ANFY1_HUMAN
Evidence for PS localization
Functions
Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 55%
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
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ANFY1_HUMAN has binary interactions with 50 proteins
Isoforms
Interacting regions
Canonical [ANFY1_HUMAN]
Isoform [Q9P2R3-2] alignment
Isoform [Q9P2R3-4] alignment
Isoform [K7EPT2] alignment
Isoform [I3L3P8] alignment
Isoform [I3L1Z9] alignment
LOADING 47%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ANFY1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 22.6667 | 4 | yes |
| GO:0046872 | metal ion binding | 22.6667 | 5 | yes |
| GO:0035091 | phosphatidylinositol binding | 18.6667 | 4 | yes |
| GO:0031267 | small GTPase binding | 12.0000 | 5 | yes |
| GO:0051020 | GTPase binding | 12.0000 | 4 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 6.6667 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ANFY1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 50.6667 | 4 | yes |
| GO:0008104 | protein localization | 46.6667 | 4 | no |
| GO:0006996 | organelle organization | 45.3333 | 4 | yes |
| GO:0010646 | regulation of cell communication | 45.3333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 41.3333 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 41.3333 | 4 | no |
| GO:0071702 | organic substance transport | 40.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
| GO:0015031 | protein transport | 37.3333 | 4 | no |
| GO:0022607 | cellular component assembly | 37.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 37.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 36.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 29.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 29.3333 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.3333 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.3333 | 5 | no |
| GO:0051049 | regulation of transport | 26.6667 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 26.6667 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 26.6667 | 4 | no |
| GO:0023056 | positive regulation of signaling | 25.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.3333 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.3333 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 25.3333 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 4F2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABC3B_HUMAN | [view interactions] | High throughput | no | no |
| ABCA2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AL9A1_HUMAN | [view interactions] | High throughput | no | yes |
| ALMS1_HUMAN | [view interactions] | High throughput | no | no |
| AMPL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| ANR44_HUMAN | [view interactions] | High throughput | no | no |
| ANR52_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP1AR_HUMAN | [view interactions] | High throughput | no | yes |
| AP2A_HUMAN | [view interactions] | High throughput | no | no |
| AP5B1_HUMAN | [view interactions] | High throughput | no | yes |
| AR13B_HUMAN | [view interactions] | High throughput | no | yes |
| ARG39_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGC_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGG_HUMAN | [view interactions] | High throughput | no | yes |
| AT133_HUMAN | [view interactions] | High throughput | no | yes |
| ATGA1_HUMAN | [view interactions] | High throughput | no | yes |
| BIG3_HUMAN | [view interactions] | High throughput | no | yes |
| BLT3B_HUMAN | [view interactions] | High throughput | no | yes |