MCCA_HUMAN
Evidence for PS localization
Functions
Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MCCA_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 40.0000 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 40.0000 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 36.6667 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 36.6667 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 33.3333 | 4 | yes |
| GO:0046872 | metal ion binding | 33.3333 | 4 | yes |
| GO:0005524 | ATP binding | 30.0000 | 5 | yes |
| GO:0003723 | RNA binding | 26.6667 | 4 | no |
| GO:0016421 | CoA carboxylase activity | 13.3333 | 4 | yes |
| GO:0031406 | carboxylic acid binding | 10.0000 | 4 | yes |
| GO:0033293 | monocarboxylic acid binding | 10.0000 | 5 | yes |
| GO:0004485 | methylcrotonoyl-CoA carboxylase activity | 6.6667 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MCCA_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 40.0000 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 33.3333 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 33.3333 | 4 | yes |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
| GO:0006996 | organelle organization | 30.0000 | 4 | no |
| GO:0032787 | monocarboxylic acid metabolic process | 26.6667 | 6 | yes |
| GO:0010646 | regulation of cell communication | 26.6667 | 4 | no |
| GO:0016054 | organic acid catabolic process | 23.3333 | 4 | yes |
| GO:0046395 | carboxylic acid catabolic process | 23.3333 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 23.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 23.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 23.3333 | 4 | no |
| GO:1901565 | organonitrogen compound catabolic process | 16.6667 | 4 | yes |
| GO:0009063 | cellular amino acid catabolic process | 13.3333 | 4 | yes |
| GO:0009081 | branched-chain amino acid metabolic process | 13.3333 | 4 | yes |
| GO:0009083 | branched-chain amino acid catabolic process | 13.3333 | 5 | yes |
| GO:0043603 | cellular amide metabolic process | 13.3333 | 4 | yes |
| GO:1901605 | alpha-amino acid metabolic process | 13.3333 | 4 | yes |
| GO:1901606 | alpha-amino acid catabolic process | 13.3333 | 5 | yes |
| GO:0006551 | leucine metabolic process | 10.0000 | 5 | yes |
| GO:0006552 | leucine catabolic process | 10.0000 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MCCA_HUMAN |
|---|---|---|---|---|
| DOID:0111198 | autosomal dominant distal hereditary motor neuronopathy | 6.6667 | 7 | no |
| DOID:12377 | spinal muscular atrophy | 6.6667 | 6 | no |
| DOID:1289 | neurodegenerative disease | 6.6667 | 4 | no |
| DOID:231 | motor neuron disease | 6.6667 | 5 | no |
| DOID:331 | central nervous system disease | 6.6667 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TRADD_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAF6_HUMAN | [view interactions] | Low throughput | no | yes |
| MAVS_HUMAN | [view interactions] | Low throughput | no | yes |
| MCCB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| RBX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SSBP2_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| MX1_HUMAN | [view interactions] | High throughput | no | yes |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| GALK1_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RN208_HUMAN | [view interactions] | High throughput | no | no |
| PCCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCCB_HUMAN | [view interactions] | High throughput | no | yes |
| PYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NP1L5_HUMAN | [view interactions] | High throughput | no | yes |
| DUS14_HUMAN | [view interactions] | High throughput | no | yes |
| ACTA_HUMAN | [view interactions] | High throughput | no | no |
| ARHGQ_HUMAN | [view interactions] | High throughput | no | yes |
| YBEY_HUMAN | [view interactions] | High throughput | no | yes |
| OTC_HUMAN | [view interactions] | High throughput | no | no |
| HTRA3_HUMAN | [view interactions] | High throughput | no | no |
| DSG4_HUMAN | [view interactions] | High throughput | no | no |
| PFD5_HUMAN | [view interactions] | High throughput | no | yes |
| ABHDA_HUMAN | [view interactions] | High throughput | no | yes |
| MASU1_HUMAN | [view interactions] | High throughput | no | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBR4_HUMAN | [view interactions] | High throughput | no | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDH6B_HUMAN | [view interactions] | High throughput | no | no |
| DHB8_HUMAN | [view interactions] | High throughput | no | yes |
| RM23_HUMAN | [view interactions] | High throughput | no | yes |
| DIC_HUMAN | [view interactions] | High throughput | no | yes |
| FA83A_HUMAN | [view interactions] | High throughput | no | no |
| MYL10_HUMAN | [view interactions] | High throughput | no | no |
| HDHD3_HUMAN | [view interactions] | High throughput | no | yes |
| AGO2_HUMAN | [view interactions] | High throughput | no | yes |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| NPS3A_HUMAN | [view interactions] | High throughput | no | yes |
| NPS3B_HUMAN | [view interactions] | High throughput | no | yes |
| NUD13_HUMAN | [view interactions] | High throughput | no | no |
| MRM2_HUMAN | [view interactions] | High throughput | no | yes |
| RT24_HUMAN | [view interactions] | High throughput | no | yes |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| COMD5_HUMAN | [view interactions] | High throughput | no | no |
| RT02_HUMAN | [view interactions] | High throughput | no | no |
| DHRS2_HUMAN | [view interactions] | High throughput | no | no |
| TRI43_HUMAN | [view interactions] | High throughput | no | no |
| RUSD3_HUMAN | [view interactions] | High throughput | no | yes |
| ATPF2_HUMAN | [view interactions] | High throughput | no | yes |
| LSMD1_HUMAN | [view interactions] | High throughput | no | no |
| PLPL4_HUMAN | [view interactions] | High throughput | no | yes |
| MTU1_HUMAN | [view interactions] | High throughput | no | no |
| STPG3_HUMAN | [view interactions] | High throughput | no | no |
| SYYM_HUMAN | [view interactions] | High throughput | no | no |
| PIGR_HUMAN | [view interactions] | High throughput | no | no |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTBP2_HUMAN | [view interactions] | High throughput | no | no |
| IVD_HUMAN | [view interactions] | High throughput | no | yes |
| HUTH_HUMAN | [view interactions] | High throughput | no | yes |
| MUTA_HUMAN | [view interactions] | High throughput | no | yes |
| FBX50_HUMAN | [view interactions] | High throughput | no | no |
| DPYS_HUMAN | [view interactions] | High throughput | no | no |
| GGCT_HUMAN | [view interactions] | High throughput | no | yes |
| ZA2G_HUMAN | [view interactions] | High throughput | no | no |
| IFT1B_HUMAN | [view interactions] | High throughput | no | no |
| IFIT2_HUMAN | [view interactions] | High throughput | no | no |
| TRFL_HUMAN | [view interactions] | High throughput | no | no |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| DCTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| PER2_HUMAN | [view interactions] | High throughput | no | yes |
| SALL1_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IFIT1_HUMAN | [view interactions] | High throughput | no | no |
| SIR4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPB_HUMAN | [view interactions] | High throughput | no | no |
| KBL_HUMAN | [view interactions] | High throughput | no | yes |
| ECH1_HUMAN | [view interactions] | High throughput | no | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCOT2_HUMAN | [view interactions] | High throughput | no | no |
| NDUF8_HUMAN | [view interactions] | High throughput | no | no |
| MAIP1_HUMAN | [view interactions] | High throughput | no | yes |
| CHC10_HUMAN | [view interactions] | High throughput | no | yes |
| ECI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHIPL_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| SOS2_HUMAN | [view interactions] | High throughput | no | yes |
| IREB2_HUMAN | [view interactions] | High throughput | no | no |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| CBLB_HUMAN | [view interactions] | High throughput | no | yes |
| GATA4_HUMAN | [view interactions] | High throughput | no | no |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| MYPC3_HUMAN | [view interactions] | High throughput | no | no |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSMR_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| STK4_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD3_HUMAN | [view interactions] | High throughput | no | yes |
| FXL19_HUMAN | [view interactions] | High throughput | no | no |
| CMBL_HUMAN | [view interactions] | High throughput | no | no |
| PAF1_HUMAN | [view interactions] | High throughput | no | yes |
| RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ISX_HUMAN | [view interactions] | High throughput | no | no |
| LHX6_HUMAN | [view interactions] | High throughput | no | yes |
| VSX1_HUMAN | [view interactions] | High throughput | no | no |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| SYRM_HUMAN | [view interactions] | High throughput | no | yes |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| FXRD1_HUMAN | [view interactions] | High throughput | no | no |
| TMM70_HUMAN | [view interactions] | High throughput | no | yes |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACSM5_HUMAN | [view interactions] | High throughput | no | yes |
| MET2A_HUMAN | [view interactions] | High throughput | no | no |
| HEMH_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| BTD_HUMAN | [view interactions] | Computational | no | no |
| ODBB_HUMAN | [view interactions] | Computational | no | yes |
| ECHP_HUMAN | [view interactions] | Computational | no | no |
| ECHA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CRCM_HUMAN | [view interactions] | Computational | no | no |
| BPL1_HUMAN | [view interactions] | Computational | no | yes |
| ECHM_HUMAN | [view interactions] | Computational | no | yes |
| ACMSD_HUMAN | [view interactions] | Computational | no | no |
| CCD62_HUMAN | [view interactions] | Computational | no | no |
| AUHM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |