Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IMPA1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in IMPA1_HUMAN
GO:0046872 metal ion binding 50.0000 4 yes
GO:0046914 transition metal ion binding 41.6667 5 yes
GO:0042803 protein homodimerization activity 33.3333 4 yes
GO:0016791 phosphatase activity 25.0000 5 yes
GO:0030145 manganese ion binding 25.0000 6 yes
GO:0042578 phosphoric ester hydrolase activity 25.0000 4 yes
GO:0052745 inositol phosphate phosphatase activity 25.0000 6 yes
GO:0000287 magnesium ion binding 16.6667 5 yes
GO:0008934 inositol monophosphate 1-phosphatase activity 16.6667 8 yes
GO:0031403 lithium ion binding 16.6667 6 yes
GO:0031420 alkali metal ion binding 16.6667 5 yes
GO:0052832 inositol monophosphate 3-phosphatase activity 16.6667 8 yes
GO:0052833 inositol monophosphate 4-phosphatase activity 16.6667 8 yes
GO:0052834 inositol monophosphate phosphatase activity 16.6667 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in IMPA1_HUMAN
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0006796 phosphate-containing compound metabolic process 41.6667 4 yes
GO:0009893 positive regulation of metabolic process 41.6667 4 no
GO:0009966 regulation of signal transduction 41.6667 4 no
GO:0010604 positive regulation of macromolecule metabolic process 41.6667 5 no
GO:0048522 positive regulation of cellular process 41.6667 4 no
GO:0048523 negative regulation of cellular process 41.6667 4 no
GO:0051171 regulation of nitrogen compound metabolic process 41.6667 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 41.6667 5 no
GO:0051246 regulation of protein metabolic process 41.6667 5 no
GO:0051247 positive regulation of protein metabolic process 41.6667 6 no
GO:0060255 regulation of macromolecule metabolic process 41.6667 4 no
GO:0080090 regulation of primary metabolic process 41.6667 4 no
GO:0006644 phospholipid metabolic process 33.3333 4 yes
GO:0006650 glycerophospholipid metabolic process 33.3333 5 yes
GO:0006661 phosphatidylinositol biosynthetic process 33.3333 6 yes
GO:0008610 lipid biosynthetic process 33.3333 4 yes
GO:0008654 phospholipid biosynthetic process 33.3333 4 yes
GO:0045017 glycerolipid biosynthetic process 33.3333 4 yes
GO:0046474 glycerophospholipid biosynthetic process 33.3333 5 yes
GO:0046486 glycerolipid metabolic process 33.3333 4 yes
GO:0046488 phosphatidylinositol metabolic process 33.3333 6 yes
GO:0090407 organophosphate biosynthetic process 33.3333 4 yes
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0031323 regulation of cellular metabolic process 33.3333 4 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0019751 polyol metabolic process 25.0000 4 yes
GO:0043647 inositol phosphate metabolic process 25.0000 4 yes
GO:0046434 organophosphate catabolic process 25.0000 4 yes
GO:0006996 organelle organization 25.0000 4 no
GO:0008104 protein localization 25.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0050890 cognition 25.0000 4 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0010941 regulation of cell death 25.0000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0042981 regulation of apoptotic process 25.0000 6 no
GO:0043067 regulation of programmed cell death 25.0000 5 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:0051345 positive regulation of hydrolase activity 25.0000 5 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0006020 inositol metabolic process 16.6667 4 yes
GO:0006021 inositol biosynthetic process 16.6667 5 yes
GO:0016051 carbohydrate biosynthetic process 16.6667 4 yes
GO:0016311 dephosphorylation 16.6667 5 yes
GO:0034637 cellular carbohydrate biosynthetic process 16.6667 4 yes
GO:0046164 alcohol catabolic process 16.6667 4 yes
GO:0046165 alcohol biosynthetic process 16.6667 4 yes
GO:0046173 polyol biosynthetic process 16.6667 5 yes
GO:0046174 polyol catabolic process 16.6667 5 yes
GO:0046838 phosphorylated carbohydrate dephosphorylation 16.6667 4 yes
GO:0046854 phosphatidylinositol phosphate biosynthetic process 16.6667 7 yes
GO:0046855 inositol phosphate dephosphorylation 16.6667 5 yes
GO:0071545 inositol phosphate catabolic process 16.6667 5 yes
GO:1901616 organic hydroxy compound catabolic process 16.6667 4 yes
GO:1901617 organic hydroxy compound biosynthetic process 16.6667 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
IMPA1_HUMAN [view entry] [view interactions] Low throughput yes yes
S100B_HUMAN [view entry] [view interactions] Low throughput yes yes
CALB1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
E2F3_HUMAN [view interactions] High throughput no no
IMPA2_HUMAN [view interactions] High throughput no no
B9D1_HUMAN [view interactions] High throughput no yes
SUMO2_HUMAN [view interactions] High throughput no yes
SUMO3_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
KC1A_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
SIR1_HUMAN [view interactions] High throughput no yes
MET18_HUMAN [view interactions] High throughput no yes
NXF1_HUMAN [view interactions] High throughput no yes
GDIR1_HUMAN [view entry] [view interactions] High throughput yes yes
DUT_HUMAN [view interactions] High throughput no yes
CYC_HUMAN [view entry] [view interactions] High throughput yes yes
IF6_HUMAN [view interactions] High throughput no yes
NUDT9_HUMAN [view interactions] High throughput no yes
6PGL_HUMAN [view interactions] High throughput no yes
ISCU_HUMAN [view interactions] High throughput no yes
PHP14_HUMAN [view interactions] High throughput no yes
RISC_HUMAN [view interactions] High throughput no yes
THIO_HUMAN [view interactions] High throughput no yes
UGDH_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
INPP_HUMAN [view interactions] Computational no no
MTM1_HUMAN [view interactions] Computational no yes
INP4B_HUMAN [view interactions] Computational no no
INO1_HUMAN [view interactions] Computational no no
INP4A_HUMAN [view entry] [view interactions] Computational yes yes
MIOX_HUMAN [view interactions] Computational no no
CDIPT_HUMAN [view entry] [view interactions] Computational yes yes
IMPA3_HUMAN [view interactions] Computational no yes