Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MYO1E_HUMAN

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. [View more on UniProt]

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Position Amino acid Mutation Disease Overlap with binding region
159 Ala Pro Focalsegmentalglomerulosclerosis6(FSGS6) -
119 Thr Ile Focalsegmentalglomerulosclerosis6(FSGS6) -
388 Asp His Focalsegmentalglomerulosclerosis6(FSGS6) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in MYO1E_HUMAN
GO:0000166 nucleotide binding 40.8451 4 yes
GO:0017076 purine nucleotide binding 40.8451 5 yes
GO:0043168 anion binding 40.8451 4 yes
GO:0032555 purine ribonucleotide binding 38.0282 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 36.6197 4 yes
GO:0043169 cation binding 32.3944 4 no
GO:0046872 metal ion binding 32.3944 5 no
GO:0003779 actin binding 28.1690 4 yes
GO:0030554 adenyl nucleotide binding 25.3521 6 yes
GO:0019900 kinase binding 25.3521 4 no
GO:0019901 protein kinase binding 25.3521 5 no
GO:0032559 adenyl ribonucleotide binding 22.5352 5 yes
GO:0003723 RNA binding 22.5352 4 no
GO:0005524 ATP binding 21.1268 5 yes
GO:0016462 pyrophosphatase activity 18.3099 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 18.3099 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 18.3099 6 yes
GO:0035091 phosphatidylinositol binding 4.2254 4 yes
GO:0016887 ATP hydrolysis activity 2.8169 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MYO1E_HUMAN
GO:0048522 positive regulation of cellular process 64.7887 4 no
GO:0031323 regulation of cellular metabolic process 50.7042 4 no
GO:0048523 negative regulation of cellular process 49.2958 4 no
GO:0060255 regulation of macromolecule metabolic process 49.2958 4 no
GO:0051128 regulation of cellular component organization 47.8873 4 no
GO:0006996 organelle organization 43.6620 4 no
GO:0009889 regulation of biosynthetic process 42.2535 4 no
GO:0010468 regulation of gene expression 42.2535 6 no
GO:0010556 regulation of macromolecule biosynthetic process 42.2535 5 no
GO:0031326 regulation of cellular biosynthetic process 42.2535 5 no
GO:0080090 regulation of primary metabolic process 42.2535 4 no
GO:0010646 regulation of cell communication 39.4366 4 no
GO:0009893 positive regulation of metabolic process 36.6197 4 no
GO:0010604 positive regulation of macromolecule metabolic process 36.6197 5 no
GO:0022607 cellular component assembly 36.6197 4 no
GO:0031325 positive regulation of cellular metabolic process 33.8028 5 no
GO:0009966 regulation of signal transduction 32.3944 4 no
GO:0007010 cytoskeleton organization 30.9859 5 no
GO:0097435 supramolecular fiber organization 29.5775 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.5775 5 no
GO:0048584 positive regulation of response to stimulus 28.1690 4 no
GO:0033043 regulation of organelle organization 28.1690 5 no
GO:1902531 regulation of intracellular signal transduction 26.7606 5 no
GO:0051252 regulation of RNA metabolic process 26.7606 5 no
GO:0006355 regulation of DNA-templated transcription 25.3521 7 no
GO:0008104 protein localization 25.3521 4 no
GO:0043933 protein-containing complex organization 25.3521 4 no
GO:0044087 regulation of cellular component biogenesis 25.3521 4 no
GO:2001141 regulation of RNA biosynthetic process 25.3521 6 no
GO:0009892 negative regulation of metabolic process 23.9437 4 no
GO:0030030 cell projection organization 23.9437 4 no
GO:0009891 positive regulation of biosynthetic process 23.9437 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 23.9437 6 no
GO:0031328 positive regulation of cellular biosynthetic process 23.9437 6 no
GO:0051493 regulation of cytoskeleton organization 23.9437 6 no
GO:0007015 actin filament organization 23.9437 5 yes
GO:0010647 positive regulation of cell communication 22.5352 5 no
GO:0023056 positive regulation of signaling 22.5352 4 no
GO:0031324 negative regulation of cellular metabolic process 22.5352 5 no
GO:0042127 regulation of cell population proliferation 22.5352 4 no
GO:0051049 regulation of transport 22.5352 4 no
GO:0051130 positive regulation of cellular component organization 22.5352 5 no
GO:0051246 regulation of protein metabolic process 22.5352 5 no
GO:0141124 intracellular signaling cassette 22.5352 4 no
GO:0009967 positive regulation of signal transduction 21.1268 5 no
GO:0010605 negative regulation of macromolecule metabolic process 21.1268 5 no
GO:0036211 protein modification process 21.1268 4 no
GO:0042981 regulation of apoptotic process 21.1268 5 no
GO:0043067 regulation of programmed cell death 21.1268 4 no
GO:0043412 macromolecule modification 21.1268 4 no
GO:0051240 positive regulation of multicellular organismal process 21.1268 4 no
GO:0051726 regulation of cell cycle 21.1268 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.1268 5 no
GO:0051129 negative regulation of cellular component organization 21.1268 5 no
GO:0030705 cytoskeleton-dependent intracellular transport 12.6761 4 yes
GO:0098657 import into cell 12.6761 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 11.2676 4 yes
GO:0051650 establishment of vesicle localization 9.8592 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 9.8592 5 yes
GO:0099518 vesicle cytoskeletal trafficking 7.0423 5 yes
GO:0043009 chordate embryonic development 5.6338 5 yes
GO:0099515 actin filament-based transport 5.6338 5 yes
GO:0001701 in utero embryonic development 5.6338 6 yes
GO:0009792 embryo development ending in birth or egg hatching 5.6338 4 yes
GO:0030050 vesicle transport along actin filament 5.6338 4 yes
GO:0030198 extracellular matrix organization 4.2254 5 yes
GO:0043062 extracellular structure organization 4.2254 4 yes
GO:0045229 external encapsulating structure organization 4.2254 4 yes
GO:0002064 epithelial cell development 4.2254 4 yes
GO:0030097 hemopoiesis 4.2254 4 yes
GO:0048008 platelet-derived growth factor receptor signaling pathway 2.8169 6 yes
GO:0072015 podocyte development 2.8169 6 yes
GO:0072310 glomerular epithelial cell development 2.8169 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SYNJ1_HUMAN [view entry] [view interactions] Low throughput yes yes
DYN2_HUMAN [view entry] [view interactions] Low throughput yes yes
DYN1_HUMAN [view entry] [view interactions] Low throughput yes yes
AL14E_HUMAN [view interactions] Low throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
CDK9_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
MICB_HUMAN [view interactions] High throughput no no
ZBT7B_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
EMC4_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
AURKB_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4C_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
F16P1_HUMAN [view interactions] High throughput no no
ISG15_HUMAN [view interactions] High throughput no no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
WDR5_HUMAN [view interactions] High throughput no no
NUDC2_HUMAN [view entry] [view interactions] High throughput yes yes
TYB4Y_HUMAN [view interactions] High throughput no no
TP4A3_HUMAN [view interactions] High throughput no no
IF16_HUMAN [view interactions] High throughput no no
ANR50_HUMAN [view interactions] High throughput no no
SH3L1_HUMAN [view interactions] High throughput no yes
TPX2_HUMAN [view interactions] High throughput no yes
MALL_HUMAN [view interactions] High throughput no no
GAGE5_HUMAN [view interactions] High throughput no no
S100B_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
UB2V2_HUMAN [view entry] [view interactions] High throughput yes no
CX001_HUMAN [view interactions] High throughput no no
BTF3_HUMAN [view interactions] High throughput no yes
EF1D_HUMAN [view entry] [view interactions] High throughput yes yes
FBXW7_HUMAN [view interactions] High throughput no yes
FGD5_HUMAN [view interactions] High throughput no yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
SMCA5_HUMAN [view interactions] High throughput no yes
NSD2_HUMAN [view interactions] High throughput no yes
SUZ12_HUMAN [view interactions] High throughput no no
H10_HUMAN [view interactions] High throughput no yes
H2AZ_HUMAN [view interactions] High throughput no yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
H13_HUMAN [view interactions] High throughput no no
SMCA1_HUMAN [view entry] [view interactions] High throughput yes yes
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
PARP2_HUMAN [view interactions] High throughput no yes
DNSL2_HUMAN [view interactions] High throughput no no
RAD50_HUMAN [view interactions] High throughput no yes
H2A1J_HUMAN [view interactions] High throughput no yes
H1X_HUMAN [view interactions] High throughput no yes
H2B1C_HUMAN [view interactions] High throughput no yes
CBX3_HUMAN [view interactions] High throughput no yes
NUMA1_HUMAN [view interactions] High throughput no yes
KIF22_HUMAN [view interactions] High throughput no no
CTSL2_HUMAN [view interactions] High throughput no no
KMT2A_HUMAN [view interactions] High throughput no yes
RS27A_HUMAN [view entry] [view interactions] High throughput yes yes
H4_HUMAN [view interactions] High throughput no yes
H2A2A_HUMAN [view interactions] High throughput no yes
RIF1_HUMAN [view interactions] High throughput no yes
SMUF1_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
HDAC6_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
PARPT_HUMAN [view interactions] High throughput no no
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
RICTR_HUMAN [view interactions] High throughput no yes
RECQ1_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
PDE4B_HUMAN [view entry] [view interactions] High throughput yes yes
DIAP1_HUMAN [view interactions] High throughput no yes
DTNA_HUMAN [view entry] [view interactions] High throughput yes yes
ILF3_HUMAN [view interactions] High throughput no yes
MYH11_HUMAN [view entry] [view interactions] High throughput yes no
BRE1A_HUMAN [view interactions] High throughput no yes
ASNS_HUMAN [view interactions] High throughput no yes
PUR9_HUMAN [view entry] [view interactions] High throughput yes yes
CPNS1_HUMAN [view interactions] High throughput no yes
ISOC1_HUMAN [view interactions] High throughput no no
MCTS1_HUMAN [view interactions] High throughput no no
STK26_HUMAN [view interactions] High throughput no no
OGFD1_HUMAN [view interactions] High throughput no yes
LIS1_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA4_HUMAN [view interactions] High throughput no yes
PLPHP_HUMAN [view interactions] High throughput no yes
RUXF_HUMAN [view interactions] High throughput no no
TBCB_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
ARPC4_HUMAN [view entry] [view interactions] High throughput yes no
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
FNBP1_HUMAN [view interactions] High throughput no yes
LEG3_HUMAN [view interactions] High throughput no yes
STMN1_HUMAN [view interactions] High throughput no yes
MYO5A_HUMAN [view entry] [view interactions] High throughput yes yes
IPYR_HUMAN [view interactions] High throughput no yes
AFG32_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP8_HUMAN [view interactions] High throughput no yes
CAVN2_HUMAN [view interactions] High throughput no no
U2AF2_HUMAN [view interactions] High throughput no yes
MAP1B_HUMAN [view entry] [view interactions] High throughput yes yes
REEP5_HUMAN [view entry] [view interactions] High throughput yes yes
ENL_HUMAN [view interactions] High throughput no yes
RBBP4_HUMAN [view interactions] High throughput no yes
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
CNN3_HUMAN [view entry] [view interactions] High throughput yes yes
HNRL2_HUMAN [view interactions] High throughput no yes
LRRF1_HUMAN [view interactions] High throughput no yes
CAVN1_HUMAN [view interactions] High throughput no no
C2D1A_HUMAN [view entry] [view interactions] High throughput yes yes
TM10C_HUMAN [view interactions] High throughput no yes
LMO7_HUMAN [view entry] [view interactions] High throughput yes yes
SMRC1_HUMAN [view interactions] High throughput no yes
TNPO1_HUMAN [view entry] [view interactions] High throughput yes yes
SNR40_HUMAN [view interactions] High throughput no yes
SIR1_HUMAN [view interactions] High throughput no yes
DPYL5_HUMAN [view entry] [view interactions] High throughput yes yes
HIRP3_HUMAN [view interactions] High throughput no no
RAD18_HUMAN [view interactions] High throughput no yes
TCF20_HUMAN [view interactions] High throughput no yes
APC5_HUMAN [view interactions] High throughput no yes
RUVB2_HUMAN [view interactions] High throughput no yes
RUVB1_HUMAN [view interactions] High throughput no yes
TR150_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RFFL_HUMAN [view interactions] High throughput no yes
NHLC2_HUMAN [view interactions] High throughput no yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
NUP35_HUMAN [view interactions] High throughput no yes
STING_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
ANLN_HUMAN [view interactions] High throughput no yes
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
MYO19_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
CALL3_HUMAN [view interactions] High throughput no yes
TMOD3_HUMAN [view interactions] High throughput no yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
MYO5C_HUMAN [view entry] [view interactions] High throughput yes yes
PDLI7_HUMAN [view entry] [view interactions] High throughput yes no
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
ACATN_HUMAN [view interactions] High throughput no yes
PGFRB_HUMAN [view interactions] High throughput no yes
WRP73_HUMAN [view interactions] High throughput no no
OSTF1_HUMAN [view interactions] High throughput no yes
ZN764_HUMAN [view interactions] High throughput no no
OCRL_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
NCBP2_HUMAN [view interactions] High throughput no yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
MB212_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
LT4R2_HUMAN [view interactions] High throughput no no
CUL1_HUMAN [view interactions] High throughput no yes
CLIC6_HUMAN [view interactions] High throughput no no
RIPK4_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
CBP_HUMAN [view interactions] High throughput no yes
EMD_HUMAN [view interactions] High throughput no yes
SP1_HUMAN [view interactions] High throughput no yes
NANP8_HUMAN [view interactions] High throughput no no
NANOG_HUMAN [view interactions] High throughput no no
PAN2_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
UN45A_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes