EPS8_HUMAN
Evidence for PS localization
Functions
Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003807 | LIG_SH3_3 | LIG | 210 | 216 | - |
| ELMI003806 | LIG_SH3_3 | LIG | 215 | 221 | - |
| ELMI003807 | LIG_SH3_3 | LIG | 210 | 216 | - |
| ELMI003806 | LIG_SH3_3 | LIG | 215 | 221 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EPS8_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 34.0000 | 4 | no |
| GO:0000166 | nucleotide binding | 32.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 30.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 30.0000 | 4 | no |
| GO:0019900 | kinase binding | 30.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.0000 | 4 | no |
| GO:0043169 | cation binding | 28.0000 | 4 | no |
| GO:0046872 | metal ion binding | 28.0000 | 5 | no |
| GO:0019901 | protein kinase binding | 24.0000 | 5 | no |
| GO:0003779 | actin binding | 12.0000 | 4 | yes |
| GO:0031267 | small GTPase binding | 10.0000 | 5 | yes |
| GO:0051020 | GTPase binding | 10.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EPS8_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 80.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 72.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 68.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 60.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 58.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 58.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 58.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 52.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 50.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 50.0000 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 48.0000 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 48.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 48.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 48.0000 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 46.0000 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 46.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 46.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 46.0000 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 44.0000 | 5 | no |
| GO:0010468 | regulation of gene expression | 44.0000 | 6 | no |
| GO:0022607 | cellular component assembly | 42.0000 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 38.0000 | 4 | no |
| GO:0031399 | regulation of protein modification process | 36.0000 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 36.0000 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 36.0000 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 36.0000 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 34.0000 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 34.0000 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 34.0000 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 34.0000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 32.0000 | 4 | no |
| GO:0006996 | organelle organization | 32.0000 | 4 | no |
| GO:0051049 | regulation of transport | 32.0000 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 32.0000 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 32.0000 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 32.0000 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.0000 | 5 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 30.0000 | 4 | no |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 30.0000 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 30.0000 | 7 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.0000 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 28.0000 | 4 | yes |
| GO:0097435 | supramolecular fiber organization | 28.0000 | 4 | yes |
| GO:0141124 | intracellular signaling cassette | 28.0000 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 28.0000 | 7 | no |
| GO:0051252 | regulation of RNA metabolic process | 28.0000 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 28.0000 | 6 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 28.0000 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 28.0000 | 6 | no |
| GO:0030030 | cell projection organization | 28.0000 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 28.0000 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 28.0000 | 7 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 28.0000 | 6 | no |
| GO:0010243 | response to organonitrogen compound | 28.0000 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 28.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 28.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 28.0000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.0000 | 5 | no |
| GO:0007010 | cytoskeleton organization | 26.0000 | 5 | no |
| GO:0030334 | regulation of cell migration | 26.0000 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.0000 | 5 | no |
| GO:2000145 | regulation of cell motility | 26.0000 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.0000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 26.0000 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 26.0000 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 26.0000 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 26.0000 | 4 | no |
| GO:0007015 | actin filament organization | 26.0000 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 26.0000 | 5 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 24.0000 | 6 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 24.0000 | 6 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.0000 | 6 | yes |
| GO:0010648 | negative regulation of cell communication | 24.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 24.0000 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 24.0000 | 4 | no |
| GO:0008284 | positive regulation of cell population proliferation | 24.0000 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 24.0000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 24.0000 | 4 | no |
| GO:0031346 | positive regulation of cell projection organization | 24.0000 | 6 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 22.0000 | 4 | no |
| GO:0002684 | positive regulation of immune system process | 22.0000 | 4 | no |
| GO:0030335 | positive regulation of cell migration | 22.0000 | 6 | no |
| GO:0032101 | regulation of response to external stimulus | 22.0000 | 4 | no |
| GO:0040017 | positive regulation of locomotion | 22.0000 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 22.0000 | 5 | no |
| GO:0008104 | protein localization | 22.0000 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 22.0000 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 22.0000 | 7 | no |
| GO:0051338 | regulation of transferase activity | 22.0000 | 4 | no |
| GO:0071417 | cellular response to organonitrogen compound | 22.0000 | 4 | no |
| GO:0080134 | regulation of response to stress | 22.0000 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 22.0000 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.0000 | 4 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 20.0000 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 20.0000 | 5 | yes |
| GO:0007264 | small GTPase-mediated signal transduction | 20.0000 | 5 | yes |
| GO:0022604 | regulation of cell morphogenesis | 20.0000 | 5 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 20.0000 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 20.0000 | 4 | yes |
| GO:0060491 | regulation of cell projection assembly | 16.0000 | 5 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 16.0000 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 14.0000 | 6 | yes |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 14.0000 | 6 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 12.0000 | 5 | yes |
| GO:0120034 | positive regulation of plasma membrane bounded cell projection assembly | 12.0000 | 6 | yes |
| GO:0016601 | Rac protein signal transduction | 12.0000 | 6 | yes |
| GO:0034097 | response to cytokine | 12.0000 | 4 | yes |
| GO:0035023 | regulation of Rho protein signal transduction | 12.0000 | 7 | yes |
| GO:0051017 | actin filament bundle assembly | 10.0000 | 5 | yes |
| GO:0061572 | actin filament bundle organization | 10.0000 | 6 | yes |
| GO:0071345 | cellular response to cytokine stimulus | 10.0000 | 5 | yes |
| GO:0032271 | regulation of protein polymerization | 10.0000 | 6 | yes |
| GO:0032535 | regulation of cellular component size | 10.0000 | 4 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 8.0000 | 6 | yes |
| GO:0010639 | negative regulation of organelle organization | 8.0000 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 8.0000 | 5 | yes |
| GO:0030833 | regulation of actin filament polymerization | 8.0000 | 7 | yes |
| GO:0044772 | mitotic cell cycle phase transition | 6.0000 | 4 | yes |
| GO:0051494 | negative regulation of cytoskeleton organization | 6.0000 | 7 | yes |
| GO:0051764 | actin crosslink formation | 6.0000 | 6 | yes |
| GO:1900027 | regulation of ruffle assembly | 6.0000 | 7 | yes |
| GO:1900029 | positive regulation of ruffle assembly | 6.0000 | 7 | yes |
| GO:1901879 | regulation of protein depolymerization | 6.0000 | 6 | yes |
| GO:1901880 | negative regulation of protein depolymerization | 6.0000 | 7 | yes |
| GO:1902904 | negative regulation of supramolecular fiber organization | 6.0000 | 6 | yes |
| GO:0007266 | Rho protein signal transduction | 6.0000 | 6 | yes |
| GO:0031333 | negative regulation of protein-containing complex assembly | 6.0000 | 6 | yes |
| GO:0043242 | negative regulation of protein-containing complex disassembly | 6.0000 | 6 | yes |
| GO:0043244 | regulation of protein-containing complex disassembly | 6.0000 | 5 | yes |
| GO:0048149 | behavioral response to ethanol | 4.0000 | 4 | yes |
| GO:0051016 | barbed-end actin filament capping | 4.0000 | 9 | yes |
| GO:0051693 | actin filament capping | 4.0000 | 8 | yes |
| GO:1990823 | response to leukemia inhibitory factor | 4.0000 | 5 | yes |
| GO:1990830 | cellular response to leukemia inhibitory factor | 4.0000 | 6 | yes |
| GO:0008344 | adult locomotory behavior | 4.0000 | 4 | yes |
| GO:0010458 | exit from mitosis | 4.0000 | 5 | yes |
| GO:0030834 | regulation of actin filament depolymerization | 4.0000 | 7 | yes |
| GO:0030835 | negative regulation of actin filament depolymerization | 4.0000 | 7 | yes |
| GO:0030837 | negative regulation of actin filament polymerization | 4.0000 | 7 | yes |
| GO:0032272 | negative regulation of protein polymerization | 4.0000 | 7 | yes |
| GO:0036336 | dendritic cell migration | 4.0000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BI2L1_HUMAN | [view interactions] | Low throughput | no | yes |
| AL7A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BAIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| FBXW5_HUMAN | [view interactions] | Low throughput | no | no |
| ABI1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSKP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LANC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LANC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| US6NL_HUMAN | [view interactions] | Low throughput | no | yes |
| MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CBL_HUMAN | [view interactions] | Low throughput | no | yes |
| EPS8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CD3E_HUMAN | [view interactions] | Low throughput | no | no |
| DVL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHB_HUMAN | [view interactions] | Low throughput | no | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXCL2_HUMAN | [view interactions] | High throughput | no | no |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| M3K11_HUMAN | [view interactions] | High throughput | no | yes |
| RFXAP_HUMAN | [view interactions] | High throughput | no | no |
| NFKB2_HUMAN | [view interactions] | High throughput | no | yes |
| BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S27A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SF3B3_HUMAN | [view interactions] | High throughput | no | yes |
| ZZZ3_HUMAN | [view interactions] | High throughput | no | yes |
| CTNA3_HUMAN | [view interactions] | High throughput | no | no |
| GULP1_HUMAN | [view interactions] | High throughput | no | no |
| ADA22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARMC1_HUMAN | [view interactions] | High throughput | no | yes |
| SCRN3_HUMAN | [view interactions] | High throughput | no | yes |
| NACC2_HUMAN | [view interactions] | High throughput | no | yes |
| PRSR2_HUMAN | [view interactions] | High throughput | no | yes |
| TPRN_HUMAN | [view interactions] | High throughput | no | yes |
| CH033_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| FGL1_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITB5_HUMAN | [view interactions] | High throughput | no | yes |
| ITB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| TYDP2_HUMAN | [view interactions] | High throughput | no | no |
| XAGE2_HUMAN | [view interactions] | High throughput | no | no |
| CF141_HUMAN | [view interactions] | High throughput | no | no |
| RCAN3_HUMAN | [view interactions] | High throughput | no | no |
| RSP14_HUMAN | [view interactions] | High throughput | no | no |
| IPSP_HUMAN | [view interactions] | High throughput | no | no |
| HNRPC_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOG8D_HUMAN | [view interactions] | High throughput | no | no |
| BYST_HUMAN | [view interactions] | High throughput | no | yes |
| PI5PA_HUMAN | [view interactions] | High throughput | no | no |
| SMCE1_HUMAN | [view interactions] | High throughput | no | yes |
| BORC6_HUMAN | [view interactions] | High throughput | no | yes |
| CS025_HUMAN | [view interactions] | High throughput | no | no |
| RM20_HUMAN | [view interactions] | High throughput | no | yes |
| MYO15_HUMAN | [view interactions] | High throughput | no | no |
| IDLC_HUMAN | [view interactions] | High throughput | no | no |
| BL1S6_HUMAN | [view interactions] | High throughput | no | yes |
| CC85B_HUMAN | [view interactions] | High throughput | no | yes |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| TEX28_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROR1_HUMAN | [view interactions] | High throughput | no | no |
| TANK_HUMAN | [view interactions] | High throughput | no | yes |
| MTG8_HUMAN | [view interactions] | High throughput | no | yes |
| MDC1_HUMAN | [view interactions] | High throughput | no | yes |
| AMPD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| MRP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GPC5B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MND1_HUMAN | [view interactions] | High throughput | no | no |
| MEIS2_HUMAN | [view interactions] | High throughput | no | yes |
| MILR1_HUMAN | [view interactions] | High throughput | no | no |
| MS18B_HUMAN | [view interactions] | High throughput | no | no |
| TMM51_HUMAN | [view interactions] | High throughput | no | yes |
| TYW3_HUMAN | [view interactions] | High throughput | no | yes |
| LYRM4_HUMAN | [view interactions] | High throughput | no | yes |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| IBP5_HUMAN | [view interactions] | High throughput | no | no |
| PDE2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| ABRX2_HUMAN | [view interactions] | High throughput | no | yes |
| RHG15_HUMAN | [view interactions] | High throughput | no | no |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHIO_HUMAN | [view interactions] | High throughput | no | yes |
| RHG42_HUMAN | [view interactions] | High throughput | no | yes |
| FBF1_HUMAN | [view interactions] | High throughput | no | no |
| TBKB1_HUMAN | [view interactions] | High throughput | no | no |
| GLI2_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RGF1B_HUMAN | [view interactions] | High throughput | no | no |
| RASF8_HUMAN | [view interactions] | High throughput | no | yes |
| SRBS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRBS2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRGP1_HUMAN | [view interactions] | High throughput | no | no |
| TBK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |