AMPL_HUMAN
Evidence for PS localization
Functions
Cytolosic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AMPL_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 36.8421 | 4 | no |
| GO:0000166 | nucleotide binding | 34.2105 | 4 | no |
| GO:0017076 | purine nucleotide binding | 34.2105 | 5 | no |
| GO:0043169 | cation binding | 31.5789 | 4 | yes |
| GO:0046872 | metal ion binding | 31.5789 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 28.9474 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 21.0526 | 4 | no |
| GO:0046914 | transition metal ion binding | 10.5263 | 6 | yes |
| GO:0008237 | metallopeptidase activity | 5.2632 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AMPL_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 44.7368 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.1053 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 42.1053 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 39.4737 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 39.4737 | 4 | no |
| GO:0009966 | regulation of signal transduction | 39.4737 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 36.8421 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 34.2105 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 34.2105 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 31.5789 | 4 | no |
| GO:0022607 | cellular component assembly | 31.5789 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 31.5789 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 31.5789 | 4 | no |
| GO:0010468 | regulation of gene expression | 28.9474 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.9474 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 28.9474 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.9474 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.9474 | 5 | no |
| GO:0031399 | regulation of protein modification process | 28.9474 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 28.9474 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.9474 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 26.3158 | 7 | no |
| GO:0008104 | protein localization | 26.3158 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.3158 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 26.3158 | 7 | no |
| GO:0009890 | negative regulation of biosynthetic process | 26.3158 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 26.3158 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 26.3158 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.3158 | 4 | no |
| GO:0043933 | protein-containing complex organization | 26.3158 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.3158 | 4 | no |
| GO:0051049 | regulation of transport | 26.3158 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 23.6842 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 23.6842 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.6842 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.6842 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 23.6842 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.6842 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.6842 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 23.6842 | 4 | no |
| GO:0080134 | regulation of response to stress | 23.6842 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 23.6842 | 4 | no |
| GO:0006996 | organelle organization | 21.0526 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.0526 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.0526 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 21.0526 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.0526 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 21.0526 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 21.0526 | 4 | no |
| GO:0043408 | regulation of MAPK cascade | 21.0526 | 6 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 21.0526 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.0526 | 5 | no |
| GO:0032880 | regulation of protein localization | 21.0526 | 5 | no |
| GO:0060341 | regulation of cellular localization | 21.0526 | 4 | no |
| GO:0006508 | proteolysis | 15.7895 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DCAF4_HUMAN | [view interactions] | High throughput | no | yes |
| HLAA_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| CBX3_HUMAN | [view interactions] | High throughput | no | yes |
| CBX5_HUMAN | [view interactions] | High throughput | no | yes |
| ZNF76_HUMAN | [view interactions] | High throughput | no | no |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIHD2_HUMAN | [view interactions] | High throughput | no | no |
| P55G_HUMAN | [view interactions] | High throughput | no | yes |
| USF1_HUMAN | [view interactions] | High throughput | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| DNLI4_HUMAN | [view interactions] | High throughput | no | yes |
| BANP_HUMAN | [view interactions] | High throughput | no | yes |
| UBA5_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| RPGF2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| ZCC17_HUMAN | [view interactions] | High throughput | no | yes |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| RMD5A_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC8_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| MT21E_HUMAN | [view interactions] | High throughput | no | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLU_HUMAN | [view interactions] | High throughput | no | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TET5C_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AASD1_HUMAN | [view interactions] | High throughput | no | yes |
| AGFG1_HUMAN | [view interactions] | High throughput | no | yes |
| HEM2_HUMAN | [view interactions] | High throughput | no | no |
| ARPC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIF3L_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| TPRKB_HUMAN | [view interactions] | High throughput | no | yes |
| FUBP1_HUMAN | [view interactions] | High throughput | no | yes |
| MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYVC_HUMAN | [view interactions] | High throughput | no | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| GLRX5_HUMAN | [view interactions] | High throughput | no | yes |
| FRDA_HUMAN | [view interactions] | High throughput | no | yes |
| MTPN_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC4_HUMAN | [view interactions] | High throughput | no | no |
| GSTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AL4A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCA_HUMAN | [view interactions] | High throughput | no | yes |
| LACB2_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | no |
| SPRE_HUMAN | [view interactions] | High throughput | no | yes |
| KGUA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THTM_HUMAN | [view interactions] | High throughput | no | yes |
| QOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CATB_HUMAN | [view interactions] | High throughput | no | yes |
| GRHPR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COA7_HUMAN | [view interactions] | High throughput | no | yes |
| HCDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAP3_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSHR_HUMAN | [view interactions] | High throughput | no | yes |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| MDHC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PUR8_HUMAN | [view interactions] | High throughput | no | yes |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AL9A1_HUMAN | [view interactions] | High throughput | no | yes |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| NAMPT_HUMAN | [view interactions] | High throughput | no | no |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| SYWC_HUMAN | [view interactions] | High throughput | no | yes |
| UGDH_HUMAN | [view interactions] | High throughput | no | no |
| AGM1_HUMAN | [view interactions] | High throughput | no | no |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPA_HUMAN | [view interactions] | High throughput | no | yes |
| RHEB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBL5_HUMAN | [view interactions] | High throughput | no | no |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| TS101_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPC2B_HUMAN | [view interactions] | High throughput | no | no |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
| TPC2L_HUMAN | [view interactions] | High throughput | no | yes |
| TAB1_HUMAN | [view interactions] | High throughput | no | yes |
| GCNT1_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDA1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS5_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |