UBE3B_HUMAN
Evidence for PS localization
Functions
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 727 | Gln | Pro | Kaufmanoculocerebrofacialsyndrome(KOS) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in UBE3B_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 35.0000 | 4 | no |
| GO:0046872 | metal ion binding | 35.0000 | 5 | no |
| GO:0005509 | calcium ion binding | 25.0000 | 6 | no |
| GO:0004842 | ubiquitin-protein transferase activity | 10.0000 | 4 | yes |
| GO:0016755 | aminoacyltransferase activity | 10.0000 | 4 | yes |
| GO:0061630 | ubiquitin protein ligase activity | 10.0000 | 5 | yes |
| GO:0061659 | ubiquitin-like protein ligase activity | 10.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in UBE3B_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 45.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 45.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 45.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | no |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | no |
| GO:0031399 | regulation of protein modification process | 40.0000 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 40.0000 | 6 | no |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 40.0000 | 5 | no |
| GO:0006996 | organelle organization | 35.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 35.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 35.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 35.0000 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.0000 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 35.0000 | 7 | no |
| GO:0022607 | cellular component assembly | 30.0000 | 4 | no |
| GO:0051049 | regulation of transport | 30.0000 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 30.0000 | 7 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 30.0000 | 8 | no |
| GO:0009967 | positive regulation of signal transduction | 30.0000 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 30.0000 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 30.0000 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.0000 | 6 | no |
| GO:0023056 | positive regulation of signaling | 30.0000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.0000 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 30.0000 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 30.0000 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 30.0000 | 7 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.0000 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.0000 | 5 | no |
| GO:0141124 | intracellular signaling cassette | 30.0000 | 4 | no |
| GO:0006508 | proteolysis | 25.0000 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 25.0000 | 4 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 25.0000 | 6 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 25.0000 | 5 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 25.0000 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 25.0000 | 4 | no |
| GO:0061024 | membrane organization | 25.0000 | 4 | no |
| GO:0030030 | cell projection organization | 25.0000 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 25.0000 | 6 | no |
| GO:0016567 | protein ubiquitination | 20.0000 | 8 | yes |
| GO:0032446 | protein modification by small protein conjugation | 20.0000 | 7 | yes |
| GO:0036211 | protein modification process | 20.0000 | 4 | yes |
| GO:0043412 | macromolecule modification | 20.0000 | 4 | yes |
| GO:0043687 | post-translational protein modification | 20.0000 | 5 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 20.0000 | 6 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 15.0000 | 7 | yes |
| GO:0000209 | protein polyubiquitination | 10.0000 | 9 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UBE3B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MYC_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2R1_HUMAN | [view interactions] | Low throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| OXND1_HUMAN | [view interactions] | High throughput | no | yes |
| DLK1_HUMAN | [view interactions] | High throughput | no | no |
| GILT_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| DRC8_HUMAN | [view interactions] | High throughput | no | yes |
| S100B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYL4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ML12B_HUMAN | [view interactions] | High throughput | no | no |
| BET1L_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EDC4_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV1_HUMAN | [view interactions] | High throughput | no | yes |
| GPAT3_HUMAN | [view interactions] | High throughput | no | yes |
| DNLI1_HUMAN | [view interactions] | High throughput | no | yes |
| LMNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MA1A2_HUMAN | [view interactions] | High throughput | no | yes |
| SNAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNAG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRCM1_HUMAN | [view interactions] | High throughput | no | yes |
| SCD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| SNF8_HUMAN | [view interactions] | High throughput | no | yes |
| TOP2A_HUMAN | [view interactions] | High throughput | no | no |
| UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP1_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAMP8_HUMAN | [view interactions] | High throughput | no | no |
| VPS28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CBS_HUMAN | [view interactions] | High throughput | no | yes |
| RPB1_HUMAN | [view interactions] | High throughput | no | no |