ANFY1_HUMAN
Evidence for PS localization
Functions
Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ANFY1_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 22.9508 | 4 | yes |
| GO:0035091 | phosphatidylinositol binding | 21.3115 | 4 | yes |
| GO:0031267 | small GTPase binding | 11.4754 | 5 | yes |
| GO:0051020 | GTPase binding | 11.4754 | 4 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 9.8361 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ANFY1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 52.4590 | 4 | yes |
| GO:0008104 | protein localization | 47.5410 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 44.2623 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 44.2623 | 4 | no |
| GO:0006996 | organelle organization | 42.6230 | 4 | yes |
| GO:0071702 | organic substance transport | 42.6230 | 4 | no |
| GO:0015031 | protein transport | 40.9836 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 37.7049 | 4 | no |
| GO:0010646 | regulation of cell communication | 37.7049 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.0656 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 34.4262 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 34.4262 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 34.4262 | 4 | no |
| GO:0022607 | cellular component assembly | 34.4262 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 32.7869 | 4 | no |
| GO:0051049 | regulation of transport | 29.5082 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 27.8689 | 4 | no |
| GO:0016197 | endosomal transport | 26.2295 | 4 | yes |
| GO:0016482 | cytosolic transport | 26.2295 | 4 | yes |
| GO:0010468 | regulation of gene expression | 26.2295 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.5902 | 5 | yes |
| GO:0061024 | membrane organization | 24.5902 | 4 | yes |
| GO:0006886 | intracellular protein transport | 24.5902 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 22.9508 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 22.9508 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 22.9508 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.9508 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.9508 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.9508 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 22.9508 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.9508 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.9508 | 4 | no |
| GO:0051050 | positive regulation of transport | 21.3115 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 21.3115 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.3115 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 21.3115 | 5 | no |
| GO:0006897 | endocytosis | 19.6721 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 19.6721 | 4 | yes |
| GO:0016050 | vesicle organization | 18.0328 | 5 | yes |
| GO:0042147 | retrograde transport, endosome to Golgi | 18.0328 | 5 | yes |
| GO:0048193 | Golgi vesicle transport | 16.3934 | 5 | yes |
| GO:0006906 | vesicle fusion | 13.1148 | 6 | yes |
| GO:0048284 | organelle fusion | 13.1148 | 5 | yes |
| GO:0061025 | membrane fusion | 13.1148 | 5 | yes |
| GO:0090174 | organelle membrane fusion | 13.1148 | 6 | yes |
| GO:0030100 | regulation of endocytosis | 9.8361 | 5 | yes |
| GO:0006892 | post-Golgi vesicle-mediated transport | 8.1967 | 6 | yes |
| GO:0007034 | vacuolar transport | 6.5574 | 4 | yes |
| GO:0007041 | lysosomal transport | 6.5574 | 5 | yes |
| GO:0045807 | positive regulation of endocytosis | 6.5574 | 5 | yes |
| GO:0006896 | Golgi to vacuole transport | 3.2787 | 5 | yes |
| GO:0034058 | endosomal vesicle fusion | 3.2787 | 7 | yes |
| GO:0048548 | regulation of pinocytosis | 3.2787 | 6 | yes |
| GO:0048549 | positive regulation of pinocytosis | 3.2787 | 6 | yes |
| GO:0090160 | Golgi to lysosome transport | 3.2787 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ANFY1_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 4.9180 | 3 | no |
| DOID:0060038 | specific developmental disorder | 3.2787 | 3 | no |
| DOID:0060307 | autosomal dominant intellectual developmental disorder | 3.2787 | 5 | no |
| DOID:1059 | intellectual disability | 3.2787 | 4 | no |
| DOID:0050890 | synucleinopathy | 3.2787 | 5 | no |
| DOID:1289 | neurodegenerative disease | 3.2787 | 4 | no |
| DOID:14330 | Parkinsons disease | 3.2787 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EHD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EHD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MILK1_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS35_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RHOD_HUMAN | [view interactions] | Low throughput | no | no |
| RHOF_HUMAN | [view interactions] | Low throughput | no | no |
| VP26A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MUL1_HUMAN | [view interactions] | Low throughput | no | no |
| SNX29_HUMAN | [view interactions] | High throughput | no | yes |
| SNX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPY4_HUMAN | [view interactions] | High throughput | no | yes |
| STEA3_HUMAN | [view interactions] | High throughput | no | yes |
| STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX8_HUMAN | [view interactions] | High throughput | no | yes |
| TBKB1_HUMAN | [view interactions] | High throughput | no | no |
| TFR1_HUMAN | [view interactions] | High throughput | no | yes |
| UH1BL_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VAMP4_HUMAN | [view interactions] | High throughput | no | yes |
| VPS45_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR91_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| YKT6_HUMAN | [view interactions] | High throughput | no | yes |
| ZFY16_HUMAN | [view interactions] | High throughput | no | yes |
| ZFYV9_HUMAN | [view interactions] | High throughput | no | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALMS1_HUMAN | [view interactions] | High throughput | no | no |
| BIG3_HUMAN | [view interactions] | High throughput | no | yes |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHGC_HUMAN | [view interactions] | High throughput | no | yes |
| C2D1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| CPNE8_HUMAN | [view interactions] | High throughput | no | yes |
| DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
| DIAP1_HUMAN | [view interactions] | High throughput | no | yes |
| DLGP5_HUMAN | [view interactions] | High throughput | no | no |
| DVL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| DVL3_HUMAN | [view interactions] | High throughput | no | yes |
| HLAA_HUMAN | [view interactions] | High throughput | no | no |
| KIF11_HUMAN | [view interactions] | High throughput | no | yes |
| KIF15_HUMAN | [view interactions] | High throughput | no | no |
| M4K4_HUMAN | [view interactions] | High throughput | no | yes |
| MAST4_HUMAN | [view interactions] | High throughput | no | no |
| MPP9_HUMAN | [view interactions] | High throughput | no | yes |
| RUFY1_HUMAN | [view interactions] | High throughput | no | yes |
| SI1L2_HUMAN | [view interactions] | High throughput | no | yes |
| S19A1_HUMAN | [view interactions] | High throughput | no | yes |
| SNX9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYTSB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNJ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCD8_HUMAN | [view interactions] | High throughput | no | yes |
| TB182_HUMAN | [view interactions] | High throughput | no | yes |
| TRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO5_HUMAN | [view interactions] | High throughput | no | yes |
| ZCCHV_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| USPL1_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P3C2A_HUMAN | [view interactions] | High throughput | no | yes |
| NIPS2_HUMAN | [view interactions] | High throughput | no | yes |
| GBRAP_HUMAN | [view interactions] | High throughput | no | no |
| DDA1_HUMAN | [view interactions] | High throughput | no | yes |
| ATGA1_HUMAN | [view interactions] | High throughput | no | yes |
| HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
| ANR52_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABCA2_HUMAN | [view interactions] | High throughput | no | yes |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUSD1_HUMAN | [view interactions] | High throughput | no | yes |
| CAMP3_HUMAN | [view interactions] | High throughput | no | no |
| ERAL1_HUMAN | [view interactions] | High throughput | no | yes |
| KSR2_HUMAN | [view interactions] | High throughput | no | yes |
| MTG8R_HUMAN | [view interactions] | High throughput | no | yes |
| PRD14_HUMAN | [view interactions] | High throughput | no | no |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGG_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG7_HUMAN | [view interactions] | High throughput | no | no |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3C_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| GRK5_HUMAN | [view interactions] | High throughput | no | yes |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| PAF15_HUMAN | [view interactions] | High throughput | no | no |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| ANR44_HUMAN | [view interactions] | High throughput | no | no |
| CC183_HUMAN | [view interactions] | High throughput | no | no |
| MEMO1_HUMAN | [view interactions] | High throughput | no | yes |
| TTC29_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| TEX45_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| KDM6B_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| NEK2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| MF2L2_HUMAN | [view interactions] | High throughput | no | no |
| RHG23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG33_HUMAN | [view interactions] | High throughput | no | yes |
| RHG36_HUMAN | [view interactions] | High throughput | no | yes |
| RHG39_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHG04_HUMAN | [view interactions] | High throughput | no | no |
| ARG39_HUMAN | [view interactions] | High throughput | no | yes |
| FARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PKHG3_HUMAN | [view interactions] | High throughput | no | yes |
| RGAP1_HUMAN | [view interactions] | High throughput | no | no |
| VAV_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
| PAGE4_HUMAN | [view interactions] | High throughput | no | no |
| MYPT2_HUMAN | [view interactions] | High throughput | no | no |
| UBP32_HUMAN | [view interactions] | High throughput | no | yes |
| SSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| GGH_HUMAN | [view interactions] | High throughput | no | yes |
| CD158_HUMAN | [view interactions] | High throughput | no | no |
| SPOPL_HUMAN | [view interactions] | High throughput | no | yes |
| CREB5_HUMAN | [view interactions] | High throughput | no | no |
| AP5B1_HUMAN | [view interactions] | High throughput | no | yes |
| ABC3B_HUMAN | [view interactions] | High throughput | no | no |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLK1_HUMAN | [view interactions] | High throughput | no | yes |
| WAC2A_HUMAN | [view interactions] | High throughput | no | yes |
| MON2_HUMAN | [view interactions] | High throughput | no | no |
| ROCK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASC4_HUMAN | [view interactions] | High throughput | no | yes |
| VPS29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| AMPL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NAMPT_HUMAN | [view interactions] | High throughput | no | no |
| AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AL9A1_HUMAN | [view interactions] | High throughput | no | yes |
| PUR8_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF5_HUMAN | [view interactions] | High throughput | no | yes |
| DSC1_HUMAN | [view interactions] | High throughput | no | no |
| K2C1B_HUMAN | [view interactions] | High throughput | no | yes |
| LKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| SNX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYWC_HUMAN | [view interactions] | High throughput | no | yes |
| DCA11_HUMAN | [view interactions] | High throughput | no | yes |
| SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1AR_HUMAN | [view interactions] | High throughput | no | yes |
| DP13B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AR13B_HUMAN | [view interactions] | High throughput | no | yes |
| AT133_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| CDC23_HUMAN | [view interactions] | High throughput | no | yes |
| CBPD_HUMAN | [view interactions] | High throughput | no | yes |
| DLG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DOCK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSC2_HUMAN | [view interactions] | High throughput | no | no |
| DSG2_HUMAN | [view interactions] | High throughput | no | no |
| ECE1_HUMAN | [view interactions] | High throughput | no | yes |
| EEA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| F135A_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCC2_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA4_HUMAN | [view interactions] | High throughput | no | yes |
| RAI3_HUMAN | [view interactions] | High throughput | no | yes |
| MPRI_HUMAN | [view interactions] | High throughput | no | yes |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JMY_HUMAN | [view interactions] | High throughput | no | yes |
| K1549_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDIS_HUMAN | [view interactions] | High throughput | no | yes |
| KI16B_HUMAN | [view interactions] | High throughput | no | yes |
| KIF1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LCAP_HUMAN | [view interactions] | High throughput | no | yes |
| LRP8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PCNT_HUMAN | [view interactions] | High throughput | no | yes |
| PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBNS5_HUMAN | [view interactions] | High throughput | no | yes |
| KS6C1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCAM1_HUMAN | [view interactions] | High throughput | no | no |
| SLAI2_HUMAN | [view interactions] | High throughput | no | no |
| S12A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNT4_HUMAN | [view interactions] | High throughput | no | no |
| S38A1_HUMAN | [view interactions] | High throughput | no | yes |
| S38A2_HUMAN | [view interactions] | High throughput | no | yes |
| 4F2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S6A15_HUMAN | [view interactions] | High throughput | no | yes |
| SNP23_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIF1C_HUMAN | [view interactions] | Computational | no | yes |