TACC1_HUMAN
Evidence for PS localization
Functions
Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed). Might promote the nuclear localization of the receptors (PubMed). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TACC1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 44.6429 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 44.6429 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 44.6429 | 4 | no |
| GO:0003924 | GTPase activity | 30.3571 | 7 | no |
| GO:0005525 | GTP binding | 30.3571 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 30.3571 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 30.3571 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 30.3571 | 6 | no |
| GO:0019001 | guanyl nucleotide binding | 30.3571 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 30.3571 | 5 | no |
| GO:0019900 | kinase binding | 21.4286 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TACC1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 64.2857 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 53.5714 | 4 | no |
| GO:0006996 | organelle organization | 50.0000 | 4 | yes |
| GO:0008104 | protein localization | 39.2857 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 39.2857 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 37.5000 | 4 | no |
| GO:0010646 | regulation of cell communication | 37.5000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 35.7143 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.9286 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 33.9286 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.9286 | 4 | no |
| GO:0007010 | cytoskeleton organization | 32.1429 | 5 | yes |
| GO:0022607 | cellular component assembly | 32.1429 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 32.1429 | 4 | no |
| GO:0033043 | regulation of organelle organization | 32.1429 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 32.1429 | 4 | no |
| GO:0051049 | regulation of transport | 32.1429 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 30.3571 | 5 | no |
| GO:0023056 | positive regulation of signaling | 30.3571 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 30.3571 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.5714 | 5 | no |
| GO:0010468 | regulation of gene expression | 28.5714 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 26.7857 | 4 | no |
| GO:0071702 | organic substance transport | 26.7857 | 4 | no |
| GO:0071705 | nitrogen compound transport | 26.7857 | 4 | no |
| GO:0010941 | regulation of cell death | 26.7857 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 26.7857 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 26.7857 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.7857 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.7857 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.7857 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.7857 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.7857 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | no |
| GO:0030030 | cell projection organization | 25.0000 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 25.0000 | 7 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 25.0000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 23.2143 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 23.2143 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.2143 | 6 | no |
| GO:0061024 | membrane organization | 23.2143 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.2143 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 23.2143 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 23.2143 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.2143 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 23.2143 | 5 | no |
| GO:0008284 | positive regulation of cell population proliferation | 21.4286 | 5 | no |
| GO:0015031 | protein transport | 21.4286 | 4 | no |
| GO:0051050 | positive regulation of transport | 21.4286 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 21.4286 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.4286 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 21.4286 | 8 | no |
| GO:0043549 | regulation of kinase activity | 21.4286 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 21.4286 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.4286 | 7 | no |
| GO:0051338 | regulation of transferase activity | 21.4286 | 4 | no |
| GO:1902850 | microtubule cytoskeleton organization involved in mitosis | 12.5000 | 4 | yes |
| GO:0007052 | mitotic spindle organization | 8.9286 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in TACC1_HUMAN |
|---|---|---|---|---|
| DOID:440 | neuromuscular disease | 3.5714 | 5 | no |
| DOID:574 | peripheral nervous system disease | 3.5714 | 3 | no |
| DOID:870 | neuropathy | 3.5714 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BARD1_HUMAN | [view interactions] | Low throughput | no | yes |
| KAT2A_HUMAN | [view interactions] | Low throughput | no | no |
| TDRD7_HUMAN | [view interactions] | Low throughput | no | yes |
| LSM7_HUMAN | [view interactions] | Low throughput | no | yes |
| RUXG_HUMAN | [view interactions] | Low throughput | no | yes |
| CKAP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| YETS4_HUMAN | [view interactions] | Low throughput | no | no |
| THA_HUMAN | [view interactions] | Low throughput | no | yes |
| AURKB_HUMAN | [view interactions] | Low throughput | no | yes |
| RARA_HUMAN | [view interactions] | Low throughput | no | no |
| AURKA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| COX14_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLRKT_HUMAN | [view interactions] | High throughput | no | yes |
| TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA8_HUMAN | [view interactions] | High throughput | no | no |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| INSRR_HUMAN | [view interactions] | High throughput | no | no |
| MUSK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| ROR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STT3B_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFHX3_HUMAN | [view interactions] | High throughput | no | yes |
| FA50B_HUMAN | [view interactions] | High throughput | no | yes |
| XPF_HUMAN | [view interactions] | High throughput | no | yes |
| ZNF48_HUMAN | [view interactions] | High throughput | no | no |
| FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| TACC2_HUMAN | [view interactions] | High throughput | no | yes |
| STAT2_HUMAN | [view interactions] | High throughput | no | yes |
| RNF41_HUMAN | [view interactions] | High throughput | no | yes |
| POC1B_HUMAN | [view interactions] | High throughput | no | no |
| SKAP_HUMAN | [view interactions] | High throughput | no | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| SOSD1_HUMAN | [view interactions] | High throughput | no | no |
| ACACB_HUMAN | [view interactions] | High throughput | no | no |
| KXDL1_HUMAN | [view interactions] | High throughput | no | yes |
| FSD2_HUMAN | [view interactions] | High throughput | no | no |
| PFD1_HUMAN | [view interactions] | High throughput | no | yes |
| PMFBP_HUMAN | [view interactions] | High throughput | no | yes |
| TPGS1_HUMAN | [view interactions] | High throughput | no | no |
| KT222_HUMAN | [view interactions] | High throughput | no | no |
| TUSC3_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| OST48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OST4_HUMAN | [view interactions] | High throughput | no | no |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| NIF3L_HUMAN | [view interactions] | High throughput | no | yes |
| S10AB_HUMAN | [view interactions] | High throughput | no | no |
| NHRF1_HUMAN | [view interactions] | High throughput | no | no |
| C10_HUMAN | [view interactions] | High throughput | no | yes |
| PLXB2_HUMAN | [view interactions] | High throughput | no | yes |
| PTH2_HUMAN | [view interactions] | High throughput | no | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARH5_HUMAN | [view interactions] | High throughput | no | no |
| MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| DJC25_HUMAN | [view interactions] | High throughput | no | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| CP2C9_HUMAN | [view interactions] | High throughput | no | no |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| DYR2_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LMAN1_HUMAN | [view interactions] | High throughput | no | yes |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| PANX1_HUMAN | [view interactions] | High throughput | no | no |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| MEMO1_HUMAN | [view interactions] | High throughput | no | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD3_HUMAN | [view interactions] | High throughput | no | yes |
| LYST_HUMAN | [view interactions] | High throughput | no | no |
| BI2L1_HUMAN | [view interactions] | High throughput | no | yes |
| SLAI1_HUMAN | [view interactions] | High throughput | no | no |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERR2_HUMAN | [view interactions] | High throughput | no | no |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROS1_HUMAN | [view interactions] | High throughput | no | no |
| P52K_HUMAN | [view interactions] | High throughput | no | yes |
| STX5_HUMAN | [view interactions] | High throughput | no | yes |
| SH24A_HUMAN | [view interactions] | High throughput | no | no |
| FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE120_HUMAN | [view interactions] | Computational | no | no |