Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

REPS2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed, PubMed, PubMed). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed). Through ASAP1 may regulate cell adhesion and migration (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in REPS2_HUMAN
GO:0043169 cation binding 28.5714 4 yes
GO:0046872 metal ion binding 28.5714 5 yes
GO:0043168 anion binding 28.5714 4 no
GO:0019900 kinase binding 28.5714 4 no
GO:0019901 protein kinase binding 28.5714 5 no
GO:0045296 cadherin binding 28.5714 4 no
GO:0000166 nucleotide binding 23.8095 4 no
GO:0005524 ATP binding 23.8095 5 no
GO:0017076 purine nucleotide binding 23.8095 5 no
GO:0030554 adenyl nucleotide binding 23.8095 6 no
GO:0032555 purine ribonucleotide binding 23.8095 4 no
GO:0032559 adenyl ribonucleotide binding 23.8095 5 no
GO:0035639 purine ribonucleoside triphosphate binding 23.8095 4 no
GO:0003779 actin binding 23.8095 4 no
GO:0005509 calcium ion binding 19.0476 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in REPS2_HUMAN
GO:0098657 import into cell 66.6667 4 yes
GO:0048522 positive regulation of cellular process 61.9048 4 no
GO:0051128 regulation of cellular component organization 61.9048 4 no
GO:0010646 regulation of cell communication 52.3810 4 no
GO:0031323 regulation of cellular metabolic process 52.3810 4 no
GO:0048523 negative regulation of cellular process 52.3810 4 no
GO:0060255 regulation of macromolecule metabolic process 52.3810 4 no
GO:0051049 regulation of transport 47.6190 4 no
GO:0009966 regulation of signal transduction 42.8571 4 no
GO:0080090 regulation of primary metabolic process 42.8571 4 no
GO:0006996 organelle organization 42.8571 4 no
GO:0008104 protein localization 42.8571 4 no
GO:0071702 organic substance transport 42.8571 4 no
GO:0071705 nitrogen compound transport 42.8571 4 no
GO:0022607 cellular component assembly 33.3333 4 yes
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0051050 positive regulation of transport 33.3333 4 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0015031 protein transport 33.3333 4 no
GO:0010648 negative regulation of cell communication 28.5714 5 no
GO:0023057 negative regulation of signaling 28.5714 4 no
GO:0042981 regulation of apoptotic process 28.5714 5 no
GO:0043067 regulation of programmed cell death 28.5714 4 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0010468 regulation of gene expression 28.5714 6 no
GO:0031324 negative regulation of cellular metabolic process 28.5714 5 no
GO:0045595 regulation of cell differentiation 28.5714 4 no
GO:0051093 negative regulation of developmental process 28.5714 4 no
GO:0051241 negative regulation of multicellular organismal process 28.5714 4 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:0006898 receptor-mediated endocytosis 28.5714 4 no
GO:0043933 protein-containing complex organization 23.8095 4 yes
GO:0140238 presynaptic endocytosis 23.8095 4 no
GO:0009968 negative regulation of signal transduction 23.8095 5 no
GO:0033043 regulation of organelle organization 23.8095 5 no
GO:0043066 negative regulation of apoptotic process 23.8095 6 no
GO:0043069 negative regulation of programmed cell death 23.8095 5 no
GO:0048585 negative regulation of response to stimulus 23.8095 4 no
GO:0051248 negative regulation of protein metabolic process 23.8095 6 no
GO:0051726 regulation of cell cycle 23.8095 4 no
GO:0009890 negative regulation of biosynthetic process 23.8095 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 23.8095 6 no
GO:0010604 positive regulation of macromolecule metabolic process 23.8095 5 no
GO:0022603 regulation of anatomical structure morphogenesis 23.8095 4 no
GO:0031325 positive regulation of cellular metabolic process 23.8095 5 no
GO:0031327 negative regulation of cellular biosynthetic process 23.8095 6 no
GO:0045664 regulation of neuron differentiation 23.8095 5 no
GO:0051094 positive regulation of developmental process 23.8095 4 no
GO:0051336 regulation of hydrolase activity 23.8095 4 no
GO:2000026 regulation of multicellular organismal development 23.8095 4 no
GO:0031623 receptor internalization 23.8095 5 no
GO:0006886 intracellular protein transport 23.8095 4 no
GO:0065003 protein-containing complex assembly 19.0476 5 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 14.2857 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 14.2857 5 yes
GO:0007173 epidermal growth factor receptor signaling pathway 9.5238 7 yes
GO:0038127 ERBB signaling pathway 9.5238 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
BIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
1433S_HUMAN [view entry] [view interactions] Low throughput yes yes
EPS15_HUMAN [view entry] [view interactions] Low throughput yes yes
RBP1_HUMAN [view entry] [view interactions] Low throughput yes yes
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
EPN1_HUMAN [view entry] [view interactions] Low throughput yes yes
1433B_HUMAN [view entry] [view interactions] Low throughput yes yes
1433F_HUMAN [view entry] [view interactions] Low throughput yes yes
ASAP1_HUMAN [view entry] [view interactions] Low throughput yes yes
ASAP2_HUMAN [view interactions] Low throughput no yes
AMPH_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2A1_HUMAN [view entry] [view interactions] Low throughput yes yes
PAXI_HUMAN [view interactions] Low throughput no yes
CDK1_HUMAN [view interactions] Low throughput no no
TPC2B_HUMAN [view interactions] High throughput no no
TPC2A_HUMAN [view interactions] High throughput no yes
TPC2L_HUMAN [view interactions] High throughput no yes
CDCA5_HUMAN [view interactions] High throughput no yes
SHOC2_HUMAN [view interactions] High throughput no yes
BUB1B_HUMAN [view interactions] High throughput no no
CHRD1_HUMAN [view interactions] High throughput no yes
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
ITB1_HUMAN [view entry] [view interactions] High throughput yes no
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
ANM7_HUMAN [view interactions] High throughput no yes
UGGG1_HUMAN [view interactions] High throughput no yes
H31T_HUMAN [view interactions] High throughput no yes
H15_HUMAN [view interactions] High throughput no no
ITSN1_HUMAN [view entry] [view interactions] High throughput yes yes
ANDR_HUMAN [view interactions] High throughput no no
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
REPS1_HUMAN [view interactions] High throughput no yes
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
MAGA9_HUMAN [view interactions] High throughput no no
AAK1_HUMAN [view entry] [view interactions] High throughput yes yes
BMP2K_HUMAN [view interactions] High throughput no yes
ITCH_HUMAN [view interactions] High throughput no yes
NOG2_HUMAN [view interactions] High throughput no yes
CK5P2_HUMAN [view interactions] High throughput no yes
AVR2A_HUMAN [view interactions] High throughput no yes