Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TBCB_HUMAN

Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth . [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in TBCB_HUMAN
GO:0000166 nucleotide binding 43.3333 4 no
GO:0017076 purine nucleotide binding 43.3333 5 no
GO:0032555 purine ribonucleotide binding 43.3333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 43.3333 4 no
GO:0043168 anion binding 43.3333 4 no
GO:0003723 RNA binding 40.0000 4 no
GO:0043169 cation binding 30.0000 4 no
GO:0046872 metal ion binding 30.0000 5 no
GO:0005524 ATP binding 26.6667 5 no
GO:0030554 adenyl nucleotide binding 26.6667 6 no
GO:0032559 adenyl ribonucleotide binding 26.6667 5 no
GO:0031625 ubiquitin protein ligase binding 26.6667 5 no
GO:0044389 ubiquitin-like protein ligase binding 26.6667 4 no
GO:0019900 kinase binding 26.6667 4 no
GO:0019901 protein kinase binding 26.6667 5 no
GO:0016462 pyrophosphatase activity 23.3333 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 23.3333 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 23.3333 6 no
GO:0015631 tubulin binding 13.3333 4 yes
GO:0008017 microtubule binding 6.6667 5 yes
GO:0043014 alpha-tubulin binding 6.6667 5 yes
GO:0051010 microtubule plus-end binding 6.6667 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TBCB_HUMAN
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 46.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 46.6667 4 no
GO:0080090 regulation of primary metabolic process 43.3333 4 no
GO:0051128 regulation of cellular component organization 40.0000 4 no
GO:0006996 organelle organization 36.6667 4 yes
GO:0043933 protein-containing complex organization 36.6667 4 yes
GO:0009893 positive regulation of metabolic process 36.6667 4 no
GO:0010604 positive regulation of macromolecule metabolic process 36.6667 5 no
GO:0010646 regulation of cell communication 36.6667 4 no
GO:0031325 positive regulation of cellular metabolic process 36.6667 5 no
GO:0051246 regulation of protein metabolic process 36.6667 5 no
GO:0009889 regulation of biosynthetic process 36.6667 4 no
GO:0010556 regulation of macromolecule biosynthetic process 36.6667 5 no
GO:0031326 regulation of cellular biosynthetic process 36.6667 5 no
GO:0022607 cellular component assembly 33.3333 4 yes
GO:0008104 protein localization 33.3333 4 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0065003 protein-containing complex assembly 30.0000 5 yes
GO:0048584 positive regulation of response to stimulus 30.0000 4 no
GO:0009891 positive regulation of biosynthetic process 30.0000 5 no
GO:0009892 negative regulation of metabolic process 30.0000 4 no
GO:0010468 regulation of gene expression 30.0000 6 no
GO:0010605 negative regulation of macromolecule metabolic process 30.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 30.0000 6 no
GO:0006796 phosphate-containing compound metabolic process 26.6667 4 no
GO:0031399 regulation of protein modification process 26.6667 6 no
GO:0044087 regulation of cellular component biogenesis 26.6667 4 no
GO:0051247 positive regulation of protein metabolic process 26.6667 6 no
GO:0010557 positive regulation of macromolecule biosynthetic process 26.6667 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.6667 5 no
GO:0031324 negative regulation of cellular metabolic process 26.6667 5 no
GO:0032880 regulation of protein localization 26.6667 5 no
GO:0060341 regulation of cellular localization 26.6667 4 no
GO:0007010 cytoskeleton organization 23.3333 5 yes
GO:0010638 positive regulation of organelle organization 23.3333 6 no
GO:0010647 positive regulation of cell communication 23.3333 5 no
GO:0023056 positive regulation of signaling 23.3333 4 no
GO:0033043 regulation of organelle organization 23.3333 5 no
GO:0043254 regulation of protein-containing complex assembly 23.3333 5 no
GO:0051130 positive regulation of cellular component organization 23.3333 5 no
GO:0042981 regulation of apoptotic process 23.3333 5 no
GO:0043067 regulation of programmed cell death 23.3333 4 no
GO:0051049 regulation of transport 23.3333 4 no
GO:0051248 negative regulation of protein metabolic process 23.3333 6 no
GO:0009894 regulation of catabolic process 23.3333 4 no
GO:0097435 supramolecular fiber organization 20.0000 4 yes
GO:0007021 tubulin complex assembly 6.6667 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PIWL2_HUMAN [view interactions] Low throughput no no
TBA1A_HUMAN [view entry] [view interactions] Low throughput yes yes
GAN_HUMAN [view interactions] Low throughput no yes
CDK9_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
IF16_HUMAN [view interactions] High throughput no no
SAR1B_HUMAN [view interactions] High throughput no yes
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2H_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
CCNK_HUMAN [view interactions] High throughput no yes
CDK12_HUMAN [view interactions] High throughput no yes
INT5_HUMAN [view interactions] High throughput no no
GANP_HUMAN [view interactions] High throughput no yes
MED17_HUMAN [view interactions] High throughput no no
RM32_HUMAN [view interactions] High throughput no yes
MZT1_HUMAN [view interactions] High throughput no yes
RL35_HUMAN [view entry] [view interactions] High throughput yes yes
SAE2_HUMAN [view interactions] High throughput no yes
YTDC1_HUMAN [view interactions] High throughput no yes
ZN830_HUMAN [view interactions] High throughput no yes
SRBP2_HUMAN [view interactions] High throughput no yes
TXND5_HUMAN [view interactions] High throughput no yes
TCTP_HUMAN [view entry] [view interactions] High throughput yes yes
AL7A1_HUMAN [view entry] [view interactions] High throughput yes no
ASNS_HUMAN [view interactions] High throughput no yes
CPNS1_HUMAN [view interactions] High throughput no yes
KCRB_HUMAN [view entry] [view interactions] High throughput yes no
ISOC1_HUMAN [view interactions] High throughput no no
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA4_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
PLPHP_HUMAN [view interactions] High throughput no yes
RISC_HUMAN [view interactions] High throughput no yes
RUXF_HUMAN [view interactions] High throughput no no
STK24_HUMAN [view interactions] High throughput no yes
XPO2_HUMAN [view entry] [view interactions] High throughput yes no
IF5_HUMAN [view interactions] High throughput no yes
ERP44_HUMAN [view interactions] High throughput no yes
FERM2_HUMAN [view interactions] High throughput no yes
GSHB_HUMAN [view interactions] High throughput no no
STK26_HUMAN [view interactions] High throughput no no
MYO1E_HUMAN [view entry] [view interactions] High throughput yes yes
OGFD1_HUMAN [view interactions] High throughput no yes
PTMA_HUMAN [view interactions] High throughput no yes
TWF2_HUMAN [view interactions] High throughput no no
UBFD1_HUMAN [view interactions] High throughput no no
VINC_HUMAN [view entry] [view interactions] High throughput yes no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
ANXA6_HUMAN [view entry] [view interactions] High throughput yes yes
D2HDH_HUMAN [view interactions] High throughput no no
HXK2_HUMAN [view interactions] High throughput no yes
LGSN_HUMAN [view interactions] High throughput no no
PLBL2_HUMAN [view interactions] High throughput no yes
PP14B_HUMAN [view interactions] High throughput no yes
AASD1_HUMAN [view interactions] High throughput no yes
XPP1_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
PCNA_HUMAN [view interactions] High throughput no no
TCPA_HUMAN [view entry] [view interactions] High throughput yes yes
PUR2_HUMAN [view interactions] High throughput no yes
SAHH_HUMAN [view entry] [view interactions] High throughput yes yes
MOES_HUMAN [view entry] [view interactions] High throughput yes no
PRI1_HUMAN [view interactions] High throughput no no
ROA3_HUMAN [view entry] [view interactions] High throughput yes yes
PSME1_HUMAN [view interactions] High throughput no yes
TBCE_HUMAN [view interactions] High throughput no no
MKRN2_HUMAN [view interactions] High throughput no yes
XRN2_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
NECD_HUMAN [view interactions] High throughput no no
NAA40_HUMAN [view interactions] High throughput no no
STING_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
LNP_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
RICTR_HUMAN [view interactions] High throughput no yes
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
RFA4_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
PAK1_HUMAN [view entry] [view interactions] High throughput yes yes
OTUB1_HUMAN [view interactions] High throughput no yes
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
RIN3_HUMAN [view interactions] High throughput no yes
SIM43_HUMAN [view interactions] High throughput no no
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
UBP7_HUMAN [view interactions] High throughput no yes
M3K7_HUMAN [view interactions] High throughput no yes
ARAF_HUMAN [view interactions] High throughput no yes
RIPK4_HUMAN [view interactions] High throughput no no
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
MYLK4_HUMAN [view interactions] High throughput no no
NEK7_HUMAN [view interactions] High throughput no yes
HSC20_HUMAN [view interactions] High throughput no yes
EGLN_HUMAN [view interactions] High throughput no no
DYR1A_HUMAN [view interactions] High throughput no yes
H2B1C_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
DUS12_HUMAN [view interactions] High throughput no no