Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

4EBP1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI001211 DOC_WD40_RPTOR_TOS_1 DOC 114 118 -
ELMI002096 LIG_eIF4E_1 LIG 54 60 -
ELMI001211 DOC_WD40_RPTOR_TOS_1 DOC 114 118 -
ELMI002096 LIG_eIF4E_1 LIG 54 60 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in 4EBP1_HUMAN
GO:0003723 RNA binding 46.8750 4 no
GO:0043168 anion binding 46.8750 4 no
GO:0000166 nucleotide binding 43.7500 4 no
GO:0005524 ATP binding 43.7500 5 no
GO:0017076 purine nucleotide binding 43.7500 5 no
GO:0030554 adenyl nucleotide binding 43.7500 6 no
GO:0032555 purine ribonucleotide binding 43.7500 4 no
GO:0032559 adenyl ribonucleotide binding 43.7500 5 no
GO:0035639 purine ribonucleoside triphosphate binding 43.7500 4 no
GO:0016301 kinase activity 34.3750 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 34.3750 4 no
GO:0004674 protein serine/threonine kinase activity 31.2500 4 no
GO:0106310 protein serine kinase activity 28.1250 4 no
GO:0043169 cation binding 25.0000 4 no
GO:0046872 metal ion binding 25.0000 5 no
GO:0003677 DNA binding 21.8750 4 no
GO:0019900 kinase binding 21.8750 4 no
GO:0019901 protein kinase binding 21.8750 5 no
GO:0140297 DNA-binding transcription factor binding 21.8750 4 no
GO:0003729 mRNA binding 21.8750 5 no
GO:0003743 translation initiation factor activity 21.8750 4 no
GO:0008190 eukaryotic initiation factor 4E binding 9.3750 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in 4EBP1_HUMAN
GO:0031323 regulation of cellular metabolic process 81.2500 4 yes
GO:0060255 regulation of macromolecule metabolic process 81.2500 4 yes
GO:0009889 regulation of biosynthetic process 78.1250 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 78.1250 5 yes
GO:0031326 regulation of cellular biosynthetic process 78.1250 5 yes
GO:0048522 positive regulation of cellular process 78.1250 4 yes
GO:0080090 regulation of primary metabolic process 78.1250 4 yes
GO:0048523 negative regulation of cellular process 75.0000 4 yes
GO:0010468 regulation of gene expression 71.8750 6 yes
GO:0051246 regulation of protein metabolic process 68.7500 5 yes
GO:0009893 positive regulation of metabolic process 59.3750 4 no
GO:0010604 positive regulation of macromolecule metabolic process 59.3750 5 no
GO:0031325 positive regulation of cellular metabolic process 59.3750 5 no
GO:0010608 post-transcriptional regulation of gene expression 56.2500 7 yes
GO:0009891 positive regulation of biosynthetic process 56.2500 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 56.2500 6 no
GO:0031328 positive regulation of cellular biosynthetic process 56.2500 6 no
GO:0006417 regulation of translation 53.1250 6 yes
GO:0010646 regulation of cell communication 53.1250 4 no
GO:0009892 negative regulation of metabolic process 46.8750 4 yes
GO:0051247 positive regulation of protein metabolic process 46.8750 6 no
GO:0010605 negative regulation of macromolecule metabolic process 43.7500 5 yes
GO:0009966 regulation of signal transduction 43.7500 4 no
GO:0010628 positive regulation of gene expression 43.7500 7 no
GO:0043412 macromolecule modification 43.7500 4 no
GO:0031324 negative regulation of cellular metabolic process 40.6250 5 yes
GO:0006796 phosphate-containing compound metabolic process 40.6250 4 no
GO:0016310 phosphorylation 40.6250 5 no
GO:0036211 protein modification process 40.6250 4 no
GO:0051726 regulation of cell cycle 37.5000 4 yes
GO:0043933 protein-containing complex organization 37.5000 4 no
GO:0022607 cellular component assembly 37.5000 4 no
GO:0051248 negative regulation of protein metabolic process 34.3750 6 yes
GO:0009894 regulation of catabolic process 34.3750 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 34.3750 5 no
GO:0042127 regulation of cell population proliferation 34.3750 4 no
GO:0045595 regulation of cell differentiation 34.3750 4 no
GO:0048584 positive regulation of response to stimulus 34.3750 4 no
GO:0071310 cellular response to organic substance 34.3750 4 no
GO:0006468 protein phosphorylation 34.3750 5 no
GO:0009890 negative regulation of biosynthetic process 31.2500 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 31.2500 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 31.2500 6 yes
GO:0010647 positive regulation of cell communication 31.2500 5 no
GO:0019220 regulation of phosphate metabolic process 31.2500 6 no
GO:0023056 positive regulation of signaling 31.2500 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 31.2500 5 no
GO:0051094 positive regulation of developmental process 31.2500 4 no
GO:0051174 regulation of phosphorus metabolic process 31.2500 5 no
GO:0042981 regulation of apoptotic process 31.2500 5 no
GO:0043067 regulation of programmed cell death 31.2500 4 no
GO:0051128 regulation of cellular component organization 31.2500 4 no
GO:0060341 regulation of cellular localization 31.2500 4 no
GO:1902531 regulation of intracellular signal transduction 31.2500 5 no
GO:0065003 protein-containing complex assembly 31.2500 5 no
GO:0006446 regulation of translational initiation 28.1250 7 yes
GO:0010629 negative regulation of gene expression 28.1250 7 yes
GO:0009967 positive regulation of signal transduction 28.1250 5 no
GO:0030334 regulation of cell migration 28.1250 5 no
GO:0034097 response to cytokine 28.1250 4 no
GO:0043085 positive regulation of catalytic activity 28.1250 4 no
GO:0051252 regulation of RNA metabolic process 28.1250 5 no
GO:2000145 regulation of cell motility 28.1250 4 no
GO:0018193 peptidyl-amino acid modification 28.1250 5 no
GO:0031399 regulation of protein modification process 28.1250 6 no
GO:0032880 regulation of protein localization 28.1250 5 no
GO:0043066 negative regulation of apoptotic process 28.1250 6 no
GO:0043069 negative regulation of programmed cell death 28.1250 5 no
GO:0045727 positive regulation of translation 28.1250 7 no
GO:0007346 regulation of mitotic cell cycle 25.0000 5 yes
GO:0008284 positive regulation of cell population proliferation 25.0000 5 no
GO:0009059 macromolecule biosynthetic process 25.0000 4 no
GO:0030335 positive regulation of cell migration 25.0000 6 no
GO:0040017 positive regulation of locomotion 25.0000 4 no
GO:0045597 positive regulation of cell differentiation 25.0000 5 no
GO:0090304 nucleic acid metabolic process 25.0000 4 no
GO:2000147 positive regulation of cell motility 25.0000 5 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:0022618 protein-RNA complex assembly 25.0000 6 no
GO:0071826 protein-RNA complex organization 25.0000 5 no
GO:0006355 regulation of DNA-templated transcription 21.8750 7 no
GO:0007167 enzyme-linked receptor protein signaling pathway 21.8750 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 21.8750 5 no
GO:0008104 protein localization 21.8750 4 no
GO:0010243 response to organonitrogen compound 21.8750 4 no
GO:0016070 RNA metabolic process 21.8750 5 no
GO:0032870 cellular response to hormone stimulus 21.8750 4 no
GO:0045893 positive regulation of DNA-templated transcription 21.8750 8 no
GO:0048585 negative regulation of response to stimulus 21.8750 4 no
GO:0051240 positive regulation of multicellular organismal process 21.8750 4 no
GO:0051254 positive regulation of RNA metabolic process 21.8750 6 no
GO:0051336 regulation of hydrolase activity 21.8750 4 no
GO:0051345 positive regulation of hydrolase activity 21.8750 5 no
GO:0060284 regulation of cell development 21.8750 5 no
GO:0071345 cellular response to cytokine stimulus 21.8750 5 no
GO:0071702 organic substance transport 21.8750 4 no
GO:0080134 regulation of response to stress 21.8750 4 no
GO:1902680 positive regulation of RNA biosynthetic process 21.8750 7 no
GO:2000026 regulation of multicellular organismal development 21.8750 4 no
GO:2001141 regulation of RNA biosynthetic process 21.8750 6 no
GO:0001934 positive regulation of protein phosphorylation 21.8750 8 no
GO:0006996 organelle organization 21.8750 4 no
GO:0010562 positive regulation of phosphorus metabolic process 21.8750 6 no
GO:0010648 negative regulation of cell communication 21.8750 5 no
GO:0018105 peptidyl-serine phosphorylation 21.8750 6 no
GO:0018209 peptidyl-serine modification 21.8750 6 no
GO:0023057 negative regulation of signaling 21.8750 4 no
GO:0033043 regulation of organelle organization 21.8750 5 no
GO:0042327 positive regulation of phosphorylation 21.8750 8 no
GO:0045937 positive regulation of phosphate metabolic process 21.8750 7 no
GO:1902533 positive regulation of intracellular signal transduction 21.8750 6 no
GO:0051049 regulation of transport 21.8750 4 no
GO:0051338 regulation of transferase activity 21.8750 4 no
GO:0017148 negative regulation of translation 18.7500 7 yes
GO:0045787 positive regulation of cell cycle 18.7500 5 yes
GO:0045931 positive regulation of mitotic cell cycle 18.7500 6 yes
GO:0031929 TOR signaling 15.6250 4 yes
GO:0000082 G1/S transition of mitotic cell cycle 12.5000 5 yes
GO:0044772 mitotic cell cycle phase transition 12.5000 4 yes
GO:0044843 cell cycle G1/S phase transition 12.5000 4 yes
GO:0045947 negative regulation of translational initiation 12.5000 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
IF4E2_HUMAN [view interactions] Low throughput no no
HS90B_HUMAN [view entry] [view interactions] Low throughput yes yes
IF4E_HUMAN [view entry] [view interactions] Low throughput yes yes
RPTOR_HUMAN [view interactions] Low throughput no yes
AGO2_HUMAN [view entry] [view interactions] Low throughput yes yes
MTOR_HUMAN [view entry] [view interactions] Low throughput yes yes
2ABA_HUMAN [view interactions] Low throughput no yes
KLH25_HUMAN [view interactions] Low throughput no yes
PTPM1_HUMAN [view interactions] Low throughput no yes
HERC5_HUMAN [view interactions] Low throughput no yes
STAT3_HUMAN [view entry] [view interactions] Low throughput yes yes
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRK2_HUMAN [view interactions] Low throughput no yes
MK14_HUMAN [view interactions] Low throughput no yes
STK3_HUMAN [view interactions] Low throughput no yes
PTPA_HUMAN [view interactions] Low throughput no yes
ATM_HUMAN [view interactions] Low throughput no yes
PRKDC_HUMAN [view entry] [view interactions] Low throughput yes yes
LATS1_HUMAN [view entry] [view interactions] Low throughput yes yes
CSK2B_HUMAN [view entry] [view interactions] Low throughput yes yes
LST8_HUMAN [view interactions] Low throughput no yes
RICTR_HUMAN [view interactions] Low throughput no yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
KS6B1_HUMAN [view entry] [view interactions] High throughput yes yes
UBAC1_HUMAN [view interactions] High throughput no yes
EID1_HUMAN [view interactions] High throughput no yes
ITF2_HUMAN [view interactions] High throughput no yes
REL_HUMAN [view interactions] High throughput no yes
PICK1_HUMAN [view entry] [view interactions] High throughput yes yes
MEOX1_HUMAN [view interactions] High throughput no no
PO6F2_HUMAN [view interactions] High throughput no no
DDT4L_HUMAN [view interactions] High throughput no no
ZN655_HUMAN [view interactions] High throughput no yes
I4E1B_HUMAN [view interactions] High throughput no no
MVD1_HUMAN [view interactions] High throughput no yes
CTF8_HUMAN [view interactions] High throughput no no
DERPC_HUMAN [view interactions] High throughput no no
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
MAPK5_HUMAN [view interactions] High throughput no yes
BUB1_HUMAN [view interactions] High throughput no no
SLMAP_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
RBTN2_HUMAN [view interactions] High throughput no yes
AMRP_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
IF4G1_HUMAN [view entry] [view interactions] High throughput yes yes
4EBP2_HUMAN [view entry] [view interactions] High throughput yes yes
4ET_HUMAN [view interactions] High throughput no yes
IF4G3_HUMAN [view interactions] High throughput no yes
IF4A2_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3B_HUMAN [view interactions] High throughput no yes
EIF3D_HUMAN [view interactions] High throughput no yes
EIF3C_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3L_HUMAN [view interactions] High throughput no yes
EIF3I_HUMAN [view interactions] High throughput no yes
EIF3K_HUMAN [view interactions] High throughput no yes
EIF3H_HUMAN [view interactions] High throughput no yes
EIF3G_HUMAN [view interactions] High throughput no yes
EIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3M_HUMAN [view interactions] High throughput no yes
EIF3E_HUMAN [view entry] [view interactions] High throughput yes yes
ANGE1_HUMAN [view interactions] High throughput no yes
RS27L_HUMAN [view entry] [view interactions] High throughput yes no
EIF3F_HUMAN [view interactions] High throughput no yes
DPYL1_HUMAN [view entry] [view interactions] High throughput yes yes
FBX11_HUMAN [view interactions] High throughput no no
CARM1_HUMAN [view interactions] High throughput no yes
PCBP3_HUMAN [view interactions] High throughput no yes
BTBD1_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
IRAK4_HUMAN [view interactions] High throughput no yes
KPCA_HUMAN [view entry] [view interactions] High throughput yes yes
AKT2_HUMAN [view entry] [view interactions] High throughput yes yes
AKT3_HUMAN [view interactions] High throughput no yes
YJU2_HUMAN [view interactions] High throughput no yes
CHM2A_HUMAN [view interactions] High throughput no yes
DDX1_HUMAN [view entry] [view interactions] High throughput yes yes
FLNB_HUMAN [view interactions] High throughput no no
GGA1_HUMAN [view interactions] High throughput no yes
ROA1_HUMAN [view entry] [view interactions] High throughput yes yes
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
ROAA_HUMAN [view entry] [view interactions] High throughput yes yes
C170B_HUMAN [view interactions] High throughput no yes
STRN_HUMAN [view entry] [view interactions] High throughput yes yes
RABX5_HUMAN [view interactions] High throughput no no
RGPA1_HUMAN [view entry] [view interactions] High throughput yes yes
STK4_HUMAN [view interactions] High throughput no yes
TRI14_HUMAN [view interactions] High throughput no yes