Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SNX9_HUMAN

Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SNX9_HUMAN
GO:0043168 anion binding 42.5926 4 no
GO:0000166 nucleotide binding 38.8889 4 no
GO:0017076 purine nucleotide binding 38.8889 5 no
GO:0032555 purine ribonucleotide binding 37.0370 4 no
GO:0035639 purine ribonucleoside triphosphate binding 37.0370 4 no
GO:0030554 adenyl nucleotide binding 27.7778 6 no
GO:0019900 kinase binding 27.7778 4 no
GO:0019901 protein kinase binding 27.7778 5 no
GO:0005524 ATP binding 25.9259 5 no
GO:0032559 adenyl ribonucleotide binding 25.9259 5 no
GO:0016301 kinase activity 24.0741 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 24.0741 4 no
GO:0043169 cation binding 22.2222 4 no
GO:0046872 metal ion binding 22.2222 5 no
GO:0031625 ubiquitin protein ligase binding 14.8148 5 yes
GO:0044389 ubiquitin-like protein ligase binding 14.8148 4 yes
GO:0045296 cadherin binding 12.9630 4 yes
GO:0035091 phosphatidylinositol binding 11.1111 4 yes
GO:0042803 protein homodimerization activity 7.4074 4 yes
GO:0005545 1-phosphatidylinositol binding 3.7037 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SNX9_HUMAN
GO:0048522 positive regulation of cellular process 77.7778 4 yes
GO:0051128 regulation of cellular component organization 64.8148 4 yes
GO:0060255 regulation of macromolecule metabolic process 64.8148 4 yes
GO:0031323 regulation of cellular metabolic process 62.9630 4 yes
GO:0080090 regulation of primary metabolic process 61.1111 4 yes
GO:0048523 negative regulation of cellular process 59.2593 4 no
GO:0009889 regulation of biosynthetic process 55.5556 4 no
GO:0031326 regulation of cellular biosynthetic process 55.5556 5 no
GO:0010556 regulation of macromolecule biosynthetic process 53.7037 5 no
GO:0010468 regulation of gene expression 50.0000 6 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0022607 cellular component assembly 48.1481 4 yes
GO:0009893 positive regulation of metabolic process 46.2963 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 46.2963 5 yes
GO:0051049 regulation of transport 42.5926 4 yes
GO:0006996 organelle organization 42.5926 4 no
GO:0008104 protein localization 40.7407 4 yes
GO:0051130 positive regulation of cellular component organization 40.7407 5 yes
GO:0051246 regulation of protein metabolic process 38.8889 5 yes
GO:0098657 import into cell 38.8889 4 yes
GO:0031325 positive regulation of cellular metabolic process 37.0370 5 yes
GO:0009966 regulation of signal transduction 37.0370 4 no
GO:0009892 negative regulation of metabolic process 35.1852 4 no
GO:0048584 positive regulation of response to stimulus 35.1852 4 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0036211 protein modification process 33.3333 4 no
GO:0043412 macromolecule modification 33.3333 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0043933 protein-containing complex organization 31.4815 4 yes
GO:0051247 positive regulation of protein metabolic process 31.4815 6 yes
GO:0060627 regulation of vesicle-mediated transport 31.4815 4 yes
GO:0071702 organic substance transport 31.4815 4 yes
GO:0071705 nitrogen compound transport 31.4815 4 yes
GO:0006796 phosphate-containing compound metabolic process 31.4815 4 no
GO:1902531 regulation of intracellular signal transduction 31.4815 5 no
GO:0031399 regulation of protein modification process 29.6296 6 yes
GO:0009967 positive regulation of signal transduction 29.6296 5 no
GO:0042127 regulation of cell population proliferation 29.6296 4 no
GO:0042981 regulation of apoptotic process 29.6296 5 no
GO:0043067 regulation of programmed cell death 29.6296 4 no
GO:0009890 negative regulation of biosynthetic process 29.6296 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 29.6296 6 no
GO:0031327 negative regulation of cellular biosynthetic process 29.6296 6 no
GO:0033043 regulation of organelle organization 27.7778 5 yes
GO:0016310 phosphorylation 27.7778 5 no
GO:0009891 positive regulation of biosynthetic process 27.7778 5 no
GO:0031328 positive regulation of cellular biosynthetic process 27.7778 6 no
GO:0006355 regulation of DNA-templated transcription 27.7778 7 no
GO:0051252 regulation of RNA metabolic process 27.7778 5 no
GO:2001141 regulation of RNA biosynthetic process 27.7778 6 no
GO:0009894 regulation of catabolic process 25.9259 4 yes
GO:0015031 protein transport 25.9259 4 yes
GO:0065003 protein-containing complex assembly 25.9259 5 yes
GO:0030030 cell projection organization 25.9259 4 no
GO:0031344 regulation of cell projection organization 25.9259 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.9259 6 no
GO:1902533 positive regulation of intracellular signal transduction 25.9259 6 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.9259 6 no
GO:0051050 positive regulation of transport 25.9259 4 no
GO:0001932 regulation of protein phosphorylation 24.0741 7 yes
GO:0019220 regulation of phosphate metabolic process 24.0741 6 yes
GO:0030100 regulation of endocytosis 24.0741 5 yes
GO:0031401 positive regulation of protein modification process 24.0741 7 yes
GO:0042325 regulation of phosphorylation 24.0741 7 yes
GO:0044087 regulation of cellular component biogenesis 24.0741 4 yes
GO:0051174 regulation of phosphorus metabolic process 24.0741 5 yes
GO:0061024 membrane organization 22.2222 4 yes
GO:0008284 positive regulation of cell population proliferation 22.2222 5 no
GO:0030334 regulation of cell migration 22.2222 5 no
GO:0071310 cellular response to organic substance 22.2222 4 no
GO:0120036 plasma membrane bounded cell projection organization 22.2222 5 no
GO:2000145 regulation of cell motility 22.2222 4 no
GO:0010629 negative regulation of gene expression 22.2222 7 no
GO:0043066 negative regulation of apoptotic process 22.2222 6 no
GO:0043069 negative regulation of programmed cell death 22.2222 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0006886 intracellular protein transport 20.3704 4 yes
GO:0006898 receptor-mediated endocytosis 20.3704 4 yes
GO:0010638 positive regulation of organelle organization 20.3704 6 yes
GO:0006468 protein phosphorylation 20.3704 5 no
GO:0031346 positive regulation of cell projection organization 20.3704 6 no
GO:0080134 regulation of response to stress 20.3704 4 no
GO:0032880 regulation of protein localization 20.3704 5 no
GO:0060341 regulation of cellular localization 20.3704 4 no
GO:0141124 intracellular signaling cassette 20.3704 4 no
GO:0006357 regulation of transcription by RNA polymerase II 20.3704 8 no
GO:0051129 negative regulation of cellular component organization 20.3704 5 no
GO:0001934 positive regulation of protein phosphorylation 18.5185 8 yes
GO:0010562 positive regulation of phosphorus metabolic process 18.5185 6 yes
GO:0042327 positive regulation of phosphorylation 18.5185 8 yes
GO:0044089 positive regulation of cellular component biogenesis 18.5185 5 yes
GO:0045937 positive regulation of phosphate metabolic process 18.5185 7 yes
GO:0030162 regulation of proteolysis 16.6667 6 yes
GO:0009896 positive regulation of catabolic process 14.8148 5 yes
GO:0032970 regulation of actin filament-based process 14.8148 4 yes
GO:0042176 regulation of protein catabolic process 14.8148 5 yes
GO:0043085 positive regulation of catalytic activity 14.8148 4 yes
GO:0043549 regulation of kinase activity 14.8148 5 yes
GO:0045862 positive regulation of proteolysis 14.8148 7 yes
GO:0051338 regulation of transferase activity 14.8148 4 yes
GO:0051493 regulation of cytoskeleton organization 14.8148 6 yes
GO:0032535 regulation of cellular component size 12.9630 4 yes
GO:0032956 regulation of actin cytoskeleton organization 12.9630 5 yes
GO:0045859 regulation of protein kinase activity 12.9630 6 yes
GO:0051336 regulation of hydrolase activity 12.9630 4 yes
GO:0110053 regulation of actin filament organization 12.9630 6 yes
GO:1902903 regulation of supramolecular fiber organization 12.9630 5 yes
GO:0031329 regulation of cellular catabolic process 11.1111 5 yes
GO:0051347 positive regulation of transferase activity 11.1111 5 yes
GO:0033674 positive regulation of kinase activity 9.2593 6 yes
GO:0043254 regulation of protein-containing complex assembly 9.2593 5 yes
GO:0045732 positive regulation of protein catabolic process 9.2593 6 yes
GO:0045860 positive regulation of protein kinase activity 9.2593 7 yes
GO:0051345 positive regulation of hydrolase activity 9.2593 5 yes
GO:0051495 positive regulation of cytoskeleton organization 9.2593 7 yes
GO:1902905 positive regulation of supramolecular fiber organization 9.2593 6 yes
GO:1903421 regulation of synaptic vesicle recycling 9.2593 5 yes
GO:0008064 regulation of actin polymerization or depolymerization 7.4074 6 yes
GO:0030832 regulation of actin filament length 7.4074 5 yes
GO:0031331 positive regulation of cellular catabolic process 7.4074 6 yes
GO:0031334 positive regulation of protein-containing complex assembly 7.4074 6 yes
GO:1900242 regulation of synaptic vesicle endocytosis 7.4074 6 yes
GO:0007009 plasma membrane organization 5.5556 5 yes
GO:0010324 membrane invagination 5.5556 5 yes
GO:0030833 regulation of actin filament polymerization 5.5556 7 yes
GO:0030838 positive regulation of actin filament polymerization 5.5556 7 yes
GO:0032271 regulation of protein polymerization 5.5556 6 yes
GO:0032273 positive regulation of protein polymerization 5.5556 7 yes
GO:0061640 cytoskeleton-dependent cytokinesis 5.5556 4 yes
GO:0099024 plasma membrane invagination 5.5556 6 yes
GO:0000281 mitotic cytokinesis 3.7037 4 yes
GO:0036089 cleavage furrow formation 3.7037 4 yes
GO:0043087 regulation of GTPase activity 3.7037 5 yes
GO:0043547 positive regulation of GTPase activity 3.7037 6 yes
GO:0051043 regulation of membrane protein ectodomain proteolysis 3.7037 6 yes
GO:0051044 positive regulation of membrane protein ectodomain proteolysis 3.7037 7 yes
GO:0060988 lipid tube assembly 3.7037 7 yes
GO:0065005 protein-lipid complex assembly 3.7037 6 yes
GO:0071825 protein-lipid complex organization 3.7037 5 yes
GO:0097320 plasma membrane tubulation 3.7037 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
INSR_HUMAN [view interactions] Low throughput no yes
IGF1R_HUMAN [view entry] [view interactions] Low throughput yes yes
PK3CA_HUMAN [view entry] [view interactions] Low throughput yes yes
PI3R5_HUMAN [view interactions] Low throughput no no
AP1G1_HUMAN [view entry] [view interactions] Low throughput yes yes
TNFL6_HUMAN [view interactions] Low throughput no yes
ADAM9_HUMAN [view interactions] Low throughput no no
ADA15_HUMAN [view interactions] Low throughput no yes
SYNJ1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACK1_HUMAN [view entry] [view interactions] Low throughput yes yes
WASP_HUMAN [view interactions] Low throughput no yes
DYN1_HUMAN [view entry] [view interactions] Low throughput yes yes
DYN2_HUMAN [view entry] [view interactions] Low throughput yes yes
SNX33_HUMAN [view interactions] Low throughput no yes
WASL_HUMAN [view entry] [view interactions] Low throughput yes yes
ITCH_HUMAN [view interactions] Low throughput no yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
OCRL_HUMAN [view interactions] Low throughput no yes
SOS2_HUMAN [view interactions] Low throughput no yes
SOS1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARAID_HUMAN [view interactions] Low throughput no no
SNX9_HUMAN [view entry] [view interactions] Low throughput yes yes
P85A_HUMAN [view interactions] Low throughput no yes
LMAN1_HUMAN [view entry] [view interactions] Low throughput yes yes
CLH1_HUMAN [view entry] [view interactions] Low throughput yes yes
P4K2A_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
RPTOR_HUMAN [view interactions] High throughput no yes
MCE1_HUMAN [view interactions] High throughput no yes
DYN3_HUMAN [view entry] [view interactions] High throughput yes no
AP2A1_HUMAN [view entry] [view interactions] High throughput yes yes
DCMC_HUMAN [view interactions] High throughput no no
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
AP2A2_HUMAN [view entry] [view interactions] High throughput yes yes
AP1B1_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
BRCA1_HUMAN [view interactions] High throughput no yes
TES_HUMAN [view interactions] High throughput no yes
BRAF_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
CLC14_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
RUNX1_HUMAN [view interactions] High throughput no yes
AGO2_HUMAN [view entry] [view interactions] High throughput yes yes
RECQ4_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
ZFY21_HUMAN [view interactions] High throughput no yes
LMBRL_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
NIPBL_HUMAN [view interactions] High throughput no yes
SCC4_HUMAN [view interactions] High throughput no no
CIC_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
M4K3_HUMAN [view interactions] High throughput no no
M4K5_HUMAN [view interactions] High throughput no no
CLXN_HUMAN [view interactions] High throughput no no
GARS_HUMAN [view interactions] High throughput no yes
RAMP1_HUMAN [view interactions] High throughput no no
RN145_HUMAN [view interactions] High throughput no yes
SLU7_HUMAN [view interactions] High throughput no yes
STK11_HUMAN [view interactions] High throughput no yes
AP2S1_HUMAN [view entry] [view interactions] High throughput yes no
EP300_HUMAN [view interactions] High throughput no yes
SIR6_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
APC16_HUMAN [view interactions] High throughput no yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
EAA1_HUMAN [view entry] [view interactions] High throughput yes no
SL2A8_HUMAN [view interactions] High throughput no yes
COPT1_HUMAN [view interactions] High throughput no no
PCGF3_HUMAN [view interactions] High throughput no yes
PCGF5_HUMAN [view interactions] High throughput no yes
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
BCKD_HUMAN [view entry] [view interactions] High throughput yes yes
KBP_HUMAN [view interactions] High throughput no yes
TRI31_HUMAN [view interactions] High throughput no no
TLS1_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
BAP1_HUMAN [view interactions] High throughput no yes
PARPT_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
DAPK3_HUMAN [view interactions] High throughput no yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
SRC_HUMAN [view entry] [view interactions] High throughput yes no
TEC_HUMAN [view interactions] High throughput no yes
YES_HUMAN [view entry] [view interactions] High throughput yes yes
GCSP_HUMAN [view interactions] High throughput no yes
DVL2_HUMAN [view interactions] High throughput no yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2H_HUMAN [view interactions] High throughput no yes
KHDR1_HUMAN [view interactions] High throughput no yes
SF3A2_HUMAN [view interactions] High throughput no yes
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
ARP3_HUMAN [view entry] [view interactions] High throughput yes yes
ANFY1_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CXAR_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
OCLN_HUMAN [view interactions] High throughput no no
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
NAA40_HUMAN [view interactions] High throughput no no
STING_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
RFA4_HUMAN [view interactions] High throughput no yes
MUC18_HUMAN [view interactions] High throughput no yes
WWTR1_HUMAN [view interactions] High throughput no yes
ADAM8_HUMAN [view interactions] High throughput no yes
ADA12_HUMAN [view interactions] High throughput no no
ADA19_HUMAN [view interactions] High throughput no no
MED28_HUMAN [view interactions] High throughput no yes
MPH6_HUMAN [view interactions] High throughput no yes
GTSE1_HUMAN [view interactions] High throughput no no
NAF1_HUMAN [view interactions] High throughput no yes
HDAC1_HUMAN [view interactions] High throughput no no
AURKA_HUMAN [view entry] [view interactions] High throughput yes no
FCSD1_HUMAN [view interactions] High throughput no yes
CPNE5_HUMAN [view entry] [view interactions] High throughput yes yes
DPPA4_HUMAN [view interactions] High throughput no no
ECH1_HUMAN [view interactions] High throughput no yes
MECOM_HUMAN [view interactions] High throughput no yes
DNMBP_HUMAN [view interactions] High throughput no no
F90A1_HUMAN [view interactions] High throughput no no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
SNX8_HUMAN [view interactions] High throughput no yes
SNX18_HUMAN [view interactions] High throughput no no
GCH1_HUMAN [view interactions] High throughput no no
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
ADA17_HUMAN [view interactions] High throughput no yes
ASAP1_HUMAN [view entry] [view interactions] High throughput yes yes
RNPS1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
PKHA7_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
LN28A_HUMAN [view interactions] High throughput no no
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
CSN5_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
FOXG1_HUMAN [view interactions] High throughput no no
FOXK2_HUMAN [view interactions] High throughput no yes
LRRK1_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
DAPK1_HUMAN [view entry] [view interactions] High throughput yes yes
NPHP1_HUMAN [view interactions] High throughput no yes
FBF1_HUMAN [view interactions] High throughput no no
SWAP1_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
PALS2_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes