ANFY1_HUMAN
Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ANFY1_HUMAN |
---|---|---|---|---|
GO:0043169 | cation binding | 22.6667 | 4 | yes |
GO:0046872 | metal ion binding | 22.6667 | 5 | yes |
GO:0035091 | phosphatidylinositol binding | 18.6667 | 4 | yes |
GO:0031267 | small GTPase binding | 12.0000 | 5 | yes |
GO:0051020 | GTPase binding | 12.0000 | 4 | yes |
GO:1901981 | phosphatidylinositol phosphate binding | 6.6667 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ANFY1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 50.6667 | 4 | yes |
GO:0008104 | protein localization | 46.6667 | 4 | no |
GO:0006996 | organelle organization | 45.3333 | 4 | yes |
GO:0010646 | regulation of cell communication | 45.3333 | 4 | no |
GO:0051128 | regulation of cellular component organization | 41.3333 | 4 | yes |
GO:0071705 | nitrogen compound transport | 41.3333 | 4 | no |
GO:0071702 | organic substance transport | 40.0000 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
GO:0015031 | protein transport | 37.3333 | 4 | no |
GO:0022607 | cellular component assembly | 37.3333 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 37.3333 | 4 | no |
GO:0048523 | negative regulation of cellular process | 36.0000 | 4 | no |
GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 29.3333 | 4 | no |
GO:0010468 | regulation of gene expression | 29.3333 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 29.3333 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 29.3333 | 5 | no |
GO:0051049 | regulation of transport | 26.6667 | 4 | yes |
GO:0051130 | positive regulation of cellular component organization | 26.6667 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 26.6667 | 4 | no |
GO:0023056 | positive regulation of signaling | 25.3333 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 25.3333 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 25.3333 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 25.3333 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 25.3333 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.0000 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 24.0000 | 5 | no |
GO:0006886 | intracellular protein transport | 24.0000 | 4 | no |
GO:0098657 | import into cell | 22.6667 | 4 | yes |
GO:0010647 | positive regulation of cell communication | 22.6667 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 22.6667 | 5 | no |
GO:0009894 | regulation of catabolic process | 22.6667 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 22.6667 | 5 | no |
GO:0061024 | membrane organization | 21.3333 | 4 | yes |
GO:0043933 | protein-containing complex organization | 21.3333 | 4 | no |
GO:0060627 | regulation of vesicle-mediated transport | 20.0000 | 4 | yes |
GO:0016482 | cytosolic transport | 18.6667 | 4 | yes |
GO:0016050 | vesicle organization | 17.3333 | 5 | yes |
GO:0042147 | retrograde transport, endosome to Golgi | 17.3333 | 4 | yes |
GO:0051050 | positive regulation of transport | 17.3333 | 4 | yes |
GO:0048284 | organelle fusion | 13.3333 | 5 | yes |
GO:0006906 | vesicle fusion | 12.0000 | 6 | yes |
GO:0061025 | membrane fusion | 12.0000 | 5 | yes |
GO:0090174 | organelle membrane fusion | 12.0000 | 6 | yes |
GO:0007034 | vacuolar transport | 10.6667 | 4 | yes |
GO:0030100 | regulation of endocytosis | 10.6667 | 5 | yes |
GO:0007041 | lysosomal transport | 8.0000 | 5 | yes |
GO:0006892 | post-Golgi vesicle-mediated transport | 6.6667 | 4 | yes |
GO:0045807 | positive regulation of endocytosis | 4.0000 | 5 | yes |
GO:0006896 | Golgi to vacuole transport | 2.6667 | 5 | yes |
GO:0034058 | endosomal vesicle fusion | 2.6667 | 7 | yes |
GO:0048548 | regulation of pinocytosis | 2.6667 | 6 | yes |
GO:0048549 | positive regulation of pinocytosis | 2.6667 | 6 | yes |
GO:0090160 | Golgi to lysosome transport | 2.6667 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
EHD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
EHD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
VPS35_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MILK1_HUMAN | [view interactions] | Low throughput | no | yes |
RAB5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CUL3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RHOD_HUMAN | [view interactions] | Low throughput | no | no |
RHOF_HUMAN | [view interactions] | Low throughput | no | no |
VP26A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
MUL1_HUMAN | [view interactions] | Low throughput | no | no |
C2D1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CE152_HUMAN | [view interactions] | High throughput | no | yes |
CPNE8_HUMAN | [view interactions] | High throughput | no | yes |
DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
DIAP1_HUMAN | [view interactions] | High throughput | no | yes |
DLGP5_HUMAN | [view interactions] | High throughput | no | no |
DVL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DVL2_HUMAN | [view interactions] | High throughput | no | yes |
DVL3_HUMAN | [view interactions] | High throughput | no | yes |
HLAA_HUMAN | [view interactions] | High throughput | no | no |
KIF11_HUMAN | [view interactions] | High throughput | no | yes |
KIF15_HUMAN | [view interactions] | High throughput | no | no |
M4K4_HUMAN | [view interactions] | High throughput | no | yes |
MAST4_HUMAN | [view interactions] | High throughput | no | no |
MPP9_HUMAN | [view interactions] | High throughput | no | yes |
RUFY1_HUMAN | [view interactions] | High throughput | no | yes |
SI1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
S19A1_HUMAN | [view interactions] | High throughput | no | yes |
SNX9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CYTSB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYNJ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBCD8_HUMAN | [view interactions] | High throughput | no | yes |
TB182_HUMAN | [view interactions] | High throughput | no | yes |
TRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XPO5_HUMAN | [view interactions] | High throughput | no | yes |
ZCCHV_HUMAN | [view interactions] | High throughput | no | yes |
PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STX6_HUMAN | [view interactions] | High throughput | no | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
HDAC1_HUMAN | [view interactions] | High throughput | no | no |
PF21A_HUMAN | [view interactions] | High throughput | no | yes |
RCOR1_HUMAN | [view interactions] | High throughput | no | yes |
TLE2_HUMAN | [view interactions] | High throughput | no | yes |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
RFA2_HUMAN | [view interactions] | High throughput | no | yes |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |
SSR3_HUMAN | [view interactions] | High throughput | no | yes |
USPL1_HUMAN | [view interactions] | High throughput | no | yes |
GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
P3C2A_HUMAN | [view interactions] | High throughput | no | yes |
NIPS2_HUMAN | [view interactions] | High throughput | no | yes |
GBRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DDA1_HUMAN | [view interactions] | High throughput | no | yes |
ATGA1_HUMAN | [view interactions] | High throughput | no | yes |
HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
ANR52_HUMAN | [view interactions] | High throughput | no | yes |
RUSD1_HUMAN | [view interactions] | High throughput | no | yes |
CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABCA2_HUMAN | [view interactions] | High throughput | no | yes |
ANXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ERAL1_HUMAN | [view interactions] | High throughput | no | yes |
CAMP3_HUMAN | [view interactions] | High throughput | no | no |
KSR2_HUMAN | [view interactions] | High throughput | no | yes |
MTG8R_HUMAN | [view interactions] | High throughput | no | yes |
PRD14_HUMAN | [view interactions] | High throughput | no | no |
NEK4_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
ARHGG_HUMAN | [view interactions] | High throughput | no | yes |
PKHG7_HUMAN | [view interactions] | High throughput | no | no |
GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
MLP3C_HUMAN | [view interactions] | High throughput | no | no |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
INSR_HUMAN | [view interactions] | High throughput | no | yes |
DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ANR28_HUMAN | [view interactions] | High throughput | no | no |
FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
GRK5_HUMAN | [view interactions] | High throughput | no | yes |
SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
PAF15_HUMAN | [view interactions] | High throughput | no | no |
EZH2_HUMAN | [view interactions] | High throughput | no | no |
EED_HUMAN | [view interactions] | High throughput | no | yes |
ANR44_HUMAN | [view interactions] | High throughput | no | no |
CC183_HUMAN | [view interactions] | High throughput | no | no |
MEMO1_HUMAN | [view interactions] | High throughput | no | yes |
TTC29_HUMAN | [view interactions] | High throughput | no | no |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
SAXO5_HUMAN | [view interactions] | High throughput | no | no |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZN598_HUMAN | [view interactions] | High throughput | no | no |
UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CGAS_HUMAN | [view interactions] | High throughput | no | yes |
KDM6B_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
NEK2_HUMAN | [view interactions] | High throughput | no | no |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
MF2L2_HUMAN | [view interactions] | High throughput | no | no |
RHG23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHG33_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHG36_HUMAN | [view interactions] | High throughput | no | yes |
RHG39_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHG04_HUMAN | [view interactions] | High throughput | no | no |
ARG39_HUMAN | [view interactions] | High throughput | no | yes |
FARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PKHG3_HUMAN | [view interactions] | High throughput | no | yes |
RGAP1_HUMAN | [view interactions] | High throughput | no | no |
VAV_HUMAN | [view interactions] | High throughput | no | no |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
IF16_HUMAN | [view interactions] | High throughput | no | no |
CUL4A_HUMAN | [view interactions] | High throughput | no | no |
UFL1_HUMAN | [view interactions] | High throughput | no | yes |
SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
PAGE4_HUMAN | [view interactions] | High throughput | no | no |
MYPT2_HUMAN | [view interactions] | High throughput | no | no |
UBP32_HUMAN | [view interactions] | High throughput | no | yes |
SSRP1_HUMAN | [view interactions] | High throughput | no | yes |
GGH_HUMAN | [view interactions] | High throughput | no | yes |
CD158_HUMAN | [view interactions] | High throughput | no | no |
SPOPL_HUMAN | [view interactions] | High throughput | no | yes |
CREB5_HUMAN | [view interactions] | High throughput | no | no |
AP5B1_HUMAN | [view interactions] | High throughput | no | yes |
ABC3B_HUMAN | [view interactions] | High throughput | no | no |
SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ANM1_HUMAN | [view interactions] | High throughput | no | yes |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LATS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
HAPR1_HUMAN | [view interactions] | High throughput | no | yes |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDK3_HUMAN | [view interactions] | High throughput | no | no |
PKN2_HUMAN | [view interactions] | High throughput | no | yes |
STK3_HUMAN | [view interactions] | High throughput | no | yes |
STK4_HUMAN | [view interactions] | High throughput | no | yes |
PD1L1_HUMAN | [view interactions] | High throughput | no | no |
CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KAT6A_HUMAN | [view interactions] | High throughput | no | yes |
UBP36_HUMAN | [view interactions] | High throughput | no | yes |
PML_HUMAN | [view interactions] | High throughput | no | yes |
UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLK1_HUMAN | [view interactions] | High throughput | no | yes |
WAC2A_HUMAN | [view interactions] | High throughput | no | yes |
MON2_HUMAN | [view interactions] | High throughput | no | no |
ROCK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WASC4_HUMAN | [view interactions] | High throughput | no | yes |
VPS29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECHM_HUMAN | [view interactions] | High throughput | no | yes |
AMPL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NAMPT_HUMAN | [view interactions] | High throughput | no | no |
AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AL9A1_HUMAN | [view interactions] | High throughput | no | yes |
PUR8_HUMAN | [view interactions] | High throughput | no | yes |
DCAF5_HUMAN | [view interactions] | High throughput | no | yes |
DSC1_HUMAN | [view interactions] | High throughput | no | no |
K2C1B_HUMAN | [view interactions] | High throughput | no | yes |
LKHA4_HUMAN | [view interactions] | High throughput | no | yes |
SNX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYWC_HUMAN | [view interactions] | High throughput | no | yes |
DCA11_HUMAN | [view interactions] | High throughput | no | yes |
SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNX2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SEP15_HUMAN | [view interactions] | High throughput | no | no |
TIPRL_HUMAN | [view interactions] | High throughput | no | yes |
AP2A_HUMAN | [view interactions] | High throughput | no | no |
IF2B_HUMAN | [view interactions] | High throughput | no | yes |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBCD5_HUMAN | [view interactions] | High throughput | no | yes |
CHM4A_HUMAN | [view interactions] | High throughput | no | no |
SNX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP1AR_HUMAN | [view interactions] | High throughput | no | yes |
DP13B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHG01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AR13B_HUMAN | [view interactions] | High throughput | no | yes |
AT133_HUMAN | [view interactions] | High throughput | no | yes |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
CBL_HUMAN | [view interactions] | High throughput | no | yes |
CDC23_HUMAN | [view interactions] | High throughput | no | yes |
CBPD_HUMAN | [view interactions] | High throughput | no | yes |
DLG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DOCK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DSC2_HUMAN | [view interactions] | High throughput | no | no |
DSG2_HUMAN | [view interactions] | High throughput | no | no |
ECE1_HUMAN | [view interactions] | High throughput | no | yes |
EEA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EPHA2_HUMAN | [view interactions] | High throughput | no | no |
F135A_HUMAN | [view interactions] | High throughput | no | yes |
FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GCC2_HUMAN | [view interactions] | High throughput | no | yes |
GOGA4_HUMAN | [view interactions] | High throughput | no | yes |
RAI3_HUMAN | [view interactions] | High throughput | no | yes |
MPRI_HUMAN | [view interactions] | High throughput | no | yes |
AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
JMY_HUMAN | [view interactions] | High throughput | no | yes |
K1549_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KDIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KI16B_HUMAN | [view interactions] | High throughput | no | yes |
KIF1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LCAP_HUMAN | [view interactions] | High throughput | no | yes |
LRP8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
OCLN_HUMAN | [view interactions] | High throughput | no | no |
PCNT_HUMAN | [view interactions] | High throughput | no | yes |
PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RBNS5_HUMAN | [view interactions] | High throughput | no | yes |
KS6C1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SCAM1_HUMAN | [view interactions] | High throughput | no | no |
SLAI2_HUMAN | [view interactions] | High throughput | no | no |
S12A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZNT4_HUMAN | [view interactions] | High throughput | no | no |
S38A1_HUMAN | [view interactions] | High throughput | no | yes |
S38A2_HUMAN | [view interactions] | High throughput | no | yes |
4F2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
S6A15_HUMAN | [view interactions] | High throughput | no | yes |
SNP23_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SNX29_HUMAN | [view interactions] | High throughput | no | yes |
SNX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SPY4_HUMAN | [view interactions] | High throughput | no | yes |
STEA3_HUMAN | [view interactions] | High throughput | no | yes |
STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STX8_HUMAN | [view interactions] | High throughput | no | yes |
TBKB1_HUMAN | [view interactions] | High throughput | no | no |
TFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BLT3B_HUMAN | [view interactions] | High throughput | no | yes |
VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
VAMP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VPS45_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VPS8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WDR91_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
YKT6_HUMAN | [view interactions] | High throughput | no | yes |
ZFY16_HUMAN | [view interactions] | High throughput | no | yes |
ZFYV9_HUMAN | [view interactions] | High throughput | no | yes |
ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ALMS1_HUMAN | [view interactions] | High throughput | no | no |
BIG3_HUMAN | [view interactions] | High throughput | no | yes |
RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARHGC_HUMAN | [view interactions] | High throughput | no | yes |