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EPS8_HUMAN

Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. [View more on UniProt]

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ELM instance Name Type Start End Partner
ELMI003807 LIG_SH3_3 LIG 210 216 -
ELMI003806 LIG_SH3_3 LIG 215 221 -

Molecular function

Term Name % Distance from the top of the tree Annotated in EPS8_HUMAN
GO:0017076 purine nucleotide binding 37.2549 4 no
GO:0032555 purine ribonucleotide binding 37.2549 4 no
GO:0035639 purine ribonucleoside triphosphate binding 35.2941 4 no
GO:0019900 kinase binding 29.4118 4 no
GO:0019901 protein kinase binding 25.4902 5 no
GO:0016301 kinase activity 23.5294 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 23.5294 4 no
GO:0046872 metal ion binding 23.5294 4 no
GO:0030554 adenyl nucleotide binding 23.5294 5 no
GO:0032559 adenyl ribonucleotide binding 23.5294 5 no
GO:0005524 ATP binding 21.5686 5 no
GO:0003779 actin binding 13.7255 4 yes
GO:0031267 small GTPase binding 7.8431 5 yes
GO:0051020 GTPase binding 7.8431 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in EPS8_HUMAN
GO:0048522 positive regulation of cellular process 76.4706 4 yes
GO:0010646 regulation of cell communication 72.5490 4 yes
GO:0009966 regulation of signal transduction 62.7451 4 yes
GO:0080090 regulation of primary metabolic process 56.8627 4 no
GO:0031323 regulation of cellular metabolic process 54.9020 4 no
GO:0051171 regulation of nitrogen compound metabolic process 54.9020 4 no
GO:0060255 regulation of macromolecule metabolic process 54.9020 4 no
GO:0048523 negative regulation of cellular process 54.9020 4 yes
GO:0010647 positive regulation of cell communication 49.0196 5 no
GO:0023056 positive regulation of signaling 49.0196 4 no
GO:0009893 positive regulation of metabolic process 49.0196 4 no
GO:0010604 positive regulation of macromolecule metabolic process 47.0588 5 no
GO:0048584 positive regulation of response to stimulus 47.0588 4 no
GO:0051128 regulation of cellular component organization 47.0588 4 yes
GO:0031325 positive regulation of cellular metabolic process 45.0980 5 no
GO:0051246 regulation of protein metabolic process 45.0980 5 no
GO:1902531 regulation of intracellular signal transduction 45.0980 5 yes
GO:0009967 positive regulation of signal transduction 43.1373 5 no
GO:0019220 regulation of phosphate metabolic process 41.1765 6 no
GO:0042325 regulation of phosphorylation 41.1765 7 no
GO:0051173 positive regulation of nitrogen compound metabolic process 41.1765 5 no
GO:0051174 regulation of phosphorus metabolic process 41.1765 5 no
GO:0031399 regulation of protein modification process 39.2157 6 no
GO:0006996 organelle organization 39.2157 4 yes
GO:0001932 regulation of protein phosphorylation 39.2157 7 no
GO:0042127 regulation of cell population proliferation 37.2549 4 no
GO:0010468 regulation of gene expression 37.2549 5 no
GO:0007010 cytoskeleton organization 37.2549 5 yes
GO:0033043 regulation of organelle organization 37.2549 5 yes
GO:0009892 negative regulation of metabolic process 35.2941 4 no
GO:0022607 cellular component assembly 35.2941 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 yes
GO:0071310 cellular response to organic substance 33.3333 4 yes
GO:0097435 supramolecular fiber organization 33.3333 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.3725 5 no
GO:0051049 regulation of transport 31.3725 4 no
GO:0010605 negative regulation of macromolecule metabolic process 31.3725 5 no
GO:0010941 regulation of cell death 31.3725 4 no
GO:0007015 actin filament organization 31.3725 5 yes
GO:0051130 positive regulation of cellular component organization 31.3725 5 yes
GO:0051493 regulation of cytoskeleton organization 31.3725 6 yes
GO:0031401 positive regulation of protein modification process 29.4118 7 no
GO:0009889 regulation of biosynthetic process 29.4118 4 no
GO:0031326 regulation of cellular biosynthetic process 29.4118 5 no
GO:0050804 modulation of chemical synaptic transmission 29.4118 5 no
GO:0099177 regulation of trans-synaptic signaling 29.4118 4 no
GO:0016192 vesicle-mediated transport 29.4118 4 no
GO:1902533 positive regulation of intracellular signal transduction 29.4118 6 no
GO:0031344 regulation of cell projection organization 29.4118 5 yes
GO:0044087 regulation of cellular component biogenesis 29.4118 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 29.4118 6 yes
GO:0001934 positive regulation of protein phosphorylation 29.4118 8 no
GO:0010243 response to organonitrogen compound 27.4510 4 no
GO:0010556 regulation of macromolecule biosynthetic process 27.4510 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 27.4510 4 no
GO:0042981 regulation of apoptotic process 27.4510 6 no
GO:0043067 regulation of programmed cell death 27.4510 5 no
GO:0045595 regulation of cell differentiation 27.4510 4 no
GO:0051094 positive regulation of developmental process 27.4510 4 no
GO:0080134 regulation of response to stress 27.4510 4 no
GO:0031346 positive regulation of cell projection organization 27.4510 6 yes
GO:0032956 regulation of actin cytoskeleton organization 27.4510 5 yes
GO:0032970 regulation of actin filament-based process 27.4510 4 yes
GO:0030334 regulation of cell migration 25.4902 5 no
GO:2000145 regulation of cell motility 25.4902 4 no
GO:0006355 regulation of DNA-templated transcription 25.4902 6 no
GO:0043085 positive regulation of catalytic activity 25.4902 4 no
GO:0051252 regulation of RNA metabolic process 25.4902 5 no
GO:1903506 regulation of nucleic acid-templated transcription 25.4902 7 no
GO:2001141 regulation of RNA biosynthetic process 25.4902 6 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 25.4902 5 no
GO:0008284 positive regulation of cell population proliferation 25.4902 5 no
GO:1901701 cellular response to oxygen-containing compound 25.4902 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 25.4902 5 no
GO:0030030 cell projection organization 25.4902 4 no
GO:0051338 regulation of transferase activity 25.4902 4 no
GO:0022604 regulation of cell morphogenesis 25.4902 5 yes
GO:0044089 positive regulation of cellular component biogenesis 25.4902 5 yes
GO:0051056 regulation of small GTPase mediated signal transduction 25.4902 6 yes
GO:0006796 phosphate-containing compound metabolic process 25.4902 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.5294 6 no
GO:0060341 regulation of cellular localization 23.5294 4 no
GO:0031324 negative regulation of cellular metabolic process 23.5294 5 no
GO:0008104 protein localization 23.5294 4 no
GO:0030335 positive regulation of cell migration 23.5294 6 no
GO:0040017 positive regulation of locomotion 23.5294 4 no
GO:2000147 positive regulation of cell motility 23.5294 5 no
GO:0120036 plasma membrane bounded cell projection organization 23.5294 5 no
GO:0043549 regulation of kinase activity 23.5294 5 no
GO:0016310 phosphorylation 21.5686 5 no
GO:0036211 protein modification process 21.5686 4 no
GO:0043412 macromolecule modification 21.5686 4 no
GO:0009891 positive regulation of biosynthetic process 21.5686 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.5686 6 no
GO:0031328 positive regulation of cellular biosynthetic process 21.5686 6 no
GO:0051050 positive regulation of transport 21.5686 4 no
GO:0010638 positive regulation of organelle organization 21.5686 6 no
GO:0010628 positive regulation of gene expression 21.5686 6 no
GO:0051240 positive regulation of multicellular organismal process 21.5686 4 no
GO:1901699 cellular response to nitrogen compound 21.5686 4 no
GO:0045859 regulation of protein kinase activity 21.5686 6 no
GO:0032101 regulation of response to external stimulus 21.5686 4 no
GO:0007264 small GTPase mediated signal transduction 21.5686 4 yes
GO:0060491 regulation of cell projection assembly 21.5686 5 yes
GO:1902903 regulation of supramolecular fiber organization 21.5686 5 yes
GO:0007265 Ras protein signal transduction 19.6078 5 yes
GO:0051129 negative regulation of cellular component organization 19.6078 5 yes
GO:0110053 regulation of actin filament organization 19.6078 6 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 19.6078 6 yes
GO:0046578 regulation of Ras protein signal transduction 17.6471 7 yes
GO:0043254 regulation of protein-containing complex assembly 15.6863 5 yes
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 15.6863 6 yes
GO:0032535 regulation of cellular component size 13.7255 4 yes
GO:0034097 response to cytokine 13.7255 4 yes
GO:0035023 regulation of Rho protein signal transduction 13.7255 8 yes
GO:0008360 regulation of cell shape 11.7647 6 yes
GO:0032271 regulation of protein polymerization 11.7647 6 yes
GO:0071345 cellular response to cytokine stimulus 11.7647 5 yes
GO:0008064 regulation of actin polymerization or depolymerization 9.8039 6 yes
GO:0010639 negative regulation of organelle organization 9.8039 6 yes
GO:0030832 regulation of actin filament length 9.8039 5 yes
GO:0031532 actin cytoskeleton reorganization 9.8039 4 yes
GO:0051017 actin filament bundle assembly 9.8039 5 yes
GO:0061572 actin filament bundle organization 9.8039 6 yes
GO:0007266 Rho protein signal transduction 7.8431 6 yes
GO:0016601 Rac protein signal transduction 7.8431 6 yes
GO:0030833 regulation of actin filament polymerization 7.8431 7 yes
GO:0031333 negative regulation of protein-containing complex assembly 7.8431 6 yes
GO:0043242 negative regulation of protein-containing complex disassembly 7.8431 6 yes
GO:0043244 regulation of protein-containing complex disassembly 7.8431 5 yes
GO:0051494 negative regulation of cytoskeleton organization 7.8431 7 yes
GO:1901879 regulation of protein depolymerization 7.8431 6 yes
GO:1901880 negative regulation of protein depolymerization 7.8431 7 yes
GO:1902904 negative regulation of supramolecular fiber organization 7.8431 6 yes
GO:0030834 regulation of actin filament depolymerization 5.8824 7 yes
GO:0030835 negative regulation of actin filament depolymerization 5.8824 7 yes
GO:0036336 dendritic cell migration 5.8824 4 yes
GO:0044772 mitotic cell cycle phase transition 5.8824 4 yes
GO:0051764 actin crosslink formation 5.8824 6 yes
GO:1900027 regulation of ruffle assembly 5.8824 7 yes
GO:1900029 positive regulation of ruffle assembly 5.8824 7 yes
GO:0008344 adult locomotory behavior 3.9216 4 yes
GO:0010458 exit from mitosis 3.9216 5 yes
GO:0030837 negative regulation of actin filament polymerization 3.9216 7 yes
GO:0032272 negative regulation of protein polymerization 3.9216 7 yes
GO:0048149 behavioral response to ethanol 3.9216 4 yes
GO:0051016 barbed-end actin filament capping 3.9216 9 yes
GO:0051693 actin filament capping 3.9216 8 yes
GO:1990823 response to leukemia inhibitory factor 3.9216 5 yes
GO:1990830 cellular response to leukemia inhibitory factor 3.9216 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in EPS8_HUMAN
DOID:1289 neurodegenerative disease 3.9216 4 no
DOID:331 central nervous system disease 3.9216 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BI2L1_HUMAN [view interactions] Low throughput no yes
AL7A1_HUMAN [view entry] [view interactions] Low throughput yes no
BAIP2_HUMAN [view entry] [view interactions] Low throughput yes yes
EGFR_HUMAN [view interactions] Low throughput no no
FBXW5_HUMAN [view interactions] Low throughput no no
ABI1_HUMAN [view entry] [view interactions] Low throughput yes yes
CSKP_HUMAN [view entry] [view interactions] Low throughput yes yes
LANC1_HUMAN [view entry] [view interactions] Low throughput yes yes
LANC2_HUMAN [view entry] [view interactions] Low throughput yes yes
SOS1_HUMAN [view entry] [view interactions] Low throughput yes yes
ABI2_HUMAN [view entry] [view interactions] Low throughput yes yes
US6NL_HUMAN [view interactions] Low throughput no yes
MK03_HUMAN [view entry] [view interactions] Low throughput yes yes
CBL_HUMAN [view interactions] Low throughput no yes
EPS8_HUMAN [view entry] [view interactions] Low throughput yes yes
CD3E_HUMAN [view interactions] Low throughput no no
DVL1_HUMAN [view entry] [view interactions] Low throughput yes yes
ITSN2_HUMAN [view entry] [view interactions] Low throughput yes yes
SHC1_HUMAN [view entry] [view interactions] Low throughput yes yes
SHB_HUMAN [view interactions] Low throughput no yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE3_HUMAN [view entry] [view interactions] Low throughput yes no
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
P85A_HUMAN [view interactions] Low throughput no yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
CXCL2_HUMAN [view interactions] High throughput no no
XRCC6_HUMAN [view interactions] High throughput no yes
M3K11_HUMAN [view interactions] High throughput no yes
NFKB2_HUMAN [view interactions] High throughput no yes
RFXAP_HUMAN [view interactions] High throughput no no
BCKD_HUMAN [view entry] [view interactions] High throughput yes yes
S27A4_HUMAN [view entry] [view interactions] High throughput yes yes
SF3B3_HUMAN [view interactions] High throughput no yes
ZZZ3_HUMAN [view interactions] High throughput no yes
CTNA3_HUMAN [view interactions] High throughput no no
GULP1_HUMAN [view interactions] High throughput no no
ADA22_HUMAN [view entry] [view interactions] High throughput yes no
ARMC1_HUMAN [view interactions] High throughput no yes
SCRN3_HUMAN [view interactions] High throughput no yes
NACC2_HUMAN [view interactions] High throughput no yes
PRSR2_HUMAN [view interactions] High throughput no yes
TPRN_HUMAN [view interactions] High throughput no yes
CH033_HUMAN [view interactions] High throughput no yes
MLP3B_HUMAN [view interactions] High throughput no yes
FGL1_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
ITB1_HUMAN [view entry] [view interactions] High throughput yes no
