VAMP4_HUMAN
Evidence for PS localization
Functions
Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VAMP4_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 29.4118 | 4 | no |
| GO:0000166 | nucleotide binding | 25.4902 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.4902 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.4902 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.4902 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 23.5294 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 23.5294 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 23.5294 | 6 | no |
| GO:0019905 | syntaxin binding | 21.5686 | 4 | no |
| GO:0003924 | GTPase activity | 21.5686 | 7 | no |
| GO:0005525 | GTP binding | 21.5686 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 21.5686 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 21.5686 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VAMP4_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 72.5490 | 4 | no |
| GO:0071702 | organic substance transport | 62.7451 | 4 | no |
| GO:0071705 | nitrogen compound transport | 60.7843 | 4 | no |
| GO:0015031 | protein transport | 58.8235 | 4 | no |
| GO:0006886 | intracellular protein transport | 49.0196 | 4 | no |
| GO:0006996 | organelle organization | 47.0588 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 43.1373 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 35.2941 | 4 | yes |
| GO:0016050 | vesicle organization | 33.3333 | 5 | yes |
| GO:0051049 | regulation of transport | 33.3333 | 4 | yes |
| GO:0022607 | cellular component assembly | 31.3725 | 4 | yes |
| GO:0061024 | membrane organization | 31.3725 | 4 | no |
| GO:0060341 | regulation of cellular localization | 27.4510 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 25.4902 | 4 | yes |
| GO:0061025 | membrane fusion | 25.4902 | 5 | no |
| GO:0032880 | regulation of protein localization | 25.4902 | 5 | no |
| GO:0048284 | organelle fusion | 23.5294 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 21.5686 | 4 | yes |
| GO:0010646 | regulation of cell communication | 21.5686 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.5686 | 4 | no |
| GO:0046903 | secretion | 21.5686 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 15.6863 | 5 | yes |
| GO:0032456 | endocytic recycling | 13.7255 | 4 | yes |
| GO:0030100 | regulation of endocytosis | 7.8431 | 5 | yes |
| GO:0007030 | Golgi organization | 5.8824 | 5 | yes |
| GO:0007032 | endosome organization | 5.8824 | 6 | yes |
| GO:0035493 | SNARE complex assembly | 3.9216 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VPS51_HUMAN | [view interactions] | Low throughput | no | yes |
| STX6_HUMAN | [view interactions] | Low throughput | no | yes |
| SCAM5_HUMAN | [view interactions] | Low throughput | no | yes |
| AP1M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS50_HUMAN | [view interactions] | Low throughput | no | yes |
| CAPS2_HUMAN | [view interactions] | Low throughput | no | no |
| STX12_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PACS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VTI1A_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS53_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS52_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CSK21_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX8_HUMAN | [view interactions] | High throughput | no | yes |
| SNP47_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOP2B_HUMAN | [view interactions] | High throughput | no | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1S3_HUMAN | [view interactions] | High throughput | no | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KASH5_HUMAN | [view interactions] | High throughput | no | yes |
| LRAD1_HUMAN | [view interactions] | High throughput | no | no |
| STX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF3M_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM205_HUMAN | [view interactions] | High throughput | no | yes |
| TMM51_HUMAN | [view interactions] | High throughput | no | yes |
| GP152_HUMAN | [view interactions] | High throughput | no | no |
| TMX2_HUMAN | [view interactions] | High throughput | no | yes |
| LEUTX_HUMAN | [view interactions] | High throughput | no | no |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EBP_HUMAN | [view interactions] | High throughput | no | no |
| NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
| REEP4_HUMAN | [view interactions] | High throughput | no | no |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| GPX8_HUMAN | [view interactions] | High throughput | no | no |
| ELOV4_HUMAN | [view interactions] | High throughput | no | no |
| CPLX4_HUMAN | [view interactions] | High throughput | no | no |
| SSMM1_HUMAN | [view interactions] | High throughput | no | no |
| RETR3_HUMAN | [view interactions] | High throughput | no | yes |
| T4S19_HUMAN | [view interactions] | High throughput | no | no |
| F209A_HUMAN | [view interactions] | High throughput | no | no |
| STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AQP6_HUMAN | [view interactions] | High throughput | no | no |
| F210B_HUMAN | [view interactions] | High throughput | no | yes |
| PTGES_HUMAN | [view interactions] | High throughput | no | no |
| SC11C_HUMAN | [view interactions] | High throughput | no | no |
| AR13B_HUMAN | [view interactions] | High throughput | no | yes |
| CISD2_HUMAN | [view interactions] | High throughput | no | yes |
| ANKS6_HUMAN | [view interactions] | High throughput | no | yes |
| SOAT_HUMAN | [view interactions] | High throughput | no | no |
| SYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNP29_HUMAN | [view interactions] | High throughput | no | yes |
| B2L13_HUMAN | [view interactions] | High throughput | no | no |
| STX16_HUMAN | [view interactions] | High throughput | no | yes |
| MFF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EVI2B_HUMAN | [view interactions] | High throughput | no | no |
| TRI54_HUMAN | [view interactions] | High throughput | no | no |
| VTI1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CL12A_HUMAN | [view interactions] | High throughput | no | no |
| STX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNAG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX18_HUMAN | [view interactions] | High throughput | no | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN526_HUMAN | [view interactions] | High throughput | no | yes |
| APC13_HUMAN | [view interactions] | High throughput | no | no |
| NTM1A_HUMAN | [view interactions] | High throughput | no | yes |
| SNAB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NBAS_HUMAN | [view interactions] | High throughput | no | yes |
| MBLC2_HUMAN | [view interactions] | High throughput | no | yes |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCFD2_HUMAN | [view interactions] | High throughput | no | yes |
| USE1_HUMAN | [view interactions] | High throughput | no | yes |
| STX10_HUMAN | [view interactions] | High throughput | no | yes |
| STX11_HUMAN | [view interactions] | High throughput | no | yes |
| SEC20_HUMAN | [view interactions] | High throughput | no | yes |
| STX5_HUMAN | [view interactions] | High throughput | no | yes |
| OXSM_HUMAN | [view interactions] | High throughput | no | yes |
| GOSR2_HUMAN | [view interactions] | High throughput | no | yes |
| GOSR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCFD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS45_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPN4_HUMAN | [view interactions] | High throughput | no | yes |
| ZW10_HUMAN | [view interactions] | High throughput | no | yes |
| GALM_HUMAN | [view interactions] | High throughput | no | yes |
| SNP23_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CZIB_HUMAN | [view interactions] | High throughput | no | no |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| SPB8_HUMAN | [view interactions] | High throughput | no | no |
| SLIK3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TR10C_HUMAN | [view interactions] | High throughput | no | no |
| LSME2_HUMAN | [view interactions] | High throughput | no | no |
| H6ST2_HUMAN | [view interactions] | High throughput | no | no |
| F234B_HUMAN | [view interactions] | High throughput | no | yes |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CS025_HUMAN | [view interactions] | High throughput | no | no |
| F234A_HUMAN | [view interactions] | High throughput | no | yes |
| TMM59_HUMAN | [view interactions] | High throughput | no | yes |
| NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RINT1_HUMAN | [view interactions] | High throughput | no | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RABL3_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| GOGA1_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMT1A_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |