Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ANFY1_HUMAN

Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ANFY1_HUMAN
GO:0043169 cation binding 22.6667 4 yes
GO:0046872 metal ion binding 22.6667 5 yes
GO:0035091 phosphatidylinositol binding 18.6667 4 yes
GO:0031267 small GTPase binding 12.0000 5 yes
GO:0051020 GTPase binding 12.0000 4 yes
GO:1901981 phosphatidylinositol phosphate binding 6.6667 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ANFY1_HUMAN
GO:0048522 positive regulation of cellular process 50.6667 4 yes
GO:0008104 protein localization 46.6667 4 no
GO:0006996 organelle organization 45.3333 4 yes
GO:0010646 regulation of cell communication 45.3333 4 no
GO:0051128 regulation of cellular component organization 41.3333 4 yes
GO:0071705 nitrogen compound transport 41.3333 4 no
GO:0071702 organic substance transport 40.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 40.0000 4 no
GO:0015031 protein transport 37.3333 4 no
GO:0022607 cellular component assembly 37.3333 4 no
GO:0080090 regulation of primary metabolic process 37.3333 4 no
GO:0048523 negative regulation of cellular process 36.0000 4 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0031323 regulation of cellular metabolic process 33.3333 4 no
GO:0009889 regulation of biosynthetic process 29.3333 4 no
GO:0010468 regulation of gene expression 29.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 29.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 29.3333 5 no
GO:0051049 regulation of transport 26.6667 4 yes
GO:0051130 positive regulation of cellular component organization 26.6667 5 yes
GO:0009893 positive regulation of metabolic process 26.6667 4 no
GO:0023056 positive regulation of signaling 25.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 25.3333 5 no
GO:0051246 regulation of protein metabolic process 25.3333 5 no
GO:0009892 negative regulation of metabolic process 25.3333 4 no
GO:0010605 negative regulation of macromolecule metabolic process 25.3333 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 24.0000 5 no
GO:0051252 regulation of RNA metabolic process 24.0000 5 no
GO:0006886 intracellular protein transport 24.0000 4 no
GO:0098657 import into cell 22.6667 4 yes
GO:0010647 positive regulation of cell communication 22.6667 5 no
GO:1902531 regulation of intracellular signal transduction 22.6667 5 no
GO:0009894 regulation of catabolic process 22.6667 4 no
GO:0031324 negative regulation of cellular metabolic process 22.6667 5 no
GO:0061024 membrane organization 21.3333 4 yes
GO:0043933 protein-containing complex organization 21.3333 4 no
GO:0060627 regulation of vesicle-mediated transport 20.0000 4 yes
GO:0016482 cytosolic transport 18.6667 4 yes
GO:0016050 vesicle organization 17.3333 5 yes
GO:0042147 retrograde transport, endosome to Golgi 17.3333 4 yes
GO:0051050 positive regulation of transport 17.3333 4 yes
GO:0048284 organelle fusion 13.3333 5 yes
GO:0006906 vesicle fusion 12.0000 6 yes
GO:0061025 membrane fusion 12.0000 5 yes
GO:0090174 organelle membrane fusion 12.0000 6 yes
GO:0007034 vacuolar transport 10.6667 4 yes
GO:0030100 regulation of endocytosis 10.6667 5 yes
GO:0007041 lysosomal transport 8.0000 5 yes
GO:0006892 post-Golgi vesicle-mediated transport 6.6667 4 yes
GO:0045807 positive regulation of endocytosis 4.0000 5 yes
GO:0006896 Golgi to vacuole transport 2.6667 5 yes
GO:0034058 endosomal vesicle fusion 2.6667 7 yes
GO:0048548 regulation of pinocytosis 2.6667 6 yes
GO:0048549 positive regulation of pinocytosis 2.6667 6 yes
GO:0090160 Golgi to lysosome transport 2.6667 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
EHD1_HUMAN [view entry] [view interactions] Low throughput yes no
EHD3_HUMAN [view entry] [view interactions] Low throughput yes no
VPS35_HUMAN [view entry] [view interactions] Low throughput yes yes
MILK1_HUMAN [view interactions] Low throughput no yes
RAB5A_HUMAN [view entry] [view interactions] Low throughput yes yes
CUL3_HUMAN [view entry] [view interactions] Low throughput yes yes
RHOD_HUMAN [view interactions] Low throughput no no
RHOF_HUMAN [view interactions] Low throughput no no
VP26A_HUMAN [view entry] [view interactions] Low throughput yes no
MUL1_HUMAN [view interactions] Low throughput no no
C2D1A_HUMAN [view entry] [view interactions] High throughput yes yes
CE152_HUMAN [view interactions] High throughput no yes
CPNE8_HUMAN [view interactions] High throughput no yes
DEP1B_HUMAN [view interactions] High throughput no yes
DIAP1_HUMAN [view interactions] High throughput no yes
DLGP5_HUMAN [view interactions] High throughput no no
DVL1_HUMAN [view entry] [view interactions] High throughput yes yes
DVL2_HUMAN [view interactions] High throughput no yes
DVL3_HUMAN [view interactions] High throughput no yes
HLAA_HUMAN [view interactions] High throughput no no
KIF11_HUMAN [view interactions] High throughput no yes
KIF15_HUMAN [view interactions] High throughput no no
M4K4_HUMAN [view interactions] High throughput no yes
MAST4_HUMAN [view interactions] High throughput no no
MPP9_HUMAN [view interactions] High throughput no yes
RUFY1_HUMAN [view interactions] High throughput no yes
SI1L2_HUMAN [view entry] [view interactions] High throughput yes yes
S19A1_HUMAN [view interactions] High throughput no yes
SNX9_HUMAN [view entry] [view interactions] High throughput yes yes
CYTSB_HUMAN [view entry] [view interactions] High throughput yes yes
SYNJ1_HUMAN [view entry] [view interactions] High throughput yes yes
TBCD8_HUMAN [view interactions] High throughput no yes
TB182_HUMAN [view interactions] High throughput no yes
TRIO_HUMAN [view entry] [view interactions] High throughput yes yes
XPO5_HUMAN [view interactions] High throughput no yes
ZCCHV_HUMAN [view interactions] High throughput no yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
STX6_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
KDM1A_HUMAN [view interactions] High throughput no yes
HDAC1_HUMAN [view interactions] High throughput no no
PF21A_HUMAN [view interactions] High throughput no yes
RCOR1_HUMAN [view interactions] High throughput no yes
TLE2_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes
USPL1_HUMAN [view interactions] High throughput no yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
P3C2A_HUMAN [view interactions] High throughput no yes
NIPS2_HUMAN [view interactions] High throughput no yes
GBRAP_HUMAN [view entry] [view interactions] High throughput yes no
DDA1_HUMAN [view interactions] High throughput no yes
ATGA1_HUMAN [view interactions] High throughput no yes
HIF1N_HUMAN [view interactions] High throughput no yes
ANR52_HUMAN [view interactions] High throughput no yes
RUSD1_HUMAN [view interactions] High throughput no yes
CX6B1_HUMAN [view entry] [view interactions] High throughput yes yes
ABCA2_HUMAN [view interactions] High throughput no yes
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
ERAL1_HUMAN [view interactions] High throughput no yes
CAMP3_HUMAN [view interactions] High throughput no no
KSR2_HUMAN [view interactions] High throughput no yes
MTG8R_HUMAN [view interactions] High throughput no yes
PRD14_HUMAN [view interactions] High throughput no no
NEK4_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
ARHGG_HUMAN [view interactions] High throughput no yes
PKHG7_HUMAN [view interactions] High throughput no no
GBRL1_HUMAN [view interactions] High throughput no yes
MLP3B_HUMAN [view interactions] High throughput no yes
MLP3C_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
INSR_HUMAN [view interactions] High throughput no yes
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
ANR28_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
LMTK1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
GRK5_HUMAN [view interactions] High throughput no yes
SMUF1_HUMAN [view interactions] High throughput no yes
PAF15_HUMAN [view interactions] High throughput no no
EZH2_HUMAN [view interactions] High throughput no no
EED_HUMAN [view interactions] High throughput no yes
ANR44_HUMAN [view interactions] High throughput no no
CC183_HUMAN [view interactions] High throughput no no
MEMO1_HUMAN [view interactions] High throughput no yes
TTC29_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
SAXO5_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
