Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

S100B_HUMAN

Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in S100B_HUMAN
GO:0043169 cation binding 46.1538 4 yes
GO:0046872 metal ion binding 46.1538 5 yes
GO:0043168 anion binding 36.5385 4 no
GO:0000166 nucleotide binding 30.7692 4 no
GO:0017076 purine nucleotide binding 30.7692 5 no
GO:0032555 purine ribonucleotide binding 30.7692 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.7692 4 no
GO:0005524 ATP binding 25.0000 5 no
GO:0030554 adenyl nucleotide binding 25.0000 6 no
GO:0032559 adenyl ribonucleotide binding 25.0000 5 no
GO:0019900 kinase binding 23.0769 4 no
GO:0019901 protein kinase binding 21.1538 5 no
GO:0005509 calcium ion binding 19.2308 6 yes
GO:0042803 protein homodimerization activity 17.3077 4 yes
GO:0046914 transition metal ion binding 17.3077 6 yes
GO:0008270 zinc ion binding 9.6154 7 yes
GO:0048156 tau protein binding 7.6923 4 yes
GO:0050786 RAGE receptor binding 7.6923 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in S100B_HUMAN
GO:0031323 regulation of cellular metabolic process 61.5385 4 no
GO:0048522 positive regulation of cellular process 59.6154 4 yes
GO:0060255 regulation of macromolecule metabolic process 59.6154 4 no
GO:0080090 regulation of primary metabolic process 59.6154 4 no
GO:0010646 regulation of cell communication 57.6923 4 yes
GO:0048523 negative regulation of cellular process 55.7692 4 no
GO:0009966 regulation of signal transduction 53.8462 4 yes
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0010468 regulation of gene expression 50.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:1902531 regulation of intracellular signal transduction 48.0769 5 yes
GO:0009893 positive regulation of metabolic process 46.1538 4 no
GO:0031325 positive regulation of cellular metabolic process 44.2308 5 no
GO:0009892 negative regulation of metabolic process 42.3077 4 no
GO:0010647 positive regulation of cell communication 40.3846 5 yes
GO:0023056 positive regulation of signaling 40.3846 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 40.3846 5 no
GO:0031324 negative regulation of cellular metabolic process 40.3846 5 no
GO:0048584 positive regulation of response to stimulus 38.4615 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 38.4615 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 38.4615 5 no
GO:0009967 positive regulation of signal transduction 36.5385 5 yes
GO:0051049 regulation of transport 34.6154 4 no
GO:0036211 protein modification process 34.6154 4 no
GO:0043412 macromolecule modification 34.6154 4 no
GO:0051128 regulation of cellular component organization 34.6154 4 no
GO:0019220 regulation of phosphate metabolic process 34.6154 6 no
GO:0031399 regulation of protein modification process 34.6154 6 no
GO:0051174 regulation of phosphorus metabolic process 34.6154 5 no
GO:0051247 positive regulation of protein metabolic process 34.6154 6 no
GO:0051252 regulation of RNA metabolic process 32.6923 5 no
GO:0042325 regulation of phosphorylation 32.6923 7 no
GO:0042127 regulation of cell population proliferation 30.7692 4 yes
GO:0006355 regulation of DNA-templated transcription 30.7692 7 no
GO:2001141 regulation of RNA biosynthetic process 30.7692 6 no
GO:0006996 organelle organization 30.7692 4 no
GO:0051094 positive regulation of developmental process 28.8462 4 yes
GO:1902533 positive regulation of intracellular signal transduction 28.8462 6 yes
GO:0001932 regulation of protein phosphorylation 28.8462 7 no
GO:0022607 cellular component assembly 28.8462 4 no
GO:0051338 regulation of transferase activity 28.8462 4 no
GO:0045595 regulation of cell differentiation 26.9231 4 yes
GO:0009891 positive regulation of biosynthetic process 26.9231 5 no
GO:0031328 positive regulation of cellular biosynthetic process 26.9231 6 no
GO:0043067 regulation of programmed cell death 26.9231 4 no
GO:0051240 positive regulation of multicellular organismal process 26.9231 4 no
GO:0009890 negative regulation of biosynthetic process 26.9231 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 26.9231 6 no
GO:0010562 positive regulation of phosphorus metabolic process 26.9231 6 no
GO:0031327 negative regulation of cellular biosynthetic process 26.9231 6 no
GO:0042327 positive regulation of phosphorylation 26.9231 8 no
GO:0043085 positive regulation of catalytic activity 26.9231 4 no
GO:0043549 regulation of kinase activity 26.9231 5 no
GO:0045937 positive regulation of phosphate metabolic process 26.9231 7 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0044057 regulation of system process 25.0000 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0042981 regulation of apoptotic process 25.0000 5 no
GO:0045859 regulation of protein kinase activity 25.0000 6 no
GO:0008104 protein localization 23.0769 4 no
GO:0043933 protein-containing complex organization 23.0769 4 no
GO:0051050 positive regulation of transport 23.0769 4 no
GO:0051726 regulation of cell cycle 23.0769 4 no
GO:0045597 positive regulation of cell differentiation 23.0769 5 yes
GO:0006357 regulation of transcription by RNA polymerase II 23.0769 8 no
GO:0030162 regulation of proteolysis 23.0769 6 no
GO:0051248 negative regulation of protein metabolic process 23.0769 6 no
GO:0001934 positive regulation of protein phosphorylation 23.0769 8 no
GO:0031401 positive regulation of protein modification process 23.0769 7 no
GO:0080134 regulation of response to stress 21.1538 4 no
GO:0141124 intracellular signaling cassette 21.1538 4 no
GO:0009894 regulation of catabolic process 21.1538 4 no
GO:0044087 regulation of cellular component biogenesis 21.1538 4 no
GO:0051130 positive regulation of cellular component organization 21.1538 5 no
GO:0008284 positive regulation of cell population proliferation 21.1538 5 yes
GO:0030030 cell projection organization 21.1538 4 yes
GO:0006796 phosphate-containing compound metabolic process 21.1538 4 no
GO:0051336 regulation of hydrolase activity 21.1538 4 no
GO:0032101 regulation of response to external stimulus 21.1538 4 no
GO:0051347 positive regulation of transferase activity 21.1538 5 no
GO:0050804 modulation of chemical synaptic transmission 17.3077 5 yes
GO:0099177 regulation of trans-synaptic signaling 17.3077 4 yes
GO:0050890 cognition 13.4615 4 yes
GO:0045664 regulation of neuron differentiation 9.6154 5 yes
GO:0048168 regulation of neuronal synaptic plasticity 9.6154 4 yes
GO:0007613 memory 7.6923 4 yes
GO:0043122 regulation of canonical NF-kappaB signal transduction 7.6923 6 yes
GO:0043123 positive regulation of canonical NF-kappaB signal transduction 7.6923 7 yes
GO:0045666 positive regulation of neuron differentiation 7.6923 6 yes
GO:0007409 axonogenesis 5.7692 6 yes
GO:0007417 central nervous system development 5.7692 4 yes
GO:0048812 neuron projection morphogenesis 5.7692 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 5.7692 4 yes
GO:1990138 neuron projection extension 5.7692 4 yes
GO:0097490 sympathetic neuron projection extension 3.8462 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
S10AB_HUMAN [view interactions] Low throughput no no
S10A6_HUMAN [view interactions] Low throughput no yes
S10A1_HUMAN [view interactions] Low throughput no yes
S100B_HUMAN [view entry] [view interactions] Low throughput yes yes
RAGE_HUMAN [view entry] [view interactions] Low throughput yes no
CYBP_HUMAN [view entry] [view interactions] Low throughput yes yes
MDM2_HUMAN [view entry] [view interactions] Low throughput yes yes
P53_HUMAN [view interactions] Low throughput no no
CAZA1_HUMAN [view entry] [view interactions] Low throughput yes yes
CEP20_HUMAN [view interactions] Low throughput no yes
MDM4_HUMAN [view interactions] Low throughput no yes
KS6A1_HUMAN [view entry] [view interactions] Low throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] Low throughput yes no
VAV_HUMAN [view interactions] Low throughput no no
PGM1_HUMAN [view interactions] Low throughput no no
AHNK_HUMAN [view entry] [view interactions] Low throughput yes yes
NDRG1_HUMAN [view entry] [view interactions] Low throughput yes yes
STK38_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
FGF2_HUMAN [view entry] [view interactions] Low throughput yes yes
ANXA6_HUMAN [view entry] [view interactions] Low throughput yes yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
IMPA1_HUMAN [view entry] [view interactions] Low throughput yes yes
IFNB_HUMAN [view interactions] Low throughput no no
IL11_HUMAN [view interactions] Low throughput no no
CT455_HUMAN [view interactions] High throughput no no
CT45A_HUMAN [view interactions] High throughput no no
NKAP1_HUMAN [view interactions] High throughput no yes
S10A4_HUMAN [view entry] [view interactions] High throughput yes no
FBXW5_HUMAN [view interactions] High throughput no no
ADTRP_HUMAN [view interactions] High throughput no no
S100P_HUMAN [view interactions] High throughput no no
AF1Q_HUMAN [view interactions] High throughput no yes
DCAF4_HUMAN [view interactions] High throughput no yes
S10A2_HUMAN [view interactions] High throughput no no
SPG21_HUMAN [view interactions] High throughput no yes
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
S10A9_HUMAN [view entry] [view interactions] High throughput yes no
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
S100Z_HUMAN [view interactions] High throughput no no
BLMH_HUMAN [view interactions] High throughput no yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB3_HUMAN [view interactions] High throughput no yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD8_HUMAN [view entry] [view interactions] High throughput yes yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
TRAF6_HUMAN [view entry] [view interactions] High throughput yes yes
ZNF24_HUMAN [view interactions] High throughput no yes
CRCT1_HUMAN [view interactions] High throughput no no
A2MG_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
NAC1_HUMAN [view entry] [view interactions] High throughput yes yes
TRPM4_HUMAN [view interactions] High throughput no no
MAPK2_HUMAN [view interactions] High throughput no yes
CEP43_HUMAN [view interactions] High throughput no no
APOE_HUMAN [view entry] [view interactions] High throughput yes yes
B2CL2_HUMAN [view interactions] High throughput no yes
DJC30_HUMAN [view interactions] High throughput no no
IMP4_HUMAN [view interactions] High throughput no no
PRAF1_HUMAN [view interactions] High throughput no yes
ATRAP_HUMAN [view interactions] High throughput no yes
LDAF1_HUMAN [view interactions] High throughput no yes
MAL2_HUMAN [view interactions] High throughput no no
TM239_HUMAN [view interactions] High throughput no no
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
LSM5_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
SOCS1_HUMAN [view interactions] High throughput no yes
CDC45_HUMAN [view interactions] High throughput no no
TB182_HUMAN [view interactions] High throughput no yes
HMCES_HUMAN [view interactions] High throughput no yes
UT14A_HUMAN [view interactions] High throughput no yes
RCOR2_HUMAN [view interactions] High throughput no no
PKHG3_HUMAN [view interactions] High throughput no yes
ZN451_HUMAN [view entry] [view interactions] High throughput yes no
SLX9_HUMAN [view interactions] High throughput no yes
ZBT21_HUMAN [view interactions] High throughput no yes
CDK18_HUMAN [view entry] [view interactions] High throughput yes yes
SLF2_HUMAN [view interactions] High throughput no yes
ZN516_HUMAN [view interactions] High throughput no yes
IASPP_HUMAN [view interactions] High throughput no yes
MTMRC_HUMAN [view interactions] High throughput no yes
ZBED1_HUMAN [view interactions] High throughput no yes
ZN714_HUMAN [view interactions] High throughput no no
ZBTB5_HUMAN [view interactions] High throughput no yes
MA7D3_HUMAN [view interactions] High throughput no no
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
TIGD4_HUMAN [view interactions] High throughput no yes
HEM1_HUMAN [view interactions] High throughput no yes
KDM3B_HUMAN [view interactions] High throughput no yes
TXNIP_HUMAN [view interactions] High throughput no no
ARI3B_HUMAN [view entry] [view interactions] High throughput yes yes
ATD3A_HUMAN [view entry] [view interactions] High throughput yes yes
PUS7_HUMAN [view interactions] High throughput no yes
NOC4L_HUMAN [view interactions] High throughput no no
ORC6_HUMAN [view interactions] High throughput no yes
CISD3_HUMAN [view interactions] High throughput no yes
RICTR_HUMAN [view interactions] High throughput no yes
MAP7_HUMAN [view interactions] High throughput no yes
ASB6_HUMAN [view interactions] High throughput no yes
HIC2_HUMAN [view interactions] High throughput no yes
NOP14_HUMAN [view interactions] High throughput no yes
MTFR1_HUMAN [view interactions] High throughput no yes
CC106_HUMAN [view interactions] High throughput no no
FWCH2_HUMAN [view interactions] High throughput no no
ALR_HUMAN [view interactions] High throughput no yes
AGAP3_HUMAN [view entry] [view interactions] High throughput yes yes
ATAD5_HUMAN [view interactions] High throughput no no
CPLN1_HUMAN [view interactions] High throughput no yes
ORC2_HUMAN [view interactions] High throughput no yes
BCL7B_HUMAN [view interactions] High throughput no yes
ZN709_HUMAN [view interactions] High throughput no no
LIPB1_HUMAN [view interactions] High throughput no yes
UBE3B_HUMAN [view entry] [view interactions] High throughput yes yes
C102A_HUMAN [view interactions] High throughput no yes
CR021_HUMAN [view interactions] High throughput no no
NSUN2_HUMAN [view interactions] High throughput no yes
IQGA2_HUMAN [view interactions] High throughput no yes
ZN507_HUMAN [view interactions] High throughput no no
SCML2_HUMAN [view interactions] High throughput no no
CTU1_HUMAN [view interactions] High throughput no no
FOXO3_HUMAN [view interactions] High throughput no yes
M3K4_HUMAN [view interactions] High throughput no yes
UIF_HUMAN [view interactions] High throughput no yes
RPC7L_HUMAN [view interactions] High throughput no yes
CE112_HUMAN [view interactions] High throughput no no
CCDC8_HUMAN [view interactions] High throughput no yes
PML_HUMAN [view interactions] High throughput no yes
JAK1_HUMAN [view interactions] High throughput no yes
RESF1_HUMAN [view interactions] High throughput no yes
MET18_HUMAN [view interactions] High throughput no yes
REXO5_HUMAN [view interactions] High throughput no no
ATD3B_HUMAN [view interactions] High throughput no yes
PRI1_HUMAN [view interactions] High throughput no no
PRI2_HUMAN [view interactions] High throughput no no
KDM2B_HUMAN [view interactions] High throughput no no
INT6_HUMAN [view interactions] High throughput no yes
TERF2_HUMAN [view interactions] High throughput no yes
ADRO_HUMAN [view interactions] High throughput no no
TTF2_HUMAN [view interactions] High throughput no yes
RL23_HUMAN [view entry] [view interactions] High throughput yes yes
PDIP3_HUMAN [view interactions] High throughput no no
UTP11_HUMAN [view interactions] High throughput no yes
NHSL1_HUMAN [view interactions] High throughput no yes
PHF8_HUMAN [view interactions] High throughput no yes
PLCD3_HUMAN [view entry] [view interactions] High throughput yes yes
BCL7A_HUMAN [view interactions] High throughput no yes
TTC28_HUMAN [view interactions] High throughput no no
RAVR1_HUMAN [view interactions] High throughput no no
PIF1_HUMAN [view interactions] High throughput no yes
SENP2_HUMAN [view interactions] High throughput no yes
ZN536_HUMAN [view interactions] High throughput no no
MET25_HUMAN [view interactions] High throughput no yes
ZN764_HUMAN [view interactions] High throughput no no
NRIP1_HUMAN [view interactions] High throughput no yes
RFIP1_HUMAN [view interactions] High throughput no yes
SYDE2_HUMAN [view interactions] High throughput no no
NR2C2_HUMAN [view interactions] High throughput no yes
FOXO4_HUMAN [view interactions] High throughput no no
ZNF3_HUMAN [view interactions] High throughput no yes
SENP5_HUMAN [view entry] [view interactions] High throughput yes no
DPOD1_HUMAN [view interactions] High throughput no yes
ZN136_HUMAN [view interactions] High throughput no no
OFD1_HUMAN [view interactions] High throughput no yes
ZC3C1_HUMAN [view interactions] High throughput no yes
XRCC3_HUMAN [view interactions] High throughput no no
CARF_HUMAN [view interactions] High throughput no yes
MYO1E_HUMAN [view entry] [view interactions] High throughput yes yes
T2FA_HUMAN [view interactions] High throughput no yes
HEMK1_HUMAN [view interactions] High throughput no yes
RM30_HUMAN [view interactions] High throughput no yes
ZBTB4_HUMAN [view interactions] High throughput no yes
DCR1B_HUMAN [view interactions] High throughput no no
PIMRE_HUMAN [view interactions] High throughput no no
DCA13_HUMAN [view interactions] High throughput no yes
ZBT10_HUMAN [view interactions] High throughput no yes
ERF_HUMAN [view interactions] High throughput no yes
CDK17_HUMAN [view interactions] High throughput no yes
ELYS_HUMAN [view interactions] High throughput no yes
CX6B1_HUMAN [view entry] [view interactions] High throughput yes yes
MORC4_HUMAN [view interactions] High throughput no no
SALL3_HUMAN [view interactions] High throughput no no
CNTRB_HUMAN [view interactions] High throughput no yes
PEAK1_HUMAN [view interactions] High throughput no yes
SGO2_HUMAN [view interactions] High throughput no no
SALL1_HUMAN [view interactions] High throughput no yes
SALL2_HUMAN [view interactions] High throughput no yes
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
HSP74_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
FBX7_HUMAN [view interactions] High throughput no yes
GFAP_HUMAN [view entry] [view interactions] High throughput yes no