ASAP1_HUMAN

G2C

SynGO

SynaptomeDB

Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types . Plays a role in ciliogenesis. [View more on UniProt]

Transmembrane

Phase separation

ELM

Phosphorylation

PFAM

Coiled coil

Anchor

Disordered

Interacting regions

Sequence

LOADING 73%

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

ASAP1_HUMAN

ABL1_HUMAN

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ASAP1_HUMAN

CRK_HUMAN

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ASAP1_HUMAN

SRC_HUMAN

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ASAP1_HUMAN

FYN_HUMAN

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ASAP1_HUMAN

GRB2_HUMAN

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ASAP1_HUMAN

PLCG1_HUMAN

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ASAP1_HUMAN

HCK_HUMAN

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ASAP1_HUMAN

SRC8_HUMAN

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ASAP1_HUMAN

PACN2_HUMAN

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ASAP1_HUMAN

SH3G2_HUMAN

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ASAP1_HUMAN

DLG1_HUMAN

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ASAP1_HUMAN

SNX9_HUMAN

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ASAP1_HUMAN

APC_HUMAN

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ASAP1_HUMAN

DNJB6_HUMAN

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ASAP1_HUMAN

EXOC1_HUMAN

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ASAP1_HUMAN has binary interactions with 50 proteins

Download full PS network for entry.

Interacting regions

Canonical [ASAP1_HUMAN]

Isoform [H0YBM4] alignment

Isoform [H0YBM4] sequence

Isoform [H0YBF7] alignment

Isoform [H0YBF7] sequence

Isoform [Q9ULH1-2] alignment

Isoform [Q9ULH1-2] sequence

Isoform [A0A0A0MRE5] alignment

Isoform [A0A0A0MRE5] sequence

Isoform [E5RHA9] alignment

Isoform [E5RHA9] sequence

Isoform [E5RHD7] alignment

Isoform [E5RHD7] sequence

Isoform [E5RFD9] alignment

Isoform [E5RFD9] sequence

LOADING 36%

No data found.

ELM instance	Name	Type	Start	End	Partner
ELMI004422	LIG_SH3_CIN85_PxpxPR_1	LIG	1055	1060	-
ELMI004422	LIG_SH3_CIN85_PxpxPR_1	LIG	1055	1060	-

Molecular function

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Search:

Term	Name	%	Distance from the top of the tree	Annotated in ASAP1_HUMAN
GO:0019900	kinase binding	36.6667	4	no
GO:0043168	anion binding	35.0000	4	yes
GO:0019901	protein kinase binding	33.3333	5	no
GO:0000166	nucleotide binding	28.3333	4	no
GO:0017076	purine nucleotide binding	28.3333	5	no
GO:0032555	purine ribonucleotide binding	28.3333	4	no
GO:0035639	purine ribonucleoside triphosphate binding	28.3333	4	no
GO:0043169	cation binding	23.3333	4	yes
GO:0045296	cadherin binding	23.3333	4	yes
GO:0046872	metal ion binding	23.3333	5	yes
GO:0003723	RNA binding	23.3333	4	no
GO:0030695	GTPase regulator activity	11.6667	4	yes
GO:0035091	phosphatidylinositol binding	8.3333	4	yes
GO:0005096	GTPase activator activity	6.6667	4	yes
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	6.6667	5	yes
GO:1901981	phosphatidylinositol phosphate binding	6.6667	5	yes
GO:1902936	phosphatidylinositol bisphosphate binding	6.6667	6	yes
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	3.3333	5	yes

Showing 1 to 18 of 18 entries

Biological process

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Search:

Term	Name	%	Distance from top the of the tree	Annotated in ASAP1_HUMAN
GO:0048523	negative regulation of cellular process	66.6667	4	no
GO:0048522	positive regulation of cellular process	63.3333	4	yes
GO:0051128	regulation of cellular component organization	61.6667	4	yes
GO:0010646	regulation of cell communication	55.0000	4	no
GO:0031323	regulation of cellular metabolic process	55.0000	4	no
GO:0060255	regulation of macromolecule metabolic process	51.6667	4	no
GO:0080090	regulation of primary metabolic process	50.0000	4	no
GO:0008104	protein localization	46.6667	4	yes
GO:0022607	cellular component assembly	45.0000	4	yes
GO:0009966	regulation of signal transduction	43.3333	4	no
GO:0006996	organelle organization	41.6667	4	yes
GO:0030030	cell projection organization	41.6667	4	yes
GO:0009889	regulation of biosynthetic process	41.6667	4	no
GO:0010468	regulation of gene expression	41.6667	6	no
GO:0010556	regulation of macromolecule biosynthetic process	41.6667	5	no
GO:0031326	regulation of cellular biosynthetic process	41.6667	5	no
GO:0051130	positive regulation of cellular component organization	40.0000	5	yes
GO:0009893	positive regulation of metabolic process	40.0000	4	no
GO:0051246	regulation of protein metabolic process	40.0000	5	no
GO:0010604	positive regulation of macromolecule metabolic process	38.3333	5	no
GO:0051049	regulation of transport	38.3333	4	no
GO:0033043	regulation of organelle organization	38.3333	5	no
GO:0031325	positive regulation of cellular metabolic process	36.6667	5	no
GO:0044087	regulation of cellular component biogenesis	36.6667	4	no
GO:0120036	plasma membrane bounded cell projection organization	35.0000	5	yes

Showing 1 to 25 of 118 entries

Disease

No data found.

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Search:

Uniprot ID	Details	Highest evidence	Localizing into PSD	HPA (protein expression in neurons)
3BP1_HUMAN	[view interactions]	High throughput	no	no
ABL1_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
ABRX2_HUMAN	[view interactions]	High throughput	no	yes
ACAD9_HUMAN	[view interactions]	High throughput	no	yes
ADDG_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
AGAP2_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
ANS1B_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
APC7_HUMAN	[view interactions]	High throughput	no	yes
APC_HUMAN	[view entry] [view interactions]	Low throughput	yes	no
ARAP3_HUMAN	[view interactions]	High throughput	no	no
ARF1_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
ARF6_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
ARHG2_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
ASAP2_HUMAN	[view interactions]	High throughput	no	yes
ASAP3_HUMAN	[view interactions]	High throughput	no	yes
ASPC1_HUMAN	[view interactions]	High throughput	no	yes
BABA2_HUMAN	[view interactions]	High throughput	no	yes
BICD2_HUMAN	[view interactions]	High throughput	no	yes
BRE1A_HUMAN	[view interactions]	High throughput	no	yes
BRSK2_HUMAN	[view interactions]	High throughput	no	no
CADH1_HUMAN	[view entry] [view interactions]	High throughput	yes	no
CBL_HUMAN	[view interactions]	Low throughput	no	yes
CBLB_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
CD2AP_HUMAN	[view interactions]	Low throughput	no	no
CIP4_HUMAN	[view interactions]	High throughput	no	no

Showing 1 to 25 of 119 entries

ASAP1_HUMAN

Evidence for PS localization

Functions

Protein features

Binary interactions with known binding regions

Network

Isoforms

Disease-causing germline mutations

Linear motifs

Fingerprint

Molecular function

Biological process

Disease

All partners