MYO5C_HUMAN
Evidence for PS localization
Functions
May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MYO5C_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 59.3750 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 32.8125 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 31.2500 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.6875 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 28.1250 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 26.5625 | 5 | yes |
| GO:0045296 | cadherin binding | 26.5625 | 4 | no |
| GO:0005524 | ATP binding | 25.0000 | 5 | yes |
| GO:0019900 | kinase binding | 21.8750 | 4 | no |
| GO:0019901 | protein kinase binding | 21.8750 | 5 | no |
| GO:0046872 | metal ion binding | 20.3125 | 4 | no |
| GO:0003723 | RNA binding | 20.3125 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MYO5C_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 54.6875 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 53.1250 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 51.5625 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 43.7500 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 43.7500 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 40.6250 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 40.6250 | 5 | no |
| GO:0007015 | actin filament organization | 39.0625 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 39.0625 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 39.0625 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 39.0625 | 4 | no |
| GO:0022607 | cellular component assembly | 39.0625 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 37.5000 | 4 | no |
| GO:0033043 | regulation of organelle organization | 35.9375 | 5 | no |
| GO:0008104 | protein localization | 34.3750 | 4 | no |
| GO:0032970 | regulation of actin filament-based process | 32.8125 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 32.8125 | 6 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 31.2500 | 5 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 31.2500 | 5 | no |
| GO:0110053 | regulation of actin filament organization | 29.6875 | 6 | no |
| GO:0009893 | positive regulation of metabolic process | 29.6875 | 4 | no |
| GO:0010468 | regulation of gene expression | 29.6875 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.6875 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 29.6875 | 4 | no |
| GO:0051049 | regulation of transport | 29.6875 | 4 | no |
| GO:0032535 | regulation of cellular component size | 26.5625 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.5625 | 5 | no |
| GO:0010646 | regulation of cell communication | 25.0000 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 23.4375 | 5 | no |
| GO:0030030 | cell projection organization | 23.4375 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 23.4375 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.4375 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.4375 | 5 | no |
| GO:0071702 | organic substance transport | 23.4375 | 4 | no |
| GO:0009966 | regulation of signal transduction | 21.8750 | 4 | no |
| GO:0008064 | regulation of actin polymerization or depolymerization | 21.8750 | 6 | no |
| GO:0030832 | regulation of actin filament length | 21.8750 | 5 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 21.8750 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.8750 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.3125 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.3125 | 5 | no |
| GO:0030833 | regulation of actin filament polymerization | 20.3125 | 7 | no |
| GO:0032271 | regulation of protein polymerization | 20.3125 | 6 | no |
| GO:0015031 | protein transport | 20.3125 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.3125 | 5 | no |
| GO:0071705 | nitrogen compound transport | 20.3125 | 4 | no |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 15.6250 | 4 | yes |
| GO:0051650 | establishment of vesicle localization | 15.6250 | 4 | yes |
| GO:0099518 | vesicle cytoskeletal trafficking | 12.5000 | 5 | yes |
| GO:0030050 | vesicle transport along actin filament | 10.9375 | 4 | yes |
| GO:0099515 | actin filament-based transport | 10.9375 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MYO5C_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 6.2500 | 3 | no |
| DOID:0050851 | glomerulosclerosis | 4.6875 | 6 | no |
| DOID:10952 | nephritis | 4.6875 | 4 | no |
| DOID:1312 | focal segmental glomerulosclerosis | 4.6875 | 7 | no |
| DOID:2921 | glomerulonephritis | 4.6875 | 5 | no |
| DOID:557 | kidney disease | 4.6875 | 3 | no |
| DOID:0050700 | cardiomyopathy | 4.6875 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 4.6875 | 5 | no |
| DOID:0080000 | muscular disease | 3.1250 | 3 | no |
| DOID:3191 | nemaline myopathy | 3.1250 | 7 | no |
| DOID:422 | congenital structural myopathy | 3.1250 | 6 | no |
| DOID:423 | myopathy | 3.1250 | 5 | no |
| DOID:66 | muscle tissue disease | 3.1250 | 4 | no |
| DOID:0050155 | sensory system disease | 3.1250 | 3 | no |
| DOID:0050563 | nonsyndromic deafness | 3.1250 | 5 | no |
| DOID:0050564 | autosomal dominant nonsyndromic deafness | 3.1250 | 6 | no |
| DOID:2742 | auditory system disease | 3.1250 | 4 | no |
| DOID:2843 | long QT syndrome | 3.1250 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RAB8A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHGBA_HUMAN | [view interactions] | High throughput | no | yes |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTL8_HUMAN | [view interactions] | High throughput | no | no |
| PGK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP5S_HUMAN | [view interactions] | High throughput | no | no |
| LUZP1_HUMAN | [view interactions] | High throughput | no | yes |
| MISP_HUMAN | [view interactions] | High throughput | no | no |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP5L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD109_HUMAN | [view interactions] | High throughput | no | no |
| CLIC1_HUMAN | [view interactions] | High throughput | no | no |
| DAPK3_HUMAN | [view interactions] | High throughput | no | yes |
| AFAP1_HUMAN | [view interactions] | High throughput | no | yes |
| ARPC5_HUMAN | [view interactions] | High throughput | no | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKAP2_HUMAN | [view interactions] | High throughput | no | no |
| ARC1B_HUMAN | [view interactions] | High throughput | no | no |
| ARP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLII_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T161A_HUMAN | [view interactions] | High throughput | no | yes |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSG2_HUMAN | [view interactions] | High throughput | no | no |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYTSA_HUMAN | [view interactions] | High throughput | no | yes |
| TPRN_HUMAN | [view interactions] | High throughput | no | yes |
| N4BP3_HUMAN | [view interactions] | High throughput | no | yes |
| LSS_HUMAN | [view interactions] | High throughput | no | yes |
| RAI14_HUMAN | [view interactions] | High throughput | no | yes |
| COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CING_HUMAN | [view interactions] | High throughput | no | no |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARPC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARPC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE162_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TULP2_HUMAN | [view interactions] | High throughput | no | no |
| TMOD4_HUMAN | [view interactions] | High throughput | no | no |
| CRYL1_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI_HUMAN | [view interactions] | High throughput | no | no |
| CADH5_HUMAN | [view interactions] | High throughput | no | yes |
| DKK3_HUMAN | [view interactions] | High throughput | no | yes |
| PEX19_HUMAN | [view interactions] | High throughput | no | yes |
| SPDEF_HUMAN | [view interactions] | High throughput | no | no |
| MOAP1_HUMAN | [view interactions] | High throughput | no | yes |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| KPCD1_HUMAN | [view interactions] | High throughput | no | yes |
| MIC19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGN2_HUMAN | [view interactions] | High throughput | no | no |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NONO_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| FOS_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| JADE2_HUMAN | [view interactions] | High throughput | no | yes |
| CREB3_HUMAN | [view interactions] | High throughput | no | no |
| SCP2_HUMAN | [view interactions] | High throughput | no | no |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPZL1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRF2_HUMAN | [view interactions] | High throughput | no | yes |
| ABCG2_HUMAN | [view interactions] | High throughput | no | no |
| SIN3B_HUMAN | [view interactions] | High throughput | no | yes |
| POC1A_HUMAN | [view interactions] | High throughput | no | yes |
| BRWD1_HUMAN | [view interactions] | High throughput | no | yes |
| INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACBD5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEXN_HUMAN | [view interactions] | High throughput | no | yes |
| CYTSB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP6R2_HUMAN | [view interactions] | High throughput | no | no |
| CDC16_HUMAN | [view interactions] | High throughput | no | yes |
| DQX1_HUMAN | [view interactions] | High throughput | no | no |
| AVIL_HUMAN | [view interactions] | High throughput | no | no |
| P4HA2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| R144A_HUMAN | [view interactions] | High throughput | no | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANO7_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPM2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI52_HUMAN | [view interactions] | High throughput | no | yes |
| ACRBP_HUMAN | [view interactions] | High throughput | no | no |
| LURA1_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF6_HUMAN | [view interactions] | High throughput | no | no |
| CXCL6_HUMAN | [view interactions] | High throughput | no | no |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| K22E_HUMAN | [view interactions] | High throughput | no | no |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| ODAD1_HUMAN | [view interactions] | High throughput | no | no |
| GAGE5_HUMAN | [view interactions] | High throughput | no | no |
| TBA3C_HUMAN | [view interactions] | High throughput | no | no |
| TBA3D_HUMAN | [view interactions] | High throughput | no | no |
| CX001_HUMAN | [view interactions] | High throughput | no | no |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EI2BE_HUMAN | [view interactions] | High throughput | no | yes |
| SAAL1_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C40_HUMAN | [view interactions] | High throughput | no | no |
| NP1L2_HUMAN | [view interactions] | High throughput | no | no |
| RBX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| ERLEC_HUMAN | [view interactions] | High throughput | no | yes |
| PNMA2_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC5_HUMAN | [view interactions] | High throughput | no | no |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANC2_HUMAN | [view interactions] | High throughput | no | no |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| K1C19_HUMAN | [view interactions] | High throughput | no | no |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| SEP10_HUMAN | [view interactions] | High throughput | no | yes |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| RAB32_HUMAN | [view interactions] | Computational | no | yes |