Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

S100B_HUMAN

Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in S100B_HUMAN
GO:0046872 metal ion binding 41.6667 4 yes
GO:0017076 purine nucleotide binding 31.2500 4 no
GO:0032555 purine ribonucleotide binding 29.1667 4 no
GO:0035639 purine ribonucleoside triphosphate binding 29.1667 4 no
GO:0030554 adenyl nucleotide binding 25.0000 5 no
GO:0019900 kinase binding 22.9167 4 no
GO:0045296 cadherin binding 22.9167 4 no
GO:0005524 ATP binding 22.9167 5 no
GO:0032559 adenyl ribonucleotide binding 22.9167 5 no
GO:0005509 calcium ion binding 20.8333 5 yes
GO:0019901 protein kinase binding 20.8333 5 no
GO:0042803 protein homodimerization activity 18.7500 4 yes
GO:0046914 transition metal ion binding 14.5833 5 yes
GO:0050786 RAGE receptor binding 10.4167 4 yes
GO:0008270 zinc ion binding 6.2500 6 yes
GO:0048156 tau protein binding 6.2500 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in S100B_HUMAN
GO:0048523 negative regulation of cellular process 62.5000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 62.5000 4 no
GO:0060255 regulation of macromolecule metabolic process 62.5000 4 no
GO:0080090 regulation of primary metabolic process 62.5000 4 no
GO:0048522 positive regulation of cellular process 60.4167 4 yes
GO:0031323 regulation of cellular metabolic process 60.4167 4 no
GO:0010646 regulation of cell communication 58.3333 4 yes
GO:0009966 regulation of signal transduction 54.1667 4 yes
GO:0010468 regulation of gene expression 52.0833 5 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:1902531 regulation of intracellular signal transduction 45.8333 5 yes
GO:0009893 positive regulation of metabolic process 43.7500 4 no
GO:0009892 negative regulation of metabolic process 41.6667 4 no
GO:0010604 positive regulation of macromolecule metabolic process 41.6667 5 no
GO:0009889 regulation of biosynthetic process 39.5833 4 no
GO:0010605 negative regulation of macromolecule metabolic process 39.5833 5 no
GO:0031326 regulation of cellular biosynthetic process 39.5833 5 no
GO:0031399 regulation of protein modification process 39.5833 6 no
GO:0051173 positive regulation of nitrogen compound metabolic process 39.5833 5 no
GO:0010647 positive regulation of cell communication 37.5000 5 yes
GO:0023056 positive regulation of signaling 37.5000 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 37.5000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.5000 5 no
GO:0051252 regulation of RNA metabolic process 37.5000 5 no
GO:0031325 positive regulation of cellular metabolic process 37.5000 5 no
GO:0051128 regulation of cellular component organization 37.5000 4 no
GO:0009967 positive regulation of signal transduction 35.4167 5 yes
GO:0048584 positive regulation of response to stimulus 35.4167 4 yes
GO:0006355 regulation of DNA-templated transcription 35.4167 6 no
GO:0031324 negative regulation of cellular metabolic process 35.4167 5 no
GO:1903506 regulation of nucleic acid-templated transcription 35.4167 7 no
GO:2001141 regulation of RNA biosynthetic process 35.4167 6 no
GO:0006996 organelle organization 35.4167 4 no
GO:0051247 positive regulation of protein metabolic process 35.4167 6 no
GO:1902533 positive regulation of intracellular signal transduction 33.3333 6 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0010941 regulation of cell death 31.2500 4 no
GO:0019220 regulation of phosphate metabolic process 31.2500 6 no
GO:0042325 regulation of phosphorylation 31.2500 7 no
GO:0051174 regulation of phosphorus metabolic process 31.2500 5 no
GO:0042127 regulation of cell population proliferation 29.1667 4 yes
GO:0051338 regulation of transferase activity 29.1667 4 no
GO:0001932 regulation of protein phosphorylation 29.1667 7 no
GO:0051248 negative regulation of protein metabolic process 27.0833 6 no
GO:0071310 cellular response to organic substance 27.0833 4 no
GO:0010562 positive regulation of phosphorus metabolic process 27.0833 6 no
GO:0022607 cellular component assembly 27.0833 4 no
GO:0042327 positive regulation of phosphorylation 27.0833 8 no
GO:0043085 positive regulation of catalytic activity 27.0833 4 no
GO:0043549 regulation of kinase activity 27.0833 5 no
GO:0045937 positive regulation of phosphate metabolic process 27.0833 7 no
GO:0051336 regulation of hydrolase activity 27.0833 4 no
GO:0006796 phosphate-containing compound metabolic process 27.0833 4 no
GO:0051726 regulation of cell cycle 25.0000 4 no
GO:0036211 protein modification process 25.0000 4 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0043067 regulation of programmed cell death 25.0000 5 no
GO:0030030 cell projection organization 22.9167 4 yes
GO:0050804 modulation of chemical synaptic transmission 22.9167 5 yes
GO:0099177 regulation of trans-synaptic signaling 22.9167 4 yes
GO:0006357 regulation of transcription by RNA polymerase II 22.9167 7 no
GO:0031400 negative regulation of protein modification process 22.9167 7 no
GO:0043933 protein-containing complex organization 22.9167 4 no
GO:0033043 regulation of organelle organization 22.9167 5 no
GO:0033674 positive regulation of kinase activity 22.9167 6 no
GO:0045595 regulation of cell differentiation 22.9167 4 no
GO:0051129 negative regulation of cellular component organization 22.9167 5 no
GO:0051347 positive regulation of transferase activity 22.9167 5 no
GO:0080134 regulation of response to stress 22.9167 4 no
GO:0045859 regulation of protein kinase activity 22.9167 6 no
GO:0051050 positive regulation of transport 22.9167 4 no
GO:0042981 regulation of apoptotic process 22.9167 6 no
GO:0008284 positive regulation of cell population proliferation 20.8333 5 yes
GO:0008104 protein localization 20.8333 4 no
GO:0009894 regulation of catabolic process 20.8333 4 no
GO:0030162 regulation of proteolysis 20.8333 6 no
GO:0044057 regulation of system process 20.8333 4 no
GO:0030334 regulation of cell migration 20.8333 5 no
GO:2000145 regulation of cell motility 20.8333 4 no
GO:0060548 negative regulation of cell death 20.8333 5 no
GO:0050890 cognition 12.5000 4 yes
GO:0007613 memory 10.4167 4 yes
GO:0032990 cell part morphogenesis 10.4167 4 yes
GO:0048168 regulation of neuronal synaptic plasticity 10.4167 4 yes
GO:0048812 neuron projection morphogenesis 10.4167 7 yes
GO:0048858 cell projection morphogenesis 10.4167 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 10.4167 6 yes
GO:0007409 axonogenesis 8.3333 8 yes
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 8.3333 6 yes
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 8.3333 7 yes
GO:0007417 central nervous system development 4.1667 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in S100B_HUMAN
DOID:0050700 cardiomyopathy 6.2500 4 no
DOID:0060036 intrinsic cardiomyopathy 6.2500 5 no
DOID:114 heart disease 6.2500 3 no
DOID:2843 long QT syndrome 4.1667 6 no
DOID:331 central nervous system disease 4.1667 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
S10AB_HUMAN [view interactions] Low throughput no no
S10A6_HUMAN [view interactions] Low throughput no yes
S10A1_HUMAN [view interactions] Low throughput no yes
S100B_HUMAN [view entry] [view interactions] Low throughput yes yes
RAGE_HUMAN [view entry] [view interactions] Low throughput yes no
CYBP_HUMAN [view entry] [view interactions] Low throughput yes yes
MDM2_HUMAN [view interactions] Low throughput no yes
P53_HUMAN [view interactions] Low throughput no no
CAZA1_HUMAN [view entry] [view interactions] Low throughput yes yes
CEP20_HUMAN [view interactions] Low throughput no yes
MDM4_HUMAN [view interactions] Low throughput no yes
KS6A1_HUMAN [view interactions] Low throughput no yes
IQGA1_HUMAN [view entry] [view interactions] Low throughput yes no
VAV_HUMAN [view interactions] Low throughput no no
PGM1_HUMAN [view interactions] Low throughput no no
AHNK_HUMAN [view entry] [view interactions] Low throughput yes yes
NDRG1_HUMAN [view entry] [view interactions] Low throughput yes yes
STK38_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
FGF2_HUMAN [view entry] [view interactions] Low throughput yes yes
ANXA6_HUMAN [view entry] [view interactions] Low throughput yes yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
IMPA1_HUMAN [view entry] [view interactions] Low throughput yes yes
CT455_HUMAN [view interactions] High throughput no no
CT45A_HUMAN [view interactions] High throughput no no
NKAP1_HUMAN [view interactions] High throughput no yes
S10A4_HUMAN [view entry] [view interactions] High throughput yes no
FBXW5_HUMAN [view interactions] High throughput no no
ADTRP_HUMAN [view interactions] High throughput no no
S100P_HUMAN [view interactions] High throughput no no
AF1Q_HUMAN [view interactions] High throughput no yes
DCAF4_HUMAN [view interactions] High throughput no yes
S10A2_HUMAN [view interactions] High throughput no no
SPG21_HUMAN [view interactions] High throughput no yes
LNX1_HUMAN [view interactions] High throughput no yes
S10A9_HUMAN [view entry] [view interactions] High throughput yes no
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
S100Z_HUMAN [view interactions] High throughput no no
A2MG_HUMAN [view interactions] High throughput no yes
CRCT1_HUMAN [view interactions] High throughput no no
TRAF6_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD8_HUMAN [view interactions] High throughput no yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB3_HUMAN [view interactions] High throughput no yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
BLMH_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
NAC1_HUMAN [view entry] [view interactions] High throughput yes yes
TRPM4_HUMAN [view interactions] High throughput no no
MAPK2_HUMAN [view interactions] High throughput no yes
CEP43_HUMAN [view interactions] High throughput no no
B2CL2_HUMAN [view interactions] High throughput no yes
DJC30_HUMAN [view interactions] High throughput no no
IMP4_HUMAN [view interactions] High throughput no no
PRAF1_HUMAN [view interactions] High throughput no yes
ATRAP_HUMAN [view interactions] High throughput no yes
LDAF1_HUMAN [view interactions] High throughput no yes
MAL2_HUMAN [view interactions] High throughput no no
TM239_HUMAN [view interactions] High throughput no no
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
LSM5_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view interactions] High throughput no yes
SOCS1_HUMAN [view interactions] High throughput no yes
CDC45_HUMAN [view interactions] High throughput no no
TB182_HUMAN [view interactions] High throughput no yes
HMCES_HUMAN [view interactions] High throughput no yes
UT14A_HUMAN [view interactions] High throughput no yes
RCOR2_HUMAN [view interactions] High throughput no no
PKHG3_HUMAN [view interactions] High throughput no yes
ZN451_HUMAN [view entry] [view interactions] High throughput yes no
SLX9_HUMAN [view interactions] High throughput no yes
ZBT21_HUMAN [view interactions] High throughput no yes
CDK18_HUMAN [view entry] [view interactions] High throughput yes yes
SLF2_HUMAN [view interactions] High throughput no yes
ZN516_HUMAN [view interactions] High throughput no yes
IASPP_HUMAN [view interactions] High throughput no yes
MTMRC_HUMAN [view interactions] High throughput no yes
ZBED1_HUMAN [view interactions] High throughput no yes
ZN714_HUMAN [view interactions] High throughput no no
ZBTB5_HUMAN [view interactions] High throughput no yes
MA7D3_HUMAN [view interactions] High throughput no no
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
TIGD4_HUMAN [view interactions] High throughput no yes
HEM1_HUMAN [view interactions] High throughput no yes
KDM3B_HUMAN [view interactions] High throughput no yes
TXNIP_HUMAN [view interactions] High throughput no no
ARI3B_HUMAN [view entry] [view interactions] High throughput yes yes
ATD3A_HUMAN [view entry] [view interactions] High throughput yes yes
PUS7_HUMAN [view interactions] High throughput no yes
NOC4L_HUMAN [view interactions] High throughput no no
ORC6_HUMAN [view interactions] High throughput no yes
CISD3_HUMAN [view interactions] High throughput no yes
RICTR_HUMAN [view interactions] High throughput no yes
MAP7_HUMAN [view interactions] High throughput no yes
ASB6_HUMAN [view interactions] High throughput no yes
HIC2_HUMAN [view interactions] High throughput no yes
NOP14_HUMAN [view interactions] High throughput no yes
MTFR1_HUMAN [view interactions] High throughput no yes
CC106_HUMAN [view interactions] High throughput no no
FWCH2_HUMAN [view interactions] High throughput no no
ALR_HUMAN [view interactions] High throughput no yes
AGAP3_HUMAN [view entry] [view interactions] High throughput yes yes
ATAD5_HUMAN [view interactions] High throughput no no
CPLN1_HUMAN [view interactions] High throughput no yes
ORC2_HUMAN [view interactions] High throughput no yes
BCL7B_HUMAN [view interactions] High throughput no yes
ZN709_HUMAN [view interactions] High throughput no no
LIPB1_HUMAN [view interactions] High throughput no yes
UBE3B_HUMAN [view interactions] High throughput no yes
C102A_HUMAN [view interactions] High throughput no yes
CR021_HUMAN [view interactions] High throughput no no
NSUN2_HUMAN [view interactions] High throughput no yes
IQGA2_HUMAN [view interactions] High throughput no yes
ZN507_HUMAN [view interactions] High throughput no no
SCML2_HUMAN [view interactions] High throughput no no
CTU1_HUMAN [view interactions] High throughput no no
FOXO3_HUMAN [view interactions] High throughput no yes
M3K4_HUMAN [view interactions] High throughput no yes
UIF_HUMAN [view interactions] High throughput no yes
RPC7L_HUMAN [view interactions] High throughput no yes
CE112_HUMAN [view interactions] High throughput no no
CCDC8_HUMAN [view interactions] High throughput no yes
PML_HUMAN [view interactions] High throughput no yes
JAK1_HUMAN [view interactions] High throughput no yes
RESF1_HUMAN [view interactions] High throughput no yes
MET18_HUMAN [view interactions] High throughput no yes
REXO5_HUMAN [view interactions] High throughput no no
ATD3B_HUMAN [view interactions] High throughput no yes
PRI1_HUMAN [view interactions] High throughput no no
PRI2_HUMAN [view interactions] High throughput no no
KDM2B_HUMAN [view interactions] High throughput no no
INT6_HUMAN [view interactions] High throughput no yes
TERF2_HUMAN [view interactions] High throughput no yes
ADRO_HUMAN [view interactions] High throughput no no
TTF2_HUMAN [view interactions] High throughput no yes
RL23_HUMAN [view entry] [view interactions] High throughput yes yes
PDIP3_HUMAN [view interactions] High throughput no no
UTP11_HUMAN [view interactions] High throughput no yes
NHSL1_HUMAN [view interactions] High throughput no yes
PHF8_HUMAN [view interactions] High throughput no yes
PLCD3_HUMAN [view entry] [view interactions] High throughput yes yes
BCL7A_HUMAN [view interactions] High throughput no yes
TTC28_HUMAN [view interactions] High throughput no no
RAVR1_HUMAN [view interactions] High throughput no yes
PIF1_HUMAN [view interactions] High throughput no yes
SENP2_HUMAN [view interactions] High throughput no yes
ZN536_HUMAN [view interactions] High throughput no no
MET25_HUMAN [view interactions] High throughput no yes
ZN764_HUMAN [view interactions] High throughput no no
NRIP1_HUMAN [view interactions] High throughput no yes
RFIP1_HUMAN [view interactions] High throughput no yes
SYDE2_HUMAN [view interactions] High throughput no no
NR2C2_HUMAN [view interactions] High throughput no yes
FOXO4_HUMAN [view interactions] High throughput no no
ZNF3_HUMAN [view interactions] High throughput no yes
SENP5_HUMAN [view interactions] High throughput no no
DPOD1_HUMAN [view interactions] High throughput no yes
ZN136_HUMAN [view interactions] High throughput no no
OFD1_HUMAN [view interactions] High throughput no yes
NIPA_HUMAN [view interactions] High throughput no yes
XRCC3_HUMAN [view interactions] High throughput no no
CARF_HUMAN [view interactions] High throughput no yes
MYO1E_HUMAN [view entry] [view interactions] High throughput yes yes
T2FA_HUMAN [view interactions] High throughput no yes
HEMK1_HUMAN [view interactions] High throughput no yes
RM30_HUMAN [view interactions] High throughput no yes
ZBTB4_HUMAN [view interactions] High throughput no yes
DCR1B_HUMAN [view interactions] High throughput no no
PIMRE_HUMAN [view interactions] High throughput no no
DCA13_HUMAN [view interactions] High throughput no yes
ZBT10_HUMAN [view interactions] High throughput no yes
ERF_HUMAN [view interactions] High throughput no yes
CDK17_HUMAN [view interactions] High throughput no yes
ELYS_HUMAN [view interactions] High throughput no yes
CX6B1_HUMAN [view entry] [view interactions] High throughput yes yes
MORC4_HUMAN [view interactions] High throughput no no
SALL3_HUMAN [view interactions] High throughput no no
CNTRB_HUMAN [view interactions] High throughput no yes
PEAK1_HUMAN [view interactions] High throughput no yes
SGO2_HUMAN [view interactions] High throughput no no
SALL1_HUMAN [view interactions] High throughput no yes
SALL2_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
FBX7_HUMAN [view interactions] High throughput no yes
GFAP_HUMAN [view entry] [view interactions] High throughput yes no
ERBB4_HUMAN [view entry] [view interactions] Computational yes yes
DRD2_HUMAN [view entry] [view interactions] Computational yes no
EGF_HUMAN [view interactions] Computational no no
HSP74_HUMAN [view entry] [view interactions] Computational yes yes
ENOG_HUMAN [view entry] [view interactions] Computational yes yes
CAZA2_HUMAN [view entry] [view interactions] Computational yes yes
TAB2_HUMAN [view interactions] Computational no yes
MTAP2_HUMAN [view entry] [view interactions] Computational yes yes
TF65_HUMAN [view entry] [view interactions] Computational yes yes
NFKB1_HUMAN [view interactions] Computational no yes
GUC2D_HUMAN [view interactions] Computational no no
NFKB2_HUMAN [view interactions] Computational no yes
NCOR1_HUMAN [view interactions] Computational no yes
DNJB1_HUMAN [view entry] [view interactions] Computational yes yes
TCHP_HUMAN [view interactions] Computational no yes
GUCNB_HUMAN [view interactions] Computational no no