Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

REPS2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed, PubMed, PubMed). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed). Through ASAP1 may regulate cell adhesion and migration (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in REPS2_HUMAN
GO:0019900 kinase binding 31.5789 4 no
GO:0019901 protein kinase binding 31.5789 5 no
GO:0045296 cadherin binding 31.5789 4 no
GO:0046872 metal ion binding 26.3158 4 yes
GO:0003779 actin binding 26.3158 4 no
GO:0005524 ATP binding 21.0526 5 no
GO:0017076 purine nucleotide binding 21.0526 4 no
GO:0030554 adenyl nucleotide binding 21.0526 5 no
GO:0032555 purine ribonucleotide binding 21.0526 4 no
GO:0032559 adenyl ribonucleotide binding 21.0526 5 no
GO:0035639 purine ribonucleoside triphosphate binding 21.0526 4 no
GO:0005509 calcium ion binding 10.5263 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in REPS2_HUMAN
GO:0048522 positive regulation of cellular process 63.1579 4 no
GO:0006897 endocytosis 57.8947 5 yes
GO:0016192 vesicle-mediated transport 57.8947 4 yes
GO:0060255 regulation of macromolecule metabolic process 57.8947 4 no
GO:0031323 regulation of cellular metabolic process 52.6316 4 no
GO:0048523 negative regulation of cellular process 52.6316 4 no
GO:0051128 regulation of cellular component organization 52.6316 4 no
GO:0051171 regulation of nitrogen compound metabolic process 52.6316 4 no
GO:0080090 regulation of primary metabolic process 52.6316 4 no
GO:0010646 regulation of cell communication 47.3684 4 no
GO:0051049 regulation of transport 47.3684 4 no
GO:0071702 organic substance transport 47.3684 4 no
GO:0071705 nitrogen compound transport 47.3684 4 no
GO:0006996 organelle organization 47.3684 4 no
GO:0008104 protein localization 42.1053 4 no
GO:0009892 negative regulation of metabolic process 36.8421 4 no
GO:0010605 negative regulation of macromolecule metabolic process 36.8421 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 36.8421 5 no
GO:0022607 cellular component assembly 36.8421 4 yes
GO:0015031 protein transport 36.8421 4 no
GO:0009966 regulation of signal transduction 36.8421 4 no
GO:0051050 positive regulation of transport 36.8421 4 no
GO:0051336 regulation of hydrolase activity 31.5789 4 no
GO:0031324 negative regulation of cellular metabolic process 31.5789 5 no
GO:0033043 regulation of organelle organization 31.5789 5 no
GO:0051246 regulation of protein metabolic process 31.5789 5 no
GO:0051130 positive regulation of cellular component organization 31.5789 5 no
GO:0006886 intracellular protein transport 31.5789 4 no
GO:0009889 regulation of biosynthetic process 31.5789 4 no
GO:0009893 positive regulation of metabolic process 31.5789 4 no
GO:0010468 regulation of gene expression 31.5789 5 no
GO:0010556 regulation of macromolecule biosynthetic process 31.5789 5 no
GO:0045595 regulation of cell differentiation 31.5789 4 no
GO:0051093 negative regulation of developmental process 31.5789 4 no
GO:0010941 regulation of cell death 31.5789 4 no
GO:0042981 regulation of apoptotic process 31.5789 6 no
GO:0043067 regulation of programmed cell death 31.5789 5 no
GO:0043085 positive regulation of catalytic activity 31.5789 4 no
GO:0051345 positive regulation of hydrolase activity 26.3158 5 no
GO:0051726 regulation of cell cycle 26.3158 4 no
GO:0060341 regulation of cellular localization 26.3158 4 no
GO:0060548 negative regulation of cell death 26.3158 5 no
GO:1902531 regulation of intracellular signal transduction 26.3158 5 no
GO:0051248 negative regulation of protein metabolic process 26.3158 6 no
GO:0010638 positive regulation of organelle organization 26.3158 6 no
GO:0043933 protein-containing complex organization 26.3158 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 26.3158 5 no
GO:0022603 regulation of anatomical structure morphogenesis 26.3158 4 no
GO:0031325 positive regulation of cellular metabolic process 26.3158 5 no
GO:0031326 regulation of cellular biosynthetic process 26.3158 5 no
GO:0051241 negative regulation of multicellular organismal process 26.3158 4 no
GO:2000026 regulation of multicellular organismal development 26.3158 4 no
GO:0006898 receptor-mediated endocytosis 26.3158 6 no
GO:0010648 negative regulation of cell communication 26.3158 5 no
GO:0023057 negative regulation of signaling 26.3158 4 no
GO:0032880 regulation of protein localization 26.3158 5 no
GO:0043066 negative regulation of apoptotic process 26.3158 7 no
GO:0043069 negative regulation of programmed cell death 26.3158 6 no
GO:0043087 regulation of GTPase activity 26.3158 5 no
GO:0043547 positive regulation of GTPase activity 26.3158 6 no
GO:0051094 positive regulation of developmental process 26.3158 4 no
GO:1903829 positive regulation of protein localization 21.0526 5 no
GO:0030162 regulation of proteolysis 21.0526 6 no
GO:0009890 negative regulation of biosynthetic process 21.0526 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.0526 6 no
GO:0031334 positive regulation of protein-containing complex assembly 21.0526 6 no
GO:0043254 regulation of protein-containing complex assembly 21.0526 5 no
GO:0044087 regulation of cellular component biogenesis 21.0526 4 no
GO:0044089 positive regulation of cellular component biogenesis 21.0526 5 no
GO:0019220 regulation of phosphate metabolic process 21.0526 6 no
GO:0031399 regulation of protein modification process 21.0526 6 no
GO:0051174 regulation of phosphorus metabolic process 21.0526 5 no
GO:0065003 protein-containing complex assembly 21.0526 5 yes
GO:0006355 regulation of DNA-templated transcription 21.0526 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.0526 5 no
GO:0043269 regulation of ion transport 21.0526 5 no
GO:0045596 negative regulation of cell differentiation 21.0526 5 no
GO:0045664 regulation of neuron differentiation 21.0526 5 no
GO:0050804 modulation of chemical synaptic transmission 21.0526 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 21.0526 5 no
GO:0051252 regulation of RNA metabolic process 21.0526 5 no
GO:0099177 regulation of trans-synaptic signaling 21.0526 4 no
GO:1903506 regulation of nucleic acid-templated transcription 21.0526 7 no
GO:2001141 regulation of RNA biosynthetic process 21.0526 6 no
GO:0009968 negative regulation of signal transduction 21.0526 5 no
GO:0048585 negative regulation of response to stimulus 21.0526 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 15.7895 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 15.7895 5 yes
GO:0007173 epidermal growth factor receptor signaling pathway 10.5263 7 yes
GO:0016197 endosomal transport 10.5263 4 yes
GO:0038127 ERBB signaling pathway 10.5263 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
BIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
1433S_HUMAN [view entry] [view interactions] Low throughput yes yes
EPS15_HUMAN [view entry] [view interactions] Low throughput yes yes
RBP1_HUMAN [view entry] [view interactions] Low throughput yes yes
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
EPN1_HUMAN [view entry] [view interactions] Low throughput yes yes
1433B_HUMAN [view entry] [view interactions] Low throughput yes yes
1433F_HUMAN [view entry] [view interactions] Low throughput yes yes
ASAP1_HUMAN [view entry] [view interactions] Low throughput yes yes
ASAP2_HUMAN [view interactions] Low throughput no yes
AMPH_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2A1_HUMAN [view entry] [view interactions] Low throughput yes yes
PAXI_HUMAN [view interactions] Low throughput no yes
CDK1_HUMAN [view interactions] Low throughput no no
TPC2B_HUMAN [view interactions] High throughput no no
TPC2A_HUMAN [view interactions] High throughput no yes
TPC2L_HUMAN [view interactions] High throughput no yes
CDCA5_HUMAN [view interactions] High throughput no yes
SHOC2_HUMAN [view interactions] High throughput no yes
BUB1B_HUMAN [view interactions] High throughput no no
CHRD1_HUMAN [view interactions] High throughput no yes
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
ITB1_HUMAN [view entry] [view interactions] High throughput yes no
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
ANM7_HUMAN [view interactions] High throughput no yes
UGGG1_HUMAN [view interactions] High throughput no yes
H31T_HUMAN [view interactions] High throughput no yes
H15_HUMAN [view interactions] High throughput no no
ANDR_HUMAN [view interactions] High throughput no no
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
REPS1_HUMAN [view interactions] High throughput no yes
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
MAGA9_HUMAN [view interactions] High throughput no no
NOG2_HUMAN [view interactions] High throughput no yes
CK5P2_HUMAN [view interactions] High throughput no yes
AVR2A_HUMAN [view interactions] High throughput no yes