Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

EPS15_HUMAN

Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. [View more on UniProt]

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No data found.

ELM instance Name Type Start End Partner
ELMI000839 LIG_AP2alpha_2 LIG 599 601 -
ELMI000840 LIG_AP2alpha_2 LIG 623 625 -
ELMI000841 LIG_AP2alpha_2 LIG 629 631 -
ELMI000842 LIG_AP2alpha_2 LIG 634 636 -
ELMI000843 LIG_AP2alpha_2 LIG 640 642 -
ELMI000844 LIG_AP2alpha_2 LIG 645 647 -
ELMI000845 LIG_AP2alpha_2 LIG 651 653 -
ELMI000846 LIG_AP2alpha_2 LIG 664 666 -
ELMI000835 LIG_AP2alpha_2 LIG 672 674 -
ELMI000836 LIG_AP2alpha_2 LIG 692 694 -
ELMI000837 LIG_AP2alpha_2 LIG 709 711 -
ELMI000838 LIG_AP2alpha_2 LIG 737 739 -
ELMI000847 LIG_AP2alpha_2 LIG 798 800 -
ELMI000848 LIG_AP2alpha_2 LIG 804 806 -
ELMI000849 LIG_AP2alpha_2 LIG 825 827 -
ELMI000839 LIG_AP2alpha_2 LIG 599 601 -
ELMI000840 LIG_AP2alpha_2 LIG 623 625 -
ELMI000841 LIG_AP2alpha_2 LIG 629 631 -
ELMI000842 LIG_AP2alpha_2 LIG 634 636 -
ELMI000843 LIG_AP2alpha_2 LIG 640 642 -
ELMI000844 LIG_AP2alpha_2 LIG 645 647 -
ELMI000845 LIG_AP2alpha_2 LIG 651 653 -
ELMI000846 LIG_AP2alpha_2 LIG 664 666 -
ELMI000835 LIG_AP2alpha_2 LIG 672 674 -
ELMI000836 LIG_AP2alpha_2 LIG 692 694 -
ELMI000837 LIG_AP2alpha_2 LIG 709 711 -
ELMI000838 LIG_AP2alpha_2 LIG 737 739 -
ELMI000847 LIG_AP2alpha_2 LIG 798 800 -
ELMI000848 LIG_AP2alpha_2 LIG 804 806 -
ELMI000849 LIG_AP2alpha_2 LIG 825 827 -

Molecular function

Term Name % Distance from the top of the tree Annotated in EPS15_HUMAN
GO:0043168 anion binding 27.2727 4 no
GO:0043169 cation binding 26.2626 4 yes
GO:0046872 metal ion binding 26.2626 5 yes
GO:0019900 kinase binding 26.2626 4 no
GO:0003723 RNA binding 26.2626 4 no
GO:0019901 protein kinase binding 25.2525 5 no
GO:0000166 nucleotide binding 23.2323 4 no
GO:0017076 purine nucleotide binding 23.2323 5 no
GO:0032555 purine ribonucleotide binding 23.2323 4 no
GO:0035639 purine ribonucleoside triphosphate binding 22.2222 4 no
GO:0045296 cadherin binding 21.2121 4 yes
GO:0030554 adenyl nucleotide binding 21.2121 6 no
GO:0032559 adenyl ribonucleotide binding 21.2121 5 no
GO:0005524 ATP binding 20.2020 5 no
GO:0017124 SH3 domain binding 12.1212 4 yes
GO:0005509 calcium ion binding 10.1010 6 yes
GO:0031593 polyubiquitin modification-dependent protein binding 2.0202 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in EPS15_HUMAN
GO:0048522 positive regulation of cellular process 56.5657 4 no
GO:0051128 regulation of cellular component organization 56.5657 4 no
GO:0048523 negative regulation of cellular process 46.4646 4 no
GO:0008104 protein localization 44.4444 4 yes
GO:0022607 cellular component assembly 44.4444 4 yes
GO:0006996 organelle organization 43.4343 4 yes
GO:0098657 import into cell 41.4141 4 yes
GO:0060255 regulation of macromolecule metabolic process 40.4040 4 yes
GO:0071702 organic substance transport 37.3737 4 yes
GO:0071705 nitrogen compound transport 37.3737 4 yes
GO:0031323 regulation of cellular metabolic process 37.3737 4 no
GO:0010646 regulation of cell communication 36.3636 4 no
GO:0080090 regulation of primary metabolic process 36.3636 4 no
GO:0009889 regulation of biosynthetic process 34.3434 4 no
GO:0010556 regulation of macromolecule biosynthetic process 34.3434 5 no
GO:0031326 regulation of cellular biosynthetic process 34.3434 5 no
GO:0009893 positive regulation of metabolic process 33.3333 4 yes
GO:0051049 regulation of transport 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 32.3232 5 yes
GO:0010468 regulation of gene expression 31.3131 6 no
GO:0015031 protein transport 30.3030 4 yes
GO:0043933 protein-containing complex organization 30.3030 4 yes
GO:0009966 regulation of signal transduction 28.2828 4 no
GO:0051130 positive regulation of cellular component organization 27.2727 5 no
GO:0051246 regulation of protein metabolic process 27.2727 5 no
GO:0031325 positive regulation of cellular metabolic process 26.2626 5 no
GO:0060341 regulation of cellular localization 26.2626 4 no
GO:0006898 receptor-mediated endocytosis 25.2525 4 yes
GO:0065003 protein-containing complex assembly 25.2525 5 yes
GO:0032880 regulation of protein localization 25.2525 5 no
GO:0009892 negative regulation of metabolic process 24.2424 4 no
GO:0033043 regulation of organelle organization 24.2424 5 no
GO:0023056 positive regulation of signaling 23.2323 4 yes
GO:0030030 cell projection organization 23.2323 4 no
GO:0031324 negative regulation of cellular metabolic process 23.2323 5 no
GO:0048584 positive regulation of response to stimulus 23.2323 4 no
GO:1902531 regulation of intracellular signal transduction 23.2323 5 no
GO:0010605 negative regulation of macromolecule metabolic process 22.2222 5 no
GO:0006886 intracellular protein transport 22.2222 4 no
GO:0007010 cytoskeleton organization 21.2121 5 no
GO:0009891 positive regulation of biosynthetic process 21.2121 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.2121 6 no
GO:0010647 positive regulation of cell communication 21.2121 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.2121 5 no
GO:0031328 positive regulation of cellular biosynthetic process 21.2121 6 no
GO:0044087 regulation of cellular component biogenesis 21.2121 4 no
GO:0051050 positive regulation of transport 21.2121 4 no
GO:0051247 positive regulation of protein metabolic process 21.2121 6 no
GO:0060627 regulation of vesicle-mediated transport 21.2121 4 no
GO:0022603 regulation of anatomical structure morphogenesis 20.2020 4 no
GO:0051252 regulation of RNA metabolic process 20.2020 5 no
GO:0071310 cellular response to organic substance 20.2020 4 no
GO:0042127 regulation of cell population proliferation 16.1616 4 yes
GO:0031623 receptor internalization 15.1515 5 yes
GO:0016050 vesicle organization 10.1010 5 yes
GO:0048268 clathrin coat assembly 10.1010 6 yes
GO:0098884 postsynaptic neurotransmitter receptor internalization 7.0707 4 yes
GO:0140239 postsynaptic endocytosis 7.0707 4 yes
GO:0006892 post-Golgi vesicle-mediated transport 6.0606 4 yes
GO:0016482 cytosolic transport 6.0606 4 yes
GO:0032456 endocytic recycling 4.0404 4 yes
GO:0006895 Golgi to endosome transport 3.0303 5 yes
GO:0001919 regulation of receptor recycling 2.0202 4 yes
GO:0001921 positive regulation of receptor recycling 2.0202 5 yes
GO:0019065 receptor-mediated endocytosis of virus by host cell 2.0202 4 yes
GO:0044409 symbiont entry into host 2.0202 4 yes
GO:0046718 symbiont entry into host cell 2.0202 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CLH1_HUMAN [view entry] [view interactions] Low throughput yes yes
PTN3_HUMAN [view interactions] Low throughput no yes
CRK_HUMAN [view entry] [view interactions] Low throughput yes no
EPS15_HUMAN [view entry] [view interactions] Low throughput yes yes
PHOCN_HUMAN [view entry] [view interactions] Low throughput yes yes
EP15R_HUMAN [view entry] [view interactions] Low throughput yes yes
AGFG1_HUMAN [view interactions] Low throughput no yes
AP2A2_HUMAN [view entry] [view interactions] Low throughput yes yes
UBQL1_HUMAN [view interactions] Low throughput no yes
PSD1_HUMAN [view entry] [view interactions] Low throughput yes no
FCHO2_HUMAN [view interactions] Low throughput no yes
EPN3_HUMAN [view interactions] Low throughput no no
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] Low throughput yes no
SGIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
SYT1_HUMAN [view entry] [view interactions] Low throughput yes no
AP2B1_HUMAN [view entry] [view interactions] Low throughput yes yes
AP1B1_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2A1_HUMAN [view entry] [view interactions] Low throughput yes yes
PTN13_HUMAN [view interactions] Low throughput no yes
PTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
TFR1_HUMAN [view entry] [view interactions] Low throughput yes yes
SCAM1_HUMAN [view interactions] Low throughput no no
SPART_HUMAN [view interactions] Low throughput no yes
OPTN_HUMAN [view interactions] Low throughput no yes
DYN2_HUMAN [view entry] [view interactions] Low throughput yes yes
STAM2_HUMAN [view interactions] Low throughput no yes
RFIP2_HUMAN [view entry] [view interactions] Low throughput yes yes
SC6A3_HUMAN [view entry] [view interactions] Low throughput yes yes
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
UBP8_HUMAN [view entry] [view interactions] Low throughput yes no
CD4_HUMAN [view interactions] Low throughput no no
OCLN_HUMAN [view interactions] Low throughput no no
CXA1_HUMAN [view entry] [view interactions] Low throughput yes yes
TGFB1_HUMAN [view interactions] Low throughput no no
UBQL2_HUMAN [view interactions] Low throughput no yes
CORO7_HUMAN [view interactions] Low throughput no no
AP1G1_HUMAN [view entry] [view interactions] Low throughput yes yes
SPOPL_HUMAN [view interactions] Low throughput no yes
FCHO1_HUMAN [view entry] [view interactions] Low throughput yes yes
RNF26_HUMAN [view interactions] Low throughput no yes
DPYL2_HUMAN [view entry] [view interactions] Low throughput yes yes
AP180_HUMAN [view entry] [view interactions] Low throughput yes yes
MSRE_HUMAN [view interactions] Low throughput no no
AGFG2_HUMAN [view interactions] Low throughput no yes
NAGPA_HUMAN [view interactions] Low throughput no no
DYN1_HUMAN [view entry] [view interactions] Low throughput yes yes
EPN4_HUMAN [view interactions] Low throughput no yes
SYNJ1_HUMAN [view entry] [view interactions] Low throughput yes yes
NUMBL_HUMAN [view entry] [view interactions] Low throughput yes yes
EPN2_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2A_HUMAN [view interactions] Low throughput no no
NEDD4_HUMAN [view entry] [view interactions] Low throughput yes yes
MK14_HUMAN [view interactions] Low throughput no yes
PRP17_HUMAN [view interactions] Low throughput no no
STON2_HUMAN [view interactions] Low throughput no yes
SH3B4_HUMAN [view interactions] Low throughput no yes
EPN1_HUMAN [view entry] [view interactions] Low throughput yes yes
NUMB_HUMAN [view entry] [view interactions] Low throughput yes yes
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
REPS2_HUMAN [view entry] [view interactions] Low throughput yes no
ITSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
HGS_HUMAN [view entry] [view interactions] Low throughput yes yes
RNF11_HUMAN [view interactions] Low throughput no yes
EGFR_HUMAN [view interactions] Low throughput no no
DAB2_HUMAN [view interactions] Low throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
MYO19_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
FLNB_HUMAN [view interactions] High throughput no no
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
CALL3_HUMAN [view interactions] High throughput no yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
SC24C_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
GTSE1_HUMAN [view interactions] High throughput no no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
PDLI7_HUMAN [view entry] [view interactions] High throughput yes no
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
GAK_HUMAN [view entry] [view interactions] High throughput yes yes
S2541_HUMAN [view interactions] High throughput no no
AURKA_HUMAN [view entry] [view interactions] High throughput yes no
STALP_HUMAN [view interactions] High throughput no yes
SPC25_HUMAN [view interactions] High throughput no no
AP2S1_HUMAN [view entry] [view interactions] High throughput yes no
LSR_HUMAN [view interactions] High throughput no yes
SCOT1_HUMAN [view entry] [view interactions] High throughput yes yes
CC172_HUMAN [view interactions] High throughput no no
VCAM1_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
PLK1_HUMAN [view interactions] High throughput no yes
WNK3_HUMAN [view interactions] High throughput no no
IMB1_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA7_HUMAN [view interactions] High throughput no yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
BMI1_HUMAN [view interactions] High throughput no yes
ZWINT_HUMAN [view entry] [view interactions] High throughput yes no
MCCB_HUMAN [view entry] [view interactions] High throughput yes yes
KT33A_HUMAN [view interactions] High throughput no no
BMP2K_HUMAN [view interactions] High throughput no yes
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
KRT36_HUMAN [view interactions] High throughput no no
TRAF2_HUMAN [view interactions] High throughput no yes
NECP2_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
MDM2_HUMAN [view entry] [view interactions] High throughput yes yes
TMM17_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
LMTK1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
ITSN2_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
RD23A_HUMAN [view interactions] High throughput no yes
KRT85_HUMAN [view interactions] High throughput no no
K2C1_HUMAN [view interactions] High throughput no no
K1C10_HUMAN [view interactions] High throughput no no
K22E_HUMAN [view interactions] High throughput no no
K1C14_HUMAN [view interactions] High throughput no no
KRT86_HUMAN [view interactions] High throughput no no
K2C5_HUMAN [view entry] [view interactions] High throughput yes no
K2C6A_HUMAN [view entry] [view interactions] High throughput yes no
K1C16_HUMAN [view interactions] High throughput no no
K1C9_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
KRT35_HUMAN [view interactions] High throughput no no
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
K1C17_HUMAN [view interactions] High throughput no no
KT33B_HUMAN [view interactions] High throughput no no
KRT83_HUMAN [view interactions] High throughput no no
KRT34_HUMAN [view interactions] High throughput no no
KRT82_HUMAN [view interactions] High throughput no no
NONO_HUMAN [view interactions] High throughput no yes
KRT38_HUMAN [view interactions] High throughput no no
K2C75_HUMAN [view interactions] High throughput no no
K2C79_HUMAN [view interactions] High throughput no no
PRDX1_HUMAN [view entry] [view interactions] High throughput yes yes
K1H2_HUMAN [view interactions] High throughput no no
MAP4_HUMAN [view entry] [view interactions] High throughput yes no
HS71L_HUMAN [view entry] [view interactions] High throughput yes no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
KRT37_HUMAN [view interactions] High throughput no no
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
K2C73_HUMAN [view interactions] High throughput no no
K2C3_HUMAN [view interactions] High throughput no no
DCAF1_HUMAN [view interactions] High throughput no yes
TBB5_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes
PCCB_HUMAN [view interactions] High throughput no yes
KRA93_HUMAN [view interactions] High throughput no no
NECP1_HUMAN [view interactions] High throughput no no
VSIG8_HUMAN [view interactions] High throughput no no
SNH28_HUMAN [view interactions] High throughput no no
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
CRKL_HUMAN [view entry] [view interactions] High throughput yes yes
ITA4_HUMAN [view interactions] High throughput no no
EPHA2_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
RUN3A_HUMAN [view interactions] High throughput no yes
TEDC2_HUMAN [view interactions] High throughput no no
HNRPL_HUMAN [view interactions] High throughput no yes
STK40_HUMAN [view interactions] High throughput no no
DYR1A_HUMAN [view interactions] High throughput no yes
DVL2_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
RIGI_HUMAN [view interactions] High throughput no yes
RNPS1_HUMAN [view interactions] High throughput no yes
MACC1_HUMAN [view interactions] High throughput no yes
SYCE1_HUMAN [view interactions] High throughput no no
TIG1_HUMAN [view interactions] High throughput no yes
RPB1B_HUMAN [view interactions] High throughput no no
INSY1_HUMAN [view entry] [view interactions] High throughput yes yes
ZCH10_HUMAN [view interactions] High throughput no yes
SYNCI_HUMAN [view interactions] High throughput no no
IN80E_HUMAN [view interactions] High throughput no yes
AUXI_HUMAN [view entry] [view interactions] High throughput yes yes
RUFY4_HUMAN [view interactions] High throughput no no
RHG18_HUMAN [view interactions] High throughput no yes
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
ROA2_HUMAN [view entry] [view interactions] High throughput yes yes
TLS1_HUMAN [view interactions] High throughput no yes
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
BCR_HUMAN [view entry] [view interactions] High throughput yes yes
UB2D1_HUMAN [view interactions] High throughput no yes
UB2D2_HUMAN [view interactions] High throughput no yes
UB2D3_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
UB2E1_HUMAN [view interactions] High throughput no yes
PALMD_HUMAN [view interactions] High throughput no no
TAC2N_HUMAN [view interactions] High throughput no yes
RABL6_HUMAN [view interactions] High throughput no yes
AMPH_HUMAN [view entry] [view interactions] High throughput yes yes
K2C4_HUMAN [view interactions] High throughput no no
K1H1_HUMAN [view interactions] High throughput no no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI56_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
DNJC5_HUMAN [view interactions] High throughput no yes
ACBD5_HUMAN [view entry] [view interactions] High throughput yes yes
VASP_HUMAN [view entry] [view interactions] High throughput yes yes
NAA40_HUMAN [view interactions] High throughput no no
PML_HUMAN [view interactions] High throughput no yes
PTN23_HUMAN [view entry] [view interactions] High throughput yes yes
TRI23_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
KDM1A_HUMAN [view interactions] High throughput no yes
HDAC1_HUMAN [view interactions] High throughput no no
PF21A_HUMAN [view interactions] High throughput no yes
RCOR1_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
RFA4_HUMAN [view interactions] High throughput no yes
TM114_HUMAN [view interactions] High throughput no no
WEE1_HUMAN [view interactions] High throughput no yes
AF10_HUMAN [view interactions] High throughput no no
AF17_HUMAN [view interactions] High throughput no yes
PICAL_HUMAN [view entry] [view interactions] High throughput yes yes
S31E1_HUMAN [view interactions] High throughput no no
DRAM1_HUMAN [view interactions] High throughput no no
LMTK3_HUMAN [view entry] [view interactions] High throughput yes yes
UBQL3_HUMAN [view interactions] High throughput no no
DLGP5_HUMAN [view interactions] High throughput no no
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
FYN_HUMAN [view entry] [view interactions] High throughput yes no
NCK1_HUMAN [view interactions] High throughput no yes
LAPM5_HUMAN [view interactions] High throughput no yes
MTR1A_HUMAN [view interactions] High throughput no no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
ANLN_HUMAN [view interactions] High throughput no yes