UBE3B_HUMAN
Evidence for PS localization
Functions
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%
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Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
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UBE3B_HUMAN has binary interactions with 19 proteins
Isoforms
Interacting regions
Canonical [UBE3B_HUMAN]
Isoform [Q7Z3V4-2] alignment
Isoform [Q7Z3V4-3] alignment
Isoform [S4R3H8] alignment
Isoform [F5H6D6] alignment
Isoform [F5H5T5] alignment
LOADING 93%
![](/static/images/legend3.gif)
Disease-causing germline mutations
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
727 | Gln | Pro | Kaufmanoculocerebrofacialsyndrome(KOS) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in UBE3B_HUMAN |
---|---|---|---|---|
GO:0043169 | cation binding | 35.0000 | 4 | no |
GO:0046872 | metal ion binding | 35.0000 | 5 | no |
GO:0005509 | calcium ion binding | 25.0000 | 6 | no |
GO:0004842 | ubiquitin-protein transferase activity | 10.0000 | 4 | yes |
GO:0016755 | aminoacyltransferase activity | 10.0000 | 4 | yes |
GO:0061630 | ubiquitin protein ligase activity | 10.0000 | 5 | yes |
GO:0061659 | ubiquitin-like protein ligase activity | 10.0000 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in UBE3B_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 45.0000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 45.0000 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 45.0000 | 4 | no |
GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | no |
GO:0010646 | regulation of cell communication | 40.0000 | 4 | no |
GO:0031399 | regulation of protein modification process | 40.0000 | 6 | no |
GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 40.0000 | 6 | no |
GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 40.0000 | 5 | no |
GO:0006996 | organelle organization | 35.0000 | 4 | no |
GO:0051128 | regulation of cellular component organization | 35.0000 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 35.0000 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 35.0000 | 5 | no |
GO:0031323 | regulation of cellular metabolic process | 35.0000 | 4 | no |
GO:0031401 | positive regulation of protein modification process | 35.0000 | 7 | no |
GO:0022607 | cellular component assembly | 30.0000 | 4 | no |
GO:0051049 | regulation of transport | 30.0000 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 30.0000 | 7 | no |
GO:0001934 | positive regulation of protein phosphorylation | 30.0000 | 8 | no |
GO:0009967 | positive regulation of signal transduction | 30.0000 | 5 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 30.0000 | 6 | no |
GO:0010647 | positive regulation of cell communication | 30.0000 | 5 | no |
Disease
No data found.
All partners
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
BET1L_HUMAN | [view interactions] | High throughput | no | yes |
CALL3_HUMAN | [view interactions] | High throughput | no | yes |
CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CBS_HUMAN | [view interactions] | High throughput | no | yes |
CRCM1_HUMAN | [view interactions] | High throughput | no | yes |
DLK1_HUMAN | [view interactions] | High throughput | no | no |
DNLI1_HUMAN | [view interactions] | High throughput | no | yes |
DRC8_HUMAN | [view interactions] | High throughput | no | yes |
EDC4_HUMAN | [view interactions] | High throughput | no | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
ELOV1_HUMAN | [view interactions] | High throughput | no | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
GILT_HUMAN | [view interactions] | High throughput | no | no |
GP182_HUMAN | [view interactions] | High throughput | no | no |
GPAT3_HUMAN | [view interactions] | High throughput | no | yes |
IQCB1_HUMAN | [view interactions] | High throughput | no | no |
LMNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MA1A2_HUMAN | [view interactions] | High throughput | no | yes |
ML12B_HUMAN | [view interactions] | High throughput | no | no |
MYC_HUMAN | [view interactions] | Low throughput | no | yes |
MYL4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
OXND1_HUMAN | [view interactions] | High throughput | no | yes |