ITB5_HUMAN [view interactions] High throughput no yes
ITB3_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
INSR_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
TYDP2_HUMAN [view interactions] High throughput no no
XAGE2_HUMAN [view interactions] High throughput no no
CF141_HUMAN [view interactions] High throughput no no
RCAN3_HUMAN [view interactions] High throughput no no
RSP14_HUMAN [view interactions] High throughput no no
IPSP_HUMAN [view interactions] High throughput no no
HNRPC_HUMAN [view interactions] High throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
GOG8D_HUMAN [view interactions] High throughput no no
BYST_HUMAN [view interactions] High throughput no yes
PI5PA_HUMAN [view interactions] High throughput no no
SMCE1_HUMAN [view interactions] High throughput no yes
BORC6_HUMAN [view interactions] High throughput no yes
CS025_HUMAN [view interactions] High throughput no no
RM20_HUMAN [view interactions] High throughput no yes
MYO15_HUMAN [view interactions] High throughput no no
IDLC_HUMAN [view interactions] High throughput no no
BL1S6_HUMAN [view interactions] High throughput no yes
CC85B_HUMAN [view interactions] High throughput no yes
AIMP2_HUMAN [view interactions] High throughput no yes
PCM1_HUMAN [view interactions] High throughput no yes
HOOK2_HUMAN [view interactions] High throughput no yes
TEX28_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
ANR28_HUMAN [view interactions] High throughput no no
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
ROR1_HUMAN [view interactions] High throughput no no
TANK_HUMAN [view interactions] High throughput no yes
MTG8_HUMAN [view interactions] High throughput no yes
MDC1_HUMAN [view interactions] High throughput no yes
AMPD2_HUMAN [view entry] [view interactions] High throughput yes yes
ESR2_HUMAN [view interactions] High throughput no no
NUPR1_HUMAN [view interactions] High throughput no no
DDX58_HUMAN [view interactions] High throughput no yes
MRP_HUMAN [view entry] [view interactions] High throughput yes no
GPC5B_HUMAN [view entry] [view interactions] High throughput yes no
MND1_HUMAN [view interactions] High throughput no no
MEIS2_HUMAN [view interactions] High throughput no yes
MILR1_HUMAN [view interactions] High throughput no no
MS18B_HUMAN [view interactions] High throughput no no
TMM51_HUMAN [view interactions] High throughput no yes
TYW3_HUMAN [view interactions] High throughput no yes
LYRM4_HUMAN [view interactions] High throughput no yes
ETFA_HUMAN [view interactions] High throughput no yes
IBP5_HUMAN [view interactions] High throughput no no
PDE2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
ABRX2_HUMAN [view interactions] High throughput no yes
RHG15_HUMAN [view interactions] High throughput no no
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
RHG26_HUMAN [view entry] [view interactions] High throughput yes yes
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
CHIO_HUMAN [view interactions] High throughput no yes
RHG42_HUMAN [view interactions] High throughput no yes
FBF1_HUMAN [view interactions] High throughput no no
TBKB1_HUMAN [view interactions] High throughput no no
GLI2_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
PRIC1_HUMAN [view interactions] High throughput no yes
PRIC2_HUMAN [view entry] [view interactions] High throughput yes no
RGF1B_HUMAN [view interactions] High throughput no no
RASF8_HUMAN [view interactions] High throughput no yes
SRBS1_HUMAN [view entry] [view interactions] High throughput yes yes
SRBS2_HUMAN [view entry] [view interactions] High throughput yes no
SRGP1_HUMAN [view interactions] High throughput no no
TBK1_HUMAN [view entry] [view interactions] High throughput yes yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
ACTC_HUMAN [view interactions] High throughput no no
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
CK052_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
IFM3_HUMAN [view interactions] High throughput no yes
PALLD_HUMAN [view interactions] Computational no yes
CDC42_HUMAN [view entry] [view interactions] Computational yes yes
PI3R6_HUMAN [view interactions] Computational no yes
PK3CB_HUMAN [view interactions] Computational no yes
WHRN_HUMAN [view interactions] Computational no no
PK3CA_HUMAN [view entry] [view interactions] Computational yes yes
RAB5A_HUMAN [view entry] [view interactions] Computational yes yes
ABL1_HUMAN [view entry] [view interactions] Computational yes yes
PK3CG_HUMAN [view interactions] Computational no yes
EGF_HUMAN [view interactions] Computational no no