ZN598_HUMAN [view interactions] High throughput no no
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
CGAS_HUMAN [view interactions] High throughput no yes
KDM6B_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
NEK2_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
RC3H2_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
MF2L2_HUMAN [view interactions] High throughput no no
RHG23_HUMAN [view entry] [view interactions] High throughput yes yes
RHG33_HUMAN [view entry] [view interactions] High throughput yes yes
RHG36_HUMAN [view interactions] High throughput no yes
RHG39_HUMAN [view entry] [view interactions] High throughput yes no
RHG04_HUMAN [view interactions] High throughput no no
ARG39_HUMAN [view interactions] High throughput no yes
FARP1_HUMAN [view entry] [view interactions] High throughput yes no
PKHG3_HUMAN [view interactions] High throughput no yes
RGAP1_HUMAN [view interactions] High throughput no no
VAV_HUMAN [view interactions] High throughput no no
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
IF16_HUMAN [view interactions] High throughput no no
CUL4A_HUMAN [view interactions] High throughput no no
UFL1_HUMAN [view interactions] High throughput no yes
SYVN1_HUMAN [view interactions] High throughput no yes
PAGE4_HUMAN [view interactions] High throughput no no
MYPT2_HUMAN [view interactions] High throughput no no
UBP32_HUMAN [view interactions] High throughput no yes
SSRP1_HUMAN [view interactions] High throughput no yes
GGH_HUMAN [view interactions] High throughput no yes
CD158_HUMAN [view interactions] High throughput no no
SPOPL_HUMAN [view interactions] High throughput no yes
CREB5_HUMAN [view interactions] High throughput no no
AP5B1_HUMAN [view interactions] High throughput no yes
ABC3B_HUMAN [view interactions] High throughput no no
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
ANM1_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
LATS1_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
HAPR1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
CDK3_HUMAN [view interactions] High throughput no no
PKN2_HUMAN [view interactions] High throughput no yes
STK3_HUMAN [view interactions] High throughput no yes
STK4_HUMAN [view interactions] High throughput no yes
PD1L1_HUMAN [view interactions] High throughput no no
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
KAT6A_HUMAN [view interactions] High throughput no yes
UBP36_HUMAN [view interactions] High throughput no yes
PML_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
CLK1_HUMAN [view interactions] High throughput no yes
WAC2A_HUMAN [view interactions] High throughput no yes
MON2_HUMAN [view interactions] High throughput no no
ROCK1_HUMAN [view entry] [view interactions] High throughput yes yes
WASC4_HUMAN [view interactions] High throughput no yes
VPS29_HUMAN [view entry] [view interactions] High throughput yes yes
ECHM_HUMAN [view interactions] High throughput no yes
AMPL_HUMAN [view entry] [view interactions] High throughput yes no
NAMPT_HUMAN [view interactions] High throughput no no
AL7A1_HUMAN [view entry] [view interactions] High throughput yes no
AL9A1_HUMAN [view interactions] High throughput no yes
PUR8_HUMAN [view interactions] High throughput no yes
DCAF5_HUMAN [view interactions] High throughput no yes
DSC1_HUMAN [view interactions] High throughput no no
K2C1B_HUMAN [view interactions] High throughput no yes
LKHA4_HUMAN [view interactions] High throughput no yes
SNX6_HUMAN [view entry] [view interactions] High throughput yes no
SYWC_HUMAN [view interactions] High throughput no yes
DCA11_HUMAN [view interactions] High throughput no yes
SNX1_HUMAN [view entry] [view interactions] High throughput yes yes
SNX2_HUMAN [view entry] [view interactions] High throughput yes no
SEP15_HUMAN [view interactions] High throughput no no
TIPRL_HUMAN [view interactions] High throughput no yes
AP2A_HUMAN [view interactions] High throughput no no
IF2B_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
DYST_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
TBCD5_HUMAN [view interactions] High throughput no yes
CHM4A_HUMAN [view interactions] High throughput no no
SNX5_HUMAN [view entry] [view interactions] High throughput yes yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
AP1AR_HUMAN [view interactions] High throughput no yes
DP13B_HUMAN [view entry] [view interactions] High throughput yes yes
RHG01_HUMAN [view entry] [view interactions] High throughput yes yes
AR13B_HUMAN [view interactions] High throughput no yes
AT133_HUMAN [view interactions] High throughput no yes
CAV1_HUMAN [view interactions] High throughput no no
CBL_HUMAN [view interactions] High throughput no yes
CDC23_HUMAN [view interactions] High throughput no yes
CBPD_HUMAN [view interactions] High throughput no yes
DLG5_HUMAN [view entry] [view interactions] High throughput yes no
DOCK1_HUMAN [view entry] [view interactions] High throughput yes yes
DSC2_HUMAN [view interactions] High throughput no no
DSG2_HUMAN [view interactions] High throughput no no
ECE1_HUMAN [view interactions] High throughput no yes
EEA1_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA2_HUMAN [view interactions] High throughput no no
F135A_HUMAN [view interactions] High throughput no yes
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
GCC2_HUMAN [view interactions] High throughput no yes
GOGA4_HUMAN [view interactions] High throughput no yes
RAI3_HUMAN [view interactions] High throughput no yes
MPRI_HUMAN [view interactions] High throughput no yes
AINX_HUMAN [view entry] [view interactions] High throughput yes yes
JMY_HUMAN [view interactions] High throughput no yes
K1549_HUMAN [view entry] [view interactions] High throughput yes yes
KDIS_HUMAN [view entry] [view interactions] High throughput yes yes
KI16B_HUMAN [view interactions] High throughput no yes
KIF1A_HUMAN [view entry] [view interactions] High throughput yes no
LCAP_HUMAN [view interactions] High throughput no yes
LRP8_HUMAN [view entry] [view interactions] High throughput yes no
OCLN_HUMAN [view interactions] High throughput no no
PCNT_HUMAN [view interactions] High throughput no yes
PTN23_HUMAN [view entry] [view interactions] High throughput yes yes
RBNS5_HUMAN [view interactions] High throughput no yes
KS6C1_HUMAN [view entry] [view interactions] High throughput yes no
SCAM1_HUMAN [view interactions] High throughput no no
SLAI2_HUMAN [view interactions] High throughput no no
S12A2_HUMAN [view entry] [view interactions] High throughput yes yes
ZNT4_HUMAN [view interactions] High throughput no no
S38A1_HUMAN [view interactions] High throughput no yes
S38A2_HUMAN [view interactions] High throughput no yes
4F2_HUMAN [view entry] [view interactions] High throughput yes no
S6A15_HUMAN [view interactions] High throughput no yes
SNP23_HUMAN [view entry] [view interactions] High throughput yes no
SNX29_HUMAN [view interactions] High throughput no yes
SNX3_HUMAN [view entry] [view interactions] High throughput yes no
SPY4_HUMAN [view interactions] High throughput no yes
STEA3_HUMAN [view interactions] High throughput no yes
STX12_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
STX8_HUMAN [view interactions] High throughput no yes
TBKB1_HUMAN [view interactions] High throughput no no
TFR1_HUMAN [view entry] [view interactions] High throughput yes yes
BLT3B_HUMAN [view interactions] High throughput no yes
VAMP2_HUMAN [view entry] [view interactions] High throughput yes no
VAMP3_HUMAN [view entry] [view interactions] High throughput yes no
VAMP4_HUMAN [view entry] [view interactions] High throughput yes yes
VPS45_HUMAN [view entry] [view interactions] High throughput yes yes
VPS8_HUMAN [view entry] [view interactions] High throughput yes yes
WDR91_HUMAN [view entry] [view interactions] High throughput yes no
YKT6_HUMAN [view interactions] High throughput no yes
ZFY16_HUMAN [view interactions] High throughput no yes
ZFYV9_HUMAN [view interactions] High throughput no yes
ACTN4_HUMAN [view entry] [view interactions] High throughput yes yes
ALMS1_HUMAN [view interactions] High throughput no no
BIG3_HUMAN [view interactions] High throughput no yes
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
ARHGC_HUMAN [view interactions] High throughput no yes