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UCRI_HUMAN

Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII). UQCRFS1 undergoes proteolytic processing once it is incorporated in the complex III dimer. One of the fragments, called subunit 9, corresponds to its mitochondrial targeting sequence (MTS). The proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer, but the persistence of UQCRFS1-derived fragments may prevent newly imported UQCRFS1 to be processed and assembled into complex III and is detrimental for the complex III structure and function. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in UCRI_HUMAN
GO:0015399 primary active transmembrane transporter activity 33.3333 4 yes
GO:0015453 oxidoreduction-driven active transmembrane transporter activity 32.3529 5 yes
GO:0046872 metal ion binding 27.4510 4 yes
GO:0003954 NADH dehydrogenase activity 22.5490 4 no
GO:0003955 NAD(P)H dehydrogenase (quinone) activity 22.5490 5 no
GO:0008137 NADH dehydrogenase (ubiquinone) activity 22.5490 4 no
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 22.5490 4 no
GO:0050136 NADH dehydrogenase (quinone) activity 22.5490 5 no
GO:0008324 cation transmembrane transporter activity 14.7059 4 yes
GO:0022853 active ion transmembrane transporter activity 13.7255 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 13.7255 4 yes
GO:0015078 proton transmembrane transporter activity 12.7451 5 yes
GO:0051537 2 iron, 2 sulfur cluster binding 4.9020 4 yes
GO:0008121 ubiquinol-cytochrome-c reductase activity 3.9216 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in UCRI_HUMAN
GO:0009060 aerobic respiration 36.2745 6 yes
GO:0015980 energy derivation by oxidation of organic compounds 36.2745 4 yes
GO:0045333 cellular respiration 36.2745 5 yes
GO:0022900 electron transport chain 35.2941 4 yes
GO:0022904 respiratory electron transport chain 35.2941 5 yes
GO:0019646 aerobic electron transport chain 33.3333 6 yes
GO:0022607 cellular component assembly 29.4118 4 yes
GO:0019752 carboxylic acid metabolic process 26.4706 5 no
GO:0043436 oxoacid metabolic process 26.4706 4 no
GO:0043933 protein-containing complex organization 25.4902 4 yes
GO:0065003 protein-containing complex assembly 25.4902 5 yes
GO:0006996 organelle organization 22.5490 4 no
GO:0048522 positive regulation of cellular process 21.5686 4 no
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 21.5686 7 no
GO:0033108 mitochondrial respiratory chain complex assembly 19.6078 6 yes
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 5.8824 7 yes
GO:0017004 cytochrome complex assembly 1.9608 6 yes
GO:0017062 respiratory chain complex III assembly 1.9608 7 yes
GO:0034551 mitochondrial respiratory chain complex III assembly 1.9608 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in UCRI_HUMAN
DOID:0050155 sensory system disease 1.9608 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
QCR2_HUMAN [view entry] [view interactions] Low throughput yes yes
LYRM7_HUMAN [view interactions] Low throughput no yes
QCR6L_HUMAN [view interactions] Low throughput no yes
CY1_HUMAN [view entry] [view interactions] Low throughput yes yes
QCR1_HUMAN [view entry] [view interactions] Low throughput yes yes
PELI1_HUMAN [view interactions] Low throughput no yes
PELI2_HUMAN [view interactions] Low throughput no yes
PELI3_HUMAN [view interactions] Low throughput no yes
QCR10_HUMAN [view interactions] Low throughput no no
UCRI_HUMAN [view entry] [view interactions] Low throughput yes yes
QCR9_HUMAN [view interactions] Low throughput no no
QCR6_HUMAN [view interactions] Low throughput no yes
CYB_HUMAN [view interactions] Low throughput no yes
QCR7_HUMAN [view entry] [view interactions] Low throughput yes yes
QCR8_HUMAN [view interactions] Low throughput no yes
NDK6_HUMAN [view interactions] High throughput no yes
GLSK_HUMAN [view entry] [view interactions] High throughput yes yes
DEFM_HUMAN [view interactions] High throughput no yes
SYEM_HUMAN [view interactions] High throughput no yes
CK5P1_HUMAN [view interactions] High throughput no no
CIA30_HUMAN [view interactions] High throughput no yes
GATB_HUMAN [view interactions] High throughput no yes
TMM70_HUMAN [view interactions] High throughput no yes
CP24A_HUMAN [view interactions] High throughput no no
ECHD3_HUMAN [view interactions] High throughput no no
LTOR4_HUMAN [view interactions] High throughput no yes
CBR4_HUMAN [view interactions] High throughput no yes
TRUA_HUMAN [view interactions] High throughput no yes
NUBPL_HUMAN [view interactions] High throughput no no
SYTM_HUMAN [view interactions] High throughput no yes
PCCA_HUMAN [view entry] [view interactions] High throughput yes yes
CX7A2_HUMAN [view interactions] High throughput no no
ODBA_HUMAN [view interactions] High throughput no yes
TMLH_HUMAN [view interactions] High throughput no yes
SPRTN_HUMAN [view interactions] High throughput no yes
WIPI1_HUMAN [view interactions] High throughput no yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
ASSY_HUMAN [view interactions] High throughput no yes
CLIP1_HUMAN [view entry] [view interactions] High throughput yes yes
HEAT3_HUMAN [view interactions] High throughput no yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
SERA_HUMAN [view entry] [view interactions] High throughput yes yes
RBM39_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
SDHA_HUMAN [view interactions] High throughput no yes
SDHB_HUMAN [view interactions] High throughput no yes
SCAF4_HUMAN [view interactions] High throughput no yes
SBP1_HUMAN [view interactions] High throughput no no
PPAL_HUMAN [view interactions] High throughput no no
UBP7_HUMAN [view interactions] High throughput no yes
VAPB_HUMAN [view entry] [view interactions] High throughput yes yes
SRSF3_HUMAN [view interactions] High throughput no yes
THTM_HUMAN [view interactions] High throughput no yes
TOM7_HUMAN [view interactions] High throughput no no
TIM9_HUMAN [view interactions] High throughput no yes
SCOT1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB14_HUMAN [view entry] [view interactions] High throughput yes yes
SDHF2_HUMAN [view interactions] High throughput no yes
NHRF1_HUMAN [view interactions] High throughput no no
ZN454_HUMAN [view interactions] High throughput no no
FKBP8_HUMAN [view entry] [view interactions] High throughput yes yes
SEPT9_HUMAN [view interactions] High throughput no no
MGT4B_HUMAN [view interactions] High throughput no no
ERGI1_HUMAN [view interactions] High throughput no yes
MPV17_HUMAN [view interactions] High throughput no no
TM9S4_HUMAN [view interactions] High throughput no yes
IF4A1_HUMAN [view interactions] High throughput no no
MRP2_HUMAN [view interactions] High throughput no no
AL1B1_HUMAN [view interactions] High throughput no yes
CYC_HUMAN [view entry] [view interactions] High throughput yes yes
LYAG_HUMAN [view interactions] High throughput no yes
LEG1_HUMAN [view interactions] High throughput no yes
MDHC_HUMAN [view entry] [view interactions] High throughput yes yes
PGM1_HUMAN [view interactions] High throughput no no
TPIS_HUMAN [view entry] [view interactions] High throughput yes yes
TXD17_HUMAN [view interactions] High throughput no yes
THIL_HUMAN [view entry] [view interactions] High throughput yes yes
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
ATP5J_HUMAN [view interactions] High throughput no yes
ATIF1_HUMAN [view interactions] High throughput no yes
CYB5B_HUMAN [view entry] [view interactions] High throughput yes yes
GSTO1_HUMAN [view entry] [view interactions] High throughput yes yes
HACL2_HUMAN [view interactions] High throughput no yes
NDUB4_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB8_HUMAN [view entry] [view interactions] High throughput yes yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
OAT_HUMAN [view interactions] High throughput no yes
TSR1_HUMAN [view interactions] High throughput no no
XPP1_HUMAN [view interactions] High throughput no yes
CISY_HUMAN [view entry] [view interactions] High throughput yes yes
CATD_HUMAN [view interactions] High throughput no yes
NPS3A_HUMAN [view interactions] High throughput no yes
ATPB_HUMAN [view interactions] High throughput no yes
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
RAE1L_HUMAN [view interactions] High throughput no no
M2OM_HUMAN [view entry] [view interactions] High throughput yes yes
ATPD_HUMAN [view interactions] High throughput no yes
ATP5H_HUMAN [view interactions] High throughput no yes
ATPO_HUMAN [view interactions] High throughput no yes
MIC19_HUMAN [view entry] [view interactions] High throughput yes yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
IDH3A_HUMAN [view entry] [view interactions] High throughput yes yes
ISCA1_HUMAN [view interactions] High throughput no yes
NDUA8_HUMAN [view entry] [view interactions] High throughput yes yes
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS4_HUMAN [view interactions] High throughput no yes
NDUS7_HUMAN [view entry] [view interactions] High throughput yes no
NDUV2_HUMAN [view entry] [view interactions] High throughput yes yes
ODPB_HUMAN [view entry] [view interactions] High throughput yes yes
SUCB1_HUMAN [view entry] [view interactions] High throughput yes yes
SUCA_HUMAN [view entry] [view interactions] High throughput yes yes
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
ATPA_HUMAN [view interactions] High throughput no yes
ATPG_HUMAN [view interactions] High throughput no yes
AT5F1_HUMAN [view interactions] High throughput no yes
ICT1_HUMAN [view interactions] High throughput no yes
ATP5I_HUMAN [view interactions] High throughput no yes
COX6C_HUMAN [view entry] [view interactions] High throughput yes yes
ATPK_HUMAN [view interactions] High throughput no yes
NDUAC_HUMAN [view entry] [view interactions] High throughput yes yes
AT5L2_HUMAN [view interactions] High throughput no no
NDUS5_HUMAN [view interactions] High throughput no yes
ATP5L_HUMAN [view interactions] High throughput no yes
NDUA9_HUMAN [view entry] [view interactions] High throughput yes yes
CISD1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUAB_HUMAN [view interactions] High throughput no no
KCRS_HUMAN [view interactions] High throughput no no
NDUAD_HUMAN [view entry] [view interactions] High throughput yes yes
COQ9_HUMAN [view interactions] High throughput no yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
COX5A_HUMAN [view entry] [view interactions] High throughput yes yes
RMD3_HUMAN [view interactions] High throughput no yes
ODP2_HUMAN [view entry] [view interactions] High throughput yes yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
GOT1B_HUMAN [view interactions] High throughput no yes
IDH3G_HUMAN [view entry] [view interactions] High throughput yes yes
NDUAA_HUMAN [view entry] [view interactions] High throughput yes yes
ISCU_HUMAN [view interactions] High throughput no yes
NDUA3_HUMAN [view interactions] High throughput no yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA5_HUMAN [view entry] [view interactions] High throughput yes yes
HSC20_HUMAN [view interactions] High throughput no yes
NDUA6_HUMAN [view interactions] High throughput no no
NMES1_HUMAN [view interactions] High throughput no no
NDUB7_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
NDUC2_HUMAN [view interactions] High throughput no yes
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
NDUCR_HUMAN [view interactions] High throughput no yes
PTPM1_HUMAN [view interactions] High throughput no yes
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
CISD3_HUMAN [view interactions] High throughput no yes
NDUS2_HUMAN [view entry] [view interactions] High throughput yes yes
SPT20_HUMAN [view interactions] High throughput no yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
PRD16_HUMAN [view interactions] High throughput no no
ADT1_HUMAN [view entry] [view interactions] High throughput yes yes
MECOM_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
MIC26_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K1_HUMAN [view entry] [view interactions] High throughput yes yes
ATP5E_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
FUMH_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
NDUB5_HUMAN [view interactions] High throughput no yes
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB6_HUMAN [view entry] [view interactions] High throughput yes yes
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
NDUV3_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
KCNQ1_HUMAN [view interactions] High throughput no yes
HINT2_HUMAN [view interactions] High throughput no yes
CAV3_HUMAN [view interactions] High throughput no no
MET17_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
S2551_HUMAN [view interactions] High throughput no no
CNDD3_HUMAN [view interactions] High throughput no no
SSBP_HUMAN [view entry] [view interactions] High throughput yes yes
G3BP1_HUMAN [view interactions] High throughput no yes
EXD2_HUMAN [view interactions] High throughput no yes
RELB_HUMAN [view interactions] High throughput no yes
MK11_HUMAN [view interactions] High throughput no yes
SOX5_HUMAN [view interactions] High throughput no no
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
5HT6R_HUMAN [view interactions] High throughput no yes
BROMI_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
FOXS1_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
CIAO1_HUMAN [view interactions] High throughput no yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
FHI2A_HUMAN [view interactions] High throughput no yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
CX6B1_HUMAN [view entry] [view interactions] High throughput yes yes
OXDA_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
PURA2_HUMAN [view interactions] High throughput no yes
CDK9_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
EMC1_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
CSN5_HUMAN [view interactions] High throughput no yes
CDK1_HUMAN [view interactions] High throughput no no
LIS1_HUMAN [view entry] [view interactions] High throughput yes yes
THIM_HUMAN [view interactions] High throughput no yes
CIA2B_HUMAN [view interactions] High throughput no yes
CIA2A_HUMAN [view interactions] High throughput no yes
AP1M1_HUMAN [view entry] [view interactions] High throughput yes yes
LKHA4_HUMAN [view interactions] High throughput no yes
ALAT2_HUMAN [view interactions] High throughput no yes
NUDT8_HUMAN [view interactions] High throughput no yes
ADRO_HUMAN [view interactions] High throughput no no
HEMH_HUMAN [view interactions] High throughput no yes
SIR3_HUMAN [view interactions] High throughput no yes
ACSF3_HUMAN [view interactions] High throughput no no
GUF1_HUMAN [view interactions] High throughput no yes
IF2M_HUMAN [view interactions] High throughput no yes
NSUN3_HUMAN [view interactions] High throughput no no
ACS2L_HUMAN [view interactions] High throughput no yes
CQ080_HUMAN [view interactions] High throughput no yes
ABHDB_HUMAN [view interactions] High throughput no yes
NDUS6_HUMAN [view entry] [view interactions] High throughput yes yes
PNPT1_HUMAN [view interactions] High throughput no yes
OSGL1_HUMAN [view interactions] High throughput no yes
CATH_HUMAN [view interactions] High throughput no no
COX7R_HUMAN [view entry] [view interactions] High throughput yes no
SYNM_HUMAN [view interactions] High throughput no yes
DPOG1_HUMAN [view interactions] High throughput no yes
NNTM_HUMAN [view entry] [view interactions] High throughput yes yes
SYLM_HUMAN [view interactions] High throughput no yes
DLP1_HUMAN [view interactions] High throughput no no
TRM2_HUMAN [view interactions] High throughput no yes
EFGM_HUMAN [view interactions] High throughput no yes
BCKD_HUMAN [view entry] [view interactions] High throughput yes yes
AUHM_HUMAN [view entry] [view interactions] High throughput yes yes
SYIM_HUMAN [view entry] [view interactions] High throughput yes yes
RT4I1_HUMAN [view interactions] High throughput no yes
RNZ2_HUMAN [view interactions] High throughput no yes
NUD19_HUMAN [view interactions] High throughput no no
NDKM_HUMAN [view interactions] High throughput no yes
CLPP_HUMAN [view interactions] High throughput no yes
SYDM_HUMAN [view interactions] High throughput no yes
SYHM_HUMAN [view entry] [view interactions] High throughput yes yes
SYVM_HUMAN [view interactions] High throughput no yes
TR61B_HUMAN [view interactions] High throughput no yes
PGES2_HUMAN [view interactions] High throughput no yes
ACPM_HUMAN [view interactions] High throughput no yes
MTG2_HUMAN [view interactions] High throughput no yes
RRF2M_HUMAN [view interactions] High throughput no yes
D39U1_HUMAN [view interactions] High throughput no no
CLPX_HUMAN [view interactions] High throughput no yes
MTG1_HUMAN [view interactions] High throughput no yes
HDHD5_HUMAN [view interactions] High throughput no yes
CACP_HUMAN [view entry] [view interactions] High throughput yes yes
HEMK1_HUMAN [view interactions] High throughput no yes
VWA8_HUMAN [view interactions] High throughput no yes
SYAM_HUMAN [view interactions] High throughput no yes
TFB1M_HUMAN [view interactions] High throughput no yes
PDK3_HUMAN [view entry] [view interactions] High throughput yes yes
PDK1_HUMAN [view interactions] High throughput no yes
RUSD3_HUMAN [view interactions] High throughput no yes
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
CPSM_HUMAN [view interactions] High throughput no no
MRM2_HUMAN [view interactions] High throughput no yes
SYYM_HUMAN [view interactions] High throughput no no
BCS1_HUMAN [view interactions] High throughput no yes
SYMM_HUMAN [view interactions] High throughput no yes
PPCEL_HUMAN [view interactions] High throughput no yes
TAZ_HUMAN [view interactions] High throughput no yes
PDK2_HUMAN [view interactions] High throughput no yes
TOP3A_HUMAN [view interactions] High throughput no yes
CHDH_HUMAN [view interactions] High throughput no yes
TRXR2_HUMAN [view interactions] High throughput no yes
ACD10_HUMAN [view interactions] High throughput no no
ACSF2_HUMAN [view interactions] High throughput no no
RSAD1_HUMAN [view interactions] High throughput no yes
NSUN4_HUMAN [view interactions] High throughput no no
PPOX_HUMAN [view interactions] High throughput no no
UNG_HUMAN [view interactions] High throughput no yes
TTC19_HUMAN [view interactions] High throughput no yes
MCCA_HUMAN [view entry] [view interactions] High throughput yes yes
L2HDH_HUMAN [view interactions] High throughput no yes
TRUB2_HUMAN [view interactions] High throughput no yes
DD19B_HUMAN [view interactions] High throughput no yes
MRPP3_HUMAN [view interactions] High throughput no yes
MACD1_HUMAN [view entry] [view interactions] High throughput yes no
NDUF7_HUMAN [view interactions] High throughput no yes
COX15_HUMAN [view interactions] Computational no yes
NDUB2_HUMAN [view interactions] Computational no yes
NDUBB_HUMAN [view interactions] Computational no yes
COX10_HUMAN [view interactions] Computational no yes
CX6A2_HUMAN [view interactions] Computational no no
COX7C_HUMAN [view interactions] Computational no yes
EFTU_HUMAN [view entry] [view interactions] Computational yes yes
NU6M_HUMAN [view interactions] Computational no no
NDUB9_HUMAN [view entry] [view interactions] Computational yes yes
NDUC1_HUMAN [view interactions] Computational no yes
AT5G3_HUMAN [view interactions] Computational no no
C560_HUMAN [view interactions] Computational no no
VDAC2_HUMAN [view entry] [view interactions] Computational yes yes
NDUB1_HUMAN [view interactions] Computational no yes
COX3_HUMAN [view interactions] Computational no yes
COX5B_HUMAN [view entry] [view interactions] Computational yes yes
COX42_HUMAN [view interactions] Computational no no
CX6B2_HUMAN [view interactions] Computational no no
MPC2_HUMAN [view interactions] Computational no yes
NU4LM_HUMAN [view interactions] Computational no no
NDUS8_HUMAN [view interactions] Computational no yes
COX2_HUMAN [view entry] [view interactions] Computational yes yes
PHB2_HUMAN [view entry] [view interactions] Computational yes yes
NU2M_HUMAN [view entry] [view interactions] Computational yes no
CX6A1_HUMAN [view interactions] Computational no yes
NU4M_HUMAN [view interactions] Computational no yes
COX1_HUMAN [view interactions] Computational no yes
MPPB_HUMAN [view interactions] Computational no yes
COA6_HUMAN [view interactions] Computational no yes
CX7A1_HUMAN [view interactions] Computational no no
NDUA2_HUMAN [view entry] [view interactions] Computational yes yes
NU1M_HUMAN [view interactions] Computational no yes
NDUA7_HUMAN [view entry] [view interactions] Computational yes yes
NU3M_HUMAN [view interactions] Computational no yes
NU5M_HUMAN [view interactions] Computational no no
NDUA1_HUMAN [view interactions] Computational no yes
MDHM_HUMAN [view entry] [view interactions] Computational yes yes
NDUB3_HUMAN [view interactions] Computational no yes
DHSD_HUMAN [view interactions] Computational no yes
MPCP_HUMAN [view entry] [view interactions] Computational yes no