Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RGPA1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RGPA1_HUMAN
GO:0017076 purine nucleotide binding 53.5714 4 no
GO:0032555 purine ribonucleotide binding 53.5714 4 no
GO:0035639 purine ribonucleoside triphosphate binding 53.5714 4 no
GO:0003924 GTPase activity 50.0000 7 no
GO:0005525 GTP binding 50.0000 5 no
GO:0016462 pyrophosphatase activity 50.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 50.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 50.0000 6 no
GO:0019001 guanyl nucleotide binding 50.0000 5 no
GO:0032561 guanyl ribonucleotide binding 50.0000 5 no
GO:0019900 kinase binding 32.1429 4 no
GO:0019003 GDP binding 28.5714 4 no
GO:0019901 protein kinase binding 28.5714 5 no
GO:0005096 GTPase activator activity 7.1429 4 yes
GO:0030695 GTPase regulator activity 7.1429 4 yes
GO:0046982 protein heterodimerization activity 7.1429 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RGPA1_HUMAN
GO:0048522 positive regulation of cellular process 71.4286 4 no
GO:0048523 negative regulation of cellular process 57.1429 4 no
GO:0051128 regulation of cellular component organization 57.1429 4 no
GO:0008104 protein localization 53.5714 4 no
GO:0006996 organelle organization 53.5714 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0022607 cellular component assembly 50.0000 4 no
GO:0051049 regulation of transport 50.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 46.4286 4 no
GO:0080090 regulation of primary metabolic process 46.4286 4 no
GO:0071702 organic substance transport 46.4286 4 no
GO:0071705 nitrogen compound transport 46.4286 4 no
GO:0009893 positive regulation of metabolic process 42.8571 4 no
GO:0010604 positive regulation of macromolecule metabolic process 42.8571 5 no
GO:0031323 regulation of cellular metabolic process 42.8571 4 no
GO:0015031 protein transport 42.8571 4 no
GO:0016192 vesicle-mediated transport 42.8571 4 no
GO:0010646 regulation of cell communication 39.2857 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 39.2857 5 no
GO:0009966 regulation of signal transduction 35.7143 4 yes
GO:0031325 positive regulation of cellular metabolic process 35.7143 5 no
GO:0042127 regulation of cell population proliferation 35.7143 4 no
GO:0051246 regulation of protein metabolic process 35.7143 5 no
GO:0010468 regulation of gene expression 35.7143 5 no
GO:0051130 positive regulation of cellular component organization 35.7143 5 no
GO:0060627 regulation of vesicle-mediated transport 35.7143 4 no
GO:0007264 small GTPase mediated signal transduction 35.7143 4 no
GO:0033043 regulation of organelle organization 35.7143 5 no
GO:0043085 positive regulation of catalytic activity 32.1429 4 yes
GO:1902531 regulation of intracellular signal transduction 32.1429 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 32.1429 6 no
GO:0019220 regulation of phosphate metabolic process 32.1429 6 no
GO:0042325 regulation of phosphorylation 32.1429 7 no
GO:0042327 positive regulation of phosphorylation 32.1429 8 no
GO:0045937 positive regulation of phosphate metabolic process 32.1429 7 no
GO:0051174 regulation of phosphorus metabolic process 32.1429 5 no
GO:0051247 positive regulation of protein metabolic process 32.1429 6 no
GO:0007010 cytoskeleton organization 32.1429 5 no
GO:0007265 Ras protein signal transduction 32.1429 5 no
GO:0010941 regulation of cell death 32.1429 4 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0001934 positive regulation of protein phosphorylation 28.5714 8 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0031401 positive regulation of protein modification process 28.5714 7 no
GO:0009889 regulation of biosynthetic process 28.5714 4 no
GO:0031326 regulation of cellular biosynthetic process 28.5714 5 no
GO:0006886 intracellular protein transport 28.5714 4 no
GO:0051050 positive regulation of transport 28.5714 4 no
GO:0061024 membrane organization 28.5714 4 no
GO:0030030 cell projection organization 28.5714 4 no
GO:0042981 regulation of apoptotic process 28.5714 6 no
GO:0043067 regulation of programmed cell death 28.5714 5 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0051493 regulation of cytoskeleton organization 28.5714 6 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0051347 positive regulation of transferase activity 25.0000 5 no
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0051726 regulation of cell cycle 25.0000 4 no
GO:0006897 endocytosis 25.0000 5 no
GO:0030100 regulation of endocytosis 25.0000 5 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0030334 regulation of cell migration 25.0000 5 no
GO:0032956 regulation of actin cytoskeleton organization 25.0000 5 no
GO:0032970 regulation of actin filament-based process 25.0000 4 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0060548 negative regulation of cell death 25.0000 5 no
GO:0097435 supramolecular fiber organization 25.0000 4 no
GO:1901214 regulation of neuron death 25.0000 5 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:2000145 regulation of cell motility 25.0000 4 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:0033674 positive regulation of kinase activity 21.4286 6 no
GO:0043549 regulation of kinase activity 21.4286 5 no
GO:0010605 negative regulation of macromolecule metabolic process 21.4286 5 no
GO:0032880 regulation of protein localization 21.4286 5 no
GO:0002684 positive regulation of immune system process 21.4286 4 no
GO:0006355 regulation of DNA-templated transcription 21.4286 6 no
GO:0007015 actin filament organization 21.4286 5 no
GO:0010628 positive regulation of gene expression 21.4286 6 no
GO:0022604 regulation of cell morphogenesis 21.4286 5 no
GO:0030335 positive regulation of cell migration 21.4286 6 no
GO:0031344 regulation of cell projection organization 21.4286 5 no
GO:0040017 positive regulation of locomotion 21.4286 4 no
GO:0043066 negative regulation of apoptotic process 21.4286 7 no
GO:0043069 negative regulation of programmed cell death 21.4286 6 no
GO:0044089 positive regulation of cellular component biogenesis 21.4286 5 no
GO:0051094 positive regulation of developmental process 21.4286 4 no
GO:0051240 positive regulation of multicellular organismal process 21.4286 4 no
GO:0051252 regulation of RNA metabolic process 21.4286 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.4286 6 no
GO:1903506 regulation of nucleic acid-templated transcription 21.4286 7 no
GO:2000147 positive regulation of cell motility 21.4286 5 no
GO:2001141 regulation of RNA biosynthetic process 21.4286 6 no
GO:0051336 regulation of hydrolase activity 14.2857 4 yes
GO:0051345 positive regulation of hydrolase activity 14.2857 5 yes
GO:0043087 regulation of GTPase activity 10.7143 5 yes
GO:0043547 positive regulation of GTPase activity 10.7143 6 yes
GO:0051056 regulation of small GTPase mediated signal transduction 10.7143 6 yes
GO:0090630 activation of GTPase activity 7.1429 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RLGPB_HUMAN [view interactions] Low throughput no yes
TFE2_HUMAN [view interactions] Low throughput no no
PDIA4_HUMAN [view interactions] High throughput no yes
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
INSR_HUMAN [view interactions] High throughput no yes
ERBB3_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
RRP1B_HUMAN [view interactions] High throughput no yes
CLUS_HUMAN [view entry] [view interactions] High throughput yes yes
SLMAP_HUMAN [view entry] [view interactions] High throughput yes yes
CEP63_HUMAN [view interactions] High throughput no yes
LAMP1_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
NECD_HUMAN [view interactions] High throughput no no
DUS23_HUMAN [view interactions] High throughput no yes
PTPRH_HUMAN [view interactions] High throughput no no
LMTK1_HUMAN [view interactions] High throughput no yes
STYK1_HUMAN [view interactions] High throughput no yes
TERF1_HUMAN [view interactions] High throughput no no
TERF2_HUMAN [view interactions] High throughput no yes
GFOD1_HUMAN [view interactions] High throughput no yes
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
KBRS2_HUMAN [view interactions] High throughput no no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
KI20A_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
NUDC2_HUMAN [view entry] [view interactions] High throughput yes yes
DLG3_HUMAN [view entry] [view interactions] High throughput yes yes
SGIP1_HUMAN [view entry] [view interactions] High throughput yes yes
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
MEA1_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND1_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
OTUD4_HUMAN [view interactions] High throughput no yes
ARHGH_HUMAN [view interactions] High throughput no yes
C170B_HUMAN [view interactions] High throughput no yes
LMAN1_HUMAN [view interactions] High throughput no yes
RABX5_HUMAN [view interactions] High throughput no no
4EBP1_HUMAN [view entry] [view interactions] High throughput yes yes
GARL3_HUMAN [view interactions] High throughput no yes
RGPA2_HUMAN [view interactions] High throughput no yes
STRN_HUMAN [view entry] [view interactions] High throughput yes yes
RPGF5_HUMAN [view interactions] High throughput no yes
SI1L2_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
DNJC5_HUMAN [view interactions] High throughput no yes
CAV1_HUMAN [view interactions] High throughput no no
DIRA3_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
OCLN_HUMAN [view interactions] High throughput no no
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB9A_HUMAN [view interactions] High throughput no yes
STX6_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
IFM1_HUMAN [view interactions] High throughput no no
AMPN_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes