ADT1_HUMAN
Evidence for PS localization
Functions
ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (PubMed, PubMed). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane . In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis . Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) . Proton transporter activity requires free fatty acids as cofactor, but does not transport it . Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed). It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it . Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ADT1_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 25.3012 | 4 | no |
| GO:0019900 | kinase binding | 22.8916 | 4 | no |
| GO:0008324 | cation transmembrane transporter activity | 16.8675 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 16.8675 | 4 | yes |
| GO:0022853 | active ion transmembrane transporter activity | 14.4578 | 4 | yes |
| GO:0008509 | anion transmembrane transporter activity | 13.2530 | 4 | yes |
| GO:0008514 | organic anion transmembrane transporter activity | 9.6386 | 5 | yes |
| GO:0015078 | proton transmembrane transporter activity | 9.6386 | 5 | yes |
| GO:0015291 | secondary active transmembrane transporter activity | 7.2289 | 4 | yes |
| GO:0015297 | antiporter activity | 6.0241 | 5 | yes |
| GO:0000295 | adenine nucleotide transmembrane transporter activity | 4.8193 | 6 | yes |
| GO:0005346 | purine ribonucleotide transmembrane transporter activity | 4.8193 | 4 | yes |
| GO:0005347 | ATP transmembrane transporter activity | 4.8193 | 5 | yes |
| GO:0005471 | ATP:ADP antiporter activity | 4.8193 | 5 | yes |
| GO:0015215 | nucleotide transmembrane transporter activity | 4.8193 | 4 | yes |
| GO:0015216 | purine nucleotide transmembrane transporter activity | 4.8193 | 5 | yes |
| GO:0015217 | ADP transmembrane transporter activity | 4.8193 | 5 | yes |
| GO:0140323 | solute:anion antiporter activity | 4.8193 | 6 | yes |
| GO:0005345 | purine nucleobase transmembrane transporter activity | 2.4096 | 4 | yes |
| GO:0015207 | adenine transmembrane transporter activity | 2.4096 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ADT1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 50.6024 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 43.3735 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 43.3735 | 4 | yes |
| GO:0022607 | cellular component assembly | 40.9639 | 4 | no |
| GO:0006996 | organelle organization | 39.7590 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 39.7590 | 4 | no |
| GO:0010646 | regulation of cell communication | 38.5542 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 38.5542 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 38.5542 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 37.3494 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 37.3494 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 34.9398 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.5301 | 5 | yes |
| GO:0051049 | regulation of transport | 32.5301 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.3253 | 5 | no |
| GO:0010941 | regulation of cell death | 30.1205 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 30.1205 | 5 | yes |
| GO:0071702 | organic substance transport | 30.1205 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.1205 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 30.1205 | 5 | no |
| GO:0008104 | protein localization | 30.1205 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 28.9157 | 5 | no |
| GO:0023056 | positive regulation of signaling | 28.9157 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 27.7108 | 5 | yes |
| GO:0071705 | nitrogen compound transport | 27.7108 | 4 | yes |
| GO:0010468 | regulation of gene expression | 27.7108 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 26.5060 | 6 | no |
| GO:0031399 | regulation of protein modification process | 26.5060 | 6 | no |
| GO:0060548 | negative regulation of cell death | 25.3012 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 25.3012 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 25.3012 | 7 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.3012 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.3012 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.3012 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 24.0964 | 7 | no |
| GO:0060341 | regulation of cellular localization | 24.0964 | 4 | no |
| GO:0033043 | regulation of organelle organization | 22.8916 | 5 | yes |
| GO:0043069 | negative regulation of programmed cell death | 22.8916 | 6 | yes |
| GO:0009967 | positive regulation of signal transduction | 22.8916 | 5 | no |
| GO:0032880 | regulation of protein localization | 22.8916 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.8916 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.8916 | 4 | no |
| GO:0036211 | protein modification process | 22.8916 | 4 | no |
| GO:0043412 | macromolecule modification | 22.8916 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 21.6867 | 7 | no |
| GO:0030030 | cell projection organization | 21.6867 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 21.6867 | 7 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.6867 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 21.6867 | 4 | no |
| GO:0071310 | cellular response to organic substance | 21.6867 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 20.4819 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 20.4819 | 4 | no |
| GO:0043933 | protein-containing complex organization | 20.4819 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 20.4819 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.4819 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 20.4819 | 4 | no |
| GO:0009894 | regulation of catabolic process | 19.2771 | 4 | yes |
| GO:0010638 | positive regulation of organelle organization | 16.8675 | 6 | yes |
| GO:0031329 | regulation of cellular catabolic process | 16.8675 | 5 | yes |
| GO:0006811 | ion transport | 15.6627 | 4 | yes |
| GO:0061024 | membrane organization | 15.6627 | 4 | yes |
| GO:0007005 | mitochondrion organization | 13.2530 | 5 | yes |
| GO:0006820 | anion transport | 12.0482 | 5 | yes |
| GO:0009896 | positive regulation of catabolic process | 12.0482 | 5 | yes |
| GO:0031331 | positive regulation of cellular catabolic process | 10.8434 | 6 | yes |
| GO:0010506 | regulation of autophagy | 9.6386 | 6 | yes |
| GO:0015711 | organic anion transport | 9.6386 | 5 | yes |
| GO:0010821 | regulation of mitochondrion organization | 8.4337 | 6 | yes |
| GO:0098656 | anion transmembrane transport | 8.4337 | 4 | yes |
| GO:0007006 | mitochondrial membrane organization | 7.2289 | 5 | yes |
| GO:0015931 | nucleobase-containing compound transport | 7.2289 | 5 | yes |
| GO:0010508 | positive regulation of autophagy | 6.0241 | 7 | yes |
| GO:0010822 | positive regulation of mitochondrion organization | 6.0241 | 7 | yes |
| GO:0016241 | regulation of macroautophagy | 6.0241 | 7 | yes |
| GO:0006862 | nucleotide transport | 4.8193 | 6 | yes |
| GO:0015748 | organophosphate ester transport | 4.8193 | 5 | yes |
| GO:0015865 | purine nucleotide transport | 4.8193 | 7 | yes |
| GO:0015866 | ADP transport | 4.8193 | 6 | yes |
| GO:0015867 | ATP transport | 4.8193 | 6 | yes |
| GO:0015868 | purine ribonucleotide transport | 4.8193 | 6 | yes |
| GO:0016239 | positive regulation of macroautophagy | 4.8193 | 8 | yes |
| GO:0046902 | regulation of mitochondrial membrane permeability | 4.8193 | 4 | yes |
| GO:0051503 | adenine nucleotide transport | 4.8193 | 8 | yes |
| GO:0140021 | mitochondrial ADP transmembrane transport | 4.8193 | 4 | yes |
| GO:1901264 | carbohydrate derivative transport | 4.8193 | 5 | yes |
| GO:1903146 | regulation of autophagy of mitochondrion | 4.8193 | 7 | yes |
| GO:1903599 | positive regulation of autophagy of mitochondrion | 4.8193 | 8 | yes |
| GO:1990544 | mitochondrial ATP transmembrane transport | 4.8193 | 4 | yes |
| GO:0008637 | apoptotic mitochondrial changes | 3.6145 | 6 | yes |
| GO:1901524 | regulation of mitophagy | 3.6145 | 8 | yes |
| GO:1901526 | positive regulation of mitophagy | 3.6145 | 9 | yes |
| GO:0000002 | mitochondrial genome maintenance | 2.4096 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ADT1_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 2.4096 | 4 | no |
| DOID:331 | central nervous system disease | 2.4096 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ANDR_HUMAN | [view interactions] | Low throughput | no | no |
| BAX_HUMAN | [view interactions] | Low throughput | no | yes |
| IKBA_HUMAN | [view interactions] | Low throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TIM44_HUMAN | [view interactions] | Low throughput | no | yes |
| TIM23_HUMAN | [view interactions] | Low throughput | no | yes |
| AR2BP_HUMAN | [view interactions] | Low throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| NR4A1_HUMAN | [view interactions] | Low throughput | no | yes |
| F16P1_HUMAN | [view interactions] | Low throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PPIF_HUMAN | [view interactions] | Low throughput | no | no |
| B2L13_HUMAN | [view interactions] | Low throughput | no | no |
| KPCE_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| TNR1B_HUMAN | [view interactions] | High throughput | no | no |
| BCLF1_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD6_HUMAN | [view interactions] | High throughput | no | no |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| CSAG2_HUMAN | [view interactions] | High throughput | no | no |
| TIFAB_HUMAN | [view interactions] | High throughput | no | no |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| MGMT_HUMAN | [view interactions] | High throughput | no | no |
| TFE2_HUMAN | [view interactions] | High throughput | no | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| LIPC_HUMAN | [view interactions] | High throughput | no | no |
| UBL4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLN3_HUMAN | [view interactions] | High throughput | no | no |
| CLN5_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| GAN_HUMAN | [view interactions] | High throughput | no | yes |
| SKI_HUMAN | [view interactions] | High throughput | no | yes |
| PODO_HUMAN | [view interactions] | High throughput | no | no |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN8_HUMAN | [view interactions] | High throughput | no | yes |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| SG2A2_HUMAN | [view interactions] | High throughput | no | no |
| GLMP_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA2_HUMAN | [view interactions] | High throughput | no | no |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| GLUC_HUMAN | [view interactions] | High throughput | no | no |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| GRIA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| PAEP_HUMAN | [view interactions] | High throughput | no | no |
| DPA1_HUMAN | [view interactions] | High throughput | no | yes |
| OSTM1_HUMAN | [view interactions] | High throughput | no | yes |
| TMEM9_HUMAN | [view interactions] | High throughput | no | no |
| CCG7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
| STR3N_HUMAN | [view interactions] | High throughput | no | yes |
| KLK1_HUMAN | [view interactions] | High throughput | no | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEL3A_HUMAN | [view interactions] | High throughput | no | no |
| DQB1_HUMAN | [view interactions] | High throughput | no | no |
| ADT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIPR2_HUMAN | [view interactions] | High throughput | no | no |
| KLK8_HUMAN | [view interactions] | High throughput | no | no |
| OIT3_HUMAN | [view interactions] | High throughput | no | no |
| GP107_HUMAN | [view interactions] | High throughput | no | yes |
| T150A_HUMAN | [view interactions] | High throughput | no | yes |
| ITLN1_HUMAN | [view interactions] | High throughput | no | no |
| ACRBP_HUMAN | [view interactions] | High throughput | no | no |
| KCNK1_HUMAN | [view interactions] | High throughput | no | yes |
| VIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| CTDS1_HUMAN | [view interactions] | High throughput | no | no |
| BTNL2_HUMAN | [view interactions] | High throughput | no | no |
| DQA1_HUMAN | [view interactions] | High throughput | no | yes |
| EDNRA_HUMAN | [view interactions] | High throughput | no | yes |
| CTDS2_HUMAN | [view interactions] | High throughput | no | yes |
| HLAG_HUMAN | [view interactions] | High throughput | no | no |
| GTR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLC2D_HUMAN | [view interactions] | High throughput | no | yes |
| NDK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| SPRY7_HUMAN | [view interactions] | High throughput | no | yes |
| OPALI_HUMAN | [view interactions] | High throughput | no | yes |
| LRN4L_HUMAN | [view interactions] | High throughput | no | yes |
| CST9L_HUMAN | [view interactions] | High throughput | no | no |
| TNFL8_HUMAN | [view interactions] | High throughput | no | no |
| THTPA_HUMAN | [view interactions] | High throughput | no | yes |
| EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DPB1_HUMAN | [view interactions] | High throughput | no | no |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| CCG4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| A4GCT_HUMAN | [view interactions] | High throughput | no | no |
| FCN3_HUMAN | [view interactions] | High throughput | no | no |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| APJ_HUMAN | [view interactions] | High throughput | no | yes |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| TSAP1_HUMAN | [view interactions] | High throughput | no | no |
| FCG3B_HUMAN | [view interactions] | High throughput | no | no |
| RAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LYAG_HUMAN | [view interactions] | High throughput | no | yes |
| MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| CD79A_HUMAN | [view interactions] | High throughput | no | no |
| DOXA2_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| SGCA_HUMAN | [view interactions] | High throughput | no | yes |
| NAAA_HUMAN | [view interactions] | High throughput | no | yes |
| DRA_HUMAN | [view interactions] | High throughput | no | no |
| THB_HUMAN | [view interactions] | High throughput | no | no |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RSSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL10L_HUMAN | [view interactions] | High throughput | no | no |
| GALT2_HUMAN | [view interactions] | High throughput | no | yes |
| RS3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VA0D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCMC1_HUMAN | [view interactions] | High throughput | no | no |
| ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ICAM1_HUMAN | [view interactions] | High throughput | no | no |
| PRDX3_HUMAN | [view interactions] | High throughput | no | yes |
| GBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLEC_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 4F2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRAF3_HUMAN | [view interactions] | High throughput | no | yes |
| MOGS_HUMAN | [view interactions] | High throughput | no | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COX5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| ATPD_HUMAN | [view interactions] | High throughput | no | yes |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5I_HUMAN | [view interactions] | High throughput | no | yes |
| AT5L2_HUMAN | [view interactions] | High throughput | no | no |
| ATP5L_HUMAN | [view interactions] | High throughput | no | yes |
| CISD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPID_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFKAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX6C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDH3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM47_HUMAN | [view interactions] | High throughput | no | yes |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCU_HUMAN | [view interactions] | High throughput | no | yes |
| MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SURF1_HUMAN | [view interactions] | High throughput | no | yes |
| TMM70_HUMAN | [view interactions] | High throughput | no | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PANX1_HUMAN | [view interactions] | High throughput | no | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| RPA49_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| HEM6_HUMAN | [view interactions] | High throughput | no | no |
| HEMH_HUMAN | [view interactions] | High throughput | no | yes |
| PPOX_HUMAN | [view interactions] | High throughput | no | no |
| CFA97_HUMAN | [view interactions] | High throughput | no | yes |
| PCNT_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGRC2_HUMAN | [view interactions] | High throughput | no | yes |
| ISLR_HUMAN | [view interactions] | High throughput | no | no |
| ACM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RRP1B_HUMAN | [view interactions] | High throughput | no | yes |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK07_HUMAN | [view interactions] | High throughput | no | yes |
| M3K14_HUMAN | [view interactions] | High throughput | no | yes |
| PAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| GRID2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COQ2_HUMAN | [view interactions] | High throughput | no | yes |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| SOAT1_HUMAN | [view interactions] | High throughput | no | no |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RD23B_HUMAN | [view interactions] | High throughput | no | yes |
| E2F3_HUMAN | [view interactions] | High throughput | no | no |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MICA3_HUMAN | [view interactions] | High throughput | no | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RD3_HUMAN | [view interactions] | High throughput | no | no |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| TOM70_HUMAN | [view interactions] | Computational | no | yes |
| TOM22_HUMAN | [view interactions] | Computational | no | yes |
| TSPO_HUMAN | [view interactions] | Computational | no | yes |
| T10B_HUMAN | [view interactions] | Computational | no | yes |
| TOM7_HUMAN | [view interactions] | Computational | no | no |
| TOM6_HUMAN | [view interactions] | Computational | no | yes |
| AT5G1_HUMAN | [view interactions] | Computational | no | no |
| TOM20_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TI17B_HUMAN | [view interactions] | Computational | no | no |
| GRP75_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TOM5_HUMAN | [view interactions] | Computational | no | yes |
| DPOG1_HUMAN | [view interactions] | Computational | no | yes |
| TOM40_HUMAN | [view interactions] | Computational | no | yes |
| TI17A_HUMAN | [view interactions] | Computational | no | yes |
| ADT4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| BCS1_HUMAN | [view interactions] | Computational | no | yes |
| TAZ_HUMAN | [view interactions] | Computational | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VDAC2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| IDH3G_HUMAN | [view entry] [view interactions] | Computational | yes | yes |