Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SYNJ2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SYNJ2_HUMAN
GO:0019900 kinase binding 35.7143 4 no
GO:0019901 protein kinase binding 35.7143 5 no
GO:0003723 RNA binding 32.1429 4 yes
GO:0045296 cadherin binding 25.0000 4 no
GO:0043168 anion binding 21.4286 4 no
GO:0043169 cation binding 21.4286 4 no
GO:0045309 protein phosphorylated amino acid binding 21.4286 4 no
GO:0046872 metal ion binding 21.4286 5 no
GO:0017124 SH3 domain binding 17.8571 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SYNJ2_HUMAN
GO:0048522 positive regulation of cellular process 75.0000 4 no
GO:0031323 regulation of cellular metabolic process 64.2857 4 no
GO:0048523 negative regulation of cellular process 64.2857 4 no
GO:0051128 regulation of cellular component organization 60.7143 4 no
GO:0060255 regulation of macromolecule metabolic process 60.7143 4 no
GO:0080090 regulation of primary metabolic process 57.1429 4 no
GO:0006996 organelle organization 50.0000 4 no
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0010468 regulation of gene expression 50.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0008104 protein localization 46.4286 4 no
GO:0051246 regulation of protein metabolic process 46.4286 5 no
GO:0007010 cytoskeleton organization 42.8571 5 no
GO:0009892 negative regulation of metabolic process 42.8571 4 no
GO:0010605 negative regulation of macromolecule metabolic process 42.8571 5 no
GO:0010646 regulation of cell communication 42.8571 4 no
GO:0031324 negative regulation of cellular metabolic process 42.8571 5 no
GO:0022607 cellular component assembly 39.2857 4 no
GO:0030030 cell projection organization 35.7143 4 no
GO:0033043 regulation of organelle organization 35.7143 5 no
GO:0051130 positive regulation of cellular component organization 35.7143 5 no
GO:0051493 regulation of cytoskeleton organization 35.7143 6 no
GO:0120036 plasma membrane bounded cell projection organization 35.7143 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 35.7143 5 no
GO:0019220 regulation of phosphate metabolic process 35.7143 6 no
GO:0031399 regulation of protein modification process 35.7143 6 no
GO:0051049 regulation of transport 35.7143 4 no
GO:0051174 regulation of phosphorus metabolic process 35.7143 5 no
GO:0051252 regulation of RNA metabolic process 35.7143 5 no
GO:0032271 regulation of protein polymerization 32.1429 6 no
GO:0043254 regulation of protein-containing complex assembly 32.1429 5 no
GO:0044087 regulation of cellular component biogenesis 32.1429 4 no
GO:1902903 regulation of supramolecular fiber organization 32.1429 5 no
GO:0006355 regulation of DNA-templated transcription 32.1429 7 no
GO:0009893 positive regulation of metabolic process 32.1429 4 no
GO:0022603 regulation of anatomical structure morphogenesis 32.1429 4 no
GO:0031325 positive regulation of cellular metabolic process 32.1429 5 no
GO:0045595 regulation of cell differentiation 32.1429 4 no
GO:0051248 negative regulation of protein metabolic process 32.1429 6 no
GO:2001141 regulation of RNA biosynthetic process 32.1429 6 no
GO:0098657 import into cell 28.5714 4 yes
GO:0010638 positive regulation of organelle organization 28.5714 6 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0044089 positive regulation of cellular component biogenesis 28.5714 5 no
GO:0051495 positive regulation of cytoskeleton organization 28.5714 7 no
GO:1902905 positive regulation of supramolecular fiber organization 28.5714 6 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0009966 regulation of signal transduction 28.5714 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0031400 negative regulation of protein modification process 28.5714 7 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0141124 intracellular signaling cassette 28.5714 4 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0031334 positive regulation of protein-containing complex assembly 25.0000 6 no
GO:0032273 positive regulation of protein polymerization 25.0000 7 no
GO:0032956 regulation of actin cytoskeleton organization 25.0000 5 no
GO:0032970 regulation of actin filament-based process 25.0000 4 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0097435 supramolecular fiber organization 25.0000 4 no
GO:0002684 positive regulation of immune system process 25.0000 4 no
GO:0010563 negative regulation of phosphorus metabolic process 25.0000 6 no
GO:0031344 regulation of cell projection organization 25.0000 5 no
GO:0045936 negative regulation of phosphate metabolic process 25.0000 7 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0051726 regulation of cell cycle 25.0000 4 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.0000 6 no
GO:0009890 negative regulation of biosynthetic process 25.0000 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0031327 negative regulation of cellular biosynthetic process 25.0000 6 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0110053 regulation of actin filament organization 21.4286 6 no
GO:0009891 positive regulation of biosynthetic process 21.4286 5 no
GO:0010243 response to organonitrogen compound 21.4286 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.4286 6 no
GO:0031328 positive regulation of cellular biosynthetic process 21.4286 6 no
GO:0034762 regulation of transmembrane transport 21.4286 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 21.4286 5 no
GO:0043269 regulation of monoatomic ion transport 21.4286 5 no
GO:0048584 positive regulation of response to stimulus 21.4286 4 no
GO:0051050 positive regulation of transport 21.4286 4 no
GO:0051247 positive regulation of protein metabolic process 21.4286 6 no
GO:0060284 regulation of cell development 21.4286 5 no
GO:0071310 cellular response to organic substance 21.4286 4 no
GO:0071417 cellular response to organonitrogen compound 21.4286 4 no
GO:1901699 cellular response to nitrogen compound 21.4286 4 no
GO:1901701 cellular response to oxygen-containing compound 21.4286 4 no
GO:1902531 regulation of intracellular signal transduction 21.4286 5 no
GO:2000026 regulation of multicellular organismal development 21.4286 4 no
GO:0022604 regulation of cell morphogenesis 21.4286 5 no
GO:0061024 membrane organization 17.8571 4 yes
GO:0006796 phosphate-containing compound metabolic process 14.2857 4 yes
GO:0048488 synaptic vesicle endocytosis 14.2857 5 yes
GO:0140238 presynaptic endocytosis 14.2857 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
SYJ2B_HUMAN [view interactions] Low throughput no no
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
FYN_HUMAN [view entry] [view interactions] High throughput yes no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
ITSN2_HUMAN [view entry] [view interactions] High throughput yes yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
H32_HUMAN [view interactions] High throughput no yes
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
H2B1H_HUMAN [view interactions] High throughput no yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
PARP2_HUMAN [view interactions] High throughput no yes
CD2AP_HUMAN [view interactions] High throughput no no
BIN1_HUMAN [view entry] [view interactions] High throughput yes yes
SWAP1_HUMAN [view interactions] High throughput no no
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
ITSN1_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
CTBP2_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
SH3G2_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
BICD2_HUMAN [view interactions] High throughput no yes
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
ANC2_HUMAN [view interactions] High throughput no no
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
SQSTM_HUMAN [view interactions] High throughput no yes
VASP_HUMAN [view entry] [view interactions] High throughput yes yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes