Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SYNJ2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SYNJ2_HUMAN
GO:0019900 kinase binding 30.0000 4 no
GO:0019901 protein kinase binding 30.0000 5 no
GO:0017076 purine nucleotide binding 25.0000 4 no
GO:0003723 RNA binding 22.5000 4 yes
GO:0046872 metal ion binding 22.5000 4 no
GO:0045296 cadherin binding 22.5000 4 no
GO:0032555 purine ribonucleotide binding 22.5000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 22.5000 4 no
GO:0016791 phosphatase activity 15.0000 5 yes
GO:0042578 phosphoric ester hydrolase activity 15.0000 4 yes
GO:0017124 SH3 domain binding 12.5000 4 yes
GO:0052866 phosphatidylinositol phosphate phosphatase activity 10.0000 6 yes
GO:0004438 phosphatidylinositol-3-phosphatase activity 7.5000 8 yes
GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 7.5000 7 yes
GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 7.5000 7 yes
GO:0052744 phosphatidylinositol monophosphate phosphatase activity 7.5000 7 yes
GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 5.0000 8 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SYNJ2_HUMAN
GO:0048522 positive regulation of cellular process 62.5000 4 no
GO:0048523 negative regulation of cellular process 55.0000 4 no
GO:0051128 regulation of cellular component organization 55.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0006996 organelle organization 50.0000 4 no
GO:0016192 vesicle-mediated transport 45.0000 4 yes
GO:0006897 endocytosis 40.0000 5 yes
GO:0008104 protein localization 40.0000 4 no
GO:0010646 regulation of cell communication 40.0000 4 no
GO:0009889 regulation of biosynthetic process 37.5000 4 no
GO:0010468 regulation of gene expression 37.5000 5 no
GO:0051049 regulation of transport 37.5000 4 no
GO:0051246 regulation of protein metabolic process 37.5000 5 no
GO:0022607 cellular component assembly 37.5000 4 no
GO:0009892 negative regulation of metabolic process 35.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 35.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 35.0000 5 no
GO:0009893 positive regulation of metabolic process 32.5000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 32.5000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 32.5000 4 no
GO:0031325 positive regulation of cellular metabolic process 32.5000 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 32.5000 5 no
GO:0007010 cytoskeleton organization 32.5000 5 no
GO:0006796 phosphate-containing compound metabolic process 30.0000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 30.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.0000 5 no
GO:0045595 regulation of cell differentiation 30.0000 4 no
GO:0051130 positive regulation of cellular component organization 30.0000 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 30.0000 5 no
GO:0051252 regulation of RNA metabolic process 30.0000 5 no
GO:0006355 regulation of DNA-templated transcription 27.5000 6 no
GO:0015031 protein transport 27.5000 4 no
GO:0031324 negative regulation of cellular metabolic process 27.5000 5 no
GO:0071702 organic substance transport 27.5000 4 no
GO:0071705 nitrogen compound transport 27.5000 4 no
GO:1903506 regulation of nucleic acid-templated transcription 27.5000 7 no
GO:2001141 regulation of RNA biosynthetic process 27.5000 6 no
GO:0019220 regulation of phosphate metabolic process 27.5000 6 no
GO:0031399 regulation of protein modification process 27.5000 6 no
GO:0051174 regulation of phosphorus metabolic process 27.5000 5 no
GO:0051248 negative regulation of protein metabolic process 27.5000 6 no
GO:0030030 cell projection organization 27.5000 4 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:2000026 regulation of multicellular organismal development 25.0000 4 no
GO:0009966 regulation of signal transduction 25.0000 4 no
GO:0006898 receptor-mediated endocytosis 25.0000 6 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:0061024 membrane organization 22.5000 4 yes
GO:0006886 intracellular protein transport 22.5000 4 no
GO:0009891 positive regulation of biosynthetic process 22.5000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.5000 6 no
GO:0030100 regulation of endocytosis 22.5000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 22.5000 6 no
GO:0031344 regulation of cell projection organization 22.5000 5 no
GO:0051129 negative regulation of cellular component organization 22.5000 5 no
GO:0060284 regulation of cell development 22.5000 5 no
GO:0060627 regulation of vesicle-mediated transport 22.5000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.5000 6 no
GO:0001932 regulation of protein phosphorylation 22.5000 7 no
GO:0031400 negative regulation of protein modification process 22.5000 7 no
GO:0042325 regulation of phosphorylation 22.5000 7 no
GO:0033043 regulation of organelle organization 22.5000 5 no
GO:0044087 regulation of cellular component biogenesis 22.5000 4 no
GO:0051493 regulation of cytoskeleton organization 22.5000 6 no
GO:0065003 protein-containing complex assembly 22.5000 5 no
GO:0006644 phospholipid metabolic process 17.5000 4 yes
GO:0006650 glycerophospholipid metabolic process 17.5000 5 yes
GO:0006661 phosphatidylinositol biosynthetic process 17.5000 6 yes
GO:0008610 lipid biosynthetic process 17.5000 4 yes
GO:0008654 phospholipid biosynthetic process 17.5000 4 yes
GO:0045017 glycerolipid biosynthetic process 17.5000 4 yes
GO:0046474 glycerophospholipid biosynthetic process 17.5000 5 yes
GO:0046486 glycerolipid metabolic process 17.5000 4 yes
GO:0046488 phosphatidylinositol metabolic process 17.5000 6 yes
GO:0048488 synaptic vesicle endocytosis 17.5000 5 yes
GO:0090407 organophosphate biosynthetic process 17.5000 4 yes
GO:0099003 vesicle-mediated transport in synapse 17.5000 5 yes
GO:0140238 presynaptic endocytosis 17.5000 4 yes
GO:0016311 dephosphorylation 12.5000 5 yes
GO:0019751 polyol metabolic process 10.0000 4 yes
GO:0043647 inositol phosphate metabolic process 10.0000 4 yes
GO:0007420 brain development 7.5000 4 yes
GO:0030258 lipid modification 7.5000 4 yes
GO:0046839 phospholipid dephosphorylation 7.5000 5 yes
GO:0046856 phosphatidylinositol dephosphorylation 7.5000 6 yes
GO:0046164 alcohol catabolic process 5.0000 4 yes
GO:0046174 polyol catabolic process 5.0000 5 yes
GO:0046434 organophosphate catabolic process 5.0000 4 yes
GO:0046838 phosphorylated carbohydrate dephosphorylation 5.0000 4 yes
GO:0046855 inositol phosphate dephosphorylation 5.0000 5 yes
GO:0071545 inositol phosphate catabolic process 5.0000 5 yes
GO:1901616 organic hydroxy compound catabolic process 5.0000 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in SYNJ2_HUMAN
DOID:331 central nervous system disease 5.0000 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
SYJ2B_HUMAN [view entry] [view interactions] Low throughput yes no
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
FYN_HUMAN [view entry] [view interactions] High throughput yes no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
ITSN2_HUMAN [view entry] [view interactions] High throughput yes yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
H32_HUMAN [view interactions] High throughput no yes
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
H2B1H_HUMAN [view interactions] High throughput no yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
PARP2_HUMAN [view interactions] High throughput no yes
BIN1_HUMAN [view entry] [view interactions] High throughput yes yes
CD2AP_HUMAN [view interactions] High throughput no no
ITSN1_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
CTBP2_HUMAN [view interactions] High throughput no no
DDX58_HUMAN [view interactions] High throughput no yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
SH3G2_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
BICD2_HUMAN [view interactions] High throughput no yes
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
ANC2_HUMAN [view interactions] High throughput no no
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
SQSTM_HUMAN [view interactions] High throughput no yes
VASP_HUMAN [view interactions] High throughput no yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
PI5L1_HUMAN [view interactions] Computational no no
IPMK_HUMAN [view interactions] Computational no yes
AP2M1_HUMAN [view entry] [view interactions] Computational yes yes
IP3KC_HUMAN [view interactions] Computational no yes
PP2BA_HUMAN [view entry] [view interactions] Computational yes yes
PICAL_HUMAN [view entry] [view interactions] Computational yes yes
DYN1_HUMAN [view entry] [view interactions] Computational yes yes
TPTE2_HUMAN [view interactions] Computational no no
PI4KA_HUMAN [view entry] [view interactions] Computational yes yes
AP2A1_HUMAN [view entry] [view interactions] Computational yes yes
PTEN_HUMAN [view entry] [view interactions] Computational yes yes
EPS15_HUMAN [view entry] [view interactions] Computational yes yes
MINP1_HUMAN [view interactions] Computational no yes
PLCH2_HUMAN [view interactions] Computational no yes
EPN1_HUMAN [view entry] [view interactions] Computational yes yes
PI51B_HUMAN [view interactions] Computational no yes
INPP_HUMAN [view interactions] Computational no no
SAC1_HUMAN [view entry] [view interactions] Computational yes yes
ITPK1_HUMAN [view interactions] Computational no yes
IP3KA_HUMAN [view entry] [view interactions] Computational yes no
IP3KB_HUMAN [view interactions] Computational no no
INP4B_HUMAN [view interactions] Computational no no
INP4A_HUMAN [view entry] [view interactions] Computational yes yes
PP2BC_HUMAN [view interactions] Computational no yes
PP2BB_HUMAN [view entry] [view interactions] Computational yes yes
INP5E_HUMAN [view interactions] Computational no yes
OCRL_HUMAN [view interactions] Computational no yes
I5P2_HUMAN [view interactions] Computational no yes
PI51A_HUMAN [view interactions] Computational no yes
PI51C_HUMAN [view entry] [view interactions] Computational yes yes