NDK3_HUMAN
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in NDK3_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 46.6667 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 46.6667 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 46.6667 | 4 | yes |
GO:0005524 | ATP binding | 40.0000 | 5 | yes |
GO:0030554 | adenyl nucleotide binding | 40.0000 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 40.0000 | 5 | yes |
GO:0016301 | kinase activity | 33.3333 | 4 | yes |
GO:0046872 | metal ion binding | 30.0000 | 4 | yes |
GO:0016776 | phosphotransferase activity, phosphate group as acceptor | 26.6667 | 4 | yes |
GO:0019205 | nucleobase-containing compound kinase activity | 26.6667 | 5 | yes |
GO:0004550 | nucleoside diphosphate kinase activity | 20.0000 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in NDK3_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 40.0000 | 4 | yes |
GO:0006753 | nucleoside phosphate metabolic process | 36.6667 | 4 | yes |
GO:0009117 | nucleotide metabolic process | 36.6667 | 5 | yes |
GO:0018130 | heterocycle biosynthetic process | 36.6667 | 4 | yes |
GO:0019438 | aromatic compound biosynthetic process | 36.6667 | 4 | yes |
GO:0034654 | nucleobase-containing compound biosynthetic process | 36.6667 | 4 | yes |
GO:0044271 | cellular nitrogen compound biosynthetic process | 36.6667 | 4 | yes |
GO:1901362 | organic cyclic compound biosynthetic process | 36.6667 | 4 | yes |
GO:0009165 | nucleotide biosynthetic process | 33.3333 | 6 | yes |
GO:0090407 | organophosphate biosynthetic process | 33.3333 | 4 | yes |
GO:1901137 | carbohydrate derivative biosynthetic process | 33.3333 | 4 | yes |
GO:1901293 | nucleoside phosphate biosynthetic process | 33.3333 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
GO:0006163 | purine nucleotide metabolic process | 30.0000 | 5 | yes |
GO:0009141 | nucleoside triphosphate metabolic process | 30.0000 | 5 | yes |
GO:0009259 | ribonucleotide metabolic process | 30.0000 | 5 | yes |
GO:0019693 | ribose phosphate metabolic process | 30.0000 | 4 | yes |
GO:0072521 | purine-containing compound metabolic process | 30.0000 | 4 | yes |
GO:1901566 | organonitrogen compound biosynthetic process | 30.0000 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 30.0000 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 30.0000 | 5 | no |
GO:0060255 | regulation of macromolecule metabolic process | 30.0000 | 4 | no |
GO:0006164 | purine nucleotide biosynthetic process | 26.6667 | 6 | yes |
GO:0009142 | nucleoside triphosphate biosynthetic process | 26.6667 | 6 | yes |
GO:0009144 | purine nucleoside triphosphate metabolic process | 26.6667 | 6 | yes |
GO:0009150 | purine ribonucleotide metabolic process | 26.6667 | 6 | yes |
GO:0009199 | ribonucleoside triphosphate metabolic process | 26.6667 | 6 | yes |
GO:0009205 | purine ribonucleoside triphosphate metabolic process | 26.6667 | 7 | yes |
GO:0009260 | ribonucleotide biosynthetic process | 26.6667 | 6 | yes |
GO:0046390 | ribose phosphate biosynthetic process | 26.6667 | 5 | yes |
GO:0072522 | purine-containing compound biosynthetic process | 26.6667 | 5 | yes |
GO:0008104 | protein localization | 26.6667 | 4 | no |
GO:0010941 | regulation of cell death | 26.6667 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 26.6667 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 26.6667 | 5 | no |
GO:0043067 | regulation of programmed cell death | 26.6667 | 5 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 26.6667 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.6667 | 5 | no |
GO:0080090 | regulation of primary metabolic process | 26.6667 | 4 | no |
GO:0006220 | pyrimidine nucleotide metabolic process | 23.3333 | 5 | yes |
GO:0009152 | purine ribonucleotide biosynthetic process | 23.3333 | 7 | yes |
GO:0009218 | pyrimidine ribonucleotide metabolic process | 23.3333 | 6 | yes |
GO:0072527 | pyrimidine-containing compound metabolic process | 23.3333 | 4 | yes |
GO:0071702 | organic substance transport | 23.3333 | 4 | no |
