AINX_HUMAN
Evidence for PS localization
Functions
Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges. May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AINX_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 25.3521 | 4 | no |
| GO:0003723 | RNA binding | 23.9437 | 4 | no |
| GO:0019900 | kinase binding | 22.5352 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AINX_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.5634 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 56.3380 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 56.3380 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 56.3380 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 54.9296 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 52.1127 | 4 | no |
| GO:0010646 | regulation of cell communication | 49.2958 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 47.8873 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 43.6620 | 4 | no |
| GO:0006996 | organelle organization | 39.4366 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 39.4366 | 4 | no |
| GO:0009966 | regulation of signal transduction | 39.4366 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.4366 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 39.4366 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 38.0282 | 6 | no |
| GO:0010468 | regulation of gene expression | 35.2113 | 5 | no |
| GO:0031399 | regulation of protein modification process | 33.8028 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.3944 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 32.3944 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.9859 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.9859 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 30.9859 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.9859 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.9859 | 5 | no |
| GO:0051049 | regulation of transport | 30.9859 | 4 | no |
| GO:0022607 | cellular component assembly | 29.5775 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.5775 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 29.5775 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 29.5775 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.1690 | 5 | no |
| GO:0009894 | regulation of catabolic process | 28.1690 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 26.7606 | 7 | no |
| GO:0010647 | positive regulation of cell communication | 26.7606 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.7606 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 26.7606 | 5 | no |
| GO:0036211 | protein modification process | 26.7606 | 4 | no |
| GO:0043412 | macromolecule modification | 26.7606 | 4 | no |
| GO:0010941 | regulation of cell death | 26.7606 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.3521 | 7 | no |
| GO:0031344 | regulation of cell projection organization | 25.3521 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 25.3521 | 7 | no |
| GO:0008104 | protein localization | 25.3521 | 4 | no |
| GO:0007010 | cytoskeleton organization | 23.9437 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 23.9437 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.9437 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.9437 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.9437 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.9437 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 23.9437 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.9437 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 22.5352 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 22.5352 | 6 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 22.5352 | 7 | no |
| GO:0042981 | regulation of apoptotic process | 22.5352 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 22.5352 | 5 | no |
| GO:0033043 | regulation of organelle organization | 21.1268 | 5 | no |
| GO:0043933 | protein-containing complex organization | 21.1268 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.1268 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.1268 | 5 | no |
| GO:0060341 | regulation of cellular localization | 21.1268 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.1268 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 21.1268 | 8 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.1268 | 6 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 21.1268 | 4 | no |
| GO:0034097 | response to cytokine | 11.2676 | 4 | yes |
| GO:0071345 | cellular response to cytokine stimulus | 8.4507 | 5 | yes |
| GO:0021762 | substantia nigra development | 2.8169 | 4 | yes |
| GO:0060052 | neurofilament cytoskeleton organization | 2.8169 | 4 | yes |
| GO:1990823 | response to leukemia inhibitory factor | 2.8169 | 5 | yes |
| GO:1990830 | cellular response to leukemia inhibitory factor | 2.8169 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in AINX_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 2.8169 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NSMF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IMA5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TANC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| CXB7_HUMAN | [view interactions] | High throughput | no | no |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| MB212_HUMAN | [view interactions] | High throughput | no | no |
| BMP1_HUMAN | [view interactions] | High throughput | no | yes |
| VSIG8_HUMAN | [view interactions] | High throughput | no | no |
| CAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RSPRY_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KLH36_HUMAN | [view interactions] | High throughput | no | yes |
| BFSP2_HUMAN | [view interactions] | High throughput | no | no |
| TIAR_HUMAN | [view interactions] | High throughput | no | no |
| GAN_HUMAN | [view interactions] | High throughput | no | yes |
| MIPEP_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGB_HUMAN | [view interactions] | High throughput | no | yes |
| RHG23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2L_HUMAN | [view interactions] | High throughput | no | no |
| NCBP2_HUMAN | [view interactions] | High throughput | no | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| M3K13_HUMAN | [view interactions] | High throughput | no | yes |
| WEE1_HUMAN | [view interactions] | High throughput | no | yes |
| PK3CB_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STK3_HUMAN | [view interactions] | High throughput | no | yes |
| CDK10_HUMAN | [view interactions] | High throughput | no | no |
| TBCK_HUMAN | [view interactions] | High throughput | no | yes |
| CDKL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAK5_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| NP1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODFP2_HUMAN | [view interactions] | High throughput | no | no |
| CNTRB_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STB5L_HUMAN | [view interactions] | High throughput | no | no |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CC183_HUMAN | [view interactions] | High throughput | no | no |
| CENPP_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| ANM8_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| SYNCI_HUMAN | [view interactions] | High throughput | no | no |
| NFH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GFAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNH28_HUMAN | [view interactions] | High throughput | no | no |
| VWA3B_HUMAN | [view interactions] | High throughput | no | no |
| BAZ2B_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| REQU_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
| GRIA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| ARHGJ_HUMAN | [view interactions] | High throughput | no | no |
| FGD1_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| NEST_HUMAN | [view interactions] | High throughput | no | no |
| K1C16_HUMAN | [view interactions] | High throughput | no | no |
| MAP7_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAN12_HUMAN | [view interactions] | High throughput | no | no |
| K2C72_HUMAN | [view interactions] | High throughput | no | no |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| S100P_HUMAN | [view interactions] | High throughput | no | no |
| K2C78_HUMAN | [view interactions] | High throughput | no | no |
| K1C14_HUMAN | [view interactions] | High throughput | no | no |
| K1C27_HUMAN | [view interactions] | High throughput | no | no |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| DESM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CRBG1_HUMAN | [view interactions] | High throughput | no | no |
| SLU7_HUMAN | [view interactions] | High throughput | no | yes |
| K1C23_HUMAN | [view interactions] | High throughput | no | no |
| SYCE1_HUMAN | [view interactions] | High throughput | no | no |
| K1H2_HUMAN | [view interactions] | High throughput | no | no |
| K2C7_HUMAN | [view interactions] | High throughput | no | no |
| ABTB2_HUMAN | [view interactions] | High throughput | no | yes |
| IDE_HUMAN | [view interactions] | High throughput | no | yes |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| K22E_HUMAN | [view interactions] | High throughput | no | no |
| KRT86_HUMAN | [view interactions] | High throughput | no | no |
| K1C39_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| RFIP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPDR1_HUMAN | [view interactions] | High throughput | no | yes |
| SYSM_HUMAN | [view interactions] | High throughput | no | yes |
| TAGL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABHDA_HUMAN | [view interactions] | High throughput | no | yes |
| DIP2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MICU1_HUMAN | [view interactions] | High throughput | no | yes |
| SYPM_HUMAN | [view interactions] | High throughput | no | yes |
| PDIP3_HUMAN | [view interactions] | High throughput | no | no |
| ROCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| K1C19_HUMAN | [view interactions] | High throughput | no | no |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |