TMOD1_HUMAN
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in TMOD1_HUMAN |
---|---|---|---|---|
GO:0003779 | actin binding | 49.3151 | 4 | yes |
GO:0045296 | cadherin binding | 24.6575 | 4 | no |
GO:0046872 | metal ion binding | 24.6575 | 4 | no |
GO:0005523 | tropomyosin binding | 4.1096 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in TMOD1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 49.3151 | 4 | no |
GO:0048523 | negative regulation of cellular process | 47.9452 | 4 | yes |
GO:0006996 | organelle organization | 45.2055 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 42.4658 | 4 | no |
GO:0051128 | regulation of cellular component organization | 41.0959 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 39.7260 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 38.3562 | 4 | no |
GO:0007010 | cytoskeleton organization | 34.2466 | 5 | yes |
GO:0022607 | cellular component assembly | 34.2466 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 34.2466 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 31.5068 | 4 | yes |
GO:0097435 | supramolecular fiber organization | 31.5068 | 4 | yes |
GO:0010646 | regulation of cell communication | 31.5068 | 4 | no |
GO:0007015 | actin filament organization | 30.1370 | 5 | yes |
GO:0051246 | regulation of protein metabolic process | 30.1370 | 5 | no |
GO:0033043 | regulation of organelle organization | 28.7671 | 5 | yes |
GO:0051493 | regulation of cytoskeleton organization | 28.7671 | 6 | yes |
GO:0032970 | regulation of actin filament-based process | 27.3973 | 4 | yes |
GO:1902903 | regulation of supramolecular fiber organization | 27.3973 | 5 | yes |
GO:0010468 | regulation of gene expression | 27.3973 | 5 | no |
GO:0008104 | protein localization | 27.3973 | 4 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 26.0274 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 26.0274 | 4 | no |
GO:0110053 | regulation of actin filament organization | 24.6575 | 6 | yes |
GO:0009966 | regulation of signal transduction | 24.6575 | 4 | no |
GO:0051129 | negative regulation of cellular component organization | 23.2877 | 5 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 23.2877 | 5 | no |
GO:0030030 | cell projection organization | 23.2877 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 21.9178 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 20.5479 | 5 | no |
GO:0016192 | vesicle-mediated transport | 20.5479 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 20.5479 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 20.5479 | 5 | no |
GO:0032535 | regulation of cellular component size | 19.1781 | 4 | yes |
GO:0008064 | regulation of actin polymerization or depolymerization | 17.8082 | 6 | yes |
GO:0010639 | negative regulation of organelle organization | 17.8082 | 6 | yes |
GO:0030832 | regulation of actin filament length | 17.8082 | 5 | yes |
GO:0051494 | negative regulation of cytoskeleton organization | 17.8082 | 7 | yes |
GO:1902904 | negative regulation of supramolecular fiber organization | 17.8082 | 6 | yes |
GO:0032271 | regulation of protein polymerization | 16.4384 | 6 | yes |
GO:0043242 | negative regulation of protein-containing complex disassembly | 16.4384 | 6 | yes |
GO:0043244 | regulation of protein-containing complex disassembly | 16.4384 | 5 | yes |
GO:0043254 | regulation of protein-containing complex assembly | 16.4384 | 5 | yes |
GO:1901879 | regulation of protein depolymerization | 16.4384 | 6 | yes |
GO:1901880 | negative regulation of protein depolymerization | 16.4384 | 7 | yes |
GO:0030833 | regulation of actin filament polymerization | 15.0685 | 7 | yes |
GO:0030834 | regulation of actin filament depolymerization | 15.0685 | 7 | yes |
GO:0030835 | negative regulation of actin filament depolymerization | 15.0685 | 7 | yes |
GO:0031032 | actomyosin structure organization | 13.6986 | 4 | yes |
GO:0031333 | negative regulation of protein-containing complex assembly | 13.6986 | 6 | yes |
GO:0032272 | negative regulation of protein polymerization | 13.6986 | 7 | yes |
GO:0030837 | negative regulation of actin filament polymerization | 12.3288 | 7 | yes |
GO:0051693 | actin filament capping | 12.3288 | 8 | yes |
GO:0006936 | muscle contraction | 10.9589 | 4 | yes |
GO:0070925 | organelle assembly | 10.9589 | 5 | yes |
GO:0140694 | non-membrane-bounded organelle assembly | 6.8493 | 6 | yes |
GO:0030239 | myofibril assembly | 4.1096 | 4 | yes |
GO:0002064 | epithelial cell development | 2.7397 | 4 | yes |
GO:0008344 | adult locomotory behavior | 2.7397 | 4 | yes |
GO:0051694 | pointed-end actin filament capping | 2.7397 | 9 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in TMOD1_HUMAN |
---|---|---|---|---|
DOID:0080000 | muscular disease | 2.7397 | 3 | no |
DOID:3191 | nemaline myopathy | 2.7397 | 7 | no |
DOID:422 | congenital structural myopathy | 2.7397 | 6 | no |
DOID:423 | myopathy | 2.7397 | 5 | no |
DOID:66 | muscle tissue disease | 2.7397 | 4 | no |
DOID:114 | heart disease | 2.7397 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
NEBU_HUMAN | [view interactions] | Low throughput | no | no |
TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDK2_HUMAN | [view interactions] | High throughput | no | yes |
ITA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
CETN2_HUMAN | [view interactions] | High throughput | no | yes |
USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADDA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LSP1_HUMAN | [view interactions] | High throughput | no | no |
SCIN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYO5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FLII_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHG6_HUMAN | [view interactions] | High throughput | no | yes |
ARHGB_HUMAN | [view interactions] | High throughput | no | yes |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
VMP1_HUMAN | [view interactions] | High throughput | no | yes |
DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KPCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BUB1_HUMAN | [view interactions] | High throughput | no | no |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DCC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHG07_HUMAN | [view interactions] | High throughput | no | no |
FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
MLH3_HUMAN | [view interactions] | High throughput | no | no |
DCOR_HUMAN | [view interactions] | High throughput | no | yes |
PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TLR2_HUMAN | [view interactions] | High throughput | no | no |
CSN5_HUMAN | [view interactions] | High throughput | no | yes |
AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
FXL17_HUMAN | [view interactions] | High throughput | no | yes |
RARA_HUMAN | [view interactions] | High throughput | no | no |
PAN2_HUMAN | [view interactions] | High throughput | no | no |
GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LRRF1_HUMAN | [view interactions] | High throughput | no | yes |
LRRF2_HUMAN | [view interactions] | High throughput | no | yes |
TBCD4_HUMAN | [view interactions] | High throughput | no | yes |
CBPC1_HUMAN | [view interactions] | High throughput | no | yes |
NIN_HUMAN | [view interactions] | High throughput | no | no |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
APEX1_HUMAN | [view interactions] | High throughput | no | yes |
RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VAV_HUMAN | [view interactions] | High throughput | no | no |
SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ABRA_HUMAN | [view interactions] | High throughput | no | no |
RRAGB_HUMAN | [view interactions] | High throughput | no | yes |
HLX_HUMAN | [view interactions] | High throughput | no | yes |
NAA40_HUMAN | [view interactions] | High throughput | no | no |
GKN1_HUMAN | [view interactions] | High throughput | no | no |
SAMTR_HUMAN | [view interactions] | High throughput | no | yes |
SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
SCP2_HUMAN | [view interactions] | High throughput | no | no |
AP2A_HUMAN | [view interactions] | High throughput | no | no |
MYO1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ERLEC_HUMAN | [view interactions] | High throughput | no | yes |
GA2L1_HUMAN | [view interactions] | High throughput | no | yes |
RT05_HUMAN | [view interactions] | High throughput | no | yes |
RSLBA_HUMAN | [view interactions] | High throughput | no | yes |
H4_HUMAN | [view interactions] | High throughput | no | yes |
PNO1_HUMAN | [view interactions] | High throughput | no | no |
C1QR1_HUMAN | [view interactions] | High throughput | no | no |
PDE7A_HUMAN | [view interactions] | High throughput | no | yes |
BIRC8_HUMAN | [view interactions] | High throughput | no | no |
GILT_HUMAN | [view interactions] | High throughput | no | no |
PROK2_HUMAN | [view interactions] | High throughput | no | no |
CACB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ZMY19_HUMAN | [view interactions] | High throughput | no | yes |
S2541_HUMAN | [view interactions] | High throughput | no | no |
ASHWN_HUMAN | [view interactions] | High throughput | no | yes |
LPAR2_HUMAN | [view interactions] | High throughput | no | yes |
RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NDUAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KLH10_HUMAN | [view interactions] | High throughput | no | no |
ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSB10_HUMAN | [view interactions] | High throughput | no | no |
EFHD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYWC_HUMAN | [view interactions] | High throughput | no | yes |
E41L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AMOL1_HUMAN | [view interactions] | High throughput | no | no |
BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CSN7B_HUMAN | [view interactions] | High throughput | no | yes |
DCAF1_HUMAN | [view interactions] | High throughput | no | yes |
HABP4_HUMAN | [view interactions] | High throughput | no | yes |
CSN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CCD18_HUMAN | [view interactions] | High throughput | no | yes |
CP110_HUMAN | [view interactions] | High throughput | no | yes |
CENPJ_HUMAN | [view interactions] | High throughput | no | no |
CP131_HUMAN | [view interactions] | High throughput | no | no |
EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
IQCB1_HUMAN | [view interactions] | High throughput | no | no |
KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
LMO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LRC49_HUMAN | [view interactions] | High throughput | no | no |
MPRIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NEXN_HUMAN | [view interactions] | High throughput | no | yes |
2A5D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SVIL_HUMAN | [view interactions] | High throughput | no | yes |
TPGS1_HUMAN | [view interactions] | High throughput | no | no |
TXNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARFG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CC138_HUMAN | [view interactions] | High throughput | no | yes |
CE152_HUMAN | [view interactions] | High throughput | no | yes |
DLG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RB6I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GCC2_HUMAN | [view interactions] | High throughput | no | yes |
GOGA4_HUMAN | [view interactions] | High throughput | no | yes |
GOGB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HAUS8_HUMAN | [view interactions] | High throughput | no | yes |
KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECM29_HUMAN | [view interactions] | High throughput | no | no |
CRACD_HUMAN | [view interactions] | High throughput | no | yes |
K1671_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
MACF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OFD1_HUMAN | [view interactions] | High throughput | no | yes |
PCNT_HUMAN | [view interactions] | High throughput | no | yes |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STRN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TACC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WIPI4_HUMAN | [view interactions] | High throughput | no | no |
CLC4E_HUMAN | [view interactions] | High throughput | no | no |
PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO19_HUMAN | [view interactions] | High throughput | no | yes |
FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FLNB_HUMAN | [view interactions] | High throughput | no | no |
LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CALL3_HUMAN | [view interactions] | High throughput | no | yes |
BAAT_HUMAN | [view interactions] | Computational | no | no |
TMOD2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TMOD4_HUMAN | [view interactions] | Computational | no | no |
TPM2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TMOD3_HUMAN | [view interactions] | Computational | no | yes |