NDUAA_HUMAN
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in NDUAA_HUMAN |
---|---|---|---|---|
GO:0015399 | primary active transmembrane transporter activity | 38.9610 | 4 | yes |
GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | 38.9610 | 5 | yes |
GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | 31.1688 | 4 | yes |
GO:0003954 | NADH dehydrogenase activity | 29.8701 | 4 | yes |
GO:0003955 | NAD(P)H dehydrogenase (quinone) activity | 29.8701 | 5 | yes |
GO:0008137 | NADH dehydrogenase (ubiquinone) activity | 29.8701 | 4 | yes |
GO:0050136 | NADH dehydrogenase (quinone) activity | 29.8701 | 5 | yes |
GO:0046872 | metal ion binding | 28.5714 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in NDUAA_HUMAN |
---|---|---|---|---|
GO:0015980 | energy derivation by oxidation of organic compounds | 44.1558 | 4 | yes |
GO:0009060 | aerobic respiration | 42.8571 | 6 | yes |
GO:0045333 | cellular respiration | 42.8571 | 5 | yes |
GO:0022607 | cellular component assembly | 41.5584 | 4 | yes |
GO:0022900 | electron transport chain | 41.5584 | 4 | yes |
GO:0022904 | respiratory electron transport chain | 41.5584 | 5 | yes |
GO:0019646 | aerobic electron transport chain | 38.9610 | 6 | yes |
GO:0043933 | protein-containing complex organization | 31.1688 | 4 | yes |
GO:0006120 | mitochondrial electron transport, NADH to ubiquinone | 28.5714 | 7 | yes |
GO:0065003 | protein-containing complex assembly | 28.5714 | 5 | yes |
GO:0031323 | regulation of cellular metabolic process | 27.2727 | 4 | no |
GO:0033108 | mitochondrial respiratory chain complex assembly | 24.6753 | 6 | yes |
GO:0006996 | organelle organization | 24.6753 | 4 | no |
GO:0048522 | positive regulation of cellular process | 24.6753 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 24.6753 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 24.6753 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 24.6753 | 4 | no |
GO:0010257 | NADH dehydrogenase complex assembly | 23.3766 | 6 | yes |
GO:0032981 | mitochondrial respiratory chain complex I assembly | 23.3766 | 7 | yes |
GO:0019752 | carboxylic acid metabolic process | 23.3766 | 5 | no |
GO:0043436 | oxoacid metabolic process | 23.3766 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 22.0779 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 22.0779 | 4 | no |
GO:0010646 | regulation of cell communication | 22.0779 | 4 | no |
GO:0048523 | negative regulation of cellular process | 22.0779 | 4 | no |
GO:0009966 | regulation of signal transduction | 20.7792 | 4 | no |
GO:0051128 | regulation of cellular component organization | 20.7792 | 4 | no |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in NDUAA_HUMAN |
---|---|---|---|---|
DOID:0050890 | synucleinopathy | 2.5974 | 5 | no |
DOID:0060894 | early-onset Parkinsons disease | 2.5974 | 7 | no |
DOID:1289 | neurodegenerative disease | 2.5974 | 4 | no |
DOID:14330 | Parkinsons disease | 2.5974 | 6 | no |
DOID:331 | central nervous system disease | 2.5974 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
NDUB5_HUMAN | [view interactions] | Low throughput | no | yes |
NDUB9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NU6M_HUMAN | [view interactions] | Low throughput | no | no |
NDUB2_HUMAN | [view interactions] | Low throughput | no | yes |
NDUB1_HUMAN | [view interactions] | Low throughput | no | yes |
NDUC1_HUMAN | [view interactions] | Low throughput | no | yes |
NU1M_HUMAN | [view interactions] | Low throughput | no | yes |
NDUB8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NU4M_HUMAN | [view interactions] | Low throughput | no | yes |
NU2M_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
NU4LM_HUMAN | [view interactions] | Low throughput | no | no |
NDUAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NU5M_HUMAN | [view interactions] | Low throughput | no | no |
NU3M_HUMAN | [view interactions] | Low throughput | no | yes |
NDUAB_HUMAN | [view interactions] | Low throughput | no | no |
ACPM_HUMAN | [view interactions] | Low throughput | no | yes |
NDUBB_HUMAN | [view interactions] | Low throughput | no | yes |
NDUB7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NDUC2_HUMAN | [view interactions] | Low throughput | no | yes |
NDUB3_HUMAN | [view interactions] | Low throughput | no | yes |
NDUA1_HUMAN | [view interactions] | Low throughput | no | yes |
NDUS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NDUA3_HUMAN | [view interactions] | Low throughput | no | yes |
NDUA8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NDUBA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NDUB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NDUS5_HUMAN | [view interactions] | Low throughput | no | yes |
NDUB6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
QCR9_HUMAN | [view interactions] | High throughput | no | no |
ASB2_HUMAN | [view interactions] | High throughput | no | no |
LEG9_HUMAN | [view interactions] | High throughput | no | yes |
SYAM_HUMAN | [view interactions] | High throughput | no | yes |
COX8A_HUMAN | [view interactions] | High throughput | no | yes |
TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BROMI_HUMAN | [view interactions] | High throughput | no | no |
TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
BRCC3_HUMAN | [view interactions] | High throughput | no | no |
WIPI2_HUMAN | [view interactions] | High throughput | no | yes |
HDA11_HUMAN | [view interactions] | High throughput | no | no |
RIPK4_HUMAN | [view interactions] | High throughput | no | no |
NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLK1_HUMAN | [view interactions] | High throughput | no | yes |
RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RMD3_HUMAN | [view interactions] | High throughput | no | yes |
MDEAS_HUMAN | [view interactions] | High throughput | no | yes |
VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
SIR3_HUMAN | [view interactions] | High throughput | no | yes |
DHRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RSPRY_HUMAN | [view interactions] | High throughput | no | yes |
KDM1B_HUMAN | [view interactions] | High throughput | no | yes |
ACD10_HUMAN | [view interactions] | High throughput | no | no |
NDUF5_HUMAN | [view interactions] | High throughput | no | yes |
CLPP_HUMAN | [view interactions] | High throughput | no | yes |
DECR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IF2M_HUMAN | [view interactions] | High throughput | no | yes |
CLU_HUMAN | [view interactions] | High throughput | no | yes |
NMES1_HUMAN | [view interactions] | High throughput | no | no |
CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
SPT20_HUMAN | [view interactions] | High throughput | no | yes |
MP2K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SOAT1_HUMAN | [view interactions] | High throughput | no | no |
NDUA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SAT2_HUMAN | [view interactions] | High throughput | no | yes |
SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ZAP70_HUMAN | [view interactions] | High throughput | no | no |
STA5B_HUMAN | [view interactions] | High throughput | no | yes |
NEP_HUMAN | [view interactions] | High throughput | no | no |
NDUA6_HUMAN | [view interactions] | High throughput | no | no |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
CAV3_HUMAN | [view interactions] | High throughput | no | no |
EGLN_HUMAN | [view interactions] | High throughput | no | no |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
RYBP_HUMAN | [view interactions] | High throughput | no | no |
NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PCNA_HUMAN | [view interactions] | High throughput | no | no |
NDUA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
MDC1_HUMAN | [view interactions] | High throughput | no | yes |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LGR4_HUMAN | [view interactions] | High throughput | no | yes |
RING2_HUMAN | [view interactions] | High throughput | no | yes |
RN123_HUMAN | [view interactions] | High throughput | no | yes |
PXDC2_HUMAN | [view interactions] | High throughput | no | yes |
NDUF7_HUMAN | [view interactions] | High throughput | no | yes |
BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PPOX_HUMAN | [view interactions] | High throughput | no | no |
B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
DCX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BMR1A_HUMAN | [view interactions] | High throughput | no | no |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
FXRD1_HUMAN | [view interactions] | High throughput | no | no |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
PRC1_HUMAN | [view interactions] | High throughput | no | yes |
MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
RNF5_HUMAN | [view interactions] | High throughput | no | yes |
SYLM_HUMAN | [view interactions] | High throughput | no | yes |
NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUV3_HUMAN | [view interactions] | High throughput | no | yes |
AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SPSB4_HUMAN | [view interactions] | High throughput | no | no |
NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TRI43_HUMAN | [view interactions] | High throughput | no | no |
AMACR_HUMAN | [view interactions] | High throughput | no | yes |
NDUA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GATA_HUMAN | [view interactions] | High throughput | no | yes |
MRM2_HUMAN | [view interactions] | High throughput | no | yes |
DJC30_HUMAN | [view interactions] | High throughput | no | no |
FAHD1_HUMAN | [view interactions] | High throughput | no | yes |
NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
WIPI1_HUMAN | [view interactions] | High throughput | no | yes |
FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BRD4_HUMAN | [view interactions] | High throughput | no | yes |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOD_HUMAN | [view interactions] | High throughput | no | no |
RHOU_HUMAN | [view interactions] | High throughput | no | no |
RHOV_HUMAN | [view interactions] | High throughput | no | no |
RHOH_HUMAN | [view interactions] | High throughput | no | yes |
RND2_HUMAN | [view interactions] | High throughput | no | no |
ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MPV17_HUMAN | [view interactions] | High throughput | no | no |
SDHB_HUMAN | [view interactions] | High throughput | no | yes |
MRP2_HUMAN | [view interactions] | High throughput | no | no |
COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COX5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
QCR7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
QCR8_HUMAN | [view interactions] | High throughput | no | yes |
ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
ATPA_HUMAN | [view interactions] | High throughput | no | yes |
ATPB_HUMAN | [view interactions] | High throughput | no | yes |
BOLA3_HUMAN | [view interactions] | High throughput | no | yes |
PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATPD_HUMAN | [view interactions] | High throughput | no | yes |
AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
DNJB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECHD1_HUMAN | [view interactions] | High throughput | no | no |
IDH3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATPG_HUMAN | [view interactions] | High throughput | no | yes |
ATP5I_HUMAN | [view interactions] | High throughput | no | yes |
ATPK_HUMAN | [view interactions] | High throughput | no | yes |
CISD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COQ9_HUMAN | [view interactions] | High throughput | no | yes |
CYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ODP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AATM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IDH3G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SDHA_HUMAN | [view interactions] | High throughput | no | yes |
NDUCR_HUMAN | [view interactions] | High throughput | no | yes |
NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
M2OM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COX5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CX6A2_HUMAN | [view interactions] | Computational | no | no |
COX7C_HUMAN | [view interactions] | Computational | no | yes |
NDUF6_HUMAN | [view interactions] | Computational | no | yes |
AT5L2_HUMAN | [view interactions] | Computational | no | no |
QCR6_HUMAN | [view interactions] | Computational | no | yes |
COA6_HUMAN | [view interactions] | Computational | no | yes |
CYB_HUMAN | [view interactions] | Computational | no | yes |
ATP5L_HUMAN | [view interactions] | Computational | no | yes |
QCR10_HUMAN | [view interactions] | Computational | no | no |
MPC2_HUMAN | [view interactions] | Computational | no | yes |
T126B_HUMAN | [view interactions] | Computational | no | yes |
NDUS8_HUMAN | [view interactions] | Computational | no | yes |
COX42_HUMAN | [view interactions] | Computational | no | no |
ATPMK_HUMAN | [view interactions] | Computational | no | no |
CX6B2_HUMAN | [view interactions] | Computational | no | no |
PINK1_HUMAN | [view interactions] | Computational | no | yes |
CIA30_HUMAN | [view interactions] | Computational | no | yes |