HCDH_HUMAN
Evidence for PS localization
Functions
Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed, PubMed, PubMed). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in HCDH_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 34.6939 | 4 | no |
| GO:0017076 | purine nucleotide binding | 24.4898 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 24.4898 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.4082 | 4 | no |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 14.2857 | 4 | yes |
| GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity | 10.2041 | 5 | yes |
| GO:0051287 | NAD binding | 10.2041 | 4 | yes |
| GO:0070403 | NAD+ binding | 6.1224 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in HCDH_HUMAN |
|---|---|---|---|---|
| GO:0019752 | carboxylic acid metabolic process | 38.7755 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 38.7755 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 38.7755 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 38.7755 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 38.7755 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 36.7347 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 36.7347 | 4 | no |
| GO:0022607 | cellular component assembly | 32.6531 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 32.6531 | 4 | no |
| GO:0010646 | regulation of cell communication | 30.6122 | 4 | yes |
| GO:0016054 | organic acid catabolic process | 28.5714 | 4 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 28.5714 | 6 | yes |
| GO:0046395 | carboxylic acid catabolic process | 28.5714 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.5714 | 5 | no |
| GO:0010468 | regulation of gene expression | 28.5714 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 26.5306 | 4 | yes |
| GO:0006996 | organelle organization | 26.5306 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 24.4898 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.4898 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 24.4898 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 24.4898 | 4 | no |
| GO:0009966 | regulation of signal transduction | 24.4898 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 24.4898 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 24.4898 | 5 | no |
| GO:0006631 | fatty acid metabolic process | 22.4490 | 4 | yes |
| GO:0006635 | fatty acid beta-oxidation | 22.4490 | 6 | yes |
| GO:0009062 | fatty acid catabolic process | 22.4490 | 5 | yes |
| GO:0016042 | lipid catabolic process | 22.4490 | 4 | yes |
| GO:0019395 | fatty acid oxidation | 22.4490 | 5 | yes |
| GO:0030258 | lipid modification | 22.4490 | 4 | yes |
| GO:0034440 | lipid oxidation | 22.4490 | 5 | yes |
| GO:0044242 | cellular lipid catabolic process | 22.4490 | 4 | yes |
| GO:0072329 | monocarboxylic acid catabolic process | 22.4490 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.4490 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.4490 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.4490 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.4490 | 4 | no |
| GO:0043933 | protein-containing complex organization | 20.4082 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 20.4082 | 5 | no |
| GO:0010941 | regulation of cell death | 20.4082 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 20.4082 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 20.4082 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.4082 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 20.4082 | 4 | no |
| GO:0051049 | regulation of transport | 18.3673 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 18.3673 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 16.3265 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 16.3265 | 4 | yes |
| GO:0032880 | regulation of protein localization | 16.3265 | 5 | yes |
| GO:0010243 | response to organonitrogen compound | 14.2857 | 4 | yes |
| GO:0051223 | regulation of protein transport | 10.2041 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 10.2041 | 6 | yes |
| GO:0120162 | positive regulation of cold-induced thermogenesis | 10.2041 | 4 | yes |
| GO:1901652 | response to peptide | 10.2041 | 4 | yes |
| GO:0046883 | regulation of hormone secretion | 8.1633 | 4 | yes |
| GO:0051046 | regulation of secretion | 8.1633 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 8.1633 | 4 | yes |
| GO:0002791 | regulation of peptide secretion | 6.1224 | 6 | yes |
| GO:0032868 | response to insulin | 6.1224 | 5 | yes |
| GO:0043434 | response to peptide hormone | 6.1224 | 4 | yes |
| GO:0046888 | negative regulation of hormone secretion | 6.1224 | 5 | yes |
| GO:0050708 | regulation of protein secretion | 6.1224 | 5 | yes |
| GO:0050796 | regulation of insulin secretion | 6.1224 | 6 | yes |
| GO:0051048 | negative regulation of secretion | 6.1224 | 5 | yes |
| GO:0051051 | negative regulation of transport | 6.1224 | 4 | yes |
| GO:0090087 | regulation of peptide transport | 6.1224 | 5 | yes |
| GO:0090276 | regulation of peptide hormone secretion | 6.1224 | 5 | yes |
| GO:1903531 | negative regulation of secretion by cell | 6.1224 | 5 | yes |
| GO:1903828 | negative regulation of protein localization | 6.1224 | 5 | yes |
| GO:0002792 | negative regulation of peptide secretion | 4.0816 | 6 | yes |
| GO:0046676 | negative regulation of insulin secretion | 4.0816 | 7 | yes |
| GO:0050709 | negative regulation of protein secretion | 4.0816 | 6 | yes |
| GO:0051224 | negative regulation of protein transport | 4.0816 | 5 | yes |
| GO:0090278 | negative regulation of peptide hormone secretion | 4.0816 | 6 | yes |
| GO:1904950 | negative regulation of establishment of protein localization | 4.0816 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in HCDH_HUMAN |
|---|---|---|---|---|
| DOID:700 | mitochondrial metabolism disease | 6.1224 | 3 | no |
| DOID:0060286 | combined oxidative phosphorylation deficiency | 4.0816 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HCDH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SF01_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLRX5_HUMAN | [view interactions] | High throughput | no | yes |
| TPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| FRDA_HUMAN | [view interactions] | High throughput | no | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| MTPN_HUMAN | [view interactions] | High throughput | no | yes |
| AMPL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THIOM_HUMAN | [view interactions] | High throughput | no | yes |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPRE_HUMAN | [view interactions] | High throughput | no | yes |
| COX17_HUMAN | [view interactions] | High throughput | no | yes |
| CYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AATM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOS2_HUMAN | [view interactions] | High throughput | no | yes |
| RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| TXD12_HUMAN | [view interactions] | High throughput | no | no |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| ACADL_HUMAN | [view interactions] | High throughput | no | no |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 3HIDH_HUMAN | [view interactions] | High throughput | no | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| SUCB2_HUMAN | [view interactions] | High throughput | no | no |
| AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACADV_HUMAN | [view interactions] | High throughput | no | yes |
| ALDH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CPT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECH1_HUMAN | [view interactions] | High throughput | no | yes |
| ECI1_HUMAN | [view interactions] | High throughput | no | yes |
| DHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| UFM1_HUMAN | [view interactions] | High throughput | no | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFC1_HUMAN | [view interactions] | High throughput | no | yes |
| DECR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACADM_HUMAN | [view interactions] | High throughput | no | yes |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTRFR_HUMAN | [view interactions] | High throughput | no | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD2_HUMAN | [view interactions] | High throughput | no | no |
| FAKD5_HUMAN | [view interactions] | High throughput | no | yes |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET15_HUMAN | [view interactions] | High throughput | no | no |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| RRFM_HUMAN | [view interactions] | High throughput | no | yes |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VWA8_HUMAN | [view interactions] | High throughput | no | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADH1A_HUMAN | [view interactions] | High throughput | no | no |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| UBA5_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEK7_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| RAD1_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXL17_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| CGRF1_HUMAN | [view interactions] | High throughput | no | yes |
| MARH2_HUMAN | [view interactions] | High throughput | no | yes |
| RN103_HUMAN | [view interactions] | High throughput | no | no |
| RNFT1_HUMAN | [view interactions] | High throughput | no | no |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITA2B_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLK1_HUMAN | [view interactions] | High throughput | no | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC3_HUMAN | [view interactions] | High throughput | no | no |
| CLIC4_HUMAN | [view interactions] | High throughput | no | no |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP2_HUMAN | [view interactions] | High throughput | no | yes |
| THIC_HUMAN | [view interactions] | High throughput | no | yes |
| MMAB_HUMAN | [view interactions] | High throughput | no | yes |
| PIPNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| PSA2_HUMAN | [view interactions] | High throughput | no | yes |
| PSB8_HUMAN | [view interactions] | High throughput | no | yes |
| RSU1_HUMAN | [view interactions] | High throughput | no | no |
| MCCB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ECHP_HUMAN | [view interactions] | Computational | no | no |
| DHE3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| THIK_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| THIL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SCP2_HUMAN | [view interactions] | Computational | no | no |
| ECHD2_HUMAN | [view interactions] | Computational | no | no |
| ACDSB_HUMAN | [view interactions] | Computational | no | yes |
| ACADS_HUMAN | [view interactions] | Computational | no | yes |