DHRS4_HUMAN
Evidence for PS localization
Functions
Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DHRS4_HUMAN |
|---|---|---|---|---|
| GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | 30.0000 | 4 | yes |
| GO:0000166 | nucleotide binding | 30.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 30.0000 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 30.0000 | 6 | no |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 25.0000 | 4 | no |
| GO:0015078 | proton transmembrane transporter activity | 25.0000 | 5 | no |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 25.0000 | 4 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 25.0000 | 4 | no |
| GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | 20.0000 | 4 | yes |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 15.0000 | 4 | yes |
| GO:0000253 | 3-keto sterol reductase activity | 10.0000 | 5 | yes |
| GO:0001758 | retinal dehydrogenase activity | 10.0000 | 5 | yes |
| GO:0004033 | aldo-keto reductase (NADPH) activity | 10.0000 | 5 | yes |
| GO:0004090 | carbonyl reductase (NADPH) activity | 10.0000 | 5 | yes |
| GO:0008106 | alcohol dehydrogenase (NADP+) activity | 10.0000 | 6 | yes |
| GO:0018455 | alcohol dehydrogenase [NAD(P)+] activity | 10.0000 | 5 | yes |
| GO:0033703 | 3beta-hydroxy-5beta-steroid dehydrogenase activity | 10.0000 | 5 | yes |
| GO:0052650 | all-trans-retinol dehydrogenase (NADP+) activity | 10.0000 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DHRS4_HUMAN |
|---|---|---|---|---|
| GO:0006796 | phosphate-containing compound metabolic process | 50.0000 | 4 | no |
| GO:0006163 | purine nucleotide metabolic process | 40.0000 | 5 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 40.0000 | 4 | no |
| GO:0009117 | nucleotide metabolic process | 40.0000 | 5 | no |
| GO:0072521 | purine-containing compound metabolic process | 40.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 35.0000 | 4 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 35.0000 | 6 | no |
| GO:0009259 | ribonucleotide metabolic process | 35.0000 | 5 | no |
| GO:0019693 | ribose phosphate metabolic process | 35.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 30.0000 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 30.0000 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 30.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 30.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 30.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 30.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | yes |
| GO:0006164 | purine nucleotide biosynthetic process | 25.0000 | 6 | no |
| GO:0009152 | purine ribonucleotide biosynthetic process | 25.0000 | 7 | no |
| GO:0009165 | nucleotide biosynthetic process | 25.0000 | 6 | no |
| GO:0009260 | ribonucleotide biosynthetic process | 25.0000 | 6 | no |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 25.0000 | 4 | no |
| GO:0046390 | ribose phosphate biosynthetic process | 25.0000 | 5 | no |
| GO:0072522 | purine-containing compound biosynthetic process | 25.0000 | 5 | no |
| GO:0090407 | organophosphate biosynthetic process | 25.0000 | 4 | no |
| GO:1901137 | carbohydrate derivative biosynthetic process | 25.0000 | 4 | no |
| GO:1901293 | nucleoside phosphate biosynthetic process | 25.0000 | 5 | no |
| GO:1901362 | organic cyclic compound biosynthetic process | 25.0000 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 25.0000 | 4 | no |
| GO:0016054 | organic acid catabolic process | 25.0000 | 4 | no |
| GO:0046395 | carboxylic acid catabolic process | 25.0000 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0009060 | aerobic respiration | 25.0000 | 6 | no |
| GO:0015980 | energy derivation by oxidation of organic compounds | 25.0000 | 4 | no |
| GO:0045333 | cellular respiration | 25.0000 | 5 | no |
| GO:0008202 | steroid metabolic process | 20.0000 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 20.0000 | 5 | yes |
| GO:2000377 | regulation of reactive oxygen species metabolic process | 15.0000 | 5 | yes |
| GO:0001523 | retinoid metabolic process | 10.0000 | 7 | yes |
| GO:0006720 | isoprenoid metabolic process | 10.0000 | 4 | yes |
| GO:0006721 | terpenoid metabolic process | 10.0000 | 5 | yes |
| GO:0016101 | diterpenoid metabolic process | 10.0000 | 6 | yes |
| GO:0042574 | retinal metabolic process | 10.0000 | 4 | yes |
| GO:2000379 | positive regulation of reactive oxygen species metabolic process | 10.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DHRS4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NDUS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHD1_HUMAN | [view interactions] | High throughput | no | no |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| MCCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHP_HUMAN | [view interactions] | High throughput | no | no |
| ABHDB_HUMAN | [view interactions] | High throughput | no | yes |
| NDUF5_HUMAN | [view interactions] | High throughput | no | yes |
| NDUF8_HUMAN | [view interactions] | High throughput | no | no |
| K2C6B_HUMAN | [view interactions] | High throughput | no | no |
| AL1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCC1L_HUMAN | [view interactions] | High throughput | no | yes |
| ACPM_HUMAN | [view interactions] | High throughput | no | yes |
| AFG1L_HUMAN | [view interactions] | High throughput | no | yes |
| PHIPL_HUMAN | [view interactions] | High throughput | no | yes |
| SAP_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| BCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRC_HUMAN | [view interactions] | High throughput | no | no |
| CBLB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DOK3_HUMAN | [view interactions] | High throughput | no | no |
| SHF_HUMAN | [view interactions] | High throughput | no | no |
| STAP2_HUMAN | [view interactions] | High throughput | no | yes |
| TENS3_HUMAN | [view interactions] | High throughput | no | no |
| SET_HUMAN | [view interactions] | High throughput | no | yes |
| CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| PEX5_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| CHCH2_HUMAN | [view interactions] | High throughput | no | yes |
| RM13_HUMAN | [view interactions] | High throughput | no | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| PREP_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| NDUF3_HUMAN | [view interactions] | High throughput | no | yes |
| PDIP2_HUMAN | [view interactions] | High throughput | no | no |
| NRDC_HUMAN | [view interactions] | High throughput | no | no |
| ECH1_HUMAN | [view interactions] | High throughput | no | yes |
| ODBA_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5E_HUMAN | [view interactions] | High throughput | no | no |
| GLRX5_HUMAN | [view interactions] | High throughput | no | yes |
| DS13A_HUMAN | [view interactions] | High throughput | no | no |
| ACADV_HUMAN | [view interactions] | High throughput | no | yes |
| RBTN2_HUMAN | [view interactions] | High throughput | no | yes |
| TMM70_HUMAN | [view interactions] | High throughput | no | yes |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| F16P1_HUMAN | [view interactions] | High throughput | no | no |
| DGKA_HUMAN | [view interactions] | High throughput | no | yes |
| MAGA9_HUMAN | [view interactions] | High throughput | no | no |
| CST11_HUMAN | [view interactions] | High throughput | no | no |
| GSX1_HUMAN | [view interactions] | High throughput | no | no |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| DHRS6_HUMAN | [view interactions] | High throughput | no | no |
| HIPL1_HUMAN | [view interactions] | High throughput | no | no |
| PDE12_HUMAN | [view interactions] | High throughput | no | yes |
| CX6A1_HUMAN | [view interactions] | High throughput | no | yes |
| FSP1_HUMAN | [view interactions] | High throughput | no | yes |
| LY65C_HUMAN | [view interactions] | High throughput | no | no |
| FAHD1_HUMAN | [view interactions] | High throughput | no | yes |
| DHB14_HUMAN | [view interactions] | High throughput | no | yes |
| S25A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NAT14_HUMAN | [view interactions] | High throughput | no | no |
| M2GD_HUMAN | [view interactions] | High throughput | no | no |
| PCCB_HUMAN | [view interactions] | High throughput | no | yes |
| TSSP_HUMAN | [view interactions] | High throughput | no | no |
| DHRS3_HUMAN | [view interactions] | High throughput | no | yes |
| DKK2_HUMAN | [view interactions] | High throughput | no | no |
| FOXA1_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| HSF1_HUMAN | [view interactions] | High throughput | no | yes |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| SMC5_HUMAN | [view interactions] | High throughput | no | yes |
| OXSM_HUMAN | [view interactions] | High throughput | no | yes |
| PEX7_HUMAN | [view interactions] | High throughput | no | yes |
| PECR_HUMAN | [view interactions] | High throughput | no | yes |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| ACD11_HUMAN | [view interactions] | High throughput | no | yes |
| DHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSDL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CACP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTGR3_HUMAN | [view interactions] | High throughput | no | yes |
| HACL1_HUMAN | [view interactions] | High throughput | no | no |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| ADAS_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SUN2_HUMAN | [view interactions] | High throughput | no | yes |
| UPAR_HUMAN | [view interactions] | High throughput | no | yes |
| C1T9A_HUMAN | [view interactions] | High throughput | no | no |
| ATPD_HUMAN | [view interactions] | High throughput | no | yes |
| SHCAF_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC7_HUMAN | [view interactions] | High throughput | no | no |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX3_HUMAN | [view interactions] | High throughput | no | yes |
| TRI43_HUMAN | [view interactions] | High throughput | no | no |
| HEXA_HUMAN | [view interactions] | High throughput | no | yes |
| RM37_HUMAN | [view interactions] | High throughput | no | yes |
| PRELP_HUMAN | [view interactions] | High throughput | no | no |
| CP2B6_HUMAN | [view interactions] | High throughput | no | no |
| QPCT_HUMAN | [view interactions] | High throughput | no | no |
| KLHL6_HUMAN | [view interactions] | High throughput | no | no |
| AL1B1_HUMAN | [view interactions] | High throughput | no | yes |
| BOLA1_HUMAN | [view interactions] | High throughput | no | yes |
| CLPB_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |