COR1A_HUMAN
Evidence for PS localization
Functions
May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in COR1A_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 35.4839 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 22.5806 | 4 | yes |
| GO:0019900 | kinase binding | 22.5806 | 4 | no |
| GO:0003723 | RNA binding | 19.3548 | 4 | yes |
| GO:0003785 | actin monomer binding | 6.4516 | 5 | yes |
| GO:0017022 | myosin binding | 6.4516 | 4 | yes |
| GO:0032036 | myosin heavy chain binding | 6.4516 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in COR1A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.0645 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 54.8387 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 54.8387 | 4 | yes |
| GO:0006996 | organelle organization | 45.1613 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 45.1613 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 41.9355 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 41.9355 | 4 | no |
| GO:0022607 | cellular component assembly | 38.7097 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 38.7097 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 38.7097 | 4 | no |
| GO:0010646 | regulation of cell communication | 38.7097 | 4 | no |
| GO:0033043 | regulation of organelle organization | 35.4839 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 35.4839 | 4 | no |
| GO:0030030 | cell projection organization | 32.2581 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 32.2581 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 32.2581 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 32.2581 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 32.2581 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 29.0323 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 29.0323 | 4 | yes |
| GO:0097435 | supramolecular fiber organization | 29.0323 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 29.0323 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 29.0323 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 29.0323 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 29.0323 | 5 | no |
| GO:0007010 | cytoskeleton organization | 25.8065 | 5 | yes |
| GO:0007015 | actin filament organization | 25.8065 | 5 | yes |
| GO:0010941 | regulation of cell death | 25.8065 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 25.8065 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 25.8065 | 5 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 25.8065 | 6 | yes |
| GO:0009889 | regulation of biosynthetic process | 25.8065 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.8065 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.8065 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.8065 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.8065 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.8065 | 5 | no |
| GO:0022604 | regulation of cell morphogenesis | 22.5806 | 5 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 22.5806 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 22.5806 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 22.5806 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 22.5806 | 5 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 22.5806 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 22.5806 | 5 | no |
| GO:0009894 | regulation of catabolic process | 22.5806 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.5806 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 22.5806 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.5806 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.5806 | 6 | no |
| GO:0031329 | regulation of cellular catabolic process | 22.5806 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 22.5806 | 7 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.5806 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.5806 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.5806 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.5806 | 5 | no |
| GO:0060491 | regulation of cell projection assembly | 22.5806 | 5 | no |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 22.5806 | 6 | no |
| GO:0030334 | regulation of cell migration | 19.3548 | 5 | yes |
| GO:0034097 | response to cytokine | 19.3548 | 4 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 19.3548 | 5 | yes |
| GO:2000145 | regulation of cell motility | 19.3548 | 4 | yes |
| GO:0010639 | negative regulation of organelle organization | 16.1290 | 6 | yes |
| GO:0016050 | vesicle organization | 16.1290 | 5 | yes |
| GO:0032271 | regulation of protein polymerization | 16.1290 | 6 | yes |
| GO:0042127 | regulation of cell population proliferation | 16.1290 | 4 | yes |
| GO:0043523 | regulation of neuron apoptotic process | 16.1290 | 6 | yes |
| GO:0051049 | regulation of transport | 16.1290 | 4 | yes |
| GO:0060548 | negative regulation of cell death | 16.1290 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 16.1290 | 4 | yes |
| GO:0070925 | organelle assembly | 16.1290 | 5 | yes |
| GO:0071345 | cellular response to cytokine stimulus | 16.1290 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 16.1290 | 6 | yes |
| GO:1901214 | regulation of neuron death | 16.1290 | 5 | yes |
| GO:0002684 | positive regulation of immune system process | 12.9032 | 4 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 12.9032 | 6 | yes |
| GO:0016482 | cytosolic transport | 12.9032 | 4 | yes |
| GO:0030155 | regulation of cell adhesion | 12.9032 | 4 | yes |
| GO:0030335 | positive regulation of cell migration | 12.9032 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 12.9032 | 5 | yes |
| GO:0030833 | regulation of actin filament polymerization | 12.9032 | 7 | yes |
| GO:0032535 | regulation of cellular component size | 12.9032 | 4 | yes |
| GO:0040017 | positive regulation of locomotion | 12.9032 | 4 | yes |
| GO:0043066 | negative regulation of apoptotic process | 12.9032 | 7 | yes |
| GO:0043069 | negative regulation of programmed cell death | 12.9032 | 6 | yes |
| GO:0043269 | regulation of ion transport | 12.9032 | 5 | yes |
| GO:0050865 | regulation of cell activation | 12.9032 | 4 | yes |
| GO:0050867 | positive regulation of cell activation | 12.9032 | 5 | yes |
| GO:0051494 | negative regulation of cytoskeleton organization | 12.9032 | 7 | yes |
| GO:1901215 | negative regulation of neuron death | 12.9032 | 6 | yes |
| GO:1902904 | negative regulation of supramolecular fiber organization | 12.9032 | 6 | yes |
| GO:2000147 | positive regulation of cell motility | 12.9032 | 5 | yes |
| GO:0002694 | regulation of leukocyte activation | 9.6774 | 4 | yes |
| GO:0002696 | positive regulation of leukocyte activation | 9.6774 | 5 | yes |
| GO:0006887 | exocytosis | 9.6774 | 4 | yes |
| GO:0006909 | phagocytosis | 9.6774 | 5 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 9.6774 | 5 | yes |
| GO:0008360 | regulation of cell shape | 9.6774 | 6 | yes |
| GO:0031338 | regulation of vesicle fusion | 9.6774 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 9.6774 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 9.6774 | 5 | yes |
| GO:0043524 | negative regulation of neuron apoptotic process | 9.6774 | 7 | yes |
| GO:0045055 | regulated exocytosis | 9.6774 | 5 | yes |
| GO:0046903 | secretion | 9.6774 | 4 | yes |
| GO:0051125 | regulation of actin nucleation | 9.6774 | 7 | yes |
| GO:0051126 | negative regulation of actin nucleation | 9.6774 | 7 | yes |
| GO:0060326 | cell chemotaxis | 9.6774 | 4 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 9.6774 | 6 | yes |
| GO:0001845 | phagolysosome assembly | 6.4516 | 6 | yes |
| GO:0001894 | tissue homeostasis | 6.4516 | 5 | yes |
| GO:0002285 | lymphocyte activation involved in immune response | 6.4516 | 4 | yes |
| GO:0002323 | natural killer cell activation involved in immune response | 6.4516 | 5 | yes |
| GO:0006811 | ion transport | 6.4516 | 4 | yes |
| GO:0006812 | cation transport | 6.4516 | 5 | yes |
| GO:0006816 | calcium ion transport | 6.4516 | 7 | yes |
| GO:0007033 | vacuole organization | 6.4516 | 5 | yes |
| GO:0007040 | lysosome organization | 6.4516 | 7 | yes |
| GO:0010959 | regulation of metal ion transport | 6.4516 | 6 | yes |
| GO:0022407 | regulation of cell-cell adhesion | 6.4516 | 5 | yes |
| GO:0022409 | positive regulation of cell-cell adhesion | 6.4516 | 6 | yes |
| GO:0030001 | metal ion transport | 6.4516 | 6 | yes |
| GO:0030101 | natural killer cell activation | 6.4516 | 4 | yes |
| GO:0031339 | negative regulation of vesicle fusion | 6.4516 | 5 | yes |
| GO:0032796 | uropod organization | 6.4516 | 6 | yes |
| GO:0032944 | regulation of mononuclear cell proliferation | 6.4516 | 6 | yes |
| GO:0032946 | positive regulation of mononuclear cell proliferation | 6.4516 | 7 | yes |
| GO:0038179 | neurotrophin signaling pathway | 6.4516 | 4 | yes |
| GO:0038180 | nerve growth factor signaling pathway | 6.4516 | 5 | yes |
| GO:0042102 | positive regulation of T cell proliferation | 6.4516 | 8 | yes |
| GO:0042129 | regulation of T cell proliferation | 6.4516 | 7 | yes |
| GO:0043029 | T cell homeostasis | 6.4516 | 4 | yes |
| GO:0043320 | natural killer cell degranulation | 6.4516 | 4 | yes |
| GO:0045785 | positive regulation of cell adhesion | 6.4516 | 5 | yes |
| GO:0048872 | homeostasis of number of cells | 6.4516 | 4 | yes |
| GO:0048873 | homeostasis of number of cells within a tissue | 6.4516 | 5 | yes |
| GO:0050670 | regulation of lymphocyte proliferation | 6.4516 | 6 | yes |
| GO:0050671 | positive regulation of lymphocyte proliferation | 6.4516 | 7 | yes |
| GO:0050863 | regulation of T cell activation | 6.4516 | 6 | yes |
| GO:0050870 | positive regulation of T cell activation | 6.4516 | 7 | yes |
| GO:0050918 | positive chemotaxis | 6.4516 | 4 | yes |
| GO:0051051 | negative regulation of transport | 6.4516 | 4 | yes |
| GO:0051249 | regulation of lymphocyte activation | 6.4516 | 5 | yes |
| GO:0051251 | positive regulation of lymphocyte activation | 6.4516 | 6 | yes |
| GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 6.4516 | 5 | yes |
| GO:0051282 | regulation of sequestering of calcium ion | 6.4516 | 4 | yes |
| GO:0051924 | regulation of calcium ion transport | 6.4516 | 7 | yes |
| GO:0060249 | anatomical structure homeostasis | 6.4516 | 4 | yes |
| GO:0061502 | early endosome to recycling endosome transport | 6.4516 | 5 | yes |
| GO:0070663 | regulation of leukocyte proliferation | 6.4516 | 5 | yes |
| GO:0070665 | positive regulation of leukocyte proliferation | 6.4516 | 6 | yes |
| GO:0070670 | response to interleukin-4 | 6.4516 | 5 | yes |
| GO:0071353 | cellular response to interleukin-4 | 6.4516 | 6 | yes |
| GO:0080171 | lytic vacuole organization | 6.4516 | 6 | yes |
| GO:0098927 | vesicle-mediated transport between endosomal compartments | 6.4516 | 5 | yes |
| GO:1903037 | regulation of leukocyte cell-cell adhesion | 6.4516 | 6 | yes |
| GO:1903039 | positive regulation of leukocyte cell-cell adhesion | 6.4516 | 7 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 6.4516 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| WDR26_HUMAN | [view interactions] | Low throughput | no | yes |
| COR1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CD5R1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CAPZB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDM6B_HUMAN | [view interactions] | High throughput | no | yes |
| NEK2_HUMAN | [view interactions] | High throughput | no | no |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MATN2_HUMAN | [view interactions] | High throughput | no | no |
| L37A2_HUMAN | [view interactions] | High throughput | no | no |
| MUC15_HUMAN | [view interactions] | High throughput | no | yes |
| NPTXR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNGA4_HUMAN | [view interactions] | High throughput | no | no |
| CA162_HUMAN | [view interactions] | High throughput | no | yes |
| GBG8_HUMAN | [view interactions] | High throughput | no | no |
| SKA2_HUMAN | [view interactions] | High throughput | no | no |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| K2C7_HUMAN | [view interactions] | High throughput | no | no |
| TMCC3_HUMAN | [view interactions] | High throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCD78_HUMAN | [view interactions] | High throughput | no | no |
| ZF69B_HUMAN | [view interactions] | High throughput | no | yes |
| COLQ_HUMAN | [view interactions] | High throughput | no | no |
| PSMD9_HUMAN | [view interactions] | High throughput | no | yes |
| CRBG2_HUMAN | [view interactions] | High throughput | no | no |
| KAPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLK10_HUMAN | [view interactions] | High throughput | no | no |
| ITA2B_HUMAN | [view interactions] | High throughput | no | no |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASPD_HUMAN | [view interactions] | High throughput | no | yes |
| NH2L1_HUMAN | [view interactions] | High throughput | no | yes |
| C1QB_HUMAN | [view interactions] | High throughput | no | no |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| PI42A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| RBTN2_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD3_HUMAN | [view interactions] | High throughput | no | yes |
| RPAC1_HUMAN | [view interactions] | High throughput | no | no |
| SMRD1_HUMAN | [view interactions] | High throughput | no | yes |
| STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GIT2_HUMAN | [view interactions] | High throughput | no | yes |
| TAB1_HUMAN | [view interactions] | High throughput | no | yes |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| YTDC1_HUMAN | [view interactions] | High throughput | no | yes |
| NAL12_HUMAN | [view interactions] | High throughput | no | yes |
| IFT57_HUMAN | [view interactions] | High throughput | no | yes |
| POC1A_HUMAN | [view interactions] | High throughput | no | yes |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| RM12_HUMAN | [view interactions] | High throughput | no | yes |
| NELL2_HUMAN | [view interactions] | High throughput | no | no |
| TM205_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBGP1_HUMAN | [view interactions] | High throughput | no | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFT80_HUMAN | [view interactions] | High throughput | no | yes |
| COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| POC1B_HUMAN | [view interactions] | High throughput | no | no |
| SYVC_HUMAN | [view interactions] | High throughput | no | yes |
| TMCC2_HUMAN | [view interactions] | High throughput | no | yes |
| FOXA3_HUMAN | [view interactions] | High throughput | no | yes |
| THMS1_HUMAN | [view interactions] | High throughput | no | no |
| UB2G2_HUMAN | [view interactions] | High throughput | no | yes |
| DKK1_HUMAN | [view interactions] | High throughput | no | no |
| FHL3_HUMAN | [view interactions] | High throughput | no | no |
| MGN_HUMAN | [view interactions] | High throughput | no | yes |
| SPT20_HUMAN | [view interactions] | High throughput | no | yes |
| FSD2_HUMAN | [view interactions] | High throughput | no | no |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAGAB_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX24_HUMAN | [view interactions] | High throughput | no | yes |
| IFT20_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| FMNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CORO6_HUMAN | [view interactions] | High throughput | no | no |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| IF172_HUMAN | [view interactions] | High throughput | no | no |
| RBG1L_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF7_HUMAN | [view interactions] | High throughput | no | yes |
| TJAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TASOR_HUMAN | [view interactions] | High throughput | no | yes |
| CEP44_HUMAN | [view interactions] | High throughput | no | yes |
| COR2A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| RASF8_HUMAN | [view interactions] | High throughput | no | yes |
| ARC1B_HUMAN | [view interactions] | Computational | no | no |
| GDIR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LAPM5_HUMAN | [view interactions] | Computational | no | yes |
| WASP_HUMAN | [view interactions] | Computational | no | yes |