Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TMOD1_HUMAN

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in TMOD1_HUMAN
GO:0003779 actin binding 49.3151 4 yes
GO:0045296 cadherin binding 24.6575 4 no
GO:0046872 metal ion binding 24.6575 4 no
GO:0005523 tropomyosin binding 4.1096 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TMOD1_HUMAN
GO:0048522 positive regulation of cellular process 49.3151 4 no
GO:0048523 negative regulation of cellular process 47.9452 4 yes
GO:0006996 organelle organization 45.2055 4 yes
GO:0060255 regulation of macromolecule metabolic process 42.4658 4 no
GO:0051128 regulation of cellular component organization 41.0959 4 yes
GO:0080090 regulation of primary metabolic process 39.7260 4 no
GO:0051171 regulation of nitrogen compound metabolic process 38.3562 4 no
GO:0007010 cytoskeleton organization 34.2466 5 yes
GO:0022607 cellular component assembly 34.2466 4 yes
GO:0031323 regulation of cellular metabolic process 34.2466 4 no
GO:0044087 regulation of cellular component biogenesis 31.5068 4 yes
GO:0097435 supramolecular fiber organization 31.5068 4 yes
GO:0010646 regulation of cell communication 31.5068 4 no
GO:0007015 actin filament organization 30.1370 5 yes
GO:0051246 regulation of protein metabolic process 30.1370 5 no
GO:0033043 regulation of organelle organization 28.7671 5 yes
GO:0051493 regulation of cytoskeleton organization 28.7671 6 yes
GO:0032970 regulation of actin filament-based process 27.3973 4 yes
GO:1902903 regulation of supramolecular fiber organization 27.3973 5 yes
GO:0010468 regulation of gene expression 27.3973 5 no
GO:0008104 protein localization 27.3973 4 no
GO:0032956 regulation of actin cytoskeleton organization 26.0274 5 yes
GO:0009893 positive regulation of metabolic process 26.0274 4 no
GO:0110053 regulation of actin filament organization 24.6575 6 yes
GO:0009966 regulation of signal transduction 24.6575 4 no
GO:0051129 negative regulation of cellular component organization 23.2877 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 23.2877 5 no
GO:0030030 cell projection organization 23.2877 4 no
GO:0009892 negative regulation of metabolic process 21.9178 4 no
GO:0010605 negative regulation of macromolecule metabolic process 20.5479 5 no
GO:0016192 vesicle-mediated transport 20.5479 4 no
GO:0051130 positive regulation of cellular component organization 20.5479 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 20.5479 5 no
GO:0032535 regulation of cellular component size 19.1781 4 yes
GO:0008064 regulation of actin polymerization or depolymerization 17.8082 6 yes
GO:0010639 negative regulation of organelle organization 17.8082 6 yes
GO:0030832 regulation of actin filament length 17.8082 5 yes
GO:0051494 negative regulation of cytoskeleton organization 17.8082 7 yes
GO:1902904 negative regulation of supramolecular fiber organization 17.8082 6 yes
GO:0032271 regulation of protein polymerization 16.4384 6 yes
GO:0043242 negative regulation of protein-containing complex disassembly 16.4384 6 yes
GO:0043244 regulation of protein-containing complex disassembly 16.4384 5 yes
GO:0043254 regulation of protein-containing complex assembly 16.4384 5 yes
GO:1901879 regulation of protein depolymerization 16.4384 6 yes
GO:1901880 negative regulation of protein depolymerization 16.4384 7 yes
GO:0030833 regulation of actin filament polymerization 15.0685 7 yes
GO:0030834 regulation of actin filament depolymerization 15.0685 7 yes
GO:0030835 negative regulation of actin filament depolymerization 15.0685 7 yes
GO:0031032 actomyosin structure organization 13.6986 4 yes
GO:0031333 negative regulation of protein-containing complex assembly 13.6986 6 yes
GO:0032272 negative regulation of protein polymerization 13.6986 7 yes
GO:0030837 negative regulation of actin filament polymerization 12.3288 7 yes
GO:0051693 actin filament capping 12.3288 8 yes
GO:0006936 muscle contraction 10.9589 4 yes
GO:0070925 organelle assembly 10.9589 5 yes
GO:0140694 non-membrane-bounded organelle assembly 6.8493 6 yes
GO:0030239 myofibril assembly 4.1096 4 yes
GO:0002064 epithelial cell development 2.7397 4 yes
GO:0008344 adult locomotory behavior 2.7397 4 yes
GO:0051694 pointed-end actin filament capping 2.7397 9 yes

Disease

Term Name % Distance from top the of the tree Annotated in TMOD1_HUMAN
DOID:0080000 muscular disease 2.7397 3 no
DOID:3191 nemaline myopathy 2.7397 7 no
DOID:422 congenital structural myopathy 2.7397 6 no
DOID:423 myopathy 2.7397 5 no
DOID:66 muscle tissue disease 2.7397 4 no
DOID:114 heart disease 2.7397 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NEBU_HUMAN [view interactions] Low throughput no no
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
TPM4_HUMAN [view entry] [view interactions] High throughput yes yes
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
MYO5C_HUMAN [view entry] [view interactions] High throughput yes yes
PDLI7_HUMAN [view entry] [view interactions] High throughput yes no
CDK2_HUMAN [view interactions] High throughput no yes
ITA5_HUMAN [view entry] [view interactions] High throughput yes no
TMEDA_HUMAN [view interactions] High throughput no yes
CETN2_HUMAN [view interactions] High throughput no yes
USO1_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
ADDA_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
LSP1_HUMAN [view interactions] High throughput no no
SCIN_HUMAN [view entry] [view interactions] High throughput yes no
MYO5B_HUMAN [view entry] [view interactions] High throughput yes yes
SNX1_HUMAN [view entry] [view interactions] High throughput yes yes
FLII_HUMAN [view entry] [view interactions] High throughput yes yes
PKHG6_HUMAN [view interactions] High throughput no yes
ARHGB_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SCRB2_HUMAN [view interactions] High throughput no yes
VMP1_HUMAN [view interactions] High throughput no yes
DAPK1_HUMAN [view entry] [view interactions] High throughput yes yes
KPCE_HUMAN [view entry] [view interactions] High throughput yes yes
BCAR1_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
APC_HUMAN [view entry] [view interactions] High throughput yes no
BUB1_HUMAN [view interactions] High throughput no no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
DCC_HUMAN [view entry] [view interactions] High throughput yes yes
RHG07_HUMAN [view interactions] High throughput no no
FBXW7_HUMAN [view interactions] High throughput no yes
MLH3_HUMAN [view interactions] High throughput no no
DCOR_HUMAN [view interactions] High throughput no yes
PK3CA_HUMAN [view entry] [view interactions] High throughput yes yes
TLR2_HUMAN [view interactions] High throughput no no
CSN5_HUMAN [view interactions] High throughput no yes
AAPK2_HUMAN [view interactions] High throughput no yes
FXL17_HUMAN [view interactions] High throughput no yes
RARA_HUMAN [view interactions] High throughput no no
PAN2_HUMAN [view interactions] High throughput no no
GELS_HUMAN [view entry] [view interactions] High throughput yes no
LRRF1_HUMAN [view interactions] High throughput no yes
LRRF2_HUMAN [view interactions] High throughput no yes
TBCD4_HUMAN [view interactions] High throughput no yes
CBPC1_HUMAN [view interactions] High throughput no yes
NIN_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
APEX1_HUMAN [view interactions] High throughput no yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
VAV_HUMAN [view interactions] High throughput no no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
ABRA_HUMAN [view interactions] High throughput no no
RRAGB_HUMAN [view interactions] High throughput no yes
HLX_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
GKN1_HUMAN [view interactions] High throughput no no
SAMTR_HUMAN [view interactions] High throughput no yes
SMAD2_HUMAN [view interactions] High throughput no yes
SCP2_HUMAN [view interactions] High throughput no no
AP2A_HUMAN [view interactions] High throughput no no
MYO1B_HUMAN [view entry] [view interactions] High throughput yes no
ERLEC_HUMAN [view interactions] High throughput no yes
GA2L1_HUMAN [view interactions] High throughput no yes
RT05_HUMAN [view interactions] High throughput no yes
RSLBA_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes
PNO1_HUMAN [view interactions] High throughput no no
C1QR1_HUMAN [view interactions] High throughput no no
PDE7A_HUMAN [view interactions] High throughput no yes
BIRC8_HUMAN [view interactions] High throughput no no
GILT_HUMAN [view interactions] High throughput no no
PROK2_HUMAN [view interactions] High throughput no no
CACB3_HUMAN [view entry] [view interactions] High throughput yes no
ZMY19_HUMAN [view interactions] High throughput no yes
S2541_HUMAN [view interactions] High throughput no no
ASHWN_HUMAN [view interactions] High throughput no yes
LPAR2_HUMAN [view interactions] High throughput no yes
RL35A_HUMAN [view entry] [view interactions] High throughput yes no
NDUAD_HUMAN [view entry] [view interactions] High throughput yes yes
KLH10_HUMAN [view interactions] High throughput no no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
CALD1_HUMAN [view entry] [view interactions] High throughput yes no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
PSB10_HUMAN [view interactions] High throughput no no
EFHD2_HUMAN [view entry] [view interactions] High throughput yes no
SYWC_HUMAN [view interactions] High throughput no yes
E41L2_HUMAN [view entry] [view interactions] High throughput yes yes
AMOL1_HUMAN [view interactions] High throughput no no
BASP1_HUMAN [view entry] [view interactions] High throughput yes yes
CSN7B_HUMAN [view interactions] High throughput no yes
DCAF1_HUMAN [view interactions] High throughput no yes
HABP4_HUMAN [view interactions] High throughput no yes
CSN3_HUMAN [view entry] [view interactions] High throughput yes yes
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
ABLM1_HUMAN [view entry] [view interactions] High throughput yes yes
CCD18_HUMAN [view interactions] High throughput no yes
CP110_HUMAN [view interactions] High throughput no yes
CENPJ_HUMAN [view interactions] High throughput no no
CP131_HUMAN [view interactions] High throughput no no
EPB41_HUMAN [view entry] [view interactions] High throughput yes no
IQCB1_HUMAN [view interactions] High throughput no no
KIF1C_HUMAN [view interactions] High throughput no yes
LMO7_HUMAN [view entry] [view interactions] High throughput yes yes
LRC49_HUMAN [view interactions] High throughput no no
MPRIP_HUMAN [view entry] [view interactions] High throughput yes yes
NEXN_HUMAN [view interactions] High throughput no yes
2A5D_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
SVIL_HUMAN [view interactions] High throughput no yes
TPGS1_HUMAN [view interactions] High throughput no no
TXNL1_HUMAN [view entry] [view interactions] High throughput yes yes
ARFG2_HUMAN [view entry] [view interactions] High throughput yes yes
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
CC138_HUMAN [view interactions] High throughput no yes
CE152_HUMAN [view interactions] High throughput no yes
DLG5_HUMAN [view entry] [view interactions] High throughput yes no
RB6I2_HUMAN [view entry] [view interactions] High throughput yes yes
GCC2_HUMAN [view interactions] High throughput no yes
GOGA4_HUMAN [view interactions] High throughput no yes
GOGB1_HUMAN [view entry] [view interactions] High throughput yes yes
HAUS8_HUMAN [view interactions] High throughput no yes
KANK2_HUMAN [view entry] [view interactions] High throughput yes yes
ECM29_HUMAN [view interactions] High throughput no no
CRACD_HUMAN [view interactions] High throughput no yes
K1671_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
MACF1_HUMAN [view entry] [view interactions] High throughput yes yes
OFD1_HUMAN [view interactions] High throughput no yes
PCNT_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
STRN_HUMAN [view entry] [view interactions] High throughput yes yes
STRN4_HUMAN [view entry] [view interactions] High throughput yes yes
TACC1_HUMAN [view entry] [view interactions] High throughput yes yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
TBB2A_HUMAN [view entry] [view interactions] High throughput yes yes
WIPI4_HUMAN [view interactions] High throughput no no
CLC4E_HUMAN [view interactions] High throughput no no
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
ANLN_HUMAN [view interactions] High throughput no yes
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
MYO19_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
FLNB_HUMAN [view interactions] High throughput no no
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
CALL3_HUMAN [view interactions] High throughput no yes
BAAT_HUMAN [view interactions] Computational no no
TMOD2_HUMAN [view entry] [view interactions] Computational yes yes
TMOD4_HUMAN [view interactions] Computational no no
TPM2_HUMAN [view entry] [view interactions] Computational yes yes
TMOD3_HUMAN [view interactions] Computational no yes