SNX9_HUMAN
Evidence for PS localization
Functions
Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SNX9_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 31.9149 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 29.7872 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.7872 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 21.2766 | 5 | no |
| GO:0045296 | cadherin binding | 17.0213 | 4 | yes |
| GO:0035091 | phosphatidylinositol binding | 14.8936 | 4 | yes |
| GO:0044389 | ubiquitin-like protein ligase binding | 12.7660 | 4 | yes |
| GO:0031625 | ubiquitin protein ligase binding | 12.7660 | 5 | yes |
| GO:0042803 | protein homodimerization activity | 8.5106 | 4 | yes |
| GO:0005545 | 1-phosphatidylinositol binding | 4.2553 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SNX9_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 72.3404 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 57.4468 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 57.4468 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 57.4468 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 57.4468 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 55.3191 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 53.1915 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 53.1915 | 4 | yes |
| GO:0010646 | regulation of cell communication | 44.6809 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 42.5532 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 42.5532 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 42.5532 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 40.4255 | 5 | yes |
| GO:0010468 | regulation of gene expression | 40.4255 | 5 | no |
| GO:0006897 | endocytosis | 40.4255 | 5 | yes |
| GO:0008104 | protein localization | 40.4255 | 4 | yes |
| GO:0071702 | organic substance transport | 38.2979 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 38.2979 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 38.2979 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 38.2979 | 5 | yes |
| GO:0006996 | organelle organization | 36.1702 | 4 | no |
| GO:0022607 | cellular component assembly | 36.1702 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 34.0426 | 4 | no |
| GO:0051049 | regulation of transport | 34.0426 | 4 | no |
| GO:0015031 | protein transport | 34.0426 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 31.9149 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.9149 | 5 | no |
| GO:0006886 | intracellular protein transport | 31.9149 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 29.7872 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 29.7872 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 29.7872 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.7872 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 27.6596 | 5 | no |
| GO:0023056 | positive regulation of signaling | 27.6596 | 4 | no |
| GO:0036211 | protein modification process | 27.6596 | 4 | no |
| GO:0043412 | macromolecule modification | 27.6596 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.6596 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.6596 | 5 | no |
| GO:0030030 | cell projection organization | 27.6596 | 4 | no |
| GO:0006898 | receptor-mediated endocytosis | 27.6596 | 6 | yes |
| GO:0033043 | regulation of organelle organization | 27.6596 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 27.6596 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 25.5319 | 5 | no |
| GO:0051050 | positive regulation of transport | 25.5319 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 25.5319 | 4 | no |
| GO:0010941 | regulation of cell death | 25.5319 | 4 | no |
| GO:0071310 | cellular response to organic substance | 25.5319 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 25.5319 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.5319 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 25.5319 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.5319 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.4043 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 23.4043 | 6 | yes |
| GO:0065003 | protein-containing complex assembly | 23.4043 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 23.4043 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 23.4043 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 23.4043 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 23.4043 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 23.4043 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.4043 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 23.4043 | 7 | yes |
| GO:0061024 | membrane organization | 21.2766 | 4 | yes |
| GO:0016310 | phosphorylation | 21.2766 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.2766 | 5 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 21.2766 | 6 | no |
| GO:0030100 | regulation of endocytosis | 21.2766 | 5 | no |
| GO:0031399 | regulation of protein modification process | 21.2766 | 6 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 21.2766 | 4 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 21.2766 | 5 | yes |
| GO:0001932 | regulation of protein phosphorylation | 19.1489 | 7 | yes |
| GO:0009894 | regulation of catabolic process | 19.1489 | 4 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 19.1489 | 6 | yes |
| GO:0010638 | positive regulation of organelle organization | 19.1489 | 6 | yes |
| GO:0042327 | positive regulation of phosphorylation | 19.1489 | 8 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 19.1489 | 7 | yes |
| GO:0051336 | regulation of hydrolase activity | 17.0213 | 4 | yes |
| GO:0031401 | positive regulation of protein modification process | 17.0213 | 7 | yes |
| GO:0043085 | positive regulation of catalytic activity | 17.0213 | 4 | yes |
| GO:0051338 | regulation of transferase activity | 14.8936 | 4 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 14.8936 | 6 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 14.8936 | 8 | yes |
| GO:0031329 | regulation of cellular catabolic process | 14.8936 | 5 | yes |
| GO:0043549 | regulation of kinase activity | 14.8936 | 5 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 12.7660 | 5 | yes |
| GO:0051347 | positive regulation of transferase activity | 12.7660 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 12.7660 | 6 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 12.7660 | 5 | yes |
| GO:0016197 | endosomal transport | 12.7660 | 4 | yes |
| GO:0030162 | regulation of proteolysis | 12.7660 | 6 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 12.7660 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 12.7660 | 4 | yes |
| GO:0033674 | positive regulation of kinase activity | 12.7660 | 6 | yes |
| GO:0042176 | regulation of protein catabolic process | 12.7660 | 5 | yes |
| GO:0051495 | positive regulation of cytoskeleton organization | 10.6383 | 7 | yes |
| GO:1902905 | positive regulation of supramolecular fiber organization | 10.6383 | 6 | yes |
| GO:0009896 | positive regulation of catabolic process | 10.6383 | 5 | yes |
| GO:0032535 | regulation of cellular component size | 10.6383 | 4 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 10.6383 | 5 | yes |
| GO:0045859 | regulation of protein kinase activity | 10.6383 | 6 | yes |
| GO:0045862 | positive regulation of proteolysis | 10.6383 | 7 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 8.5106 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 8.5106 | 5 | yes |
| GO:0031331 | positive regulation of cellular catabolic process | 8.5106 | 6 | yes |
| GO:0031334 | positive regulation of protein-containing complex assembly | 8.5106 | 6 | yes |
| GO:0045732 | positive regulation of protein catabolic process | 8.5106 | 6 | yes |
| GO:0061640 | cytoskeleton-dependent cytokinesis | 6.3830 | 4 | yes |
| GO:0099024 | plasma membrane invagination | 6.3830 | 6 | yes |
| GO:0010324 | membrane invagination | 6.3830 | 5 | yes |
| GO:0030833 | regulation of actin filament polymerization | 6.3830 | 7 | yes |
| GO:0030838 | positive regulation of actin filament polymerization | 6.3830 | 7 | yes |
| GO:0032271 | regulation of protein polymerization | 6.3830 | 6 | yes |
| GO:0032273 | positive regulation of protein polymerization | 6.3830 | 7 | yes |
| GO:0043087 | regulation of GTPase activity | 6.3830 | 5 | yes |
| GO:0043547 | positive regulation of GTPase activity | 6.3830 | 6 | yes |
| GO:0045860 | positive regulation of protein kinase activity | 6.3830 | 7 | yes |
| GO:0060988 | lipid tube assembly | 4.2553 | 7 | yes |
| GO:0065005 | protein-lipid complex assembly | 4.2553 | 6 | yes |
| GO:0071825 | protein-lipid complex subunit organization | 4.2553 | 5 | yes |
| GO:0097320 | plasma membrane tubulation | 4.2553 | 6 | yes |
| GO:0000281 | mitotic cytokinesis | 4.2553 | 4 | yes |
| GO:0007009 | plasma membrane organization | 4.2553 | 5 | yes |
| GO:0036089 | cleavage furrow formation | 4.2553 | 4 | yes |
| GO:0051043 | regulation of membrane protein ectodomain proteolysis | 4.2553 | 6 | yes |
| GO:0051044 | positive regulation of membrane protein ectodomain proteolysis | 4.2553 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PK3CA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PI3R5_HUMAN | [view interactions] | Low throughput | no | no |
| AP1G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TNFL6_HUMAN | [view interactions] | Low throughput | no | yes |
| ADAM9_HUMAN | [view interactions] | Low throughput | no | no |
| ADA15_HUMAN | [view interactions] | Low throughput | no | yes |
| SYNJ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACK1_HUMAN | [view interactions] | Low throughput | no | yes |
| WASP_HUMAN | [view interactions] | Low throughput | no | yes |
| DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNX33_HUMAN | [view interactions] | Low throughput | no | yes |
| WASL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITCH_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OCRL_HUMAN | [view interactions] | Low throughput | no | yes |
| SOS2_HUMAN | [view interactions] | Low throughput | no | yes |
| SOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARAID_HUMAN | [view interactions] | Low throughput | no | no |
| SNX9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LMAN1_HUMAN | [view interactions] | Low throughput | no | yes |
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| INSR_HUMAN | [view interactions] | Low throughput | no | yes |
| CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KBP_HUMAN | [view interactions] | High throughput | no | yes |
| KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| ARP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| ADAM8_HUMAN | [view interactions] | High throughput | no | yes |
| ADA12_HUMAN | [view interactions] | High throughput | no | no |
| ADA19_HUMAN | [view interactions] | High throughput | no | no |
| MED28_HUMAN | [view interactions] | High throughput | no | yes |
| MPH6_HUMAN | [view interactions] | High throughput | no | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| NAF1_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FCSD1_HUMAN | [view interactions] | High throughput | no | yes |
| CPNE5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPPA4_HUMAN | [view interactions] | High throughput | no | no |
| ECH1_HUMAN | [view interactions] | High throughput | no | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| DNMBP_HUMAN | [view interactions] | High throughput | no | no |
| F90A1_HUMAN | [view interactions] | High throughput | no | no |
| SNX8_HUMAN | [view interactions] | High throughput | no | yes |
| SNX18_HUMAN | [view interactions] | High throughput | no | no |
| GCH1_HUMAN | [view interactions] | High throughput | no | no |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADA17_HUMAN | [view interactions] | High throughput | no | yes |
| ERBIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXG1_HUMAN | [view interactions] | High throughput | no | no |
| FOXK2_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPHP1_HUMAN | [view interactions] | High throughput | no | yes |
| FBF1_HUMAN | [view interactions] | High throughput | no | no |
| PALS2_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| P4K2A_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
| MCE1_HUMAN | [view interactions] | High throughput | no | yes |
| DYN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCMC_HUMAN | [view interactions] | High throughput | no | no |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| BRAF_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| CLC14_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| RUNX1_HUMAN | [view interactions] | High throughput | no | yes |
| AGO2_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFY21_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| NIPBL_HUMAN | [view interactions] | High throughput | no | yes |
| SCC4_HUMAN | [view interactions] | High throughput | no | no |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| M4K3_HUMAN | [view interactions] | High throughput | no | no |
| M4K5_HUMAN | [view interactions] | High throughput | no | no |
| EFCB1_HUMAN | [view interactions] | High throughput | no | no |
| GARS_HUMAN | [view interactions] | High throughput | no | yes |
| RAMP1_HUMAN | [view interactions] | High throughput | no | no |
| RN145_HUMAN | [view interactions] | High throughput | no | yes |
| SLU7_HUMAN | [view interactions] | High throughput | no | yes |
| STK11_HUMAN | [view interactions] | High throughput | no | yes |
| AP2S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APC16_HUMAN | [view interactions] | High throughput | no | yes |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EAA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GTR8_HUMAN | [view interactions] | High throughput | no | yes |
| COPT1_HUMAN | [view interactions] | High throughput | no | no |
| PCGF3_HUMAN | [view interactions] | High throughput | no | yes |
| PCGF5_HUMAN | [view interactions] | High throughput | no | yes |
| CBPD_HUMAN | [view interactions] | Computational | no | yes |
| YIPF6_HUMAN | [view interactions] | Computational | no | yes |
| AP3B1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SORT_HUMAN | [view interactions] | Computational | no | yes |
| SH3G2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SNAPN_HUMAN | [view interactions] | Computational | no | yes |
| SNX2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SNX5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP4E1_HUMAN | [view interactions] | Computational | no | no |
| AP4B1_HUMAN | [view interactions] | Computational | no | yes |
| AMPH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP3S1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AUXI_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| P3C2A_HUMAN | [view interactions] | Computational | no | yes |