GO:0071705 | nitrogen compound transport | 23.3333 | 4 | no |
GO:0006996 | organelle organization | 23.3333 | 4 | no |
GO:0009894 | regulation of catabolic process | 23.3333 | 4 | no |
GO:0009132 | nucleoside diphosphate metabolic process | 23.3333 | 5 | no |
GO:0031399 | regulation of protein modification process | 23.3333 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 23.3333 | 7 | no |
GO:0048584 | positive regulation of response to stimulus | 23.3333 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 23.3333 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 23.3333 | 6 | no |
GO:0042981 | regulation of apoptotic process | 23.3333 | 6 | no |
GO:0006221 | pyrimidine nucleotide biosynthetic process | 20.0000 | 6 | yes |
GO:0009220 | pyrimidine ribonucleotide biosynthetic process | 20.0000 | 7 | yes |
GO:0072528 | pyrimidine-containing compound biosynthetic process | 20.0000 | 5 | yes |
GO:0006915 | apoptotic process | 16.6667 | 4 | yes |
GO:0009145 | purine nucleoside triphosphate biosynthetic process | 16.6667 | 7 | yes |
GO:0009147 | pyrimidine nucleoside triphosphate metabolic process | 16.6667 | 6 | yes |
GO:0009201 | ribonucleoside triphosphate biosynthetic process | 16.6667 | 7 | yes |
GO:0009206 | purine ribonucleoside triphosphate biosynthetic process | 16.6667 | 8 | yes |
GO:0009208 | pyrimidine ribonucleoside triphosphate metabolic process | 16.6667 | 7 | yes |
GO:0046039 | GTP metabolic process | 16.6667 | 7 | yes |
GO:0046051 | UTP metabolic process | 16.6667 | 7 | yes |
GO:0006183 | GTP biosynthetic process | 13.3333 | 8 | yes |
GO:0006228 | UTP biosynthetic process | 13.3333 | 8 | yes |
GO:0006241 | CTP biosynthetic process | 13.3333 | 8 | yes |
GO:0009148 | pyrimidine nucleoside triphosphate biosynthetic process | 13.3333 | 7 | yes |
GO:0009209 | pyrimidine ribonucleoside triphosphate biosynthetic process | 13.3333 | 8 | yes |
GO:0046036 | CTP metabolic process | 13.3333 | 7 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
NDK3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NDKA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NDKB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
5HT2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IFT27_HUMAN | [view interactions] | High throughput | no | yes |
EXD2_HUMAN | [view interactions] | High throughput | no | yes |
BBS2_HUMAN | [view interactions] | High throughput | no | no |
BBS7_HUMAN | [view interactions] | High throughput | no | no |
PTHB1_HUMAN | [view interactions] | High throughput | no | yes |
NDK8_HUMAN | [view interactions] | High throughput | no | no |
NDKM_HUMAN | [view interactions] | High throughput | no | yes |
NMES1_HUMAN | [view interactions] | High throughput | no | no |
COQ9_HUMAN | [view interactions] | High throughput | no | yes |
PHLA3_HUMAN | [view interactions] | High throughput | no | yes |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
JAM2_HUMAN | [view interactions] | High throughput | no | no |
SGTA_HUMAN | [view interactions] | High throughput | no | yes |
UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
SGTB_HUMAN | [view interactions] | High throughput | no | yes |
UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
DESI1_HUMAN | [view interactions] | High throughput | no | yes |
FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
INT11_HUMAN | [view interactions] | High throughput | no | yes |
COX14_HUMAN | [view interactions] | High throughput | no | yes |
MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLRKT_HUMAN | [view interactions] | High throughput | no | yes |
SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOM22_HUMAN | [view interactions] | High throughput | no | yes |
TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
FLT3_HUMAN | [view interactions] | High throughput | no | no |
VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
RING2_HUMAN | [view interactions] | High throughput | no | yes |
KS6B2_HUMAN | [view interactions] | High throughput | no | yes |
DUS22_HUMAN | [view interactions] | High throughput | no | yes |
DUS23_HUMAN | [view interactions] | High throughput | no | yes |
DUS6_HUMAN | [view interactions] | High throughput | no | yes |
DUS9_HUMAN | [view interactions] | High throughput | no | no |
BBS5_HUMAN | [view interactions] | High throughput | no | yes |
BBS4_HUMAN | [view interactions] | High throughput | no | no |
TTC8_HUMAN | [view interactions] | High throughput | no | no |
PEX14_HUMAN | [view interactions] | High throughput | no | yes |
AAR2_HUMAN | [view interactions] | High throughput | no | no |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
M3K15_HUMAN | [view interactions] | High throughput | no | no |
SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MIA40_HUMAN | [view interactions] | High throughput | no | yes |
BBS1_HUMAN | [view interactions] | High throughput | no | no |
AAKG1_HUMAN | [view interactions] | High throughput | no | no |
SFXN2_HUMAN | [view interactions] | High throughput | no | no |
EHD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NUBP2_HUMAN | [view interactions] | High throughput | no | yes |
AL3B1_HUMAN | [view interactions] | High throughput | no | yes |
S2540_HUMAN | [view interactions] | High throughput | no | no |
TBB1_HUMAN | [view interactions] | High throughput | no | yes |
XPO5_HUMAN | [view interactions] | High throughput | no | yes |
MCATL_HUMAN | [view interactions] | High throughput | no | no |
HEAT6_HUMAN | [view interactions] | High throughput | no | no |
ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBR4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPAT2_HUMAN | [view interactions] | High throughput | no | no |
TKFC_HUMAN | [view interactions] | High throughput | no | no |
MROH1_HUMAN | [view interactions] | High throughput | no | yes |
NRBP_HUMAN | [view interactions] | High throughput | no | yes |
VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLH2_HUMAN | [view interactions] | High throughput | no | no |
TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBB5_HUMAN | [view interactions] | High throughput | no | yes |
TBB8_HUMAN | [view interactions] | High throughput | no | no |
NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TM11B_HUMAN | [view interactions] | High throughput | no | no |
TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTH2_HUMAN | [view interactions] | High throughput | no | yes |
TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VP33B_HUMAN | [view interactions] | High throughput | no | yes |
CATL1_HUMAN | [view interactions] | High throughput | no | yes |
DCTP1_HUMAN | [view interactions] | Computational | no | no |
KAD5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AP4A_HUMAN | [view interactions] | Computational | no | no |
KAD3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NDK7_HUMAN | [view interactions] | Computational | no | yes |
KCY_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MESH1_HUMAN | [view interactions] | Computational | no | yes |
KAT5_HUMAN | [view interactions] | Computational | no | yes |
RIR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KAD9_HUMAN | [view interactions] | Computational | no | yes |
DUT_HUMAN | [view interactions] | Computational | no | yes |
KPYR_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ENTP2_HUMAN | [view interactions] | Computational | no | yes |
NTPCR_HUMAN | [view interactions] | Computational | no | yes |
KGUA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CMPK2_HUMAN | [view interactions] | Computational | no | yes |
NUD16_HUMAN | [view interactions] | Computational | no | yes |
KTHY_HUMAN | [view interactions] | Computational | no | yes |
RIR2_HUMAN | [view interactions] | Computational | no | no |
PYRG2_HUMAN | [view interactions] | Computational | no | yes |
GCH1_HUMAN | [view interactions] | Computational | no | no |
RIR2B_HUMAN | [view interactions] | Computational | no | yes |
ITPA_HUMAN | [view interactions] | Computational | no | yes |
KPYM_HUMAN | [view interactions] | Computational | no | yes |