Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

WIPF2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI001706 LIG_EVH1_3 LIG 400 412 -
ELMI002696 LIG_WH1 LIG 397 407 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in WIPF2_HUMAN
GO:0003779 actin binding 30.0000 4 yes
GO:0019900 kinase binding 30.0000 4 no
GO:0019901 protein kinase binding 30.0000 5 no
GO:0017076 purine nucleotide binding 30.0000 4 no
GO:0032555 purine ribonucleotide binding 30.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.0000 4 no
GO:0005524 ATP binding 25.0000 5 no
GO:0030554 adenyl nucleotide binding 25.0000 5 no
GO:0032559 adenyl ribonucleotide binding 25.0000 5 no
GO:0017124 SH3 domain binding 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in WIPF2_HUMAN
GO:0048522 positive regulation of cellular process 85.0000 4 no
GO:0051128 regulation of cellular component organization 70.0000 4 no
GO:0030030 cell projection organization 65.0000 4 no
GO:0022607 cellular component assembly 60.0000 4 no
GO:0009893 positive regulation of metabolic process 55.0000 4 no
GO:0031323 regulation of cellular metabolic process 55.0000 4 no
GO:0048523 negative regulation of cellular process 55.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 55.0000 4 no
GO:0006996 organelle organization 55.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0033043 regulation of organelle organization 50.0000 5 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0051493 regulation of cytoskeleton organization 50.0000 6 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0120036 plasma membrane bounded cell projection organization 50.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 45.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 45.0000 5 no
GO:0032956 regulation of actin cytoskeleton organization 45.0000 5 no
GO:0032970 regulation of actin filament-based process 45.0000 4 no
GO:0044087 regulation of cellular component biogenesis 45.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 45.0000 5 no
GO:0006897 endocytosis 45.0000 5 no
GO:0007010 cytoskeleton organization 45.0000 5 no
GO:0016192 vesicle-mediated transport 45.0000 4 no
GO:0007015 actin filament organization 40.0000 5 no
GO:0009966 regulation of signal transduction 40.0000 4 no
GO:0010468 regulation of gene expression 40.0000 5 no
GO:0048584 positive regulation of response to stimulus 40.0000 4 no
GO:0051130 positive regulation of cellular component organization 40.0000 5 no
GO:0097435 supramolecular fiber organization 40.0000 4 no
GO:0110053 regulation of actin filament organization 40.0000 6 no
GO:1902903 regulation of supramolecular fiber organization 40.0000 5 no
GO:0071310 cellular response to organic substance 40.0000 4 no
GO:0009889 regulation of biosynthetic process 35.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 35.0000 5 no
GO:0010638 positive regulation of organelle organization 35.0000 6 no
GO:0031326 regulation of cellular biosynthetic process 35.0000 5 no
GO:0044089 positive regulation of cellular component biogenesis 35.0000 5 no
GO:0051252 regulation of RNA metabolic process 35.0000 5 no
GO:0051495 positive regulation of cytoskeleton organization 35.0000 7 no
GO:0080134 regulation of response to stress 35.0000 4 no
GO:1902905 positive regulation of supramolecular fiber organization 35.0000 6 no
GO:0051049 regulation of transport 35.0000 4 no
GO:0022603 regulation of anatomical structure morphogenesis 35.0000 4 no
GO:0032990 cell part morphogenesis 35.0000 4 no
GO:0048858 cell projection morphogenesis 35.0000 5 no
GO:0031344 regulation of cell projection organization 35.0000 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 35.0000 6 no
GO:0006355 regulation of DNA-templated transcription 30.0000 6 no
GO:0030155 regulation of cell adhesion 30.0000 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 30.0000 6 no
GO:0051246 regulation of protein metabolic process 30.0000 5 no
GO:1902531 regulation of intracellular signal transduction 30.0000 5 no
GO:1903506 regulation of nucleic acid-templated transcription 30.0000 7 no
GO:2001141 regulation of RNA biosynthetic process 30.0000 6 no
GO:0008104 protein localization 30.0000 4 no
GO:0030334 regulation of cell migration 30.0000 5 no
GO:0034330 cell junction organization 30.0000 4 no
GO:2000145 regulation of cell motility 30.0000 4 no
GO:0022604 regulation of cell morphogenesis 30.0000 5 no
GO:0031175 neuron projection development 30.0000 6 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 30.0000 6 no
GO:0006357 regulation of transcription by RNA polymerase II 25.0000 7 no
GO:0007167 enzyme-linked receptor protein signaling pathway 25.0000 4 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 25.0000 5 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0043254 regulation of protein-containing complex assembly 25.0000 5 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0036211 protein modification process 25.0000 4 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0048812 neuron projection morphogenesis 25.0000 7 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0060491 regulation of cell projection assembly 25.0000 5 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 25.0000 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
WASP_HUMAN [view interactions] Low throughput no yes
NCK2_HUMAN [view entry] [view interactions] Low throughput yes yes
ANRA2_HUMAN [view interactions] High throughput no no
CRK_HUMAN [view entry] [view interactions] High throughput yes no
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
YAP1_HUMAN [view interactions] High throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
WASL_HUMAN [view entry] [view interactions] High throughput yes yes
WWOX_HUMAN [view interactions] High throughput no yes
VINEX_HUMAN [view interactions] High throughput no no
TV23A_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
ITSN2_HUMAN [view entry] [view interactions] High throughput yes yes
DNMBP_HUMAN [view interactions] High throughput no no
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
PACN2_HUMAN [view entry] [view interactions] High throughput yes no
TRI25_HUMAN [view interactions] High throughput no yes
ACTC_HUMAN [view interactions] High throughput no no
DDX58_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOV_HUMAN [view interactions] High throughput no no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
FIBA_HUMAN [view interactions] High throughput no no
TCRG1_HUMAN [view interactions] High throughput no yes
APBB1_HUMAN [view interactions] High throughput no yes
IF4A3_HUMAN [view entry] [view interactions] High throughput yes yes
TXLNG_HUMAN [view interactions] High throughput no no
NADAP_HUMAN [view interactions] High throughput no yes
HNRDL_HUMAN [view interactions] High throughput no yes
ZFAN5_HUMAN [view interactions] High throughput no yes
ZN830_HUMAN [view interactions] High throughput no yes
EVL_HUMAN [view entry] [view interactions] High throughput yes yes
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
PSPC1_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
WASF1_HUMAN [view entry] [view interactions] Computational yes yes
WIPF3_HUMAN [view interactions] Computational no yes
ARP2_HUMAN [view entry] [view interactions] Computational yes yes
WIPF1_HUMAN [view interactions] Computational no no
BTK_HUMAN [view interactions] Computational no no
FAK1_HUMAN [view entry] [view interactions] Computational yes yes