RGPA1_HUMAN
Evidence for PS localization
Functions
Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RGPA1_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 39.4737 | 4 | no |
| GO:0017076 | purine nucleotide binding | 39.4737 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 39.4737 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 39.4737 | 4 | no |
| GO:0043168 | anion binding | 39.4737 | 4 | no |
| GO:0003924 | GTPase activity | 36.8421 | 7 | no |
| GO:0005525 | GTP binding | 36.8421 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 36.8421 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 36.8421 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 36.8421 | 6 | no |
| GO:0019001 | guanyl nucleotide binding | 36.8421 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 36.8421 | 5 | no |
| GO:0019900 | kinase binding | 28.9474 | 4 | no |
| GO:0019901 | protein kinase binding | 26.3158 | 5 | no |
| GO:0005096 | GTPase activator activity | 7.8947 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 7.8947 | 4 | yes |
| GO:0046982 | protein heterodimerization activity | 7.8947 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RGPA1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.7895 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 63.1579 | 4 | no |
| GO:0008104 | protein localization | 60.5263 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 55.2632 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 52.6316 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
| GO:0051049 | regulation of transport | 44.7368 | 4 | no |
| GO:0006996 | organelle organization | 44.7368 | 4 | no |
| GO:0010646 | regulation of cell communication | 42.1053 | 4 | yes |
| GO:0071702 | organic substance transport | 42.1053 | 4 | no |
| GO:0071705 | nitrogen compound transport | 42.1053 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.8421 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 36.8421 | 4 | no |
| GO:0010468 | regulation of gene expression | 36.8421 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.8421 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 36.8421 | 5 | no |
| GO:0009966 | regulation of signal transduction | 36.8421 | 4 | yes |
| GO:0015031 | protein transport | 36.8421 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 36.8421 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.8421 | 5 | no |
| GO:0141124 | intracellular signaling cassette | 34.2105 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 34.2105 | 4 | no |
| GO:0060341 | regulation of cellular localization | 34.2105 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.5789 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.5789 | 5 | no |
| GO:0022607 | cellular component assembly | 31.5789 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 31.5789 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 31.5789 | 5 | no |
| GO:0031399 | regulation of protein modification process | 28.9474 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 28.9474 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 28.9474 | 5 | no |
| GO:0007264 | small GTPase-mediated signal transduction | 28.9474 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 28.9474 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.9474 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 28.9474 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.9474 | 4 | no |
| GO:0032880 | regulation of protein localization | 28.9474 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 28.9474 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.3158 | 7 | no |
| GO:0051252 | regulation of RNA metabolic process | 26.3158 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 26.3158 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 26.3158 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 26.3158 | 4 | no |
| GO:0051050 | positive regulation of transport | 26.3158 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.3158 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 23.6842 | 7 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.6842 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.6842 | 4 | no |
| GO:0051726 | regulation of cell cycle | 23.6842 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 23.6842 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.6842 | 4 | no |
| GO:0006886 | intracellular protein transport | 23.6842 | 4 | no |
| GO:0098657 | import into cell | 23.6842 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.6842 | 7 | no |
| GO:0051338 | regulation of transferase activity | 21.0526 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 21.0526 | 5 | no |
| GO:0002684 | positive regulation of immune system process | 21.0526 | 4 | no |
| GO:0007010 | cytoskeleton organization | 21.0526 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 21.0526 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 21.0526 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.0526 | 4 | no |
| GO:0030334 | regulation of cell migration | 21.0526 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 21.0526 | 6 | no |
| GO:0061024 | membrane organization | 21.0526 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 21.0526 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 21.0526 | 6 | no |
| GO:2000145 | regulation of cell motility | 21.0526 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.0526 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.0526 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.0526 | 6 | no |
| GO:0043066 | negative regulation of apoptotic process | 21.0526 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 21.0526 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 21.0526 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 21.0526 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.0526 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 21.0526 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 13.1579 | 4 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 10.5263 | 6 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 10.5263 | 5 | yes |
| GO:0043087 | regulation of GTPase activity | 7.8947 | 5 | yes |
| GO:0043547 | positive regulation of GTPase activity | 7.8947 | 6 | yes |
| GO:0090630 | activation of GTPase activity | 5.2632 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RLGPB_HUMAN | [view interactions] | Low throughput | no | yes |
| TFE2_HUMAN | [view interactions] | Low throughput | no | no |
| SPTCS_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| RRP1B_HUMAN | [view interactions] | High throughput | no | yes |
| CLUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLMAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| DUS23_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRH_HUMAN | [view interactions] | High throughput | no | no |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| STYK1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| TERF2_HUMAN | [view interactions] | High throughput | no | yes |
| GFOD1_HUMAN | [view interactions] | High throughput | no | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KBRS2_HUMAN | [view interactions] | High throughput | no | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEA1_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGH_HUMAN | [view interactions] | High throughput | no | yes |
| C170B_HUMAN | [view interactions] | High throughput | no | yes |
| LMAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RABX5_HUMAN | [view interactions] | High throughput | no | no |
| 4EBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GARL3_HUMAN | [view interactions] | High throughput | no | yes |
| RGPA2_HUMAN | [view interactions] | High throughput | no | yes |
| STRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPGF5_HUMAN | [view interactions] | High throughput | no | yes |
| SI1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| AMPN_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |