ECI2_HUMAN
Evidence for PS localization
Functions
Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ECI2_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 31.2500 | 4 | no |
| GO:0000166 | nucleotide binding | 25.0000 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 25.0000 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 21.8750 | 6 | yes |
| GO:0032555 | purine ribonucleotide binding | 21.8750 | 4 | yes |
| GO:0043168 | anion binding | 21.8750 | 4 | yes |
| GO:0043169 | cation binding | 21.8750 | 4 | no |
| GO:0046872 | metal ion binding | 21.8750 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 18.7500 | 5 | yes |
| GO:0000062 | fatty-acyl-CoA binding | 6.2500 | 4 | yes |
| GO:0004165 | delta(3)-delta(2)-enoyl-CoA isomerase activity | 6.2500 | 5 | yes |
| GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds | 6.2500 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ECI2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 37.5000 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 34.3750 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 34.3750 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 34.3750 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 31.2500 | 4 | no |
| GO:0022607 | cellular component assembly | 31.2500 | 4 | no |
| GO:0010646 | regulation of cell communication | 31.2500 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 28.1250 | 4 | no |
| GO:0032787 | monocarboxylic acid metabolic process | 25.0000 | 6 | yes |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 25.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
| GO:0016054 | organic acid catabolic process | 21.8750 | 4 | yes |
| GO:0046395 | carboxylic acid catabolic process | 21.8750 | 5 | yes |
| GO:0006163 | purine nucleotide metabolic process | 21.8750 | 5 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 21.8750 | 4 | no |
| GO:0009117 | nucleotide metabolic process | 21.8750 | 5 | no |
| GO:0072521 | purine-containing compound metabolic process | 21.8750 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 21.8750 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 21.8750 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 21.8750 | 4 | no |
| GO:0006631 | fatty acid metabolic process | 18.7500 | 4 | yes |
| GO:0006635 | fatty acid beta-oxidation | 15.6250 | 6 | yes |
| GO:0009062 | fatty acid catabolic process | 15.6250 | 5 | yes |
| GO:0016042 | lipid catabolic process | 15.6250 | 4 | yes |
| GO:0019395 | fatty acid oxidation | 15.6250 | 5 | yes |
| GO:0030258 | lipid modification | 15.6250 | 4 | yes |
| GO:0034440 | lipid oxidation | 15.6250 | 5 | yes |
| GO:0044242 | cellular lipid catabolic process | 15.6250 | 4 | yes |
| GO:0072329 | monocarboxylic acid catabolic process | 15.6250 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ECI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| UBP20_HUMAN | [view interactions] | High throughput | no | yes |
| TYSD1_HUMAN | [view interactions] | High throughput | no | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| ECH1_HUMAN | [view interactions] | High throughput | no | yes |
| MCCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACS2L_HUMAN | [view interactions] | High throughput | no | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| IVD_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COQ6_HUMAN | [view interactions] | High throughput | no | yes |
| AL1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRID2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| S22AI_HUMAN | [view interactions] | High throughput | no | no |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| H11_HUMAN | [view interactions] | High throughput | no | no |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| TNPO3_HUMAN | [view interactions] | High throughput | no | yes |
| CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| NEUL4_HUMAN | [view interactions] | High throughput | no | yes |
| PEX5_HUMAN | [view interactions] | High throughput | no | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DHB13_HUMAN | [view interactions] | High throughput | no | yes |
| EF2KT_HUMAN | [view interactions] | High throughput | no | no |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSF2_HUMAN | [view interactions] | High throughput | no | no |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| TPX2_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF1_HUMAN | [view interactions] | High throughput | no | no |
| IDE_HUMAN | [view interactions] | High throughput | no | yes |
| FBXL5_HUMAN | [view interactions] | High throughput | no | yes |
| KANL1_HUMAN | [view interactions] | High throughput | no | yes |
| MA7D2_HUMAN | [view interactions] | High throughput | no | yes |
| NHRF3_HUMAN | [view interactions] | High throughput | no | no |
| PRIPO_HUMAN | [view interactions] | High throughput | no | no |
| PDGFD_HUMAN | [view interactions] | High throughput | no | no |
| Z286A_HUMAN | [view interactions] | High throughput | no | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| SOCS6_HUMAN | [view interactions] | High throughput | no | yes |
| SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| TNNC2_HUMAN | [view interactions] | High throughput | no | no |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPA_HUMAN | [view interactions] | High throughput | no | yes |
| CART_HUMAN | [view interactions] | High throughput | no | yes |
| RM12_HUMAN | [view interactions] | High throughput | no | yes |
| PEPL_HUMAN | [view interactions] | High throughput | no | yes |
| SERB1_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACO13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCP2_HUMAN | [view interactions] | High throughput | no | no |
| ACSL1_HUMAN | [view interactions] | High throughput | no | no |
| PECR_HUMAN | [view interactions] | High throughput | no | yes |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| CACP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DR4L2_HUMAN | [view interactions] | High throughput | no | no |
| DHRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HACL1_HUMAN | [view interactions] | High throughput | no | no |
| HSDL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTGR3_HUMAN | [view interactions] | High throughput | no | yes |
| ACD11_HUMAN | [view interactions] | High throughput | no | yes |
| ECHP_HUMAN | [view interactions] | High throughput | no | no |
| DHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| PEX7_HUMAN | [view interactions] | High throughput | no | yes |
| SF01_HUMAN | [view interactions] | High throughput | no | yes |
| UEVLD_HUMAN | [view interactions] | High throughput | no | yes |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | no |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADAS_HUMAN | [view interactions] | High throughput | no | yes |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |