ANXA6_HUMAN
Evidence for PS localization
Functions
May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ANXA6_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 34.2105 | 4 | yes |
| GO:0043169 | cation binding | 31.5789 | 4 | yes |
| GO:0046872 | metal ion binding | 31.5789 | 5 | yes |
| GO:0000166 | nucleotide binding | 28.9474 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 28.9474 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 28.9474 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.3158 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 26.3158 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 26.3158 | 5 | no |
| GO:0005524 | ATP binding | 23.6842 | 5 | no |
| GO:0045296 | cadherin binding | 21.0526 | 4 | no |
| GO:0003723 | RNA binding | 21.0526 | 4 | no |
| GO:0005509 | calcium ion binding | 13.1579 | 6 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 13.1579 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 13.1579 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 13.1579 | 5 | yes |
| GO:0003779 | actin binding | 10.5263 | 4 | yes |
| GO:0005216 | monoatomic ion channel activity | 10.5263 | 4 | yes |
| GO:0005261 | monoatomic cation channel activity | 10.5263 | 5 | yes |
| GO:0015267 | channel activity | 10.5263 | 4 | yes |
| GO:0022836 | gated channel activity | 7.8947 | 5 | yes |
| GO:0005262 | calcium channel activity | 5.2632 | 6 | yes |
| GO:0005544 | calcium-dependent phospholipid binding | 5.2632 | 4 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 5.2632 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ANXA6_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 55.2632 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 52.6316 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 47.3684 | 4 | no |
| GO:0010468 | regulation of gene expression | 47.3684 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 47.3684 | 5 | no |
| GO:0010646 | regulation of cell communication | 47.3684 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 47.3684 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 47.3684 | 4 | no |
| GO:0009966 | regulation of signal transduction | 44.7368 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 42.1053 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 39.4737 | 5 | no |
| GO:0022607 | cellular component assembly | 39.4737 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 36.8421 | 5 | no |
| GO:0006996 | organelle organization | 34.2105 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 34.2105 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 34.2105 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 34.2105 | 4 | no |
| GO:0043933 | protein-containing complex organization | 34.2105 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 31.5789 | 7 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 31.5789 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 31.5789 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.5789 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.5789 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 31.5789 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 31.5789 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 31.5789 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 31.5789 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 31.5789 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 28.9474 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 28.9474 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 28.9474 | 5 | no |
| GO:0023057 | negative regulation of signaling | 28.9474 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 28.9474 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 28.9474 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.9474 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 28.9474 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.3158 | 6 | no |
| GO:0043066 | negative regulation of apoptotic process | 26.3158 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 26.3158 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 26.3158 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 26.3158 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 26.3158 | 6 | no |
| GO:0032880 | regulation of protein localization | 26.3158 | 5 | no |
| GO:0060341 | regulation of cellular localization | 26.3158 | 4 | no |
| GO:0008104 | protein localization | 23.6842 | 4 | no |
| GO:0031399 | regulation of protein modification process | 23.6842 | 6 | no |
| GO:0051129 | negative regulation of cellular component organization | 23.6842 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 23.6842 | 5 | no |
| GO:0071310 | cellular response to organic substance | 23.6842 | 4 | no |
| GO:0034330 | cell junction organization | 23.6842 | 4 | no |
| GO:0061024 | membrane organization | 21.0526 | 4 | yes |
| GO:0036211 | protein modification process | 21.0526 | 4 | no |
| GO:0043412 | macromolecule modification | 21.0526 | 4 | no |
| GO:0007010 | cytoskeleton organization | 21.0526 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 21.0526 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.0526 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 21.0526 | 5 | no |
| GO:2000145 | regulation of cell motility | 21.0526 | 4 | no |
| GO:0051049 | regulation of transport | 21.0526 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.0526 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 21.0526 | 4 | no |
| GO:0032101 | regulation of response to external stimulus | 21.0526 | 4 | no |
| GO:0033043 | regulation of organelle organization | 21.0526 | 5 | no |
| GO:0080134 | regulation of response to stress | 21.0526 | 4 | no |
| GO:0006811 | monoatomic ion transport | 13.1579 | 4 | yes |
| GO:0044057 | regulation of system process | 10.5263 | 4 | yes |
| GO:0090257 | regulation of muscle system process | 10.5263 | 5 | yes |
| GO:0006873 | intracellular monoatomic ion homeostasis | 7.8947 | 4 | yes |
| GO:0030003 | intracellular monoatomic cation homeostasis | 7.8947 | 5 | yes |
| GO:0051282 | regulation of sequestering of calcium ion | 7.8947 | 4 | yes |
| GO:0055080 | monoatomic cation homeostasis | 7.8947 | 4 | yes |
| GO:0006937 | regulation of muscle contraction | 5.2632 | 6 | yes |
| GO:0007009 | plasma membrane organization | 5.2632 | 5 | yes |
| GO:0051283 | negative regulation of sequestering of calcium ion | 5.2632 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| KCNQ3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KCNQ2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLCB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UCHL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RASA1_HUMAN | [view interactions] | Low throughput | no | yes |
| S10A1_HUMAN | [view interactions] | Low throughput | no | yes |
| S100B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CR2_HUMAN | [view interactions] | Low throughput | no | no |
| KPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MLH1_HUMAN | [view interactions] | High throughput | no | yes |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| VPP2_HUMAN | [view interactions] | High throughput | no | yes |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| SHOC2_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| NF2L2_HUMAN | [view interactions] | High throughput | no | yes |
| LRC45_HUMAN | [view interactions] | High throughput | no | yes |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CPNE6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHSTB_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEP_HUMAN | [view interactions] | High throughput | no | no |
| SF01_HUMAN | [view interactions] | High throughput | no | yes |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IL16_HUMAN | [view interactions] | High throughput | no | no |
| H2AX_HUMAN | [view interactions] | High throughput | no | yes |
| CD4_HUMAN | [view interactions] | High throughput | no | no |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| MET18_HUMAN | [view interactions] | High throughput | no | yes |
| ATP4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| PPME1_HUMAN | [view interactions] | High throughput | no | yes |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK8_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| PAK6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FOXC1_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCTD9_HUMAN | [view interactions] | High throughput | no | no |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RHG24_HUMAN | [view interactions] | High throughput | no | yes |
| MOB3C_HUMAN | [view interactions] | High throughput | no | no |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDE4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PURA2_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTAP_HUMAN | [view interactions] | High throughput | no | no |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| DPOE3_HUMAN | [view interactions] | High throughput | no | yes |
| THOP1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| HPRT_HUMAN | [view interactions] | High throughput | no | yes |
| IDHC_HUMAN | [view interactions] | High throughput | no | no |
| NAMPT_HUMAN | [view interactions] | High throughput | no | no |
| MSH2_HUMAN | [view interactions] | High throughput | no | yes |
| TBCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIOM_HUMAN | [view interactions] | High throughput | no | yes |
| AADAT_HUMAN | [view interactions] | High throughput | no | no |
| MIA40_HUMAN | [view interactions] | High throughput | no | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| KAT3_HUMAN | [view interactions] | High throughput | no | yes |
| MCFD2_HUMAN | [view interactions] | High throughput | no | yes |
| SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAOK3_HUMAN | [view interactions] | High throughput | no | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IGSF8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTL1_HUMAN | [view interactions] | High throughput | no | no |
| DNJC2_HUMAN | [view interactions] | High throughput | no | yes |
| XPP1_HUMAN | [view interactions] | High throughput | no | yes |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |