SRBS2_HUMAN
Evidence for PS localization
Functions
Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SRBS2_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 35.6164 | 4 | no |
| GO:0019900 | kinase binding | 32.8767 | 4 | no |
| GO:0019901 | protein kinase binding | 32.8767 | 5 | no |
| GO:0045296 | cadherin binding | 30.1370 | 4 | no |
| GO:0003723 | RNA binding | 24.6575 | 4 | yes |
| GO:0046872 | metal ion binding | 24.6575 | 4 | no |
| GO:0017076 | purine nucleotide binding | 23.2877 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 21.9178 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.9178 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 20.5479 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SRBS2_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 58.9041 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 56.1644 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 56.1644 | 4 | no |
| GO:0006996 | organelle organization | 52.0548 | 4 | no |
| GO:0010646 | regulation of cell communication | 49.3151 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.9452 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 46.5753 | 4 | no |
| GO:0022607 | cellular component assembly | 45.2055 | 4 | no |
| GO:0009966 | regulation of signal transduction | 45.2055 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 43.8356 | 4 | no |
| GO:0008104 | protein localization | 43.8356 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 43.8356 | 4 | no |
| GO:0051049 | regulation of transport | 36.9863 | 4 | no |
| GO:0033043 | regulation of organelle organization | 35.6164 | 5 | no |
| GO:0007010 | cytoskeleton organization | 32.8767 | 5 | no |
| GO:0030030 | cell projection organization | 32.8767 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 32.8767 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 30.1370 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 30.1370 | 6 | no |
| GO:0009893 | positive regulation of metabolic process | 30.1370 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 28.7671 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.7671 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.7671 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 28.7671 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.7671 | 5 | no |
| GO:0031399 | regulation of protein modification process | 27.3973 | 6 | no |
| GO:0060341 | regulation of cellular localization | 27.3973 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 27.3973 | 5 | no |
| GO:0010941 | regulation of cell death | 27.3973 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.0274 | 5 | no |
| GO:0032880 | regulation of protein localization | 26.0274 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.0274 | 5 | no |
| GO:0071702 | organic substance transport | 26.0274 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.0274 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 26.0274 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 26.0274 | 5 | no |
| GO:0051050 | positive regulation of transport | 26.0274 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.0274 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 24.6575 | 4 | yes |
| GO:0032970 | regulation of actin filament-based process | 24.6575 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 24.6575 | 5 | no |
| GO:0036211 | protein modification process | 24.6575 | 4 | no |
| GO:0043412 | macromolecule modification | 24.6575 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 24.6575 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 24.6575 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 24.6575 | 5 | no |
| GO:0071705 | nitrogen compound transport | 24.6575 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 24.6575 | 4 | no |
| GO:0071310 | cellular response to organic substance | 24.6575 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 24.6575 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 24.6575 | 5 | no |
| GO:0023056 | positive regulation of signaling | 24.6575 | 4 | no |
| GO:0007015 | actin filament organization | 23.2877 | 5 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 23.2877 | 5 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 23.2877 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.2877 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.2877 | 6 | no |
| GO:0016192 | vesicle-mediated transport | 23.2877 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.2877 | 6 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.2877 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.2877 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.2877 | 5 | no |
| GO:0015031 | protein transport | 21.9178 | 4 | no |
| GO:0034330 | cell junction organization | 21.9178 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.5479 | 5 | no |
| GO:0110053 | regulation of actin filament organization | 20.5479 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.5479 | 6 | no |
| GO:0043933 | protein-containing complex organization | 20.5479 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 20.5479 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.5479 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 20.5479 | 7 | no |
| GO:2000145 | regulation of cell motility | 20.5479 | 4 | no |
| GO:0061049 | cell growth involved in cardiac muscle cell development | 4.1096 | 4 | yes |
| GO:0007219 | Notch signaling pathway | 2.7397 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SRBS2_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 2.7397 | 3 | no |
| DOID:1247 | blood coagulation disease | 2.7397 | 3 | no |
| DOID:2218 | blood platelet disease | 2.7397 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SYNJ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PALLD_HUMAN | [view interactions] | Low throughput | no | yes |
| WASF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ABL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CBL_HUMAN | [view interactions] | Low throughput | no | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FAT1_HUMAN | [view interactions] | Low throughput | no | yes |
| DLGP4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTN12_HUMAN | [view interactions] | Low throughput | no | yes |
| VINC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AFAD_HUMAN | [view interactions] | Low throughput | no | yes |
| SH3G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PAXI_HUMAN | [view interactions] | Low throughput | no | yes |
| SPTA1_HUMAN | [view interactions] | Low throughput | no | no |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADAM9_HUMAN | [view interactions] | High throughput | no | no |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEM6A_HUMAN | [view interactions] | High throughput | no | yes |
| AKT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDM2_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR1H2_HUMAN | [view interactions] | High throughput | no | yes |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYJ2B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADA15_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| VP37C_HUMAN | [view interactions] | High throughput | no | yes |
| NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFS_HUMAN | [view interactions] | High throughput | no | no |
| WASP_HUMAN | [view interactions] | High throughput | no | yes |
| ATPF2_HUMAN | [view interactions] | High throughput | no | yes |
| SRBS2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH24A_HUMAN | [view interactions] | High throughput | no | no |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBLB_HUMAN | [view interactions] | High throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3H_HUMAN | [view interactions] | High throughput | no | yes |
| SH3R1_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP4AT_HUMAN | [view interactions] | High throughput | no | no |
| SOCS7_HUMAN | [view interactions] | High throughput | no | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SUZ12_HUMAN | [view interactions] | High throughput | no | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| ODFP2_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHG15_HUMAN | [view interactions] | High throughput | no | no |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| CHIO_HUMAN | [view interactions] | High throughput | no | yes |
| OPHN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRIC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRBS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPS8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM44_HUMAN | [view interactions] | High throughput | no | yes |
| VAV_HUMAN | [view interactions] | High throughput | no | no |
| VINEX_HUMAN | [view interactions] | High throughput | no | no |
| SRGP1_HUMAN | [view interactions] | High throughput | no | no |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| NLGN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |