ANXA6_HUMAN
Evidence for PS localization
Functions
May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ANXA6_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 40.0000 | 4 | yes |
| GO:0005509 | calcium ion binding | 25.7143 | 5 | yes |
| GO:0045296 | cadherin binding | 22.8571 | 4 | no |
| GO:0017076 | purine nucleotide binding | 20.0000 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 20.0000 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 17.1429 | 4 | yes |
| GO:0008324 | cation transmembrane transporter activity | 14.2857 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 14.2857 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 14.2857 | 5 | yes |
| GO:0003779 | actin binding | 11.4286 | 4 | yes |
| GO:0005216 | ion channel activity | 11.4286 | 4 | yes |
| GO:0005261 | cation channel activity | 11.4286 | 5 | yes |
| GO:0005544 | calcium-dependent phospholipid binding | 11.4286 | 4 | yes |
| GO:0015267 | channel activity | 11.4286 | 4 | yes |
| GO:0005262 | calcium channel activity | 8.5714 | 6 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 8.5714 | 6 | yes |
| GO:0022836 | gated channel activity | 5.7143 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ANXA6_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 51.4286 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 48.5714 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.5714 | 4 | yes |
| GO:0010646 | regulation of cell communication | 45.7143 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 45.7143 | 4 | no |
| GO:0010468 | regulation of gene expression | 42.8571 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 42.8571 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 34.2857 | 4 | no |
| GO:0022607 | cellular component assembly | 34.2857 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.4286 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.4286 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.5714 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 28.5714 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.5714 | 5 | no |
| GO:0036211 | protein modification process | 28.5714 | 4 | no |
| GO:0043412 | macromolecule modification | 28.5714 | 4 | no |
| GO:0051049 | regulation of transport | 28.5714 | 4 | no |
| GO:0006996 | organelle organization | 28.5714 | 4 | no |
| GO:0010941 | regulation of cell death | 25.7143 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 25.7143 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.7143 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.7143 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 25.7143 | 4 | no |
| GO:0071310 | cellular response to organic substance | 25.7143 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.7143 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.7143 | 5 | no |
| GO:0031399 | regulation of protein modification process | 22.8571 | 6 | no |
| GO:0033043 | regulation of organelle organization | 22.8571 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.8571 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.8571 | 4 | no |
| GO:0060341 | regulation of cellular localization | 22.8571 | 4 | no |
| GO:0034330 | cell junction organization | 22.8571 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 22.8571 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.8571 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.8571 | 4 | no |
| GO:0051050 | positive regulation of transport | 22.8571 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 22.8571 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.8571 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.8571 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 22.8571 | 4 | no |
| GO:0061024 | membrane organization | 20.0000 | 4 | yes |
| GO:0006811 | ion transport | 14.2857 | 4 | yes |
| GO:0044057 | regulation of system process | 11.4286 | 4 | yes |
| GO:0048878 | chemical homeostasis | 11.4286 | 4 | yes |
| GO:0090257 | regulation of muscle system process | 11.4286 | 5 | yes |
| GO:0006873 | cellular ion homeostasis | 8.5714 | 4 | yes |
| GO:0006875 | cellular metal ion homeostasis | 8.5714 | 6 | yes |
| GO:0030003 | cellular cation homeostasis | 8.5714 | 5 | yes |
| GO:0050801 | ion homeostasis | 8.5714 | 5 | yes |
| GO:0055065 | metal ion homeostasis | 8.5714 | 7 | yes |
| GO:0055080 | cation homeostasis | 8.5714 | 6 | yes |
| GO:0098771 | inorganic ion homeostasis | 8.5714 | 6 | yes |
| GO:0006937 | regulation of muscle contraction | 5.7143 | 6 | yes |
| GO:0007009 | plasma membrane organization | 5.7143 | 5 | yes |
| GO:0051282 | regulation of sequestering of calcium ion | 5.7143 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ANXA6_HUMAN |
|---|---|---|---|---|
| DOID:65 | connective tissue disease | 5.7143 | 3 | no |
| DOID:331 | central nervous system disease | 5.7143 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| KCNQ3_HUMAN | [view interactions] | Low throughput | no | no |
| KCNQ2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLCB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UCHL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RASA1_HUMAN | [view interactions] | Low throughput | no | yes |
| S10A1_HUMAN | [view interactions] | Low throughput | no | yes |
| S100B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CR2_HUMAN | [view interactions] | Low throughput | no | no |
| KPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MLH1_HUMAN | [view interactions] | High throughput | no | yes |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| VPP2_HUMAN | [view interactions] | High throughput | no | yes |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| SHOC2_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| LRC45_HUMAN | [view interactions] | High throughput | no | yes |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CPNE6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHSTB_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEP_HUMAN | [view interactions] | High throughput | no | no |
| SF01_HUMAN | [view interactions] | High throughput | no | yes |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IL16_HUMAN | [view interactions] | High throughput | no | no |
| H2AX_HUMAN | [view interactions] | High throughput | no | yes |
| CD4_HUMAN | [view interactions] | High throughput | no | no |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| MET18_HUMAN | [view interactions] | High throughput | no | yes |
| ATP4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| PPME1_HUMAN | [view interactions] | High throughput | no | yes |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK8_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| PAK6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDE4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PURA2_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTAP_HUMAN | [view interactions] | High throughput | no | no |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| DPOE3_HUMAN | [view interactions] | High throughput | no | yes |
| THOP1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| HPRT_HUMAN | [view interactions] | High throughput | no | yes |
| IDHC_HUMAN | [view interactions] | High throughput | no | no |
| NAMPT_HUMAN | [view interactions] | High throughput | no | no |
| MSH2_HUMAN | [view interactions] | High throughput | no | yes |
| TBCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIOM_HUMAN | [view interactions] | High throughput | no | yes |
| AADAT_HUMAN | [view interactions] | High throughput | no | no |
| MIA40_HUMAN | [view interactions] | High throughput | no | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| KAT3_HUMAN | [view interactions] | High throughput | no | yes |
| MCFD2_HUMAN | [view interactions] | High throughput | no | yes |
| SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAOK3_HUMAN | [view interactions] | High throughput | no | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IGSF8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTL1_HUMAN | [view interactions] | High throughput | no | no |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANXA1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CAV3_HUMAN | [view interactions] | Computational | no | no |
| DYSF_HUMAN | [view interactions] | Computational | no | no |
| ANXA2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| TRI72_HUMAN | [view interactions] | Computational | no | no |
| LRP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |