TPP1_HUMAN
Lysosomal serine protease with tripeptidyl-peptidase I activity (PubMed, PubMed, PubMed). May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases (PubMed, PubMed, PubMed). Requires substrates with an unsubstituted N-terminus (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in TPP1_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 40.5405 | 4 | yes |
GO:0015399 | primary active transmembrane transporter activity | 29.7297 | 4 | no |
GO:0005524 | ATP binding | 21.6216 | 5 | no |
GO:0017076 | purine nucleotide binding | 21.6216 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 21.6216 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 21.6216 | 4 | no |
GO:0032559 | adenyl ribonucleotide binding | 21.6216 | 5 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 21.6216 | 4 | no |
GO:0004175 | endopeptidase activity | 10.8108 | 4 | yes |
GO:0004252 | serine-type endopeptidase activity | 8.1081 | 5 | yes |
GO:0008236 | serine-type peptidase activity | 8.1081 | 4 | yes |
GO:0008238 | exopeptidase activity | 5.4054 | 4 | yes |
GO:0008240 | tripeptidyl-peptidase activity | 5.4054 | 6 | yes |
GO:0070008 | serine-type exopeptidase activity | 5.4054 | 5 | yes |
GO:0120146 | sulfatide binding | 5.4054 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in TPP1_HUMAN |
---|---|---|---|---|
GO:0031323 | regulation of cellular metabolic process | 37.8378 | 4 | no |
GO:0048523 | negative regulation of cellular process | 37.8378 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 37.8378 | 4 | no |
GO:0048522 | positive regulation of cellular process | 35.1351 | 4 | no |
GO:0010646 | regulation of cell communication | 32.4324 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 32.4324 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 32.4324 | 4 | no |
GO:0008104 | protein localization | 29.7297 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 29.7297 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 29.7297 | 4 | no |
GO:0006996 | organelle organization | 27.0270 | 4 | yes |
GO:0022607 | cellular component assembly | 27.0270 | 4 | no |
GO:0010243 | response to organonitrogen compound | 27.0270 | 4 | no |
GO:0009966 | regulation of signal transduction | 27.0270 | 4 | no |
GO:0022900 | electron transport chain | 24.3243 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 24.3243 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 24.3243 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 24.3243 | 5 | no |
GO:0010468 | regulation of gene expression | 24.3243 | 5 | no |
GO:0010941 | regulation of cell death | 24.3243 | 4 | no |
GO:0043067 | regulation of programmed cell death | 24.3243 | 5 | no |
GO:0048585 | negative regulation of response to stimulus | 24.3243 | 4 | no |
GO:0009060 | aerobic respiration | 21.6216 | 6 | no |
GO:0015980 | energy derivation by oxidation of organic compounds | 21.6216 | 4 | no |
GO:0022904 | respiratory electron transport chain | 21.6216 | 5 | no |
GO:0045333 | cellular respiration | 21.6216 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 21.6216 | 6 | no |
GO:0031324 | negative regulation of cellular metabolic process | 21.6216 | 5 | no |
GO:0031399 | regulation of protein modification process | 21.6216 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 21.6216 | 5 | no |
GO:0043933 | protein-containing complex organization | 21.6216 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 21.6216 | 4 | no |
GO:0009894 | regulation of catabolic process | 21.6216 | 4 | no |
GO:0010648 | negative regulation of cell communication | 21.6216 | 5 | no |
GO:0023057 | negative regulation of signaling | 21.6216 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 21.6216 | 5 | no |
GO:0031329 | regulation of cellular catabolic process | 21.6216 | 5 | no |
GO:0042981 | regulation of apoptotic process | 21.6216 | 6 | no |
GO:1902531 | regulation of intracellular signal transduction | 21.6216 | 5 | no |
GO:0006508 | proteolysis | 16.2162 | 4 | yes |
GO:0009057 | macromolecule catabolic process | 16.2162 | 4 | yes |
GO:1901565 | organonitrogen compound catabolic process | 16.2162 | 4 | yes |
GO:0030163 | protein catabolic process | 13.5135 | 4 | yes |
GO:0033365 | protein localization to organelle | 13.5135 | 5 | yes |
GO:0006518 | peptide metabolic process | 8.1081 | 4 | yes |
GO:0007033 | vacuole organization | 8.1081 | 5 | yes |
GO:0007417 | central nervous system development | 8.1081 | 4 | yes |
GO:0043603 | cellular amide metabolic process | 8.1081 | 4 | yes |
GO:0001894 | tissue homeostasis | 5.4054 | 5 | yes |
GO:0007039 | protein catabolic process in the vacuole | 5.4054 | 5 | yes |
GO:0007040 | lysosome organization | 5.4054 | 7 | yes |
GO:0007399 | nervous system development | 5.4054 | 4 | yes |
GO:0030855 | epithelial cell differentiation | 5.4054 | 4 | yes |
GO:0034502 | protein localization to chromosome | 5.4054 | 6 | yes |
GO:0043171 | peptide catabolic process | 5.4054 | 4 | yes |
GO:0045453 | bone resorption | 5.4054 | 6 | yes |
GO:0050885 | neuromuscular process controlling balance | 5.4054 | 5 | yes |
GO:0050905 | neuromuscular process | 5.4054 | 4 | yes |
GO:0060249 | anatomical structure homeostasis | 5.4054 | 4 | yes |
GO:0070198 | protein localization to chromosome, telomeric region | 5.4054 | 7 | yes |
GO:0080171 | lytic vacuole organization | 5.4054 | 6 | yes |
GO:1905146 | lysosomal protein catabolic process | 5.4054 | 6 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in TPP1_HUMAN |
---|---|---|---|---|
DOID:1289 | neurodegenerative disease | 8.1081 | 4 | yes |
DOID:331 | central nervous system disease | 8.1081 | 3 | yes |
DOID:0050753 | cerebellar ataxia | 5.4054 | 6 | yes |
DOID:0050950 | autosomal recessive cerebellar ataxia | 5.4054 | 7 | yes |
DOID:0050951 | hereditary ataxia | 5.4054 | 5 | yes |
DOID:0080059 | autosomal recessive spinocerebellar ataxia 7 | 5.4054 | 8 | yes |
DOID:0110726 | neuronal ceroid lipofuscinosis 2 | 5.4054 | 6 | yes |
DOID:14503 | neuronal ceroid lipofuscinosis | 5.4054 | 5 | yes |
DOID:3211 | lysosomal storage disease | 5.4054 | 3 | yes |
DOID:9455 | lipid storage disease | 5.4054 | 4 | yes |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
POTE1_HUMAN | [view interactions] | Low throughput | no | no |
STN1_HUMAN | [view interactions] | Low throughput | no | no |
CTC1_HUMAN | [view interactions] | Low throughput | no | no |
TERT_HUMAN | [view interactions] | Low throughput | no | no |
RNF8_HUMAN | [view interactions] | Low throughput | no | yes |
UBP7_HUMAN | [view interactions] | Low throughput | no | yes |
TINF2_HUMAN | [view interactions] | Low throughput | no | no |
TPP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GLUT4_HUMAN | [view interactions] | High throughput | no | no |
MBD2_HUMAN | [view interactions] | High throughput | no | yes |
GRDN_HUMAN | [view interactions] | High throughput | no | no |
NALP2_HUMAN | [view interactions] | High throughput | no | no |
ELK1_HUMAN | [view interactions] | High throughput | no | yes |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKN3_HUMAN | [view interactions] | High throughput | no | yes |
PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
ANGI_HUMAN | [view interactions] | High throughput | no | no |
TX101_HUMAN | [view interactions] | High throughput | no | no |
CEP55_HUMAN | [view interactions] | High throughput | no | yes |
FBX42_HUMAN | [view interactions] | High throughput | no | yes |
FBXL4_HUMAN | [view interactions] | High throughput | no | yes |
WWP2_HUMAN | [view interactions] | High throughput | no | no |
TRAF4_HUMAN | [view interactions] | High throughput | no | yes |
CISH_HUMAN | [view interactions] | High throughput | no | yes |
ZBT38_HUMAN | [view interactions] | High throughput | no | no |
RN183_HUMAN | [view interactions] | High throughput | no | no |
OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
A2MG_HUMAN | [view interactions] | High throughput | no | yes |
TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FBX6_HUMAN | [view interactions] | High throughput | no | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
MCM2_HUMAN | [view interactions] | High throughput | no | no |
MPIP3_HUMAN | [view interactions] | High throughput | no | yes |
OMA1_HUMAN | [view interactions] | High throughput | no | no |
NDKM_HUMAN | [view interactions] | High throughput | no | yes |
GDC_HUMAN | [view interactions] | High throughput | no | no |
RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
MAGF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
APEX1_HUMAN | [view interactions] | High throughput | no | yes |
CUL7_HUMAN | [view interactions] | High throughput | no | yes |
WDR5_HUMAN | [view interactions] | High throughput | no | no |
KMCP1_HUMAN | [view interactions] | High throughput | no | no |
DGKG_HUMAN | [view interactions] | High throughput | no | no |
TSN2_HUMAN | [view interactions] | High throughput | no | no |
POP5_HUMAN | [view interactions] | High throughput | no | no |
DHB8_HUMAN | [view interactions] | High throughput | no | yes |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TM192_HUMAN | [view interactions] | High throughput | no | yes |
XRN2_HUMAN | [view interactions] | High throughput | no | yes |
BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CCD47_HUMAN | [view interactions] | High throughput | no | yes |
OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ODBB_HUMAN | [view interactions] | High throughput | no | yes |
PON2_HUMAN | [view interactions] | High throughput | no | yes |
QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NCPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HXK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NNTM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
P4HA1_HUMAN | [view interactions] | High throughput | no | yes |
AT2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HCDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GSTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ASPH_HUMAN | [view interactions] | High throughput | no | yes |
LTOR2_HUMAN | [view interactions] | High throughput | no | yes |
COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TFR1_HUMAN | [view interactions] | High throughput | no | yes |
ATPG_HUMAN | [view interactions] | High throughput | no | yes |
ATPB_HUMAN | [view interactions] | High throughput | no | yes |
ETFD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADAS_HUMAN | [view interactions] | High throughput | no | yes |
NDUS8_HUMAN | [view interactions] | High throughput | no | yes |
EMC4_HUMAN | [view interactions] | High throughput | no | yes |
CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPRE_HUMAN | [view interactions] | High throughput | no | yes |
THTM_HUMAN | [view interactions] | High throughput | no | yes |
COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CYB5_HUMAN | [view interactions] | High throughput | no | no |
MCCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUBB_HUMAN | [view interactions] | High throughput | no | yes |
BGAL_HUMAN | [view interactions] | High throughput | no | yes |
ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
CLN5_HUMAN | [view interactions] | Computational | no | yes |
CLN3_HUMAN | [view interactions] | Computational | no | no |
TERF1_HUMAN | [view interactions] | Computational | no | no |
CLN6_HUMAN | [view interactions] | Computational | no | no |
MFSD8_HUMAN | [view interactions] | Computational | no | yes |
XBP1_HUMAN | [view interactions] | Computational | no | no |