Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

4EBP2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Repressor of translation initiation involved in synaptic plasticity, learning and memory formation . Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation . Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI001212 DOC_WD40_RPTOR_TOS_1 DOC 116 120 -
ELMI002097 LIG_eIF4E_1 LIG 54 60 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in 4EBP2_HUMAN
GO:0003723 RNA binding 56.2500 4 no
GO:0017076 purine nucleotide binding 43.7500 4 no
GO:0030554 adenyl nucleotide binding 43.7500 5 no
GO:0003743 translation initiation factor activity 37.5000 4 no
GO:0005524 ATP binding 37.5000 5 no
GO:0032555 purine ribonucleotide binding 37.5000 4 no
GO:0032559 adenyl ribonucleotide binding 37.5000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 37.5000 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 25.0000 4 no
GO:0106310 protein serine kinase activity 25.0000 4 no
GO:0003729 mRNA binding 25.0000 5 no
GO:0004674 protein serine/threonine kinase activity 25.0000 4 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 25.0000 4 no
GO:0016301 kinase activity 25.0000 4 no
GO:0008190 eukaryotic initiation factor 4E binding 18.7500 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in 4EBP2_HUMAN
GO:0010468 regulation of gene expression 93.7500 5 yes
GO:0031323 regulation of cellular metabolic process 93.7500 4 yes
GO:0048523 negative regulation of cellular process 93.7500 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 93.7500 4 yes
GO:0060255 regulation of macromolecule metabolic process 93.7500 4 yes
GO:0080090 regulation of primary metabolic process 93.7500 4 yes
GO:0009889 regulation of biosynthetic process 87.5000 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 87.5000 5 yes
GO:0031326 regulation of cellular biosynthetic process 87.5000 5 yes
GO:0051246 regulation of protein metabolic process 81.2500 5 yes
GO:0048522 positive regulation of cellular process 81.2500 4 no
GO:0006417 regulation of translation 68.7500 6 yes
GO:0010608 post-transcriptional regulation of gene expression 68.7500 6 yes
GO:0034248 regulation of cellular amide metabolic process 68.7500 5 yes
GO:2000112 regulation of cellular macromolecule biosynthetic process 68.7500 6 yes
GO:0009892 negative regulation of metabolic process 62.5000 4 yes
GO:0031324 negative regulation of cellular metabolic process 62.5000 5 yes
GO:0009893 positive regulation of metabolic process 62.5000 4 no
GO:0031325 positive regulation of cellular metabolic process 62.5000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 56.2500 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 56.2500 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 56.2500 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 56.2500 5 no
GO:0009891 positive regulation of biosynthetic process 50.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 50.0000 6 no
GO:0010628 positive regulation of gene expression 50.0000 6 no
GO:0031328 positive regulation of cellular biosynthetic process 50.0000 6 no
GO:0051247 positive regulation of protein metabolic process 50.0000 6 no
GO:0006446 regulation of translational initiation 43.7500 7 yes
GO:0009890 negative regulation of biosynthetic process 43.7500 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 43.7500 6 yes
GO:0010646 regulation of cell communication 43.7500 4 yes
GO:0031327 negative regulation of cellular biosynthetic process 43.7500 6 yes
GO:0022607 cellular component assembly 43.7500 4 no
GO:0034250 positive regulation of cellular amide metabolic process 43.7500 6 no
GO:0045727 positive regulation of translation 43.7500 7 no
GO:0071310 cellular response to organic substance 37.5000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.5000 5 no
GO:0010629 negative regulation of gene expression 37.5000 6 yes
GO:0043933 protein-containing complex organization 37.5000 4 no
GO:0065003 protein-containing complex assembly 37.5000 5 no
GO:0051726 regulation of cell cycle 37.5000 4 no
GO:0009966 regulation of signal transduction 31.2500 4 no
GO:1901701 cellular response to oxygen-containing compound 31.2500 4 no
GO:0051252 regulation of RNA metabolic process 31.2500 5 no
GO:0051248 negative regulation of protein metabolic process 31.2500 6 yes
GO:0007346 regulation of mitotic cell cycle 31.2500 5 no
GO:0009894 regulation of catabolic process 31.2500 4 no
GO:0031329 regulation of cellular catabolic process 31.2500 5 no
GO:0045595 regulation of cell differentiation 31.2500 4 no
GO:0051128 regulation of cellular component organization 31.2500 4 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0014070 response to organic cyclic compound 25.0000 4 no
GO:0016310 phosphorylation 25.0000 5 no
GO:0018105 peptidyl-serine phosphorylation 25.0000 6 no
GO:0018193 peptidyl-amino acid modification 25.0000 5 no
GO:0018209 peptidyl-serine modification 25.0000 6 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0036211 protein modification process 25.0000 4 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0051049 regulation of transport 25.0000 4 no
GO:0071407 cellular response to organic cyclic compound 25.0000 5 no
GO:0071417 cellular response to organonitrogen compound 25.0000 4 no
GO:0071702 organic substance transport 25.0000 4 no
GO:1901699 cellular response to nitrogen compound 25.0000 4 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 25.0000 6 no
GO:0051253 negative regulation of RNA metabolic process 25.0000 6 no
GO:1903506 regulation of nucleic acid-templated transcription 25.0000 7 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0017148 negative regulation of translation 25.0000 7 yes
GO:0031929 TOR signaling 25.0000 4 yes
GO:0034249 negative regulation of cellular amide metabolic process 25.0000 6 yes
GO:0044271 cellular nitrogen compound biosynthetic process 25.0000 4 yes
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 yes
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 yes
GO:1901566 organonitrogen compound biosynthetic process 25.0000 4 yes
GO:2000113 negative regulation of cellular macromolecule biosynthetic process 25.0000 7 yes
GO:0022618 ribonucleoprotein complex assembly 25.0000 6 no
GO:0071826 ribonucleoprotein complex subunit organization 25.0000 5 no
GO:0045787 positive regulation of cell cycle 25.0000 5 no
GO:0045931 positive regulation of mitotic cell cycle 25.0000 6 no
GO:0010506 regulation of autophagy 25.0000 6 no
GO:0031667 response to nutrient levels 25.0000 4 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0006468 protein phosphorylation 25.0000 5 no
GO:0006796 phosphate-containing compound metabolic process 25.0000 4 no
GO:0006412 translation 18.7500 4 yes
GO:0006518 peptide metabolic process 18.7500 4 yes
GO:0009059 macromolecule biosynthetic process 18.7500 4 yes
GO:0034645 cellular macromolecule biosynthetic process 18.7500 4 yes
GO:0043043 peptide biosynthetic process 18.7500 5 yes
GO:0043603 cellular amide metabolic process 18.7500 4 yes
GO:0043604 amide biosynthetic process 18.7500 5 yes
GO:0045947 negative regulation of translational initiation 18.7500 8 yes
GO:0050890 cognition 18.7500 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 12.5000 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 12.5000 5 yes
GO:0007613 memory 12.5000 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
IF4E_HUMAN [view entry] [view interactions] Low throughput yes yes
RPTOR_HUMAN [view interactions] Low throughput no yes
MTOR_HUMAN [view entry] [view interactions] Low throughput yes yes
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
IF4E2_HUMAN [view interactions] High throughput no no
RDH12_HUMAN [view interactions] High throughput no no
LSM3_HUMAN [view interactions] High throughput no yes
FHL3_HUMAN [view interactions] High throughput no no
CDK4_HUMAN [view interactions] High throughput no no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
NFYA_HUMAN [view interactions] High throughput no yes
4ET_HUMAN [view interactions] High throughput no yes
4EBP1_HUMAN [view entry] [view interactions] High throughput yes yes
IF4G1_HUMAN [view entry] [view interactions] High throughput yes yes
IF4G3_HUMAN [view interactions] High throughput no yes
IF4A2_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3B_HUMAN [view interactions] High throughput no yes
EIF3D_HUMAN [view interactions] High throughput no yes
EIF3C_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3L_HUMAN [view interactions] High throughput no yes
EIF3I_HUMAN [view interactions] High throughput no yes
EIF3K_HUMAN [view interactions] High throughput no yes
EIF3H_HUMAN [view interactions] High throughput no yes
EIF3G_HUMAN [view interactions] High throughput no yes
EIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3M_HUMAN [view interactions] High throughput no yes
EIF3E_HUMAN [view entry] [view interactions] High throughput yes yes
ANGE1_HUMAN [view interactions] High throughput no yes
RS27L_HUMAN [view entry] [view interactions] High throughput yes no
EIF3F_HUMAN [view interactions] High throughput no yes
RHG17_HUMAN [view interactions] High throughput no no
ROA2_HUMAN [view entry] [view interactions] High throughput yes yes
THIO_HUMAN [view interactions] High throughput no yes
TBCA_HUMAN [view interactions] High throughput no yes
KS6B1_HUMAN [view entry] [view interactions] Computational yes yes
4EBP3_HUMAN [view interactions] Computational no yes