SGIP1_HUMAN
Evidence for PS localization
Functions
May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SGIP1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 38.7097 | 4 | no |
| GO:0046872 | metal ion binding | 38.7097 | 5 | no |
| GO:0043168 | anion binding | 22.5806 | 4 | no |
| GO:0017124 | SH3 domain binding | 16.1290 | 4 | yes |
| GO:0008017 | microtubule binding | 9.6774 | 5 | yes |
| GO:0015631 | tubulin binding | 9.6774 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SGIP1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.0645 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 58.0645 | 4 | yes |
| GO:0098657 | import into cell | 48.3871 | 4 | yes |
| GO:0010646 | regulation of cell communication | 45.1613 | 4 | no |
| GO:0008104 | protein localization | 41.9355 | 4 | no |
| GO:0071702 | organic substance transport | 41.9355 | 4 | no |
| GO:0071705 | nitrogen compound transport | 41.9355 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 41.9355 | 4 | no |
| GO:0051049 | regulation of transport | 38.7097 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 38.7097 | 4 | no |
| GO:0015031 | protein transport | 35.4839 | 4 | no |
| GO:0022607 | cellular component assembly | 35.4839 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.4839 | 4 | no |
| GO:0006898 | receptor-mediated endocytosis | 32.2581 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 32.2581 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 32.2581 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 32.2581 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 32.2581 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 32.2581 | 6 | no |
| GO:0031323 | regulation of cellular metabolic process | 32.2581 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 29.0323 | 4 | yes |
| GO:0072583 | clathrin-dependent endocytosis | 29.0323 | 5 | yes |
| GO:0050890 | cognition | 29.0323 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.0323 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 29.0323 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 29.0323 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.0323 | 5 | no |
| GO:0006886 | intracellular protein transport | 25.8065 | 4 | no |
| GO:0006996 | organelle organization | 25.8065 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.8065 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 25.8065 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 25.8065 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.8065 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.8065 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.8065 | 5 | no |
| GO:0050807 | regulation of synapse organization | 25.8065 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.8065 | 5 | no |
| GO:0048488 | synaptic vesicle endocytosis | 22.5806 | 5 | no |
| GO:0140238 | presynaptic endocytosis | 22.5806 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 22.5806 | 7 | no |
| GO:0030030 | cell projection organization | 22.5806 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 22.5806 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 22.5806 | 5 | no |
| GO:0010468 | regulation of gene expression | 22.5806 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 22.5806 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.5806 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.5806 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 22.5806 | 4 | no |
| GO:0043933 | protein-containing complex organization | 22.5806 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.5806 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.5806 | 5 | no |
| GO:0051050 | positive regulation of transport | 19.3548 | 4 | yes |
| GO:0030100 | regulation of endocytosis | 16.1290 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 16.1290 | 4 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 12.9032 | 6 | yes |
| GO:0045807 | positive regulation of endocytosis | 9.6774 | 5 | yes |
| GO:0048260 | positive regulation of receptor-mediated endocytosis | 9.6774 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| WLS_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CALX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPS15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| REPS1_HUMAN | [view interactions] | Low throughput | no | yes |
| AMPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RLGPB_HUMAN | [view interactions] | High throughput | no | yes |
| NCOR2_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RGPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSG4_HUMAN | [view interactions] | High throughput | no | no |
| DUS14_HUMAN | [view interactions] | High throughput | no | yes |
| PLCD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRBG1_HUMAN | [view interactions] | High throughput | no | no |
| H2A2C_HUMAN | [view interactions] | High throughput | no | yes |
| PADI3_HUMAN | [view interactions] | High throughput | no | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| S10A3_HUMAN | [view interactions] | High throughput | no | no |
| SPAG6_HUMAN | [view interactions] | High throughput | no | no |
| HPHL1_HUMAN | [view interactions] | High throughput | no | no |
| LRC15_HUMAN | [view interactions] | High throughput | no | no |
| LYG2_HUMAN | [view interactions] | High throughput | no | no |
| VSIG8_HUMAN | [view interactions] | High throughput | no | no |
| SNH28_HUMAN | [view interactions] | High throughput | no | no |
| CAHM4_HUMAN | [view interactions] | High throughput | no | no |
| CASP4_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAB2_HUMAN | [view interactions] | High throughput | no | yes |
| CDKL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |