Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IMPA1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in IMPA1_HUMAN
GO:0043169 cation binding 45.4545 4 yes
GO:0046872 metal ion binding 45.4545 5 yes
GO:0042803 protein homodimerization activity 36.3636 4 yes
GO:0046914 transition metal ion binding 36.3636 6 yes
GO:0000287 magnesium ion binding 18.1818 6 yes
GO:0008934 inositol monophosphate 1-phosphatase activity 18.1818 8 yes
GO:0016791 phosphatase activity 18.1818 5 yes
GO:0030145 manganese ion binding 18.1818 7 yes
GO:0031403 lithium ion binding 18.1818 7 yes
GO:0031420 alkali metal ion binding 18.1818 6 yes
GO:0042578 phosphoric ester hydrolase activity 18.1818 4 yes
GO:0052745 inositol phosphate phosphatase activity 18.1818 6 yes
GO:0052832 inositol monophosphate 3-phosphatase activity 18.1818 8 yes
GO:0052833 inositol monophosphate 4-phosphatase activity 18.1818 8 yes
GO:0052834 inositol monophosphate phosphatase activity 18.1818 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in IMPA1_HUMAN
GO:0010646 regulation of cell communication 54.5455 4 no
GO:0009893 positive regulation of metabolic process 45.4545 4 no
GO:0009966 regulation of signal transduction 45.4545 4 no
GO:0010604 positive regulation of macromolecule metabolic process 45.4545 5 no
GO:0048522 positive regulation of cellular process 45.4545 4 no
GO:0048523 negative regulation of cellular process 45.4545 4 no
GO:0051246 regulation of protein metabolic process 45.4545 5 no
GO:0051247 positive regulation of protein metabolic process 45.4545 6 no
GO:0060255 regulation of macromolecule metabolic process 45.4545 4 no
GO:0080090 regulation of primary metabolic process 45.4545 4 no
GO:0009967 positive regulation of signal transduction 36.3636 5 no
GO:0010647 positive regulation of cell communication 36.3636 5 no
GO:0023056 positive regulation of signaling 36.3636 4 no
GO:0031323 regulation of cellular metabolic process 36.3636 4 no
GO:0031325 positive regulation of cellular metabolic process 36.3636 5 no
GO:0043085 positive regulation of catalytic activity 36.3636 4 no
GO:0043933 protein-containing complex organization 36.3636 4 no
GO:0048584 positive regulation of response to stimulus 36.3636 4 no
GO:0006796 phosphate-containing compound metabolic process 27.2727 4 yes
GO:0032880 regulation of protein localization 27.2727 5 no
GO:0060341 regulation of cellular localization 27.2727 4 no
GO:0006996 organelle organization 27.2727 4 no
GO:0008104 protein localization 27.2727 4 no
GO:0010562 positive regulation of phosphorus metabolic process 27.2727 6 no
GO:0019220 regulation of phosphate metabolic process 27.2727 6 no
GO:0022607 cellular component assembly 27.2727 4 no
GO:0031399 regulation of protein modification process 27.2727 6 no
GO:0031401 positive regulation of protein modification process 27.2727 7 no
GO:0045937 positive regulation of phosphate metabolic process 27.2727 7 no
GO:0050804 modulation of chemical synaptic transmission 27.2727 5 no
GO:0050890 cognition 27.2727 4 no
GO:0051128 regulation of cellular component organization 27.2727 4 no
GO:0051174 regulation of phosphorus metabolic process 27.2727 5 no
GO:0099177 regulation of trans-synaptic signaling 27.2727 4 no
GO:0009889 regulation of biosynthetic process 27.2727 4 no
GO:0009891 positive regulation of biosynthetic process 27.2727 5 no
GO:0009894 regulation of catabolic process 27.2727 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.2727 5 no
GO:0042981 regulation of apoptotic process 27.2727 5 no
GO:0043067 regulation of programmed cell death 27.2727 4 no
GO:0051336 regulation of hydrolase activity 27.2727 4 no
GO:0051345 positive regulation of hydrolase activity 27.2727 5 no
GO:1902531 regulation of intracellular signal transduction 27.2727 5 no
GO:0006020 inositol metabolic process 18.1818 5 yes
GO:0006021 inositol biosynthetic process 18.1818 6 yes
GO:0006644 phospholipid metabolic process 18.1818 4 yes
GO:0006650 glycerophospholipid metabolic process 18.1818 5 yes
GO:0006661 phosphatidylinositol biosynthetic process 18.1818 6 yes
GO:0008610 lipid biosynthetic process 18.1818 4 yes
GO:0008654 phospholipid biosynthetic process 18.1818 5 yes
GO:0019751 polyol metabolic process 18.1818 4 yes
GO:0045017 glycerolipid biosynthetic process 18.1818 4 yes
GO:0046165 alcohol biosynthetic process 18.1818 4 yes
GO:0046173 polyol biosynthetic process 18.1818 5 yes
GO:0046474 glycerophospholipid biosynthetic process 18.1818 5 yes
GO:0046486 glycerolipid metabolic process 18.1818 4 yes
GO:0046488 phosphatidylinositol metabolic process 18.1818 6 yes
GO:0046854 phosphatidylinositol phosphate biosynthetic process 18.1818 7 yes
GO:0090407 organophosphate biosynthetic process 18.1818 4 yes
GO:1901617 organic hydroxy compound biosynthetic process 18.1818 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
IMPA1_HUMAN [view entry] [view interactions] Low throughput yes yes
S100B_HUMAN [view entry] [view interactions] Low throughput yes yes
CALB1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
E2F3_HUMAN [view interactions] High throughput no no
IMPA2_HUMAN [view interactions] High throughput no no
B9D1_HUMAN [view interactions] High throughput no yes
SUMO3_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
KC1A_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
SIR1_HUMAN [view interactions] High throughput no yes
MET18_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
GDIR1_HUMAN [view entry] [view interactions] High throughput yes yes
DUT_HUMAN [view interactions] High throughput no yes
CYC_HUMAN [view entry] [view interactions] High throughput yes yes
IF6_HUMAN [view interactions] High throughput no yes
NUDT9_HUMAN [view interactions] High throughput no yes
6PGL_HUMAN [view interactions] High throughput no yes
ISCU_HUMAN [view interactions] High throughput no yes
PHP14_HUMAN [view interactions] High throughput no yes
RISC_HUMAN [view interactions] High throughput no yes
THIO_HUMAN [view interactions] High throughput no yes
UGDH_HUMAN [view interactions] High throughput no no
ACY1_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes