SGIP1_HUMAN
Evidence for PS localization
Functions
May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SGIP1_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 32.1429 | 4 | no |
| GO:0005509 | calcium ion binding | 25.0000 | 5 | no |
| GO:0008017 | microtubule binding | 10.7143 | 5 | yes |
| GO:0015631 | tubulin binding | 10.7143 | 4 | yes |
| GO:0017124 | SH3 domain binding | 10.7143 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SGIP1_HUMAN |
|---|---|---|---|---|
| GO:0016192 | vesicle-mediated transport | 64.2857 | 4 | yes |
| GO:0006897 | endocytosis | 57.1429 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 53.5714 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | yes |
| GO:0071702 | organic substance transport | 50.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 50.0000 | 4 | no |
| GO:0008104 | protein localization | 46.4286 | 4 | no |
| GO:0015031 | protein transport | 46.4286 | 4 | no |
| GO:0022607 | cellular component assembly | 42.8571 | 4 | yes |
| GO:0006898 | receptor-mediated endocytosis | 39.2857 | 6 | yes |
| GO:0051049 | regulation of transport | 39.2857 | 4 | yes |
| GO:0010646 | regulation of cell communication | 39.2857 | 4 | no |
| GO:0072583 | clathrin-dependent endocytosis | 35.7143 | 7 | yes |
| GO:0006886 | intracellular protein transport | 35.7143 | 4 | no |
| GO:0009966 | regulation of signal transduction | 35.7143 | 4 | no |
| GO:0043933 | protein-containing complex organization | 32.1429 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 32.1429 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 32.1429 | 4 | no |
| GO:0051050 | positive regulation of transport | 28.5714 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 28.5714 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 28.5714 | 5 | no |
| GO:0032880 | regulation of protein localization | 28.5714 | 5 | no |
| GO:0060341 | regulation of cellular localization | 28.5714 | 4 | no |
| GO:0030100 | regulation of endocytosis | 25.0000 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 25.0000 | 4 | yes |
| GO:0048488 | synaptic vesicle endocytosis | 25.0000 | 5 | no |
| GO:0099003 | vesicle-mediated transport in synapse | 25.0000 | 5 | no |
| GO:0140238 | presynaptic endocytosis | 25.0000 | 4 | no |
| GO:0006996 | organelle organization | 25.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 25.0000 | 4 | no |
| GO:0071310 | cellular response to organic substance | 25.0000 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.4286 | 4 | yes |
| GO:0010468 | regulation of gene expression | 21.4286 | 5 | no |
| GO:0010941 | regulation of cell death | 21.4286 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 21.4286 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 21.4286 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 21.4286 | 4 | no |
| GO:0030030 | cell projection organization | 21.4286 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 21.4286 | 5 | no |
| GO:0033043 | regulation of organelle organization | 21.4286 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.4286 | 6 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 21.4286 | 4 | no |
| GO:1903829 | positive regulation of protein localization | 21.4286 | 5 | no |
| GO:0048259 | regulation of receptor-mediated endocytosis | 17.8571 | 6 | yes |
| GO:0048268 | clathrin coat assembly | 17.8571 | 6 | yes |
| GO:0045807 | positive regulation of endocytosis | 14.2857 | 5 | yes |
| GO:0048260 | positive regulation of receptor-mediated endocytosis | 10.7143 | 6 | yes |
| GO:0031667 | response to nutrient levels | 7.1429 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| WLS_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CALX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPS15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| REPS1_HUMAN | [view interactions] | Low throughput | no | yes |
| AMPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CRBG1_HUMAN | [view interactions] | High throughput | no | no |
| H2A2C_HUMAN | [view interactions] | High throughput | no | yes |
| PADI3_HUMAN | [view interactions] | High throughput | no | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| S10A3_HUMAN | [view interactions] | High throughput | no | no |
| SPAG6_HUMAN | [view interactions] | High throughput | no | no |
| HPHL1_HUMAN | [view interactions] | High throughput | no | no |
| LRC15_HUMAN | [view interactions] | High throughput | no | no |
| LYG2_HUMAN | [view interactions] | High throughput | no | no |
| VSIG8_HUMAN | [view interactions] | High throughput | no | no |
| SNH28_HUMAN | [view interactions] | High throughput | no | no |
| CAHM4_HUMAN | [view interactions] | High throughput | no | no |
| CASP4_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAB2_HUMAN | [view interactions] | High throughput | no | yes |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACK1_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RLGPB_HUMAN | [view interactions] | High throughput | no | yes |
| NCOR2_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RGPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSG4_HUMAN | [view interactions] | High throughput | no | no |
| DUS14_HUMAN | [view interactions] | High throughput | no | yes |
| PLCD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AAK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARFG1_HUMAN | [view interactions] | Computational | no | no |
| NECP2_HUMAN | [view interactions] | Computational | no | yes |
| CLCA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| UBQL2_HUMAN | [view interactions] | Computational | no | yes |
| SYNRG_HUMAN | [view interactions] | Computational | no | yes |