MYO1E_HUMAN
Evidence for PS localization
Functions
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 159 | Ala | Pro | Focalsegmentalglomerulosclerosis6(FSGS6) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MYO1E_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 43.7500 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 43.7500 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 42.1875 | 4 | yes |
| GO:0019900 | kinase binding | 32.8125 | 4 | no |
| GO:0019901 | protein kinase binding | 32.8125 | 5 | no |
| GO:0046872 | metal ion binding | 31.2500 | 4 | no |
| GO:0003779 | actin binding | 31.2500 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 26.5625 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 26.5625 | 5 | yes |
| GO:0005524 | ATP binding | 25.0000 | 5 | yes |
| GO:0003723 | RNA binding | 21.8750 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 20.3125 | 6 | yes |
| GO:0016462 | pyrophosphatase activity | 20.3125 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 20.3125 | 4 | yes |
| GO:0016887 | ATP hydrolysis activity | 3.1250 | 7 | yes |
| GO:0035091 | phosphatidylinositol binding | 3.1250 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MYO1E_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.6250 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 54.6875 | 4 | no |
| GO:0006996 | organelle organization | 51.5625 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.8750 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 45.3125 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.7500 | 4 | no |
| GO:0022607 | cellular component assembly | 42.1875 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 42.1875 | 4 | no |
| GO:0010468 | regulation of gene expression | 40.6250 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 40.6250 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.6250 | 5 | no |
| GO:0033043 | regulation of organelle organization | 40.6250 | 5 | no |
| GO:0010646 | regulation of cell communication | 39.0625 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 35.9375 | 5 | no |
| GO:0007010 | cytoskeleton organization | 35.9375 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 34.3750 | 4 | no |
| GO:0009966 | regulation of signal transduction | 34.3750 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 34.3750 | 6 | no |
| GO:0097435 | supramolecular fiber organization | 32.8125 | 4 | yes |
| GO:0051049 | regulation of transport | 32.8125 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.8125 | 5 | no |
| GO:0030030 | cell projection organization | 31.2500 | 4 | no |
| GO:0032970 | regulation of actin filament-based process | 31.2500 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.6875 | 4 | no |
| GO:0007015 | actin filament organization | 28.1250 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.1250 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.1250 | 5 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 28.1250 | 5 | no |
| GO:0036211 | protein modification process | 26.5625 | 4 | no |
| GO:0043412 | macromolecule modification | 26.5625 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 26.5625 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.5625 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.5625 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 25.0000 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 25.0000 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 25.0000 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 25.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.0000 | 4 | no |
| GO:0008104 | protein localization | 25.0000 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.4375 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 23.4375 | 5 | no |
| GO:0010941 | regulation of cell death | 23.4375 | 4 | no |
| GO:0061024 | membrane organization | 23.4375 | 4 | no |
| GO:0045597 | positive regulation of cell differentiation | 21.8750 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.8750 | 6 | no |
| GO:0043933 | protein-containing complex organization | 21.8750 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 21.8750 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 21.8750 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.8750 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 21.8750 | 4 | no |
| GO:0051726 | regulation of cell cycle | 21.8750 | 4 | no |
| GO:0022604 | regulation of cell morphogenesis | 21.8750 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 21.8750 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 21.8750 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.8750 | 6 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 21.8750 | 5 | no |
| GO:0071310 | cellular response to organic substance | 20.3125 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.3125 | 6 | no |
| GO:0051050 | positive regulation of transport | 20.3125 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 20.3125 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 20.3125 | 5 | no |
| GO:0110053 | regulation of actin filament organization | 20.3125 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.3125 | 5 | no |
| GO:0006897 | endocytosis | 14.0625 | 5 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 12.5000 | 4 | yes |
| GO:0051650 | establishment of vesicle localization | 12.5000 | 4 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 9.3750 | 4 | yes |
| GO:0099518 | vesicle cytoskeletal trafficking | 9.3750 | 5 | yes |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 7.8125 | 5 | yes |
| GO:0030050 | vesicle transport along actin filament | 7.8125 | 4 | yes |
| GO:0099515 | actin filament-based transport | 7.8125 | 5 | yes |
| GO:0001701 | in utero embryonic development | 6.2500 | 6 | yes |
| GO:0009792 | embryo development ending in birth or egg hatching | 6.2500 | 4 | yes |
| GO:0043009 | chordate embryonic development | 6.2500 | 5 | yes |
| GO:0030198 | extracellular matrix organization | 4.6875 | 5 | yes |
| GO:0043062 | extracellular structure organization | 4.6875 | 4 | yes |
| GO:0045229 | external encapsulating structure organization | 4.6875 | 4 | yes |
| GO:0002064 | epithelial cell development | 3.1250 | 4 | yes |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway | 3.1250 | 6 | yes |
| GO:0072015 | podocyte development | 3.1250 | 6 | yes |
| GO:0072310 | glomerular epithelial cell development | 3.1250 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MYO1E_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 6.2500 | 3 | no |
| DOID:0050700 | cardiomyopathy | 4.6875 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 4.6875 | 5 | no |
| DOID:2843 | long QT syndrome | 3.1250 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SYNJ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AL14E_HUMAN | [view interactions] | Low throughput | no | yes |
| OGFD1_HUMAN | [view interactions] | High throughput | no | yes |
| LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| PLPHP_HUMAN | [view interactions] | High throughput | no | yes |
| RUXF_HUMAN | [view interactions] | High throughput | no | no |
| TBCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FNBP1_HUMAN | [view interactions] | High throughput | no | yes |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| STMN1_HUMAN | [view interactions] | High throughput | no | yes |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPYR_HUMAN | [view interactions] | High throughput | no | yes |
| AFG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFFL_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACATN_HUMAN | [view interactions] | High throughput | no | yes |
| PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
| WRP73_HUMAN | [view interactions] | High throughput | no | no |
| OSTF1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN764_HUMAN | [view interactions] | High throughput | no | no |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| NCBP2_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MB212_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| LT4R2_HUMAN | [view interactions] | High throughput | no | no |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CBP_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| SP1_HUMAN | [view interactions] | High throughput | no | yes |
| NANOG_HUMAN | [view interactions] | High throughput | no | no |
| NANP8_HUMAN | [view interactions] | High throughput | no | no |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| UN45A_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| MICB_HUMAN | [view interactions] | High throughput | no | no |
| ZBT7B_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| F16P1_HUMAN | [view interactions] | High throughput | no | no |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TYB4Y_HUMAN | [view interactions] | High throughput | no | no |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| ANR50_HUMAN | [view interactions] | High throughput | no | no |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| TPX2_HUMAN | [view interactions] | High throughput | no | yes |
| MALL_HUMAN | [view interactions] | High throughput | no | no |
| GAGE5_HUMAN | [view interactions] | High throughput | no | no |
| S100B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2V2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CX001_HUMAN | [view interactions] | High throughput | no | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| EF1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| SMCA5_HUMAN | [view interactions] | High throughput | no | yes |
| NSD2_HUMAN | [view interactions] | High throughput | no | yes |
| SUZ12_HUMAN | [view interactions] | High throughput | no | no |
| H10_HUMAN | [view interactions] | High throughput | no | yes |
| H2AZ_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H13_HUMAN | [view interactions] | High throughput | no | no |
| SMCA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARP2_HUMAN | [view interactions] | High throughput | no | yes |
| DNSL2_HUMAN | [view interactions] | High throughput | no | no |
| RAD50_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1J_HUMAN | [view interactions] | High throughput | no | yes |
| H1X_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| CBX3_HUMAN | [view interactions] | High throughput | no | yes |
| NUMA1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF22_HUMAN | [view interactions] | High throughput | no | no |
| CTSL2_HUMAN | [view interactions] | High throughput | no | no |
| KMT2A_HUMAN | [view interactions] | High throughput | no | yes |
| RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| H2A2A_HUMAN | [view interactions] | High throughput | no | yes |
| RIF1_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDE4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIAP1_HUMAN | [view interactions] | High throughput | no | yes |
| DTNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| MYH11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BRE1A_HUMAN | [view interactions] | High throughput | no | yes |
| ASNS_HUMAN | [view interactions] | High throughput | no | yes |
| PUR9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPNS1_HUMAN | [view interactions] | High throughput | no | yes |
| ISOC1_HUMAN | [view interactions] | High throughput | no | no |
| MCTS1_HUMAN | [view interactions] | High throughput | no | no |
| STK26_HUMAN | [view interactions] | High throughput | no | no |
| ARP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ACTG_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RALA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| WASP_HUMAN | [view interactions] | Computational | no | yes |
| WASL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |