TBCB_HUMAN
Evidence for PS localization
Functions
Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TBCB_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 45.8333 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 45.8333 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 45.8333 | 4 | no |
| GO:0005525 | GTP binding | 29.1667 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 29.1667 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 29.1667 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 29.1667 | 6 | no |
| GO:0019001 | guanyl nucleotide binding | 29.1667 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 29.1667 | 5 | no |
| GO:0003924 | GTPase activity | 25.0000 | 7 | no |
| GO:0003723 | RNA binding | 25.0000 | 4 | no |
| GO:0019900 | kinase binding | 20.8333 | 4 | no |
| GO:0019901 | protein kinase binding | 20.8333 | 5 | no |
| GO:0046872 | metal ion binding | 20.8333 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TBCB_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 45.8333 | 4 | no |
| GO:0006996 | organelle organization | 41.6667 | 4 | no |
| GO:0007010 | cytoskeleton organization | 41.6667 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 37.5000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0010646 | regulation of cell communication | 29.1667 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 29.1667 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 29.1667 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 29.1667 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 29.1667 | 4 | no |
| GO:0008104 | protein localization | 29.1667 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 20.8333 | 4 | no |
| GO:0009966 | regulation of signal transduction | 20.8333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 20.8333 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 20.8333 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 20.8333 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.8333 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GAN_HUMAN | [view interactions] | Low throughput | no | yes |
| PIWL2_HUMAN | [view interactions] | Low throughput | no | no |
| TBA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLBL2_HUMAN | [view interactions] | High throughput | no | yes |
| PP14B_HUMAN | [view interactions] | High throughput | no | yes |
| AASD1_HUMAN | [view interactions] | High throughput | no | yes |
| XPP1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| ARAF_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYLK4_HUMAN | [view interactions] | High throughput | no | no |
| NEK7_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| DUS12_HUMAN | [view interactions] | High throughput | no | no |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| CCNK_HUMAN | [view interactions] | High throughput | no | yes |
| CDK12_HUMAN | [view interactions] | High throughput | no | yes |
| INT5_HUMAN | [view interactions] | High throughput | no | no |
| GANP_HUMAN | [view interactions] | High throughput | no | yes |
| MED17_HUMAN | [view interactions] | High throughput | no | no |
| RM32_HUMAN | [view interactions] | High throughput | no | yes |
| MZT1_HUMAN | [view interactions] | High throughput | no | yes |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAE2_HUMAN | [view interactions] | High throughput | no | yes |
| YTDC1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN830_HUMAN | [view interactions] | High throughput | no | yes |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| TXND5_HUMAN | [view interactions] | High throughput | no | yes |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ASNS_HUMAN | [view interactions] | High throughput | no | yes |
| CPNS1_HUMAN | [view interactions] | High throughput | no | yes |
| KCRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ISOC1_HUMAN | [view interactions] | High throughput | no | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLPHP_HUMAN | [view interactions] | High throughput | no | yes |
| RISC_HUMAN | [view interactions] | High throughput | no | yes |
| RUXF_HUMAN | [view interactions] | High throughput | no | no |
| STK24_HUMAN | [view interactions] | High throughput | no | yes |
| XPO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IF5_HUMAN | [view interactions] | High throughput | no | yes |
| ERP44_HUMAN | [view interactions] | High throughput | no | yes |
| FERM2_HUMAN | [view interactions] | High throughput | no | yes |
| GSHB_HUMAN | [view interactions] | High throughput | no | no |
| STK26_HUMAN | [view interactions] | High throughput | no | no |
| MYO1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGFD1_HUMAN | [view interactions] | High throughput | no | yes |
| PTMA_HUMAN | [view interactions] | High throughput | no | yes |
| TWF2_HUMAN | [view interactions] | High throughput | no | no |
| UBFD1_HUMAN | [view interactions] | High throughput | no | no |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| D2HDH_HUMAN | [view interactions] | High throughput | no | no |
| HXK2_HUMAN | [view interactions] | High throughput | no | yes |
| LGSN_HUMAN | [view interactions] | High throughput | no | no |
| ARL2_HUMAN | [view interactions] | Computational | no | yes |
| TBCA_HUMAN | [view interactions] | Computational | no | yes |
| TBA8_HUMAN | [view interactions] | Computational | no | yes |
| TBB2B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TBB6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TBB2A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TBA1C_HUMAN | [view interactions] | Computational | no | yes |
| TBCC_HUMAN | [view interactions] | Computational | no | yes |
| TBAL3_HUMAN | [view interactions] | Computational | no | no |
| TBB4B_HUMAN | [view interactions] | Computational | no | yes |
| TBCE_HUMAN | [view interactions] | Computational | no | no |
| TBB1_HUMAN | [view interactions] | Computational | no | yes |
| TBA3E_HUMAN | [view interactions] | Computational | no | no |
| TBCD_HUMAN | [view entry] [view interactions] | Computational | yes | no |