TMOD1_HUMAN
Evidence for PS localization
Functions
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TMOD1_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 45.3333 | 4 | yes |
| GO:0043169 | cation binding | 28.0000 | 4 | no |
| GO:0046872 | metal ion binding | 28.0000 | 5 | no |
| GO:0043168 | anion binding | 26.6667 | 4 | no |
| GO:0045296 | cadherin binding | 25.3333 | 4 | no |
| GO:0000166 | nucleotide binding | 21.3333 | 4 | no |
| GO:0017076 | purine nucleotide binding | 21.3333 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 21.3333 | 4 | no |
| GO:0005523 | tropomyosin binding | 2.6667 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TMOD1_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 50.6667 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 49.3333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 45.3333 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 44.0000 | 4 | no |
| GO:0006996 | organelle organization | 44.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 36.0000 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 33.3333 | 5 | yes |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 32.0000 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 30.6667 | 4 | yes |
| GO:0008104 | protein localization | 30.6667 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 29.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 29.3333 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.3333 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.3333 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 28.0000 | 4 | yes |
| GO:0007015 | actin filament organization | 26.6667 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 26.6667 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 26.6667 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 25.3333 | 5 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 25.3333 | 6 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 25.3333 | 5 | yes |
| GO:0030030 | cell projection organization | 24.0000 | 4 | no |
| GO:0032970 | regulation of actin filament-based process | 24.0000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 24.0000 | 4 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 22.6667 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 22.6667 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 22.6667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 22.6667 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.3333 | 5 | no |
| GO:0030155 | regulation of cell adhesion | 21.3333 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.3333 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.3333 | 5 | no |
| GO:0010639 | negative regulation of organelle organization | 17.3333 | 6 | yes |
| GO:0032535 | regulation of cellular component size | 17.3333 | 4 | yes |
| GO:0051494 | negative regulation of cytoskeleton organization | 17.3333 | 7 | yes |
| GO:1902904 | negative regulation of supramolecular fiber organization | 17.3333 | 6 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 16.0000 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 16.0000 | 5 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 16.0000 | 5 | yes |
| GO:0031333 | negative regulation of protein-containing complex assembly | 14.6667 | 6 | yes |
| GO:0032271 | regulation of protein polymerization | 14.6667 | 6 | yes |
| GO:0043242 | negative regulation of protein-containing complex disassembly | 14.6667 | 6 | yes |
| GO:0043244 | regulation of protein-containing complex disassembly | 14.6667 | 5 | yes |
| GO:1901879 | regulation of protein depolymerization | 14.6667 | 6 | yes |
| GO:1901880 | negative regulation of protein depolymerization | 14.6667 | 7 | yes |
| GO:0030833 | regulation of actin filament polymerization | 13.3333 | 7 | yes |
| GO:0030834 | regulation of actin filament depolymerization | 13.3333 | 7 | yes |
| GO:0030835 | negative regulation of actin filament depolymerization | 13.3333 | 7 | yes |
| GO:0032272 | negative regulation of protein polymerization | 13.3333 | 7 | yes |
| GO:0030837 | negative regulation of actin filament polymerization | 12.0000 | 7 | yes |
| GO:0031032 | actomyosin structure organization | 12.0000 | 4 | yes |
| GO:0051693 | actin filament capping | 10.6667 | 8 | yes |
| GO:0070925 | organelle assembly | 9.3333 | 5 | yes |
| GO:0006936 | muscle contraction | 8.0000 | 4 | yes |
| GO:0140694 | non-membrane-bounded organelle assembly | 5.3333 | 6 | yes |
| GO:0002064 | epithelial cell development | 4.0000 | 4 | yes |
| GO:0008344 | adult locomotory behavior | 2.6667 | 4 | yes |
| GO:0030239 | myofibril assembly | 2.6667 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NEBU_HUMAN | [view interactions] | Low throughput | no | no |
| ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD18_HUMAN | [view interactions] | High throughput | no | yes |
| CP110_HUMAN | [view interactions] | High throughput | no | yes |
| CENPJ_HUMAN | [view interactions] | High throughput | no | no |
| CP131_HUMAN | [view interactions] | High throughput | no | no |
| EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
| LMO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC49_HUMAN | [view interactions] | High throughput | no | no |
| MPRIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEXN_HUMAN | [view interactions] | High throughput | no | yes |
| 2A5D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| TPGS1_HUMAN | [view interactions] | High throughput | no | no |
| TXNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARFG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC138_HUMAN | [view interactions] | High throughput | no | yes |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| DLG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB6I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCC2_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA4_HUMAN | [view interactions] | High throughput | no | yes |
| GOGB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAUS8_HUMAN | [view interactions] | High throughput | no | yes |
| KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| CRACD_HUMAN | [view interactions] | High throughput | no | yes |
| K1671_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| MACF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| PCNT_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STRN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TACC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WIPI4_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| ITA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| CETN2_HUMAN | [view interactions] | High throughput | no | yes |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADDA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LSP1_HUMAN | [view interactions] | High throughput | no | no |
| FLII_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCIN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PKHG6_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGB_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
| VMP1_HUMAN | [view interactions] | High throughput | no | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BUB1_HUMAN | [view interactions] | High throughput | no | no |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG07_HUMAN | [view interactions] | High throughput | no | no |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| MLH3_HUMAN | [view interactions] | High throughput | no | no |
| DCOR_HUMAN | [view interactions] | High throughput | no | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLR2_HUMAN | [view interactions] | High throughput | no | no |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
| FXL17_HUMAN | [view interactions] | High throughput | no | yes |
| RARA_HUMAN | [view interactions] | High throughput | no | no |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRRF1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRF2_HUMAN | [view interactions] | High throughput | no | yes |
| TBCD4_HUMAN | [view interactions] | High throughput | no | yes |
| CBPC1_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAV_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABRA_HUMAN | [view interactions] | High throughput | no | no |
| RRAGB_HUMAN | [view interactions] | High throughput | no | yes |
| HLX_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| GKN1_HUMAN | [view interactions] | High throughput | no | no |
| SAMTR_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| SCP2_HUMAN | [view interactions] | High throughput | no | no |
| AP2A_HUMAN | [view interactions] | High throughput | no | no |
| MYO1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERLEC_HUMAN | [view interactions] | High throughput | no | yes |
| GA2L1_HUMAN | [view interactions] | High throughput | no | yes |
| RT05_HUMAN | [view interactions] | High throughput | no | yes |
| RSLBA_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| PNO1_HUMAN | [view interactions] | High throughput | no | no |
| C1QR1_HUMAN | [view interactions] | High throughput | no | no |
| PDE7A_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC8_HUMAN | [view interactions] | High throughput | no | no |
| GILT_HUMAN | [view interactions] | High throughput | no | no |
| PROK2_HUMAN | [view interactions] | High throughput | no | no |
| CACB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZMY19_HUMAN | [view interactions] | High throughput | no | yes |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| ASHWN_HUMAN | [view interactions] | High throughput | no | yes |
| LPAR2_HUMAN | [view interactions] | High throughput | no | yes |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLH10_HUMAN | [view interactions] | High throughput | no | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSB10_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFHD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYWC_HUMAN | [view interactions] | High throughput | no | yes |
| E41L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMOL1_HUMAN | [view interactions] | High throughput | no | no |
| BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN7B_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF1_HUMAN | [view interactions] | High throughput | no | yes |
| HABP4_HUMAN | [view interactions] | High throughput | no | yes |
| CSN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |