MCCB_HUMAN
Evidence for PS localization
Functions
Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MCCB_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 29.5455 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.2727 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 27.2727 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 27.2727 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 27.2727 | 5 | yes |
| GO:0005524 | ATP binding | 22.7273 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.7273 | 4 | yes |
| GO:0003723 | RNA binding | 22.7273 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 20.4545 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 20.4545 | 4 | no |
| GO:0016421 | CoA carboxylase activity | 11.3636 | 4 | yes |
| GO:0004485 | methylcrotonoyl-CoA carboxylase activity | 6.8182 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MCCB_HUMAN |
|---|---|---|---|---|
| GO:0022607 | cellular component assembly | 52.2727 | 4 | no |
| GO:0006996 | organelle organization | 40.9091 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 40.9091 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 38.6364 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 36.3636 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 36.3636 | 4 | no |
| GO:0043933 | protein-containing complex organization | 34.0909 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 31.8182 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 31.8182 | 4 | yes |
| GO:0010468 | regulation of gene expression | 31.8182 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 31.8182 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 31.8182 | 4 | no |
| GO:1901565 | organonitrogen compound catabolic process | 29.5455 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 29.5455 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.5455 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 29.5455 | 5 | no |
| GO:0008104 | protein localization | 29.5455 | 4 | no |
| GO:0010646 | regulation of cell communication | 27.2727 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 27.2727 | 4 | no |
| GO:0016054 | organic acid catabolic process | 25.0000 | 4 | yes |
| GO:0046395 | carboxylic acid catabolic process | 25.0000 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 25.0000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 22.7273 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 22.7273 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.7273 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 22.7273 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.7273 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.7273 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 22.7273 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.7273 | 6 | no |
| GO:0071310 | cellular response to organic substance | 22.7273 | 4 | no |
| GO:0032787 | monocarboxylic acid metabolic process | 20.4545 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 20.4545 | 5 | no |
| GO:0031399 | regulation of protein modification process | 20.4545 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.4545 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.4545 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 20.4545 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.4545 | 5 | no |
| GO:0051049 | regulation of transport | 20.4545 | 4 | no |
| GO:0071702 | organic substance transport | 20.4545 | 4 | no |
| GO:0071705 | nitrogen compound transport | 20.4545 | 4 | no |
| GO:0072521 | purine-containing compound metabolic process | 18.1818 | 4 | yes |
| GO:0006163 | purine nucleotide metabolic process | 15.9091 | 5 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 15.9091 | 4 | yes |
| GO:0009063 | cellular amino acid catabolic process | 15.9091 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 15.9091 | 5 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 15.9091 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 15.9091 | 5 | yes |
| GO:0019693 | ribose phosphate metabolic process | 15.9091 | 4 | yes |
| GO:1901605 | alpha-amino acid metabolic process | 15.9091 | 4 | yes |
| GO:1901606 | alpha-amino acid catabolic process | 15.9091 | 5 | yes |
| GO:0009081 | branched-chain amino acid metabolic process | 13.6364 | 4 | yes |
| GO:0009083 | branched-chain amino acid catabolic process | 13.6364 | 5 | yes |
| GO:0006551 | leucine metabolic process | 9.0909 | 5 | yes |
| GO:0006552 | leucine catabolic process | 9.0909 | 6 | yes |
| GO:0033865 | nucleoside bisphosphate metabolic process | 9.0909 | 5 | yes |
| GO:0033875 | ribonucleoside bisphosphate metabolic process | 9.0909 | 6 | yes |
| GO:0034032 | purine nucleoside bisphosphate metabolic process | 9.0909 | 5 | yes |
| GO:0015936 | coenzyme A metabolic process | 4.5455 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MCCB_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 6.8182 | 4 | no |
| DOID:331 | central nervous system disease | 6.8182 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MCCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KATIP_HUMAN | [view interactions] | High throughput | no | yes |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| VSX1_HUMAN | [view interactions] | High throughput | no | no |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| TERF2_HUMAN | [view interactions] | High throughput | no | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NANOG_HUMAN | [view interactions] | High throughput | no | no |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5E_HUMAN | [view interactions] | High throughput | no | no |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| RECK_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SSBP2_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| PCCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCCB_HUMAN | [view interactions] | High throughput | no | yes |
| PYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NP1L5_HUMAN | [view interactions] | High throughput | no | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC4_HUMAN | [view interactions] | High throughput | no | yes |
| NR4A1_HUMAN | [view interactions] | High throughput | no | yes |
| NPS3A_HUMAN | [view interactions] | High throughput | no | yes |
| KBL_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RT24_HUMAN | [view interactions] | High throughput | no | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| NALP7_HUMAN | [view interactions] | High throughput | no | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGCL_HUMAN | [view interactions] | High throughput | no | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUBB_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUS8_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| TPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 3HIDH_HUMAN | [view interactions] | High throughput | no | yes |
| MMSA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HUTH_HUMAN | [view interactions] | High throughput | no | yes |
| WNK2_HUMAN | [view interactions] | High throughput | no | yes |
| RIPL1_HUMAN | [view interactions] | High throughput | no | yes |
| MUTA_HUMAN | [view interactions] | High throughput | no | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLN11_HUMAN | [view interactions] | High throughput | no | yes |
| PER2_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| IFIT1_HUMAN | [view interactions] | High throughput | no | no |
| HDA11_HUMAN | [view interactions] | High throughput | no | no |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| SIR4_HUMAN | [view interactions] | High throughput | no | yes |
| ECSIT_HUMAN | [view interactions] | High throughput | no | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXRD1_HUMAN | [view interactions] | High throughput | no | no |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| PDIP2_HUMAN | [view interactions] | High throughput | no | no |
| ECH1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYPC3_HUMAN | [view interactions] | High throughput | no | no |
| LITD1_HUMAN | [view interactions] | High throughput | no | no |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| UBS3B_HUMAN | [view interactions] | High throughput | no | yes |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK4_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD3_HUMAN | [view interactions] | High throughput | no | yes |
| FXL19_HUMAN | [view interactions] | High throughput | no | no |
| CMBL_HUMAN | [view interactions] | High throughput | no | no |
| PAF1_HUMAN | [view interactions] | High throughput | no | yes |
| ODBB_HUMAN | [view interactions] | Computational | no | yes |
| ECHP_HUMAN | [view interactions] | Computational | no | no |
| ECHA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| USBP1_HUMAN | [view interactions] | Computational | no | no |
| BPL1_HUMAN | [view interactions] | Computational | no | yes |
| ECHM_HUMAN | [view interactions] | Computational | no | yes |
| CRCM_HUMAN | [view interactions] | Computational | no | no |
| HCDH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AUHM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |