4EBP2_HUMAN
Evidence for PS localization
Functions
Repressor of translation initiation involved in synaptic plasticity, learning and memory formation . Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation . Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001212 | DOC_WD40_RPTOR_TOS_1 | DOC | 116 | 120 | - |
| ELMI002097 | LIG_eIF4E_1 | LIG | 54 | 60 | - |
| ELMI001212 | DOC_WD40_RPTOR_TOS_1 | DOC | 116 | 120 | - |
| ELMI002097 | LIG_eIF4E_1 | LIG | 54 | 60 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in 4EBP2_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 60.0000 | 4 | no |
| GO:0003743 | translation initiation factor activity | 40.0000 | 4 | no |
| GO:0000166 | nucleotide binding | 33.3333 | 4 | no |
| GO:0003729 | mRNA binding | 33.3333 | 5 | no |
| GO:0005524 | ATP binding | 33.3333 | 5 | no |
| GO:0017076 | purine nucleotide binding | 33.3333 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 33.3333 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 33.3333 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 33.3333 | 4 | no |
| GO:0043168 | anion binding | 33.3333 | 4 | no |
| GO:0008190 | eukaryotic initiation factor 4E binding | 20.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in 4EBP2_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 93.3333 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 86.6667 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 86.6667 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 86.6667 | 5 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 86.6667 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 86.6667 | 4 | yes |
| GO:0010468 | regulation of gene expression | 80.0000 | 6 | yes |
| GO:0048523 | negative regulation of cellular process | 80.0000 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 80.0000 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 80.0000 | 4 | no |
| GO:0006417 | regulation of translation | 66.6667 | 6 | yes |
| GO:0010608 | post-transcriptional regulation of gene expression | 66.6667 | 7 | yes |
| GO:0009893 | positive regulation of metabolic process | 66.6667 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 60.0000 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 60.0000 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 60.0000 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 53.3333 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 53.3333 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 53.3333 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 46.6667 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 46.6667 | 6 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 46.6667 | 5 | yes |
| GO:0010629 | negative regulation of gene expression | 46.6667 | 7 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 46.6667 | 6 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 46.6667 | 6 | no |
| GO:0022607 | cellular component assembly | 46.6667 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 46.6667 | 6 | no |
| GO:0006446 | regulation of translational initiation | 40.0000 | 7 | yes |
| GO:0010628 | positive regulation of gene expression | 40.0000 | 7 | no |
| GO:0043933 | protein-containing complex organization | 40.0000 | 4 | no |
| GO:0045727 | positive regulation of translation | 40.0000 | 7 | no |
| GO:0065003 | protein-containing complex assembly | 40.0000 | 5 | no |
| GO:0071310 | cellular response to organic substance | 40.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | yes |
| GO:0017148 | negative regulation of translation | 33.3333 | 7 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 33.3333 | 6 | yes |
| GO:0009894 | regulation of catabolic process | 33.3333 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 33.3333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0051726 | regulation of cell cycle | 33.3333 | 4 | no |
| GO:0060341 | regulation of cellular localization | 33.3333 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.3333 | 5 | no |
| GO:0071702 | organic substance transport | 33.3333 | 4 | no |
| GO:0071705 | nitrogen compound transport | 33.3333 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 26.6667 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 26.6667 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 26.6667 | 4 | yes |
| GO:0022618 | protein-RNA complex assembly | 26.6667 | 6 | no |
| GO:0071826 | protein-RNA complex organization | 26.6667 | 5 | no |
| GO:0007346 | regulation of mitotic cell cycle | 26.6667 | 5 | no |
| GO:0009895 | negative regulation of catabolic process | 26.6667 | 5 | no |
| GO:0010506 | regulation of autophagy | 26.6667 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.6667 | 6 | no |
| GO:0031329 | regulation of cellular catabolic process | 26.6667 | 5 | no |
| GO:0032880 | regulation of protein localization | 26.6667 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.6667 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.6667 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 26.6667 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 26.6667 | 4 | no |
| GO:0006913 | nucleocytoplasmic transport | 26.6667 | 5 | no |
| GO:0051169 | nuclear transport | 26.6667 | 4 | no |
| GO:0006412 | translation | 20.0000 | 4 | yes |
| GO:0009059 | macromolecule biosynthetic process | 20.0000 | 4 | yes |
| GO:0031929 | TOR signaling | 20.0000 | 4 | yes |
| GO:0045947 | negative regulation of translational initiation | 20.0000 | 8 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 13.3333 | 4 | yes |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 13.3333 | 5 | yes |
| GO:0008286 | insulin receptor signaling pathway | 13.3333 | 6 | yes |
| GO:0050890 | cognition | 13.3333 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| IF4E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RPTOR_HUMAN | [view interactions] | Low throughput | no | yes |
| MTOR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IF4E2_HUMAN | [view interactions] | High throughput | no | no |
| RDH12_HUMAN | [view interactions] | High throughput | no | no |
| LSM3_HUMAN | [view interactions] | High throughput | no | yes |
| FHL3_HUMAN | [view interactions] | High throughput | no | no |
| CDK4_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NFYA_HUMAN | [view interactions] | High throughput | no | yes |
| 4ET_HUMAN | [view interactions] | High throughput | no | yes |
| 4EBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4G3_HUMAN | [view interactions] | High throughput | no | yes |
| IF4A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3B_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3D_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3L_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3I_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3K_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3H_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3G_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3M_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANGE1_HUMAN | [view interactions] | High throughput | no | yes |
| RS27L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EIF3F_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| RHG17_HUMAN | [view interactions] | High throughput | no | no |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| TBCA_HUMAN | [view interactions] | High throughput | no | yes |