MCCA_HUMAN
Evidence for PS localization
Functions
Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MCCA_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 45.8333 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 45.8333 | 5 | yes |
| GO:0043168 | anion binding | 45.8333 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 43.7500 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 39.5833 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 35.4167 | 6 | yes |
| GO:0043169 | cation binding | 35.4167 | 4 | yes |
| GO:0046872 | metal ion binding | 35.4167 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 33.3333 | 5 | yes |
| GO:0005524 | ATP binding | 29.1667 | 5 | yes |
| GO:0003723 | RNA binding | 27.0833 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 22.9167 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 22.9167 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 22.9167 | 6 | no |
| GO:0016421 | CoA carboxylase activity | 8.3333 | 4 | yes |
| GO:0031406 | carboxylic acid binding | 6.2500 | 4 | yes |
| GO:0033293 | monocarboxylic acid binding | 6.2500 | 5 | yes |
| GO:0004485 | methylcrotonoyl-CoA carboxylase activity | 4.1667 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MCCA_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 43.7500 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 43.7500 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 41.6667 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 41.6667 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 37.5000 | 4 | no |
| GO:0010468 | regulation of gene expression | 37.5000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 37.5000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 37.5000 | 5 | no |
| GO:0022607 | cellular component assembly | 35.4167 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 35.4167 | 4 | no |
| GO:0008104 | protein localization | 35.4167 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 31.2500 | 5 | no |
| GO:0006996 | organelle organization | 31.2500 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.2500 | 5 | no |
| GO:0010646 | regulation of cell communication | 31.2500 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.1667 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 29.1667 | 4 | no |
| GO:0051049 | regulation of transport | 27.0833 | 4 | no |
| GO:0071702 | organic substance transport | 27.0833 | 4 | no |
| GO:0071705 | nitrogen compound transport | 27.0833 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 25.0000 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0043933 | protein-containing complex organization | 25.0000 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 22.9167 | 7 | no |
| GO:0009891 | positive regulation of biosynthetic process | 22.9167 | 5 | no |
| GO:0009966 | regulation of signal transduction | 22.9167 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.9167 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 22.9167 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.9167 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.9167 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.9167 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.9167 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.9167 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 22.9167 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.9167 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.9167 | 6 | no |
| GO:0033043 | regulation of organelle organization | 22.9167 | 5 | no |
| GO:0071310 | cellular response to organic substance | 20.8333 | 4 | no |
| GO:0015031 | protein transport | 20.8333 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 20.8333 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 20.8333 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.8333 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 18.7500 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 18.7500 | 4 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 18.7500 | 4 | yes |
| GO:0016054 | organic acid catabolic process | 12.5000 | 4 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 12.5000 | 6 | yes |
| GO:0046395 | carboxylic acid catabolic process | 12.5000 | 5 | yes |
| GO:0009081 | branched-chain amino acid metabolic process | 10.4167 | 4 | yes |
| GO:0009063 | amino acid catabolic process | 8.3333 | 4 | yes |
| GO:0009083 | branched-chain amino acid catabolic process | 8.3333 | 5 | yes |
| GO:1901605 | alpha-amino acid metabolic process | 6.2500 | 4 | yes |
| GO:1901606 | alpha-amino acid catabolic process | 6.2500 | 5 | yes |
| GO:0006551 | L-leucine metabolic process | 4.1667 | 5 | yes |
| GO:0006552 | L-leucine catabolic process | 4.1667 | 6 | yes |
| GO:0009078 | pyruvate family amino acid metabolic process | 4.1667 | 5 | yes |
| GO:0009080 | pyruvate family amino acid catabolic process | 4.1667 | 6 | yes |
| GO:0170033 | L-amino acid metabolic process | 4.1667 | 5 | yes |
| GO:0170035 | L-amino acid catabolic process | 4.1667 | 6 | yes |
| GO:0170039 | proteinogenic amino acid metabolic process | 4.1667 | 4 | yes |
| GO:0170040 | proteinogenic amino acid catabolic process | 4.1667 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TRADD_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAVS_HUMAN | [view interactions] | Low throughput | no | yes |
| MCCB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HDHD3_HUMAN | [view interactions] | High throughput | no | yes |
| AGO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| NPS3A_HUMAN | [view interactions] | High throughput | no | yes |
| NPS3B_HUMAN | [view interactions] | High throughput | no | yes |
| NUD13_HUMAN | [view interactions] | High throughput | no | no |
| MRM2_HUMAN | [view interactions] | High throughput | no | yes |
| RT24_HUMAN | [view interactions] | High throughput | no | yes |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| COMD5_HUMAN | [view interactions] | High throughput | no | no |
| RT02_HUMAN | [view interactions] | High throughput | no | no |
| DHRS2_HUMAN | [view interactions] | High throughput | no | no |
| TRI43_HUMAN | [view interactions] | High throughput | no | no |
| RUSD3_HUMAN | [view interactions] | High throughput | no | yes |
| ATPF2_HUMAN | [view interactions] | High throughput | no | yes |
| LSMD1_HUMAN | [view interactions] | High throughput | no | no |
| PLPL4_HUMAN | [view interactions] | High throughput | no | yes |
| MTU1_HUMAN | [view interactions] | High throughput | no | no |
| STPG3_HUMAN | [view interactions] | High throughput | no | no |
| SYYM_HUMAN | [view interactions] | High throughput | no | no |
| PIGR_HUMAN | [view interactions] | High throughput | no | no |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP53_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUFY1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMC5_HUMAN | [view interactions] | High throughput | no | yes |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTBP2_HUMAN | [view interactions] | High throughput | no | no |
| IVD_HUMAN | [view interactions] | High throughput | no | yes |
| HUTH_HUMAN | [view interactions] | High throughput | no | yes |
| MUTA_HUMAN | [view interactions] | High throughput | no | yes |
| FBX50_HUMAN | [view interactions] | High throughput | no | no |
| DPYS_HUMAN | [view interactions] | High throughput | no | no |
| GGCT_HUMAN | [view interactions] | High throughput | no | yes |
| ZA2G_HUMAN | [view interactions] | High throughput | no | no |
| IFT1B_HUMAN | [view interactions] | High throughput | no | no |
| IFIT2_HUMAN | [view interactions] | High throughput | no | no |
| TRFL_HUMAN | [view interactions] | High throughput | no | no |
| HIP1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAI1_HUMAN | [view interactions] | High throughput | no | no |
| MTDC_HUMAN | [view interactions] | High throughput | no | yes |
| PUR8_HUMAN | [view interactions] | High throughput | no | yes |
| PP1R8_HUMAN | [view interactions] | High throughput | no | yes |
| SCFD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIPEP_HUMAN | [view interactions] | High throughput | no | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| DCTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| PER2_HUMAN | [view interactions] | High throughput | no | yes |
| SALL1_HUMAN | [view interactions] | High throughput | no | yes |
| DTX2_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| ARF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARF5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| ARL4D_HUMAN | [view interactions] | High throughput | no | no |
| ARL5A_HUMAN | [view interactions] | High throughput | no | yes |
| ARL5B_HUMAN | [view interactions] | High throughput | no | yes |
| ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
| ARL10_HUMAN | [view interactions] | High throughput | no | yes |
| ARL16_HUMAN | [view interactions] | High throughput | no | no |
| TRI23_HUMAN | [view interactions] | High throughput | no | yes |
| BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GEPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| PF21A_HUMAN | [view interactions] | High throughput | no | yes |
| RCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCDH7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| DET1_HUMAN | [view interactions] | High throughput | no | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IFIT1_HUMAN | [view interactions] | High throughput | no | no |
| SIR4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPB_HUMAN | [view interactions] | High throughput | no | no |
| KBL_HUMAN | [view interactions] | High throughput | no | yes |
| ECH1_HUMAN | [view interactions] | High throughput | no | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCOT2_HUMAN | [view interactions] | High throughput | no | no |
| NDUF8_HUMAN | [view interactions] | High throughput | no | no |
| MAIP1_HUMAN | [view interactions] | High throughput | no | yes |
| CHC10_HUMAN | [view interactions] | High throughput | no | yes |
| ECI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHIPL_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| SOS2_HUMAN | [view interactions] | High throughput | no | yes |
| IREB2_HUMAN | [view interactions] | High throughput | no | no |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| CBLB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GATA4_HUMAN | [view interactions] | High throughput | no | no |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| MYPC3_HUMAN | [view interactions] | High throughput | no | no |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSMR_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLK2_HUMAN | [view interactions] | High throughput | no | no |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| STK4_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD3_HUMAN | [view interactions] | High throughput | no | yes |
| FXL19_HUMAN | [view interactions] | High throughput | no | no |
| CMBL_HUMAN | [view interactions] | High throughput | no | no |
| PAF1_HUMAN | [view interactions] | High throughput | no | yes |
| RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ISX_HUMAN | [view interactions] | High throughput | no | no |
| LHX6_HUMAN | [view interactions] | High throughput | no | yes |
| VSX1_HUMAN | [view interactions] | High throughput | no | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| SYRM_HUMAN | [view interactions] | High throughput | no | yes |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| FXRD1_HUMAN | [view interactions] | High throughput | no | no |
| TMM70_HUMAN | [view interactions] | High throughput | no | yes |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACSM5_HUMAN | [view interactions] | High throughput | no | yes |
| MET2A_HUMAN | [view interactions] | High throughput | no | no |
| HEMH_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| RBX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SSBP2_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| MX1_HUMAN | [view interactions] | High throughput | no | yes |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| GALK1_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RN208_HUMAN | [view interactions] | High throughput | no | no |
| PCCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCCB_HUMAN | [view interactions] | High throughput | no | yes |
| PYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NP1L5_HUMAN | [view interactions] | High throughput | no | yes |
| DUS14_HUMAN | [view interactions] | High throughput | no | yes |
| ACTA_HUMAN | [view interactions] | High throughput | no | no |
| ARHGQ_HUMAN | [view interactions] | High throughput | no | yes |
| YBEY_HUMAN | [view interactions] | High throughput | no | yes |
| OTC_HUMAN | [view interactions] | High throughput | no | no |
| HTRA3_HUMAN | [view interactions] | High throughput | no | no |
| DSG4_HUMAN | [view interactions] | High throughput | no | no |
| PFD5_HUMAN | [view interactions] | High throughput | no | yes |
| ABHDA_HUMAN | [view interactions] | High throughput | no | yes |
| MASU1_HUMAN | [view interactions] | High throughput | no | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBR4_HUMAN | [view interactions] | High throughput | no | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDH6B_HUMAN | [view interactions] | High throughput | no | no |
| DHB8_HUMAN | [view interactions] | High throughput | no | yes |
| RM23_HUMAN | [view interactions] | High throughput | no | yes |
| DIC_HUMAN | [view interactions] | High throughput | no | yes |
| FA83A_HUMAN | [view interactions] | High throughput | no | no |
| MYL10_HUMAN | [view interactions] | High throughput | no | no |