Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IP3KA_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

[View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in IP3KA_HUMAN
GO:0019900 kinase binding 42.1053 4 no
GO:0019901 protein kinase binding 42.1053 5 no
GO:0046872 metal ion binding 36.8421 4 no
GO:0005524 ATP binding 26.3158 5 yes
GO:0017076 purine nucleotide binding 26.3158 4 yes
GO:0030554 adenyl nucleotide binding 26.3158 5 yes
GO:0032555 purine ribonucleotide binding 26.3158 4 yes
GO:0032559 adenyl ribonucleotide binding 26.3158 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 26.3158 4 yes
GO:0005509 calcium ion binding 26.3158 5 no
GO:0016301 kinase activity 21.0526 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 21.0526 4 yes
GO:0004674 protein serine/threonine kinase activity 15.7895 4 yes
GO:0004683 calmodulin-dependent protein kinase activity 10.5263 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in IP3KA_HUMAN
GO:0048522 positive regulation of cellular process 73.6842 4 yes
GO:0010646 regulation of cell communication 68.4211 4 yes
GO:0031323 regulation of cellular metabolic process 57.8947 4 no
GO:0051171 regulation of nitrogen compound metabolic process 57.8947 4 no
GO:0060255 regulation of macromolecule metabolic process 57.8947 4 no
GO:0080090 regulation of primary metabolic process 57.8947 4 no
GO:0009966 regulation of signal transduction 57.8947 4 no
GO:0051128 regulation of cellular component organization 52.6316 4 yes
GO:0048523 negative regulation of cellular process 52.6316 4 no
GO:0006996 organelle organization 52.6316 4 yes
GO:0050804 modulation of chemical synaptic transmission 47.3684 5 yes
GO:0099177 regulation of trans-synaptic signaling 47.3684 4 yes
GO:0051049 regulation of transport 47.3684 4 no
GO:0051246 regulation of protein metabolic process 47.3684 5 no
GO:0051050 positive regulation of transport 42.1053 4 no
GO:0051336 regulation of hydrolase activity 42.1053 4 no
GO:1902531 regulation of intracellular signal transduction 42.1053 5 no
GO:0006796 phosphate-containing compound metabolic process 42.1053 4 yes
GO:0001932 regulation of protein phosphorylation 36.8421 7 no
GO:0009893 positive regulation of metabolic process 36.8421 4 no
GO:0010604 positive regulation of macromolecule metabolic process 36.8421 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 36.8421 5 no
GO:0019220 regulation of phosphate metabolic process 36.8421 6 no
GO:0031325 positive regulation of cellular metabolic process 36.8421 5 no
GO:0031399 regulation of protein modification process 36.8421 6 no
GO:0036211 protein modification process 36.8421 4 no
GO:0042325 regulation of phosphorylation 36.8421 7 no
GO:0043269 regulation of ion transport 36.8421 5 no
GO:0043412 macromolecule modification 36.8421 4 no
GO:0043549 regulation of kinase activity 36.8421 5 no
GO:0045859 regulation of protein kinase activity 36.8421 6 no
GO:0051173 positive regulation of nitrogen compound metabolic process 36.8421 5 no
GO:0051174 regulation of phosphorus metabolic process 36.8421 5 no
GO:0051338 regulation of transferase activity 36.8421 4 no
GO:0071900 regulation of protein serine/threonine kinase activity 36.8421 7 no
GO:0010468 regulation of gene expression 36.8421 5 no
GO:0043085 positive regulation of catalytic activity 36.8421 4 no
GO:0045595 regulation of cell differentiation 36.8421 4 yes
GO:2000026 regulation of multicellular organismal development 31.5789 4 yes
GO:0022607 cellular component assembly 31.5789 4 no
GO:0034762 regulation of transmembrane transport 31.5789 4 no
GO:0043270 positive regulation of ion transport 31.5789 5 no
GO:0051726 regulation of cell cycle 31.5789 4 no
GO:0006355 regulation of DNA-templated transcription 31.5789 6 no
GO:0009889 regulation of biosynthetic process 31.5789 4 no
GO:0010556 regulation of macromolecule biosynthetic process 31.5789 5 no
GO:0010959 regulation of metal ion transport 31.5789 6 no
GO:0031326 regulation of cellular biosynthetic process 31.5789 5 no
GO:0044057 regulation of system process 31.5789 4 no
GO:0051247 positive regulation of protein metabolic process 31.5789 6 no
GO:0051252 regulation of RNA metabolic process 31.5789 5 no
GO:0051345 positive regulation of hydrolase activity 31.5789 5 no
GO:0051924 regulation of calcium ion transport 31.5789 7 no
GO:1903506 regulation of nucleic acid-templated transcription 31.5789 7 no
GO:2001141 regulation of RNA biosynthetic process 31.5789 6 no
GO:0009892 negative regulation of metabolic process 31.5789 4 no
GO:0010605 negative regulation of macromolecule metabolic process 31.5789 5 no
GO:0010941 regulation of cell death 31.5789 4 no
GO:0031324 negative regulation of cellular metabolic process 31.5789 5 no
GO:0042981 regulation of apoptotic process 31.5789 6 no
GO:0043067 regulation of programmed cell death 31.5789 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 31.5789 5 no
GO:0022603 regulation of anatomical structure morphogenesis 31.5789 4 yes
GO:0030030 cell projection organization 31.5789 4 yes
GO:0050767 regulation of neurogenesis 26.3158 6 yes
GO:0051960 regulation of nervous system development 26.3158 5 yes
GO:0060284 regulation of cell development 26.3158 5 yes
GO:0008104 protein localization 26.3158 4 no
GO:0022898 regulation of transmembrane transporter activity 26.3158 4 no
GO:0034330 cell junction organization 26.3158 4 no
GO:0034765 regulation of ion transmembrane transport 26.3158 5 no
GO:0051928 positive regulation of calcium ion transport 26.3158 6 no
GO:1903169 regulation of calcium ion transmembrane transport 26.3158 7 no
GO:1904062 regulation of cation transmembrane transport 26.3158 6 no
GO:0006468 protein phosphorylation 26.3158 5 no
GO:0016310 phosphorylation 26.3158 5 no
GO:0031401 positive regulation of protein modification process 26.3158 7 no
GO:0043408 regulation of MAPK cascade 26.3158 6 no
GO:0051347 positive regulation of transferase activity 26.3158 5 no
GO:0001933 negative regulation of protein phosphorylation 26.3158 8 no
GO:0010563 negative regulation of phosphorus metabolic process 26.3158 6 no
GO:0031400 negative regulation of protein modification process 26.3158 7 no
GO:0042326 negative regulation of phosphorylation 26.3158 8 no
GO:0045936 negative regulation of phosphate metabolic process 26.3158 7 no
GO:0051248 negative regulation of protein metabolic process 26.3158 6 no
GO:0050807 regulation of synapse organization 21.0526 5 yes
GO:0051094 positive regulation of developmental process 21.0526 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.0526 6 yes
GO:0120036 plasma membrane bounded cell projection organization 21.0526 5 yes
GO:0010243 response to organonitrogen compound 21.0526 4 no
GO:0018193 peptidyl-amino acid modification 21.0526 5 no
GO:0021762 substantia nigra development 21.0526 4 no
GO:0048584 positive regulation of response to stimulus 21.0526 4 no
GO:0060341 regulation of cellular localization 21.0526 4 no
GO:0010647 positive regulation of cell communication 21.0526 5 no
GO:0023056 positive regulation of signaling 21.0526 4 no
GO:0034764 positive regulation of transmembrane transport 21.0526 5 no
GO:0034767 positive regulation of ion transmembrane transport 21.0526 6 no
GO:0050890 cognition 21.0526 4 no
GO:1904064 positive regulation of cation transmembrane transport 21.0526 7 no
GO:1904427 positive regulation of calcium ion transmembrane transport 21.0526 7 no
GO:0001934 positive regulation of protein phosphorylation 21.0526 8 no
GO:0010562 positive regulation of phosphorus metabolic process 21.0526 6 no
GO:0033674 positive regulation of kinase activity 21.0526 6 no
GO:0042327 positive regulation of phosphorylation 21.0526 8 no
GO:0045860 positive regulation of protein kinase activity 21.0526 7 no
GO:0045937 positive regulation of phosphate metabolic process 21.0526 7 no
GO:0046777 protein autophosphorylation 21.0526 6 no
GO:0050808 synapse organization 21.0526 5 no
GO:0070372 regulation of ERK1 and ERK2 cascade 21.0526 7 no
GO:0071902 positive regulation of protein serine/threonine kinase activity 21.0526 8 no
GO:0006937 regulation of muscle contraction 21.0526 6 no
GO:0006942 regulation of striated muscle contraction 21.0526 7 no
GO:0008016 regulation of heart contraction 21.0526 6 no
GO:0010564 regulation of cell cycle process 21.0526 5 no
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 21.0526 6 no
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 21.0526 7 no
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 21.0526 6 no
GO:0019722 calcium-mediated signaling 21.0526 5 no
GO:0019932 second-messenger-mediated signaling 21.0526 4 no
GO:0032412 regulation of ion transmembrane transporter activity 21.0526 5 no
GO:0044772 mitotic cell cycle phase transition 21.0526 4 no
GO:0051051 negative regulation of transport 21.0526 4 no
GO:0051279 regulation of release of sequestered calcium ion into cytosol 21.0526 5 no
GO:0051282 regulation of sequestering of calcium ion 21.0526 4 no
GO:0055117 regulation of cardiac muscle contraction 21.0526 7 no
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 21.0526 6 no
GO:0061024 membrane organization 21.0526 4 no
GO:0090257 regulation of muscle system process 21.0526 5 no
GO:1901019 regulation of calcium ion transmembrane transporter activity 21.0526 6 no
GO:1903522 regulation of blood circulation 21.0526 5 no
GO:2001257 regulation of cation channel activity 21.0526 6 no
GO:0009968 negative regulation of signal transduction 21.0526 5 no
GO:0010648 negative regulation of cell communication 21.0526 5 no
GO:0023057 negative regulation of signaling 21.0526 4 no
GO:0048585 negative regulation of response to stimulus 21.0526 4 no
GO:0043066 negative regulation of apoptotic process 21.0526 7 no
GO:0043069 negative regulation of programmed cell death 21.0526 6 no
GO:0060548 negative regulation of cell death 21.0526 5 no
GO:0044087 regulation of cellular component biogenesis 21.0526 4 no
GO:0007010 cytoskeleton organization 21.0526 5 yes
GO:0010975 regulation of neuron projection development 21.0526 7 yes
GO:0031344 regulation of cell projection organization 21.0526 5 yes
GO:0045597 positive regulation of cell differentiation 15.7895 5 yes
GO:0046474 glycerophospholipid biosynthetic process 15.7895 5 yes
GO:0046486 glycerolipid metabolic process 15.7895 4 yes
GO:0046488 phosphatidylinositol metabolic process 15.7895 6 yes
GO:0050769 positive regulation of neurogenesis 15.7895 6 yes
GO:0051130 positive regulation of cellular component organization 15.7895 5 yes
GO:0051240 positive regulation of multicellular organismal process 15.7895 4 yes
GO:0051962 positive regulation of nervous system development 15.7895 5 yes
GO:0060998 regulation of dendritic spine development 15.7895 4 yes
GO:0061001 regulation of dendritic spine morphogenesis 15.7895 5 yes
GO:0090407 organophosphate biosynthetic process 15.7895 4 yes
GO:0099175 regulation of postsynapse organization 15.7895 6 yes
GO:0006644 phospholipid metabolic process 15.7895 4 yes
GO:0006650 glycerophospholipid metabolic process 15.7895 5 yes
GO:0006661 phosphatidylinositol biosynthetic process 15.7895 6 yes
GO:0008610 lipid biosynthetic process 15.7895 4 yes
GO:0008654 phospholipid biosynthetic process 15.7895 4 yes
GO:0010720 positive regulation of cell development 15.7895 6 yes
GO:0019751 polyol metabolic process 15.7895 4 yes
GO:0022604 regulation of cell morphogenesis 15.7895 5 yes
GO:0043647 inositol phosphate metabolic process 15.7895 4 yes
GO:0045017 glycerolipid biosynthetic process 15.7895 4 yes
GO:0048814 regulation of dendrite morphogenesis 10.5263 5 yes
GO:0050773 regulation of dendrite development 10.5263 4 yes
GO:0050775 positive regulation of dendrite morphogenesis 10.5263 6 yes
GO:0060999 positive regulation of dendritic spine development 10.5263 5 yes
GO:0061003 positive regulation of dendritic spine morphogenesis 10.5263 6 yes
GO:0097061 dendritic spine organization 10.5263 5 yes
GO:0099173 postsynapse organization 10.5263 4 yes
GO:0106027 neuron projection organization 10.5263 6 yes
GO:0010769 regulation of cell morphogenesis involved in differentiation 10.5263 6 yes
GO:0010770 positive regulation of cell morphogenesis involved in differentiation 10.5263 7 yes
GO:0010976 positive regulation of neuron projection development 10.5263 7 yes
GO:0031346 positive regulation of cell projection organization 10.5263 6 yes
GO:0043954 cellular component maintenance 10.5263 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in IP3KA_HUMAN
DOID:0050686 organ system cancer 10.5263 3 no
DOID:120 female reproductive organ cancer 10.5263 5 no
DOID:193 reproductive organ cancer 10.5263 4 no
DOID:0050700 cardiomyopathy 10.5263 4 no
DOID:0060036 intrinsic cardiomyopathy 10.5263 5 no
DOID:114 heart disease 10.5263 3 no
DOID:2843 long QT syndrome 10.5263 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
ITSN2_HUMAN [view entry] [view interactions] High throughput yes yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
GRIA4_HUMAN [view entry] [view interactions] High throughput yes no
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
ACTS_HUMAN [view interactions] High throughput no no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
I5P2_HUMAN [view interactions] Computational no yes
SHIP2_HUMAN [view interactions] Computational no yes
MINP1_HUMAN [view interactions] Computational no yes
PLCB2_HUMAN [view interactions] Computational no no
OCRL_HUMAN [view interactions] Computational no yes
PTEN_HUMAN [view entry] [view interactions] Computational yes yes
INP5K_HUMAN [view interactions] Computational no no
I5P1_HUMAN [view interactions] Computational no yes
IP3KB_HUMAN [view interactions] Computational no no
PI5PA_HUMAN [view interactions] Computational no no
SHIP1_HUMAN [view interactions] Computational no no
SYNJ2_HUMAN [view entry] [view interactions] Computational yes yes
ITPK1_HUMAN [view interactions] Computational no yes
IP3KC_HUMAN [view interactions] Computational no yes
IPMK_HUMAN [view interactions] Computational no yes