Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CYC_HUMAN

Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in CYC_HUMAN
GO:0043169 cation binding 34.1463 4 yes
GO:0046872 metal ion binding 32.9268 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 26.8293 4 no
GO:0008324 monoatomic cation transmembrane transporter activity 26.8293 4 no
GO:0015078 proton transmembrane transporter activity 25.6098 5 no
GO:0000166 nucleotide binding 24.3902 4 no
GO:0015399 primary active transmembrane transporter activity 23.1707 4 no
GO:0015453 oxidoreduction-driven active transmembrane transporter activity 23.1707 5 no
GO:0022853 active monoatomic ion transmembrane transporter activity 23.1707 4 no
GO:0017076 purine nucleotide binding 20.7317 5 no
GO:0020037 heme binding 6.0976 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CYC_HUMAN
GO:0006796 phosphate-containing compound metabolic process 37.8049 4 no
GO:0048522 positive regulation of cellular process 37.8049 4 no
GO:0048523 negative regulation of cellular process 37.8049 4 no
GO:0031323 regulation of cellular metabolic process 36.5854 4 no
GO:0009893 positive regulation of metabolic process 35.3659 4 yes
GO:0010646 regulation of cell communication 35.3659 4 no
GO:0015980 energy derivation by oxidation of organic compounds 34.1463 4 yes
GO:0045333 cellular respiration 32.9268 5 yes
GO:0060255 regulation of macromolecule metabolic process 32.9268 4 yes
GO:0009966 regulation of signal transduction 32.9268 4 no
GO:0009060 aerobic respiration 31.7073 6 yes
GO:0022900 electron transport chain 31.7073 4 yes
GO:0080090 regulation of primary metabolic process 31.7073 4 yes
GO:0022904 respiratory electron transport chain 30.4878 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 29.2683 5 yes
GO:0022607 cellular component assembly 29.2683 4 no
GO:0031325 positive regulation of cellular metabolic process 29.2683 5 no
GO:0006753 nucleoside phosphate metabolic process 29.2683 4 no
GO:0009117 nucleotide metabolic process 29.2683 5 no
GO:0043933 protein-containing complex organization 29.2683 4 no
GO:0019646 aerobic electron transport chain 28.0488 6 yes
GO:0006163 purine nucleotide metabolic process 28.0488 5 no
GO:0072521 purine-containing compound metabolic process 28.0488 4 no
GO:0042981 regulation of apoptotic process 28.0488 5 no
GO:0043067 regulation of programmed cell death 28.0488 4 no
GO:0048584 positive regulation of response to stimulus 26.8293 4 no
GO:0009889 regulation of biosynthetic process 26.8293 4 no
GO:0010647 positive regulation of cell communication 25.6098 5 no
GO:0023056 positive regulation of signaling 25.6098 4 no
GO:1902531 regulation of intracellular signal transduction 25.6098 5 no
GO:0009150 purine ribonucleotide metabolic process 25.6098 6 no
GO:0009259 ribonucleotide metabolic process 25.6098 5 no
GO:0019693 ribose phosphate metabolic process 25.6098 4 no
GO:1901566 organonitrogen compound biosynthetic process 25.6098 4 no
GO:0010468 regulation of gene expression 25.6098 6 no
GO:0010556 regulation of macromolecule biosynthetic process 25.6098 5 no
GO:0031326 regulation of cellular biosynthetic process 25.6098 5 no
GO:0051049 regulation of transport 25.6098 4 no
GO:0051246 regulation of protein metabolic process 24.3902 5 yes
GO:0006996 organelle organization 24.3902 4 no
GO:0051128 regulation of cellular component organization 24.3902 4 no
GO:1901362 organic cyclic compound biosynthetic process 24.3902 4 no
GO:0009892 negative regulation of metabolic process 24.3902 4 no
GO:0009967 positive regulation of signal transduction 23.1707 5 no
GO:0034654 nucleobase-containing compound biosynthetic process 23.1707 4 no
GO:0065003 protein-containing complex assembly 23.1707 5 no
GO:0031324 negative regulation of cellular metabolic process 23.1707 5 no
GO:0051247 positive regulation of protein metabolic process 21.9512 6 yes
GO:0090407 organophosphate biosynthetic process 21.9512 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.9512 5 no
GO:0043066 negative regulation of apoptotic process 21.9512 6 no
GO:0043069 negative regulation of programmed cell death 21.9512 5 no
GO:0010648 negative regulation of cell communication 21.9512 5 no
GO:0023057 negative regulation of signaling 21.9512 4 no
GO:0031399 regulation of protein modification process 20.7317 6 no
GO:1902533 positive regulation of intracellular signal transduction 20.7317 6 no
GO:0006164 purine nucleotide biosynthetic process 20.7317 6 no
GO:0009152 purine ribonucleotide biosynthetic process 20.7317 7 no
GO:0009165 nucleotide biosynthetic process 20.7317 6 no
GO:0009260 ribonucleotide biosynthetic process 20.7317 6 no
GO:0046390 ribose phosphate biosynthetic process 20.7317 5 no
GO:0072522 purine-containing compound biosynthetic process 20.7317 5 no
GO:1901137 carbohydrate derivative biosynthetic process 20.7317 4 no
GO:1901293 nucleoside phosphate biosynthetic process 20.7317 5 no
GO:0010605 negative regulation of macromolecule metabolic process 20.7317 5 no
GO:0043085 positive regulation of catalytic activity 18.2927 4 yes
GO:0051336 regulation of hydrolase activity 12.1951 4 yes
GO:0030162 regulation of proteolysis 10.9756 6 yes
GO:0051345 positive regulation of hydrolase activity 10.9756 5 yes
GO:0045862 positive regulation of proteolysis 9.7561 7 yes
GO:0052547 regulation of peptidase activity 9.7561 5 yes
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen 8.5366 7 yes
GO:0010952 positive regulation of peptidase activity 8.5366 6 yes
GO:0052548 regulation of endopeptidase activity 8.5366 6 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 8.5366 7 yes
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 7.3171 7 yes
GO:0010950 positive regulation of endopeptidase activity 7.3171 7 yes
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 7.3171 8 yes
GO:2001056 positive regulation of cysteine-type endopeptidase activity 7.3171 8 yes
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 6.0976 10 yes
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 6.0976 9 yes
GO:0097193 intrinsic apoptotic signaling pathway 3.6585 4 yes
GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c 2.4390 11 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
APAF_HUMAN [view interactions] Low throughput no no
R144B_HUMAN [view interactions] Low throughput no yes
SPNS1_HUMAN [view interactions] Low throughput no yes
NCPR_HUMAN [view entry] [view interactions] Low throughput yes yes
CISD2_HUMAN [view interactions] Low throughput no yes
B2CL1_HUMAN [view interactions] Low throughput no yes
HSPB1_HUMAN [view entry] [view interactions] Low throughput yes no
CUL9_HUMAN [view interactions] Low throughput no no
AAPK1_HUMAN [view interactions] Low throughput no no
UBP53_HUMAN [view interactions] Low throughput no yes
HSP7C_HUMAN [view entry] [view interactions] Low throughput yes yes
COX42_HUMAN [view interactions] Low throughput no no
CYB5_HUMAN [view interactions] Low throughput no no
QCR1_HUMAN [view entry] [view interactions] Low throughput yes yes
NDOR1_HUMAN [view interactions] Low throughput no yes
CY1_HUMAN [view entry] [view interactions] Low throughput yes yes
VDAC1_HUMAN [view entry] [view interactions] Low throughput yes yes
BAX_HUMAN [view interactions] Low throughput no yes
CBPE_HUMAN [view interactions] Low throughput no yes
CYC_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3G3_HUMAN [view entry] [view interactions] High throughput yes no
CAV1_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
VCAM1_HUMAN [view interactions] High throughput no no
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
UCRIL_HUMAN [view interactions] High throughput no no
MED4_HUMAN [view interactions] High throughput no yes
MED23_HUMAN [view interactions] High throughput no no
MED20_HUMAN [view interactions] High throughput no no
M3K7_HUMAN [view interactions] High throughput no yes
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
TRM7_HUMAN [view interactions] High throughput no yes
CRCM_HUMAN [view interactions] High throughput no no
PINX1_HUMAN [view interactions] High throughput no yes
TR10D_HUMAN [view interactions] High throughput no no
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
GSTK1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
SOMA_HUMAN [view interactions] High throughput no no
EPB41_HUMAN [view entry] [view interactions] High throughput yes no
AAKB1_HUMAN [view interactions] High throughput no yes
IKKE_HUMAN [view interactions] High throughput no yes
TRAF6_HUMAN [view entry] [view interactions] High throughput yes yes
HLAB_HUMAN [view interactions] High throughput no yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
CBPC1_HUMAN [view interactions] High throughput no yes
K1C40_HUMAN [view interactions] High throughput no no
FAM9A_HUMAN [view interactions] High throughput no no
FYN_HUMAN [view entry] [view interactions] High throughput yes no
ZBT14_HUMAN [view interactions] High throughput no yes
EIF3F_HUMAN [view interactions] High throughput no yes
SNW1_HUMAN [view interactions] High throughput no yes
COA7_HUMAN [view interactions] High throughput no yes
PHF23_HUMAN [view interactions] High throughput no yes
KCD17_HUMAN [view interactions] High throughput no yes
CC036_HUMAN [view interactions] High throughput no no
LRC56_HUMAN [view interactions] High throughput no no
ASCL4_HUMAN [view interactions] High throughput no no
LONF2_HUMAN [view interactions] High throughput no yes
RUAS1_HUMAN [view interactions] High throughput no no
FX4L6_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
ESR2_HUMAN [view interactions] High throughput no no
TIF1A_HUMAN [view interactions] High throughput no yes
CASP9_HUMAN [view interactions] High throughput no yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
IMP1L_HUMAN [view interactions] High throughput no yes
LACTB_HUMAN [view interactions] High throughput no yes
OMA1_HUMAN [view interactions] High throughput no no
PARL_HUMAN [view interactions] High throughput no yes
YMEL1_HUMAN [view interactions] High throughput no yes
UBE2N_HUMAN [view entry] [view interactions] High throughput yes yes
MEOX2_HUMAN [view interactions] High throughput no no
RD23B_HUMAN [view interactions] High throughput no yes
CDK2_HUMAN [view interactions] High throughput no yes
PARK7_HUMAN [view entry] [view interactions] High throughput yes yes
ITA4_HUMAN [view interactions] High throughput no no
FBX32_HUMAN [view interactions] High throughput no no
HECW2_HUMAN [view entry] [view interactions] High throughput yes no
CQ10B_HUMAN [view entry] [view interactions] High throughput yes yes
MIC13_HUMAN [view interactions] High throughput no yes
MIX23_HUMAN [view interactions] High throughput no yes
PPA6_HUMAN [view interactions] High throughput no no
TRUB2_HUMAN [view interactions] High throughput no yes
ETFR1_HUMAN [view interactions] High throughput no no
NDKM_HUMAN [view interactions] High throughput no yes
TES_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
EGLN3_HUMAN [view interactions] High throughput no no
RNF4_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
TIF1B_HUMAN [view interactions] High throughput no yes
ARHG4_HUMAN [view interactions] High throughput no yes
GMIP_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
GDIR1_HUMAN [view entry] [view interactions] High throughput yes yes
MTPN_HUMAN [view interactions] High throughput no yes
MDHC_HUMAN [view entry] [view interactions] High throughput yes yes
TBCA_HUMAN [view interactions] High throughput no yes
DOPD_HUMAN [view interactions] High throughput no yes
CYTB_HUMAN [view interactions] High throughput no no
RS28_HUMAN [view entry] [view interactions] High throughput yes yes
RIGI_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
SELS_HUMAN [view interactions] High throughput no yes
PHF3_HUMAN [view interactions] High throughput no yes
SFSWA_HUMAN [view interactions] High throughput no yes
RSRC1_HUMAN [view interactions] High throughput no yes
PR38B_HUMAN [view interactions] High throughput no no
UBP36_HUMAN [view interactions] High throughput no yes
ESF1_HUMAN [view interactions] High throughput no yes
DCNL5_HUMAN [view interactions] High throughput no yes
CD11B_HUMAN [view interactions] High throughput no yes
UBP4_HUMAN [view interactions] High throughput no no
FANCB_HUMAN [view interactions] High throughput no no
RBM27_HUMAN [view interactions] High throughput no yes
SUGP1_HUMAN [view interactions] High throughput no yes
DIDO1_HUMAN [view interactions] High throughput no yes
AL1A1_HUMAN [view entry] [view interactions] High throughput yes yes
NSRP1_HUMAN [view interactions] High throughput no yes
RP9_HUMAN [view interactions] High throughput no yes
RBM25_HUMAN [view interactions] High throughput no yes
PRC2A_HUMAN [view interactions] High throughput no yes
ZGPAT_HUMAN [view interactions] High throughput no no
SIR1_HUMAN [view interactions] High throughput no yes
PRP16_HUMAN [view interactions] High throughput no yes
FANCL_HUMAN [view interactions] High throughput no yes
RBL2_HUMAN [view interactions] High throughput no yes
CCHL_HUMAN [view interactions] High throughput no yes
HABP4_HUMAN [view interactions] High throughput no yes
FP100_HUMAN [view interactions] High throughput no yes
DDX46_HUMAN [view interactions] High throughput no yes
LYRIC_HUMAN [view entry] [view interactions] High throughput yes yes
PR38A_HUMAN [view interactions] High throughput no no
SNIP1_HUMAN [view interactions] High throughput no no
RBM33_HUMAN [view interactions] High throughput no yes
SFPQ_HUMAN [view entry] [view interactions] High throughput yes yes
RBL1_HUMAN [view interactions] High throughput no yes
CWC25_HUMAN [view interactions] High throughput no yes
AL1A3_HUMAN [view interactions] High throughput no yes
CDK12_HUMAN [view interactions] High throughput no yes
ELOA1_HUMAN [view interactions] High throughput no yes
UTP11_HUMAN [view interactions] High throughput no yes
SNR27_HUMAN [view interactions] High throughput no yes
RB15B_HUMAN [view interactions] High throughput no yes
RRP36_HUMAN [view interactions] High throughput no yes
ZC3H4_HUMAN [view interactions] High throughput no yes
ZO2_HUMAN [view entry] [view interactions] High throughput yes no
RSRC2_HUMAN [view interactions] High throughput no yes
PAUF_HUMAN [view interactions] High throughput no no
ARGL1_HUMAN [view interactions] High throughput no yes
CCNA2_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
BAG1_HUMAN [view interactions] High throughput no yes
YTDC1_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
HDAC6_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
LOXL2_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
UBE2O_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
SMC5_HUMAN [view interactions] High throughput no yes
RL40_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
SPPL3_HUMAN [view interactions] High throughput no no
ARL2_HUMAN [view interactions] High throughput no yes
PRDX2_HUMAN [view entry] [view interactions] High throughput yes yes
THIL_HUMAN [view entry] [view interactions] High throughput yes yes
CATA_HUMAN [view entry] [view interactions] High throughput yes no
CYB5B_HUMAN [view entry] [view interactions] High throughput yes yes
GPD1L_HUMAN [view interactions] High throughput no no
UCRI_HUMAN [view entry] [view interactions] High throughput yes yes
GLRX2_HUMAN [view interactions] High throughput no yes
IMPA1_HUMAN [view entry] [view interactions] High throughput yes yes
IMPA2_HUMAN [view interactions] High throughput no no
NLE1_HUMAN [view interactions] High throughput no yes
HCDH_HUMAN [view entry] [view interactions] High throughput yes yes
AT5L2_HUMAN [view interactions] High throughput no no
ATP5L_HUMAN [view interactions] High throughput no yes
COX5A_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS5_HUMAN [view interactions] High throughput no yes
