AINX_HUMAN
Evidence for PS localization
Functions
Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges. May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AINX_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 25.3165 | 4 | no |
| GO:0019900 | kinase binding | 24.0506 | 4 | no |
| GO:0046872 | metal ion binding | 24.0506 | 5 | no |
| GO:0043168 | anion binding | 22.7848 | 4 | no |
| GO:0003723 | RNA binding | 22.7848 | 4 | no |
| GO:0019901 | protein kinase binding | 20.2532 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AINX_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 59.4937 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 58.2278 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 55.6962 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 55.6962 | 4 | no |
| GO:0010646 | regulation of cell communication | 53.1646 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 51.8987 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 41.7722 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 40.5063 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 39.2405 | 4 | no |
| GO:0010468 | regulation of gene expression | 39.2405 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 39.2405 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 39.2405 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 37.9747 | 4 | no |
| GO:0009966 | regulation of signal transduction | 37.9747 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.9747 | 5 | no |
| GO:0006996 | organelle organization | 36.7089 | 4 | yes |
| GO:0022607 | cellular component assembly | 35.4430 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 34.1772 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 31.6456 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 31.6456 | 4 | no |
| GO:0051049 | regulation of transport | 31.6456 | 4 | no |
| GO:0008104 | protein localization | 30.3797 | 4 | no |
| GO:0031399 | regulation of protein modification process | 30.3797 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.3797 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.3797 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.3797 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 29.1139 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 29.1139 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 29.1139 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 27.8481 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 27.8481 | 5 | no |
| GO:0009894 | regulation of catabolic process | 26.5823 | 4 | no |
| GO:0023056 | positive regulation of signaling | 25.3165 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 25.3165 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.3165 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 25.3165 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 25.3165 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.3165 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 24.0506 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 24.0506 | 7 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 24.0506 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 22.7848 | 7 | no |
| GO:0031344 | regulation of cell projection organization | 22.7848 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 22.7848 | 7 | no |
| GO:0036211 | protein modification process | 22.7848 | 4 | no |
| GO:0043412 | macromolecule modification | 22.7848 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.7848 | 4 | no |
| GO:0043933 | protein-containing complex organization | 22.7848 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 22.7848 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.7848 | 6 | no |
| GO:0071310 | cellular response to organic substance | 21.5190 | 4 | yes |
| GO:0097435 | supramolecular fiber organization | 21.5190 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.5190 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.5190 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 21.5190 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 21.5190 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 20.2532 | 4 | no |
| GO:0060341 | regulation of cellular localization | 20.2532 | 4 | no |
| GO:0007010 | cytoskeleton organization | 18.9873 | 5 | yes |
| GO:0034097 | response to cytokine | 11.3924 | 4 | yes |
| GO:0045109 | intermediate filament organization | 8.8608 | 4 | yes |
| GO:0071345 | cellular response to cytokine stimulus | 8.8608 | 5 | yes |
| GO:0021762 | substantia nigra development | 5.0633 | 4 | yes |
| GO:0060052 | neurofilament cytoskeleton organization | 2.5316 | 4 | yes |
| GO:0099170 | postsynaptic modulation of chemical synaptic transmission | 2.5316 | 6 | yes |
| GO:1990823 | response to leukemia inhibitory factor | 2.5316 | 5 | yes |
| GO:1990830 | cellular response to leukemia inhibitory factor | 2.5316 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TANC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NSMF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IMA5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| CE192_HUMAN | [view interactions] | High throughput | no | yes |
| CP110_HUMAN | [view interactions] | High throughput | no | yes |
| POC5_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| NP1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODFP2_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STB5L_HUMAN | [view interactions] | High throughput | no | no |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CC183_HUMAN | [view interactions] | High throughput | no | no |
| CENPP_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| ANM8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| SYNCI_HUMAN | [view interactions] | High throughput | no | no |
| NFH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GFAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNH28_HUMAN | [view interactions] | High throughput | no | no |
| VWA3B_HUMAN | [view interactions] | High throughput | no | no |
| BAZ2B_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| REQU_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
| GRIA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| ARHGJ_HUMAN | [view interactions] | High throughput | no | no |
| FGD1_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| NEST_HUMAN | [view interactions] | High throughput | no | no |
| K1C16_HUMAN | [view interactions] | High throughput | no | no |
| MAP7_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAN12_HUMAN | [view interactions] | High throughput | no | no |
| K2C72_HUMAN | [view interactions] | High throughput | no | no |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| S100P_HUMAN | [view interactions] | High throughput | no | no |
| K2C78_HUMAN | [view interactions] | High throughput | no | no |
| K1C14_HUMAN | [view interactions] | High throughput | no | no |
| K1C27_HUMAN | [view interactions] | High throughput | no | no |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| DESM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CRBG1_HUMAN | [view interactions] | High throughput | no | no |
| SLU7_HUMAN | [view interactions] | High throughput | no | yes |
| K1C23_HUMAN | [view interactions] | High throughput | no | no |
| SYCE1_HUMAN | [view interactions] | High throughput | no | no |
| K1H2_HUMAN | [view interactions] | High throughput | no | no |
| K2C7_HUMAN | [view interactions] | High throughput | no | no |
| ABTB2_HUMAN | [view interactions] | High throughput | no | yes |
| IDE_HUMAN | [view interactions] | High throughput | no | yes |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| K22E_HUMAN | [view interactions] | High throughput | no | no |
| KRT86_HUMAN | [view interactions] | High throughput | no | no |
| K1C39_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| PIAS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| RFIP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPDR1_HUMAN | [view interactions] | High throughput | no | yes |
| SYSM_HUMAN | [view interactions] | High throughput | no | yes |
| TAGL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABHDA_HUMAN | [view interactions] | High throughput | no | yes |
| DIP2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MICU1_HUMAN | [view interactions] | High throughput | no | yes |
| SYPM_HUMAN | [view interactions] | High throughput | no | yes |
| PDIP3_HUMAN | [view interactions] | High throughput | no | no |
| ROCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| K1C19_HUMAN | [view interactions] | High throughput | no | no |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| BRSK2_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| CXB7_HUMAN | [view interactions] | High throughput | no | no |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| MB212_HUMAN | [view interactions] | High throughput | no | no |
| BMP1_HUMAN | [view interactions] | High throughput | no | yes |
| CAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VSIG8_HUMAN | [view interactions] | High throughput | no | no |
| NFM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RSPRY_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KLH36_HUMAN | [view interactions] | High throughput | no | yes |
| BFSP2_HUMAN | [view interactions] | High throughput | no | no |
| TIAR_HUMAN | [view interactions] | High throughput | no | no |
| GAN_HUMAN | [view interactions] | High throughput | no | yes |
| MIPEP_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGB_HUMAN | [view interactions] | High throughput | no | yes |
| RHG23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2L_HUMAN | [view interactions] | High throughput | no | no |
| NCBP2_HUMAN | [view interactions] | High throughput | no | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| M3K13_HUMAN | [view interactions] | High throughput | no | yes |
| WEE1_HUMAN | [view interactions] | High throughput | no | yes |
| PK3CB_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STK3_HUMAN | [view interactions] | High throughput | no | yes |
| CDK10_HUMAN | [view interactions] | High throughput | no | no |
| TBCK_HUMAN | [view interactions] | High throughput | no | yes |
| CDKL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAK5_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| CNTRB_HUMAN | [view interactions] | High throughput | no | yes |