ARP3_HUMAN
Evidence for PS localization
Functions
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed). Seems to contact the pointed end of the daughter actin filament (PubMed). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed, PubMed). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed). Plays a role in ciliogenesis (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ARP3_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 41.0256 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 31.6239 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 31.6239 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 31.6239 | 4 | yes |
| GO:0005524 | ATP binding | 29.0598 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 29.0598 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 29.0598 | 5 | yes |
| GO:0045296 | cadherin binding | 23.0769 | 4 | no |
| GO:0003723 | RNA binding | 21.3675 | 4 | no |
| GO:0046872 | metal ion binding | 20.5128 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ARP3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.2479 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 57.2650 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 50.4274 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 48.7179 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 47.0085 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 47.0085 | 4 | yes |
| GO:0022607 | cellular component assembly | 45.2991 | 4 | yes |
| GO:0006996 | organelle organization | 44.4444 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 44.4444 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 44.4444 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 38.4615 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 35.8974 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 35.0427 | 5 | yes |
| GO:0010646 | regulation of cell communication | 35.0427 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 35.0427 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.1880 | 5 | yes |
| GO:0007010 | cytoskeleton organization | 32.4786 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.7692 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 30.7692 | 4 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 30.7692 | 5 | no |
| GO:0010468 | regulation of gene expression | 29.9145 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 29.9145 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 29.9145 | 4 | no |
| GO:0032970 | regulation of actin filament-based process | 29.9145 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 29.0598 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 29.0598 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 29.0598 | 5 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 29.0598 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.2051 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.3504 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 27.3504 | 6 | no |
| GO:0007015 | actin filament organization | 26.4957 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 26.4957 | 4 | no |
| GO:0010941 | regulation of cell death | 26.4957 | 4 | no |
| GO:0008104 | protein localization | 26.4957 | 4 | no |
| GO:0030030 | cell projection organization | 25.6410 | 4 | yes |
| GO:0043067 | regulation of programmed cell death | 25.6410 | 5 | no |
| GO:0051049 | regulation of transport | 25.6410 | 4 | no |
| GO:0071310 | cellular response to organic substance | 24.7863 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 24.7863 | 6 | no |
| GO:0016192 | vesicle-mediated transport | 23.9316 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 23.0769 | 5 | yes |
| GO:0010638 | positive regulation of organelle organization | 23.0769 | 6 | no |
| GO:0060341 | regulation of cellular localization | 23.0769 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 23.0769 | 5 | no |
| GO:0043412 | macromolecule modification | 23.0769 | 4 | no |
| GO:0036211 | protein modification process | 22.2222 | 4 | no |
| GO:0031399 | regulation of protein modification process | 22.2222 | 6 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 22.2222 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.3675 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 21.3675 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 20.5128 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.5128 | 6 | yes |
| GO:0032880 | regulation of protein localization | 20.5128 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 20.5128 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.5128 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 18.8034 | 5 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 17.9487 | 6 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 17.9487 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 17.9487 | 6 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 17.9487 | 6 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 17.9487 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 17.9487 | 6 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 17.0940 | 6 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 17.0940 | 5 | yes |
| GO:0031346 | positive regulation of cell projection organization | 15.3846 | 6 | yes |
| GO:0030031 | cell projection assembly | 11.9658 | 5 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 11.1111 | 7 | yes |
| GO:0034097 | response to cytokine | 11.1111 | 4 | yes |
| GO:0060491 | regulation of cell projection assembly | 11.1111 | 5 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 11.1111 | 6 | yes |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 11.1111 | 6 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 9.4017 | 7 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 9.4017 | 6 | yes |
| GO:0071345 | cellular response to cytokine stimulus | 9.4017 | 5 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 9.4017 | 7 | yes |
| GO:1902743 | regulation of lamellipodium organization | 9.4017 | 7 | yes |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 9.4017 | 8 | yes |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 8.5470 | 8 | yes |
| GO:0070925 | organelle assembly | 8.5470 | 5 | yes |
| GO:0120034 | positive regulation of plasma membrane bounded cell projection assembly | 8.5470 | 6 | yes |
| GO:0010591 | regulation of lamellipodium assembly | 7.6923 | 7 | yes |
| GO:0034341 | response to interferon-gamma | 7.6923 | 5 | yes |
| GO:1902745 | positive regulation of lamellipodium organization | 7.6923 | 7 | yes |
| GO:0071346 | cellular response to interferon-gamma | 6.8376 | 6 | yes |
| GO:0010592 | positive regulation of lamellipodium assembly | 5.9829 | 7 | yes |
| GO:0034314 | Arp2/3 complex-mediated actin nucleation | 5.9829 | 7 | yes |
| GO:0045010 | actin nucleation | 5.9829 | 6 | yes |
| GO:0061640 | cytoskeleton-dependent cytokinesis | 5.9829 | 4 | yes |
| GO:0044782 | cilium organization | 3.4188 | 5 | yes |
| GO:0060271 | cilium assembly | 3.4188 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ARP3_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 1.7094 | 3 | no |
| DOID:1247 | blood coagulation disease | 1.7094 | 3 | no |
| DOID:2218 | blood platelet disease | 1.7094 | 4 | no |
| DOID:0050686 | organ system cancer | 1.7094 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ARP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARC1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARP5L_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARPC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARC1B_HUMAN | [view interactions] | Low throughput | no | no |
| ARPC5_HUMAN | [view interactions] | Low throughput | no | yes |
| WASP_HUMAN | [view interactions] | Low throughput | no | yes |
| WASL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTS_HUMAN | [view interactions] | Low throughput | no | no |
| CD44_HUMAN | [view interactions] | Low throughput | no | yes |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| K1C18_HUMAN | [view interactions] | Low throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WASF3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WASF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HCLS1_HUMAN | [view interactions] | Low throughput | no | no |
| WASF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHRPN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK049_HUMAN | [view interactions] | High throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CE350_HUMAN | [view interactions] | High throughput | no | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHYS_HUMAN | [view interactions] | High throughput | no | no |
| MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DVL3_HUMAN | [view interactions] | High throughput | no | yes |
| ITA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB6I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKB15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRACD_HUMAN | [view interactions] | High throughput | no | yes |
| MICA3_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| MPRIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC3_HUMAN | [view interactions] | High throughput | no | yes |
| RBM11_HUMAN | [view interactions] | High throughput | no | no |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PACE1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SI1L3_HUMAN | [view interactions] | High throughput | no | yes |
| ZN536_HUMAN | [view interactions] | High throughput | no | no |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFR1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| CYTN_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CYTS_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAP_HUMAN | [view interactions] | High throughput | no | yes |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| CASP9_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPM1J_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AICDA_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
| VMP1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| HTRA4_HUMAN | [view interactions] | High throughput | no | no |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| WIPF1_HUMAN | [view interactions] | High throughput | no | no |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| LMX1B_HUMAN | [view interactions] | High throughput | no | no |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| LITD1_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| CDK5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CENPH_HUMAN | [view interactions] | High throughput | no | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK1_HUMAN | [view interactions] | High throughput | no | no |
| JUND_HUMAN | [view interactions] | High throughput | no | yes |
| IDLC_HUMAN | [view interactions] | High throughput | no | no |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPCAM_HUMAN | [view interactions] | High throughput | no | no |
| S15A1_HUMAN | [view interactions] | High throughput | no | no |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| FOS_HUMAN | [view interactions] | High throughput | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| P5F1B_HUMAN | [view interactions] | High throughput | no | no |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| CEP97_HUMAN | [view interactions] | High throughput | no | yes |
| CP110_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| ARP3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIP4_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC8_HUMAN | [view interactions] | High throughput | no | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| SOCS6_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| ANO7_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| IFIX_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| F16P1_HUMAN | [view interactions] | High throughput | no | no |
| MT21E_HUMAN | [view interactions] | High throughput | no | no |
| CHUR_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3H_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SKA3_HUMAN | [view interactions] | High throughput | no | no |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS4Y1_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| SLN11_HUMAN | [view interactions] | High throughput | no | yes |
