAN | [view interactions] | High throughput | no | yes |
IF4H_HUMAN | [view interactions] | High throughput | no | yes |
DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EIF3F_HUMAN | [view interactions] | High throughput | no | yes |
RPAP2_HUMAN | [view interactions] | High throughput | no | yes |
CD4_HUMAN | [view interactions] | High throughput | no | no |
TFE2_HUMAN | [view interactions] | High throughput | no | no |
TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CD81_HUMAN | [view interactions] | High throughput | no | no |
PLCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UNK_HUMAN | [view interactions] | High throughput | no | yes |
CRY1_HUMAN | [view interactions] | High throughput | no | yes |
CRY2_HUMAN | [view interactions] | High throughput | no | yes |
MCM2_HUMAN | [view interactions] | High throughput | no | no |
DUS28_HUMAN | [view interactions] | High throughput | no | yes |
IF4A1_HUMAN | [view interactions] | High throughput | no | no |
CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FBX7_HUMAN | [view interactions] | High throughput | no | yes |
LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
RUNX1_HUMAN | [view interactions] | High throughput | no | yes |
SUZ12_HUMAN | [view interactions] | High throughput | no | no |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
GLUC_HUMAN | [view interactions] | High throughput | no | no |
AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
APEX1_HUMAN | [view interactions] | High throughput | no | yes |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MN1_HUMAN | [view interactions] | High throughput | no | yes |
CDCA5_HUMAN | [view interactions] | High throughput | no | yes |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
KIF23_HUMAN | [view interactions] | High throughput | no | yes |
PRC1_HUMAN | [view interactions] | High throughput | no | yes |
NUPR1_HUMAN | [view interactions] | High throughput | no | no |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
4EBP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
4ET_HUMAN | [view interactions] | High throughput | no | yes |
4EBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EIF3B_HUMAN | [view interactions] | High throughput | no | yes |
EIF3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EIF3I_HUMAN | [view interactions] | High throughput | no | yes |
EIF3G_HUMAN | [view interactions] | High throughput | no | yes |
EIF3E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANGE1_HUMAN | [view interactions] | High throughput | no | yes |
SPOP_HUMAN | [view interactions] | High throughput | no | no |
DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
HECD1_HUMAN | [view interactions] | High throughput | no | yes |
BAG1_HUMAN | [view interactions] | High throughput | no | yes |
CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CP51A_HUMAN | [view interactions] | High throughput | no | no |
DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DRG1_HUMAN | [view interactions] | High throughput | no | yes |
NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
RBM42_HUMAN | [view interactions] | High throughput | no | yes |
RBM8A_HUMAN | [view interactions] | High throughput | no | yes |
RS11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRP09_HUMAN | [view interactions] | High throughput | no | no |
OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
DX39B_HUMAN | [view interactions] | High throughput | no | no |
AIMP1_HUMAN | [view interactions] | High throughput | no | yes |
CETN2_HUMAN | [view interactions] | High throughput | no | yes |
RSSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IF4A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LAGE3_HUMAN | [view interactions] | High throughput | no | yes |
ATX2_HUMAN | [view interactions] | High throughput | no | yes |
IF4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PABP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRC2A_HUMAN | [view interactions] | High throughput | no | yes |
PRC2B_HUMAN | [view interactions] | High throughput | no | no |
PRC2C_HUMAN | [view interactions] | High throughput | no | yes |
TDRD3_HUMAN | [view interactions] | High throughput | no | yes |
TOP3B_HUMAN | [view interactions] | High throughput | no | no |
RENT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBP10_HUMAN | [view interactions] | High throughput | no | yes |
YTHD2_HUMAN | [view interactions] | High throughput | no | yes |
TBB5_HUMAN | [view interactions] | High throughput | no | yes |
CCNF_HUMAN | [view interactions] | High throughput | no | no |
OPTN_HUMAN | [view interactions] | High throughput | no | yes |
4EBP3_HUMAN | [view interactions] | Computational | no | yes |
CNOT3_HUMAN | [view interactions] | Computational | no | yes |
NOM1_HUMAN | [view interactions] | Computational | no | yes |
EF1G_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PAIP1_HUMAN | [view interactions] | Computational | no | yes |
IF2G_HUMAN | [view interactions] | Computational | no | yes |
IF2A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CNOT8_HUMAN | [view interactions] | Computational | no | yes |
EF2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CNOT7_HUMAN | [view interactions] | Computational | no | no |
PAN2_HUMAN | [view interactions] | Computational | no | no |
CNO10_HUMAN | [view interactions] | Computational | no | yes |
CNOT4_HUMAN | [view interactions] | Computational | no | yes |
CNO11_HUMAN | [view interactions] | Computational | no | yes |
IF4E2_HUMAN | [view interactions] | Computational | no | no |
EIF1_HUMAN | [view interactions] | Computational | no | no |
CNO6L_HUMAN | [view interactions] | Computational | no | no |
CNOT9_HUMAN | [view interactions] | Computational | no | yes |
IF2P_HUMAN | [view interactions] | Computational | no | yes |
I4E1B_HUMAN | [view interactions] | Computational | no | no |
PAN3_HUMAN | [view interactions] | Computational | no | yes |
EF1A1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IF1AX_HUMAN | [view interactions] | Computational | no | yes |
CNOT6_HUMAN | [view interactions] | Computational | no | yes |
IF2B_HUMAN | [view interactions] | Computational | no | yes |
PARN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IF5_HUMAN | [view interactions] | Computational | no | yes |
TUT7_HUMAN | [view interactions] | Computational | no | yes |
IF4E3_HUMAN | [view interactions] | Computational | no | no |
TB182_HUMAN | [view interactions] | Computational | no | yes |
CNOT1_HUMAN | [view interactions] | Computational | no | yes |
CNOT2_HUMAN | [view interactions] | Computational | no | yes |