TBCB_HUMAN
Evidence for PS localization
Functions
Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TBCB_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 43.3333 | 4 | no |
| GO:0017076 | purine nucleotide binding | 43.3333 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 43.3333 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 43.3333 | 4 | no |
| GO:0043168 | anion binding | 43.3333 | 4 | no |
| GO:0003723 | RNA binding | 40.0000 | 4 | no |
| GO:0043169 | cation binding | 30.0000 | 4 | no |
| GO:0046872 | metal ion binding | 30.0000 | 5 | no |
| GO:0005524 | ATP binding | 26.6667 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 26.6667 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 26.6667 | 5 | no |
| GO:0031625 | ubiquitin protein ligase binding | 26.6667 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 26.6667 | 4 | no |
| GO:0019900 | kinase binding | 26.6667 | 4 | no |
| GO:0019901 | protein kinase binding | 26.6667 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 23.3333 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 23.3333 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 23.3333 | 6 | no |
| GO:0015631 | tubulin binding | 13.3333 | 4 | yes |
| GO:0008017 | microtubule binding | 6.6667 | 5 | yes |
| GO:0043014 | alpha-tubulin binding | 6.6667 | 5 | yes |
| GO:0051010 | microtubule plus-end binding | 6.6667 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TBCB_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.6667 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 46.6667 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.3333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
| GO:0006996 | organelle organization | 36.6667 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 36.6667 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 36.6667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.6667 | 5 | no |
| GO:0010646 | regulation of cell communication | 36.6667 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.6667 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 36.6667 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 36.6667 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.6667 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 36.6667 | 5 | no |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | yes |
| GO:0008104 | protein localization | 33.3333 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 30.0000 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 30.0000 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 30.0000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 30.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.0000 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.0000 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 30.0000 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 26.6667 | 4 | no |
| GO:0031399 | regulation of protein modification process | 26.6667 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.6667 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.6667 | 6 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.6667 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.6667 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.6667 | 5 | no |
| GO:0032880 | regulation of protein localization | 26.6667 | 5 | no |
| GO:0060341 | regulation of cellular localization | 26.6667 | 4 | no |
| GO:0007010 | cytoskeleton organization | 23.3333 | 5 | yes |
| GO:0010638 | positive regulation of organelle organization | 23.3333 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 23.3333 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.3333 | 4 | no |
| GO:0033043 | regulation of organelle organization | 23.3333 | 5 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 23.3333 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.3333 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 23.3333 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 23.3333 | 4 | no |
| GO:0051049 | regulation of transport | 23.3333 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 23.3333 | 6 | no |
| GO:0009894 | regulation of catabolic process | 23.3333 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 20.0000 | 4 | yes |
| GO:0007021 | tubulin complex assembly | 6.6667 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PIWL2_HUMAN | [view interactions] | Low throughput | no | no |
| TBA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GAN_HUMAN | [view interactions] | Low throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| CCNK_HUMAN | [view interactions] | High throughput | no | yes |
| CDK12_HUMAN | [view interactions] | High throughput | no | yes |
| INT5_HUMAN | [view interactions] | High throughput | no | no |
| GANP_HUMAN | [view interactions] | High throughput | no | yes |
| MED17_HUMAN | [view interactions] | High throughput | no | no |
| RM32_HUMAN | [view interactions] | High throughput | no | yes |
| MZT1_HUMAN | [view interactions] | High throughput | no | yes |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAE2_HUMAN | [view interactions] | High throughput | no | yes |
| YTDC1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN830_HUMAN | [view interactions] | High throughput | no | yes |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| TXND5_HUMAN | [view interactions] | High throughput | no | yes |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ASNS_HUMAN | [view interactions] | High throughput | no | yes |
| CPNS1_HUMAN | [view interactions] | High throughput | no | yes |
| KCRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ISOC1_HUMAN | [view interactions] | High throughput | no | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLPHP_HUMAN | [view interactions] | High throughput | no | yes |
| RISC_HUMAN | [view interactions] | High throughput | no | yes |
| RUXF_HUMAN | [view interactions] | High throughput | no | no |
| STK24_HUMAN | [view interactions] | High throughput | no | yes |
| XPO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IF5_HUMAN | [view interactions] | High throughput | no | yes |
| ERP44_HUMAN | [view interactions] | High throughput | no | yes |
| FERM2_HUMAN | [view interactions] | High throughput | no | yes |
| GSHB_HUMAN | [view interactions] | High throughput | no | no |
| STK26_HUMAN | [view interactions] | High throughput | no | no |
| MYO1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGFD1_HUMAN | [view interactions] | High throughput | no | yes |
| PTMA_HUMAN | [view interactions] | High throughput | no | yes |
| TWF2_HUMAN | [view interactions] | High throughput | no | no |
| UBFD1_HUMAN | [view interactions] | High throughput | no | no |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| D2HDH_HUMAN | [view interactions] | High throughput | no | no |
| HXK2_HUMAN | [view interactions] | High throughput | no | yes |
| LGSN_HUMAN | [view interactions] | High throughput | no | no |
| PLBL2_HUMAN | [view interactions] | High throughput | no | yes |
| PP14B_HUMAN | [view interactions] | High throughput | no | yes |
| AASD1_HUMAN | [view interactions] | High throughput | no | yes |
| XPP1_HUMAN | [view interactions] | High throughput | no | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUR2_HUMAN | [view interactions] | High throughput | no | yes |
| SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRI1_HUMAN | [view interactions] | High throughput | no | no |
| ROA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSME1_HUMAN | [view interactions] | High throughput | no | yes |
| TBCE_HUMAN | [view interactions] | High throughput | no | no |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| XRN2_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA4_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| SIM43_HUMAN | [view interactions] | High throughput | no | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| ARAF_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYLK4_HUMAN | [view interactions] | High throughput | no | no |
| NEK7_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| DUS12_HUMAN | [view interactions] | High throughput | no | no |