| JMJD6_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| SIK2_HUMAN | [view interactions] | High throughput | no | yes |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| PLK4_HUMAN | [view interactions] | High throughput | no | yes |
| ARL3_HUMAN | [view interactions] | High throughput | no | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK26_HUMAN | [view interactions] | High throughput | no | no |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
| UBP22_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBE3A_HUMAN | [view interactions] | High throughput | no | yes |
| ITA2B_HUMAN | [view interactions] | High throughput | no | no |
| ERCC6_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AN32B_HUMAN | [view interactions] | High throughput | no | yes |
| FKB10_HUMAN | [view interactions] | High throughput | no | yes |
| DAAF5_HUMAN | [view interactions] | High throughput | no | no |
| HNRPF_HUMAN | [view interactions] | High throughput | no | yes |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRUA_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNPO3_HUMAN | [view interactions] | High throughput | no | yes |
| TTL12_HUMAN | [view interactions] | High throughput | no | yes |
| CALU_HUMAN | [view interactions] | High throughput | no | yes |
| FUBP1_HUMAN | [view interactions] | High throughput | no | yes |
| KBP_HUMAN | [view interactions] | High throughput | no | yes |
| TRMB_HUMAN | [view interactions] | High throughput | no | yes |
| NIF3L_HUMAN | [view interactions] | High throughput | no | yes |
| NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RPR1B_HUMAN | [view interactions] | High throughput | no | yes |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| PRPK_HUMAN | [view interactions] | High throughput | no | yes |
| TPD54_HUMAN | [view interactions] | High throughput | no | yes |
| TPRKB_HUMAN | [view interactions] | High throughput | no | yes |
| UGGG1_HUMAN | [view interactions] | High throughput | no | yes |
| ZPR1_HUMAN | [view interactions] | High throughput | no | yes |
| COR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG17_HUMAN | [view interactions] | High throughput | no | no |
| COG3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL3A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR26_HUMAN | [view interactions] | High throughput | no | yes |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARPIN_HUMAN | [view interactions] | High throughput | no | yes |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLMN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CORO7_HUMAN | [view interactions] | High throughput | no | no |
| DLG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLII_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JMY_HUMAN | [view interactions] | High throughput | no | yes |
| K1671_HUMAN | [view interactions] | High throughput | no | yes |
| KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
| LIMD1_HUMAN | [view interactions] | High throughput | no | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| PDXD1_HUMAN | [view interactions] | High throughput | no | no |
| PFD2_HUMAN | [view interactions] | High throughput | no | yes |
| PFD5_HUMAN | [view interactions] | High throughput | no | yes |
| PFD6_HUMAN | [view interactions] | High throughput | no | yes |
| PKP2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG1_HUMAN | [view interactions] | High throughput | no | yes |
| GRL1A_HUMAN | [view interactions] | High throughput | no | no |
| RGPD8_HUMAN | [view interactions] | High throughput | no | no |
| ENTR1_HUMAN | [view interactions] | High throughput | no | no |
| SH319_HUMAN | [view interactions] | High throughput | no | no |
| SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SI1L2_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA2_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA4_HUMAN | [view interactions] | High throughput | no | yes |
| SNX9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOGA1_HUMAN | [view interactions] | High throughput | no | yes |
| SRBS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYDE1_HUMAN | [view interactions] | High throughput | no | yes |
| TCF25_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNR6B_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| PFD3_HUMAN | [view interactions] | High throughput | no | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WAC2A_HUMAN | [view interactions] | High throughput | no | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WAC2C_HUMAN | [view interactions] | High throughput | no | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALMS1_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BIRC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FCG2A_HUMAN | [view interactions] | Computational | no | no |
| FCGR1_HUMAN | [view interactions] | Computational | no | no |
| BRK1_HUMAN | [view interactions] | Computational | no | no |
| AVIL_HUMAN | [view interactions] | Computational | no | no |
| IGLL5_HUMAN | [view interactions] | Computational | no | no |
| ARF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| WHAMM_HUMAN | [view interactions] | Computational | no | yes |
| NCK1_HUMAN | [view interactions] | Computational | no | yes |
| ACTG_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RHG10_HUMAN | [view interactions] | Computational | no | no |
| GAB1_HUMAN | [view interactions] | Computational | no | yes |
| CD3Z_HUMAN | [view interactions] | Computational | no | no |
| PSA7_HUMAN | [view interactions] | Computational | no | yes |
| PGFRB_HUMAN | [view interactions] | Computational | no | yes |
| SPN90_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ABI1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NCK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SUMO2_HUMAN | [view interactions] | Computational | no | yes |
| TRIPC_HUMAN | [view interactions] | Computational | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PDGFB_HUMAN | [view interactions] | Computational | no | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |