ITSN2_HUMAN
Evidence for PS localization
Functions
Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ITSN2_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 24.6154 | 4 | no |
| GO:0019901 | protein kinase binding | 24.6154 | 5 | no |
| GO:0046872 | metal ion binding | 16.9231 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 12.3077 | 4 | yes |
| GO:0005509 | calcium ion binding | 9.2308 | 5 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 7.6923 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ITSN2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 55.3846 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 50.7692 | 4 | yes |
| GO:0006897 | endocytosis | 44.6154 | 5 | yes |
| GO:0022607 | cellular component assembly | 43.0769 | 4 | no |
| GO:0008104 | protein localization | 41.5385 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 38.4615 | 4 | yes |
| GO:0006996 | organelle organization | 38.4615 | 4 | no |
| GO:0010646 | regulation of cell communication | 36.9231 | 4 | no |
| GO:0071702 | organic substance transport | 35.3846 | 4 | no |
| GO:0051049 | regulation of transport | 33.8462 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 33.8462 | 4 | no |
| GO:0071705 | nitrogen compound transport | 33.8462 | 4 | no |
| GO:0015031 | protein transport | 32.3077 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 30.7692 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 30.7692 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 30.7692 | 4 | no |
| GO:0010468 | regulation of gene expression | 29.2308 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 29.2308 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.2308 | 5 | no |
| GO:0009966 | regulation of signal transduction | 29.2308 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 27.6923 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 27.6923 | 5 | no |
| GO:0006898 | receptor-mediated endocytosis | 26.1538 | 6 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.1538 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.1538 | 5 | no |
| GO:0043933 | protein-containing complex organization | 26.1538 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.6154 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.6154 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 24.6154 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 24.6154 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 24.6154 | 5 | no |
| GO:0030030 | cell projection organization | 24.6154 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.0769 | 5 | no |
| GO:0007010 | cytoskeleton organization | 23.0769 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.0769 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.5385 | 4 | yes |
| GO:0051050 | positive regulation of transport | 21.5385 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.5385 | 5 | no |
| GO:0072583 | clathrin-dependent endocytosis | 18.4615 | 7 | yes |
| GO:0048488 | synaptic vesicle endocytosis | 16.9231 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 16.9231 | 4 | yes |
| GO:0099003 | vesicle-mediated transport in synapse | 16.9231 | 5 | yes |
| GO:0140238 | presynaptic endocytosis | 16.9231 | 4 | yes |
| GO:0022604 | regulation of cell morphogenesis | 12.3077 | 5 | yes |
| GO:0016197 | endosomal transport | 10.7692 | 4 | yes |
| GO:0048638 | regulation of developmental growth | 7.6923 | 4 | yes |
| GO:0001558 | regulation of cell growth | 6.1538 | 4 | yes |
| GO:0045927 | positive regulation of growth | 6.1538 | 4 | yes |
| GO:0030307 | positive regulation of cell growth | 4.6154 | 5 | yes |
| GO:0048639 | positive regulation of developmental growth | 4.6154 | 5 | yes |
| GO:0150007 | clathrin-dependent synaptic vesicle endocytosis | 4.6154 | 4 | yes |
| GO:1903859 | regulation of dendrite extension | 3.0769 | 5 | yes |
| GO:1903861 | positive regulation of dendrite extension | 3.0769 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ITSN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KHDR1_HUMAN | [view interactions] | Low throughput | no | yes |
| WASP_HUMAN | [view interactions] | Low throughput | no | yes |
| RABE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WIPF1_HUMAN | [view interactions] | Low throughput | no | no |
| EPS8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WIPF3_HUMAN | [view interactions] | Low throughput | no | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TNFL6_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| ADA12_HUMAN | [view interactions] | High throughput | no | no |
| SYNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEM6A_HUMAN | [view interactions] | High throughput | no | yes |
| K1549_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEG10_HUMAN | [view interactions] | High throughput | no | no |
| LSM8_HUMAN | [view interactions] | High throughput | no | yes |
| YTHD1_HUMAN | [view interactions] | High throughput | no | no |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| CBLB_HUMAN | [view interactions] | High throughput | no | yes |
| MCRS1_HUMAN | [view interactions] | High throughput | no | yes |
| BCCIP_HUMAN | [view interactions] | High throughput | no | no |
| PTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBL3_HUMAN | [view interactions] | High throughput | no | yes |
| M4K3_HUMAN | [view interactions] | High throughput | no | no |
| SOS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EIF3H_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3L_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3G_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3B_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3I_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| FBF1_HUMAN | [view interactions] | High throughput | no | no |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FNBP4_HUMAN | [view interactions] | High throughput | no | yes |
| SNP29_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| KXDL1_HUMAN | [view interactions] | High throughput | no | yes |
| LC7L3_HUMAN | [view interactions] | High throughput | no | yes |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB6I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOG8A_HUMAN | [view interactions] | High throughput | no | no |
| GOGB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| BACD3_HUMAN | [view interactions] | High throughput | no | yes |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| BRE1A_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TACC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR17_HUMAN | [view interactions] | High throughput | no | yes |
| DAPLE_HUMAN | [view interactions] | High throughput | no | yes |
| DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROCK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUFY1_HUMAN | [view interactions] | High throughput | no | yes |
| TMF1_HUMAN | [view interactions] | High throughput | no | yes |
| ANGT_HUMAN | [view interactions] | High throughput | no | no |
| AHDC1_HUMAN | [view interactions] | High throughput | no | yes |
| CHIC2_HUMAN | [view interactions] | High throughput | no | no |
| CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
| DYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FCSD1_HUMAN | [view interactions] | High throughput | no | yes |
| FCSD2_HUMAN | [view interactions] | High throughput | no | no |
| GPNMB_HUMAN | [view interactions] | High throughput | no | no |
| IP3KA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LARP6_HUMAN | [view interactions] | High throughput | no | yes |
| LTBP4_HUMAN | [view interactions] | High throughput | no | yes |
| MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
| PDC6I_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAP_HUMAN | [view interactions] | High throughput | no | no |
| P3C2B_HUMAN | [view interactions] | High throughput | no | no |
| RBMX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REPS1_HUMAN | [view interactions] | High throughput | no | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOS2_HUMAN | [view interactions] | High throughput | no | yes |
| SYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WASL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WIPF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AMPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YLPM1_HUMAN | [view interactions] | High throughput | no | yes |
| WASF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GARE2_HUMAN | [view interactions] | High throughput | no | no |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| TM9S4_HUMAN | [view interactions] | High throughput | no | yes |
| RNF41_HUMAN | [view interactions] | High throughput | no | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| P4R3A_HUMAN | [view interactions] | High throughput | no | yes |
| RM09_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPN90_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOL7_HUMAN | [view interactions] | High throughput | no | yes |
| PABP2_HUMAN | [view interactions] | High throughput | no | yes |
| RBM22_HUMAN | [view interactions] | High throughput | no | yes |
| SNR40_HUMAN | [view interactions] | High throughput | no | yes |
| RU2B_HUMAN | [view interactions] | High throughput | no | yes |
| SRFB1_HUMAN | [view interactions] | High throughput | no | no |
| PSMD7_HUMAN | [view interactions] | High throughput | no | yes |
| NUP50_HUMAN | [view interactions] | High throughput | no | yes |
| PPIL4_HUMAN | [view interactions] | High throughput | no | yes |
| TAB1_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| SGIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GARE1_HUMAN | [view interactions] | High throughput | no | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| FXL19_HUMAN | [view interactions] | High throughput | no | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6B_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6C_HUMAN | [view interactions] | High throughput | no | no |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SF3B6_HUMAN | [view interactions] | Computational | no | yes |
| SYNRG_HUMAN | [view interactions] | Computational | no | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NUMB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EPN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EPN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CLH2_HUMAN | [view interactions] | Computational | no | no |
| DYN3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AP180_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARFG1_HUMAN | [view interactions] | Computational | no | no |
| DYN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Computational | yes | yes |