Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

WIPF2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI001706 LIG_EVH1_3 LIG 400 412 -
ELMI002696 LIG_WH1 LIG 397 407 -
ELMI001706 LIG_EVH1_3 LIG 400 412 -
ELMI002696 LIG_WH1 LIG 397 407 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in WIPF2_HUMAN
GO:0043168 anion binding 36.8421 4 no
GO:0019900 kinase binding 31.5789 4 no
GO:0019901 protein kinase binding 31.5789 5 no
GO:0000166 nucleotide binding 31.5789 4 no
GO:0017076 purine nucleotide binding 31.5789 5 no
GO:0032555 purine ribonucleotide binding 31.5789 4 no
GO:0035639 purine ribonucleoside triphosphate binding 31.5789 4 no
GO:0005524 ATP binding 26.3158 5 no
GO:0030554 adenyl nucleotide binding 26.3158 6 no
GO:0032559 adenyl ribonucleotide binding 26.3158 5 no
GO:0045296 cadherin binding 21.0526 4 no
GO:0017124 SH3 domain binding 21.0526 4 no
GO:0003779 actin binding 15.7895 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in WIPF2_HUMAN
GO:0048522 positive regulation of cellular process 84.2105 4 no
GO:0051128 regulation of cellular component organization 73.6842 4 no
GO:0048523 negative regulation of cellular process 63.1579 4 no
GO:0009893 positive regulation of metabolic process 63.1579 4 no
GO:0031323 regulation of cellular metabolic process 57.8947 4 no
GO:0031325 positive regulation of cellular metabolic process 57.8947 5 no
GO:0060255 regulation of macromolecule metabolic process 57.8947 4 no
GO:0022607 cellular component assembly 57.8947 4 no
GO:0030030 cell projection organization 57.8947 4 no
GO:0010604 positive regulation of macromolecule metabolic process 57.8947 5 no
GO:0080090 regulation of primary metabolic process 52.6316 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 47.3684 5 no
GO:0031326 regulation of cellular biosynthetic process 47.3684 5 no
GO:0006996 organelle organization 47.3684 4 no
GO:0009889 regulation of biosynthetic process 47.3684 4 no
GO:0010468 regulation of gene expression 47.3684 6 no
GO:0010556 regulation of macromolecule biosynthetic process 47.3684 5 no
GO:0031328 positive regulation of cellular biosynthetic process 42.1053 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 42.1053 5 no
GO:0051252 regulation of RNA metabolic process 42.1053 5 no
GO:0051049 regulation of transport 42.1053 4 no
GO:0007010 cytoskeleton organization 42.1053 5 no
GO:0044087 regulation of cellular component biogenesis 42.1053 4 no
GO:0051130 positive regulation of cellular component organization 42.1053 5 no
GO:0009891 positive regulation of biosynthetic process 42.1053 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 42.1053 6 no
GO:0010646 regulation of cell communication 42.1053 4 no
GO:0048584 positive regulation of response to stimulus 36.8421 4 no
GO:0051246 regulation of protein metabolic process 36.8421 5 no
GO:2001141 regulation of RNA biosynthetic process 36.8421 6 no
GO:2000145 regulation of cell motility 36.8421 4 no
GO:0031344 regulation of cell projection organization 36.8421 5 no
GO:0033043 regulation of organelle organization 36.8421 5 no
GO:0048812 neuron projection morphogenesis 36.8421 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 36.8421 6 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 36.8421 4 no
GO:0006355 regulation of DNA-templated transcription 36.8421 7 no
GO:0042127 regulation of cell population proliferation 31.5789 4 no
GO:0042981 regulation of apoptotic process 31.5789 5 no
GO:0043067 regulation of programmed cell death 31.5789 4 no
GO:0043933 protein-containing complex organization 31.5789 4 no
GO:0045893 positive regulation of DNA-templated transcription 31.5789 8 no
GO:0051254 positive regulation of RNA metabolic process 31.5789 6 no
GO:0097435 supramolecular fiber organization 31.5789 4 no
GO:0120036 plasma membrane bounded cell projection organization 31.5789 5 no
GO:1902680 positive regulation of RNA biosynthetic process 31.5789 7 no
GO:0008104 protein localization 31.5789 4 no
GO:0030334 regulation of cell migration 31.5789 5 no
GO:0051050 positive regulation of transport 31.5789 4 no
GO:0051129 negative regulation of cellular component organization 31.5789 5 no
GO:0032956 regulation of actin cytoskeleton organization 31.5789 5 no
GO:0032970 regulation of actin filament-based process 31.5789 4 no
GO:0043254 regulation of protein-containing complex assembly 31.5789 5 no
GO:0044089 positive regulation of cellular component biogenesis 31.5789 5 no
GO:0051493 regulation of cytoskeleton organization 31.5789 6 no
GO:0110053 regulation of actin filament organization 31.5789 6 no
GO:1902903 regulation of supramolecular fiber organization 31.5789 5 no
GO:0006357 regulation of transcription by RNA polymerase II 31.5789 8 no
GO:0007015 actin filament organization 31.5789 5 no
GO:0009966 regulation of signal transduction 31.5789 4 no
GO:0019220 regulation of phosphate metabolic process 26.3158 6 no
GO:0030155 regulation of cell adhesion 26.3158 4 no
GO:0031399 regulation of protein modification process 26.3158 6 no
GO:0042325 regulation of phosphorylation 26.3158 7 no
GO:0051174 regulation of phosphorus metabolic process 26.3158 5 no
GO:0051247 positive regulation of protein metabolic process 26.3158 6 no
GO:1902531 regulation of intracellular signal transduction 26.3158 5 no
GO:0032880 regulation of protein localization 26.3158 5 no
GO:0060341 regulation of cellular localization 26.3158 4 no
GO:0098657 import into cell 26.3158 4 no
GO:0030100 regulation of endocytosis 26.3158 5 no
GO:0060627 regulation of vesicle-mediated transport 26.3158 4 no
GO:0010638 positive regulation of organelle organization 26.3158 6 no
GO:0031346 positive regulation of cell projection organization 26.3158 6 no
GO:0051495 positive regulation of cytoskeleton organization 26.3158 7 no
GO:0141124 intracellular signaling cassette 26.3158 4 no
GO:1902905 positive regulation of supramolecular fiber organization 26.3158 6 no
GO:0001932 regulation of protein phosphorylation 26.3158 7 no
GO:0007167 enzyme-linked receptor protein signaling pathway 26.3158 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 26.3158 5 no
GO:0009892 negative regulation of metabolic process 26.3158 4 no
GO:0010605 negative regulation of macromolecule metabolic process 26.3158 5 no
GO:0023056 positive regulation of signaling 21.0526 4 no
GO:0031324 negative regulation of cellular metabolic process 21.0526 5 no
GO:0045944 positive regulation of transcription by RNA polymerase II 21.0526 9 no
GO:0051240 positive regulation of multicellular organismal process 21.0526 4 no
GO:0065003 protein-containing complex assembly 21.0526 5 no
GO:1902533 positive regulation of intracellular signal transduction 21.0526 6 no
GO:0022603 regulation of anatomical structure morphogenesis 21.0526 4 no
GO:0031175 neuron projection development 21.0526 6 no
GO:0034329 cell junction assembly 21.0526 5 no
GO:0034330 cell junction organization 21.0526 4 no
GO:0045216 cell-cell junction organization 21.0526 5 no
GO:0045595 regulation of cell differentiation 21.0526 4 no
GO:0071310 cellular response to organic substance 21.0526 4 no
GO:0002009 morphogenesis of an epithelium 21.0526 4 no
GO:0043408 regulation of MAPK cascade 21.0526 6 no
GO:0010564 regulation of cell cycle process 21.0526 5 no
GO:0051726 regulation of cell cycle 21.0526 4 no
GO:0006915 apoptotic process 21.0526 4 no
GO:0008064 regulation of actin polymerization or depolymerization 21.0526 6 no
GO:0030031 cell projection assembly 21.0526 5 no
GO:0030832 regulation of actin filament length 21.0526 5 no
GO:0030833 regulation of actin filament polymerization 21.0526 7 no
GO:0030838 positive regulation of actin filament polymerization 21.0526 7 no
GO:0031334 positive regulation of protein-containing complex assembly 21.0526 6 no
GO:0032271 regulation of protein polymerization 21.0526 6 no
GO:0032273 positive regulation of protein polymerization 21.0526 7 no
GO:0032535 regulation of cellular component size 21.0526 4 no
GO:0060491 regulation of cell projection assembly 21.0526 5 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 21.0526 6 no
GO:0002684 positive regulation of immune system process 21.0526 4 no
GO:0008284 positive regulation of cell population proliferation 21.0526 5 no
GO:0009967 positive regulation of signal transduction 21.0526 5 no
GO:0010647 positive regulation of cell communication 21.0526 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
WASP_HUMAN [view interactions] Low throughput no yes
NCK2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
WASL_HUMAN [view entry] [view interactions] High throughput yes yes
WWOX_HUMAN [view interactions] High throughput no yes
CE192_HUMAN [view interactions] High throughput no yes
VINEX_HUMAN [view interactions] High throughput no no
TV23A_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR4_HUMAN [view interactions] High throughput no no
ITSN2_HUMAN [view entry] [view interactions] High throughput yes yes
DNMBP_HUMAN [view interactions] High throughput no no
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
PACN2_HUMAN [view entry] [view interactions] High throughput yes no
TRI25_HUMAN [view interactions] High throughput no yes
ACTC_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOV_HUMAN [view interactions] High throughput no no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
FIBA_HUMAN [view interactions] High throughput no no
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TCRG1_HUMAN [view interactions] High throughput no yes
APBB1_HUMAN [view entry] [view interactions] High throughput yes yes
TP4A2_HUMAN [view interactions] High throughput no yes
IF4A3_HUMAN [view entry] [view interactions] High throughput yes yes
TXLNG_HUMAN [view interactions] High throughput no no
NADAP_HUMAN [view interactions] High throughput no yes
HNRDL_HUMAN [view interactions] High throughput no yes
ZFAN5_HUMAN [view interactions] High throughput no yes
ZN830_HUMAN [view interactions] High throughput no yes
EVL_HUMAN [view entry] [view interactions] High throughput yes yes
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
PSPC1_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no