ODPB_HUMAN [view entry] [view interactions] High throughput yes yes
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
ATPA_HUMAN [view interactions] High throughput no yes
ATPG_HUMAN [view interactions] High throughput no yes
ATPD_HUMAN [view interactions] High throughput no yes
ATP5H_HUMAN [view interactions] High throughput no yes
ATP5I_HUMAN [view interactions] High throughput no yes
ATPO_HUMAN [view interactions] High throughput no yes
COX6C_HUMAN [view entry] [view interactions] High throughput yes yes
CISY_HUMAN [view entry] [view interactions] High throughput yes yes
NB5R3_HUMAN [view interactions] High throughput no yes
ATPK_HUMAN [view interactions] High throughput no yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
CX6B1_HUMAN [view entry] [view interactions] High throughput yes yes
CX7A2_HUMAN [view interactions] High throughput no no
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
MDHM_HUMAN [view entry] [view interactions] High throughput yes yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
ADT1_HUMAN [view entry] [view interactions] High throughput yes yes
ADT2_HUMAN [view entry] [view interactions] High throughput yes yes
ODP2_HUMAN [view entry] [view interactions] High throughput yes yes
IDH3A_HUMAN [view entry] [view interactions] High throughput yes yes
NDUAA_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA3_HUMAN [view interactions] High throughput no yes
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA5_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA6_HUMAN [view interactions] High throughput no no
NDUA8_HUMAN [view entry] [view interactions] High throughput yes yes
ACPM_HUMAN [view interactions] High throughput no yes
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB7_HUMAN [view entry] [view interactions] High throughput yes yes
NDUC2_HUMAN [view interactions] High throughput no yes
NDUCR_HUMAN [view interactions] High throughput no yes
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
NDUS2_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS4_HUMAN [view interactions] High throughput no yes
NDUS7_HUMAN [view entry] [view interactions] High throughput yes no
RBX2_HUMAN [view interactions] High throughput no yes
SDHA_HUMAN [view interactions] High throughput no yes
SDHB_HUMAN [view interactions] High throughput no yes
QCR9_HUMAN [view interactions] High throughput no no
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
QCR6L_HUMAN [view interactions] High throughput no yes
QCR6_HUMAN [view interactions] High throughput no yes
ATPMK_HUMAN [view interactions] High throughput no no
AT5F1_HUMAN [view interactions] High throughput no yes
PFKAM_HUMAN [view entry] [view interactions] High throughput yes yes
NDUAC_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB5_HUMAN [view interactions] High throughput no yes
NDUB6_HUMAN [view entry] [view interactions] High throughput yes yes
NDUV2_HUMAN [view entry] [view interactions] High throughput yes yes
SUCA_HUMAN [view entry] [view interactions] High throughput yes yes
ERI3_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
ST38L_HUMAN [view entry] [view interactions] High throughput yes yes
ATF2_HUMAN [view interactions] High throughput no yes
OPTN_HUMAN [view interactions] High throughput no yes
A2GL_HUMAN [view interactions] High throughput no no
DJB11_HUMAN [view interactions] High throughput no yes
SUCHY_HUMAN [view interactions] High throughput no yes
MIC26_HUMAN [view entry] [view interactions] High throughput yes yes
FMC1_HUMAN [view interactions] High throughput no no
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
COQ7_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
OPA3_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
PTPM1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
COQ6_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
SPT20_HUMAN [view interactions] High throughput no yes
COQ8B_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes