S27A4_HUMAN
Evidence for PS localization
Functions
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane (PubMed, PubMed). Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs) (PubMed). Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis . Probably involved in fatty acid transport across the blood barrier (PubMed). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in S27A4_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 23.5294 | 4 | no |
| GO:0017076 | purine nucleotide binding | 23.5294 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 23.5294 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.5294 | 4 | no |
| GO:0008028 | monocarboxylic acid transmembrane transporter activity | 11.7647 | 5 | yes |
| GO:0008509 | anion transmembrane transporter activity | 11.7647 | 4 | yes |
| GO:0008514 | organic anion transmembrane transporter activity | 11.7647 | 5 | yes |
| GO:0016405 | CoA-ligase activity | 11.7647 | 4 | yes |
| GO:0016878 | acid-thiol ligase activity | 11.7647 | 4 | yes |
| GO:0046943 | carboxylic acid transmembrane transporter activity | 11.7647 | 4 | yes |
| GO:0047676 | arachidonate-CoA ligase activity | 11.7647 | 4 | yes |
| GO:0090434 | oleoyl-CoA ligase activity | 11.7647 | 4 | yes |
| GO:1901480 | oleate transmembrane transporter activity | 11.7647 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in S27A4_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.8235 | 4 | yes |
| GO:0010646 | regulation of cell communication | 52.9412 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 47.0588 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 41.1765 | 4 | yes |
| GO:0051049 | regulation of transport | 35.2941 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 35.2941 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.2941 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 35.2941 | 4 | no |
| GO:0006996 | organelle organization | 35.2941 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 29.4118 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 29.4118 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 29.4118 | 5 | no |
| GO:0036211 | protein modification process | 29.4118 | 4 | no |
| GO:0043412 | macromolecule modification | 29.4118 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 29.4118 | 4 | yes |
| GO:0023057 | negative regulation of signaling | 23.5294 | 4 | yes |
| GO:0043085 | positive regulation of catalytic activity | 23.5294 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 23.5294 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 23.5294 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 23.5294 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.5294 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.5294 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.5294 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.5294 | 5 | no |
| GO:0051050 | positive regulation of transport | 23.5294 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 23.5294 | 5 | no |
| GO:0071310 | cellular response to organic substance | 23.5294 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.5294 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 23.5294 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.5294 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.5294 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.5294 | 4 | no |
| GO:0006811 | ion transport | 23.5294 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 23.5294 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 23.5294 | 5 | yes |
| GO:0042981 | regulation of apoptotic process | 17.6471 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 17.6471 | 5 | yes |
| GO:0071702 | organic substance transport | 17.6471 | 4 | yes |
| GO:0010941 | regulation of cell death | 17.6471 | 4 | yes |
| GO:0015908 | fatty acid transport | 11.7647 | 6 | yes |
| GO:0015909 | long-chain fatty acid transport | 11.7647 | 7 | yes |
| GO:0016042 | lipid catabolic process | 11.7647 | 4 | yes |
| GO:0031667 | response to nutrient levels | 11.7647 | 4 | yes |
| GO:0043086 | negative regulation of catalytic activity | 11.7647 | 4 | yes |
| GO:0043087 | regulation of GTPase activity | 11.7647 | 5 | yes |
| GO:0044381 | glucose import in response to insulin stimulus | 11.7647 | 8 | yes |
| GO:0044539 | long-chain fatty acid import into cell | 11.7647 | 6 | yes |
| GO:0046323 | glucose import | 11.7647 | 7 | yes |
| GO:0046626 | regulation of insulin receptor signaling pathway | 11.7647 | 5 | yes |
| GO:0046942 | carboxylic acid transport | 11.7647 | 6 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 11.7647 | 5 | yes |
| GO:0051346 | negative regulation of hydrolase activity | 11.7647 | 5 | yes |
| GO:0098657 | import into cell | 11.7647 | 4 | yes |
| GO:0140354 | lipid import into cell | 11.7647 | 5 | yes |
| GO:0150104 | transport across blood-brain barrier | 11.7647 | 5 | yes |
| GO:1900076 | regulation of cellular response to insulin stimulus | 11.7647 | 4 | yes |
| GO:1904659 | glucose transmembrane transport | 11.7647 | 6 | yes |
| GO:1990379 | lipid transport across blood-brain barrier | 11.7647 | 6 | yes |
| GO:0001579 | medium-chain fatty acid transport | 11.7647 | 6 | yes |
| GO:0003018 | vascular process in circulatory system | 11.7647 | 4 | yes |
| GO:0006820 | anion transport | 11.7647 | 5 | yes |
| GO:0006869 | lipid transport | 11.7647 | 5 | yes |
| GO:0008643 | carbohydrate transport | 11.7647 | 5 | yes |
| GO:0008645 | hexose transmembrane transport | 11.7647 | 5 | yes |
| GO:0010232 | vascular transport | 11.7647 | 4 | yes |
| GO:0010942 | positive regulation of cell death | 11.7647 | 5 | yes |
| GO:0015711 | organic anion transport | 11.7647 | 5 | yes |
| GO:0015718 | monocarboxylic acid transport | 11.7647 | 7 | yes |
| GO:0015749 | monosaccharide transmembrane transport | 11.7647 | 4 | yes |
| GO:0015849 | organic acid transport | 11.7647 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NIPA4_HUMAN | [view interactions] | Low throughput | no | no |
| ATG4B_HUMAN | [view interactions] | Low throughput | no | yes |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| PANX1_HUMAN | [view interactions] | High throughput | no | no |
| REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPS8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BECN1_HUMAN | [view interactions] | High throughput | no | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| TPX2_HUMAN | [view interactions] | High throughput | no | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| DEN6A_HUMAN | [view interactions] | High throughput | no | yes |
| STRN3_HUMAN | [view interactions] | High throughput | no | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATG2A_HUMAN | [view interactions] | High throughput | no | yes |
| E2F3_HUMAN | [view interactions] | High throughput | no | no |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| ST32C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LFG4_HUMAN | [view interactions] | High throughput | no | no |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| TET5B_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| PEX19_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN4_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| S15A3_HUMAN | [view interactions] | High throughput | no | yes |
| DUS6_HUMAN | [view interactions] | High throughput | no | yes |
| DUS7_HUMAN | [view interactions] | High throughput | no | yes |
| MTMR7_HUMAN | [view interactions] | High throughput | no | no |
| CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ANR55_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| FA20C_HUMAN | [view interactions] | High throughput | no | no |
| FSD2_HUMAN | [view interactions] | High throughput | no | no |
| LRBA_HUMAN | [view interactions] | High throughput | no | yes |
| RDH13_HUMAN | [view interactions] | High throughput | no | no |
| CA210_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BE_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH12_HUMAN | [view interactions] | High throughput | no | yes |
| S39A4_HUMAN | [view interactions] | High throughput | no | no |
| CD63_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| ARMC6_HUMAN | [view interactions] | High throughput | no | yes |
| SMUG1_HUMAN | [view interactions] | High throughput | no | no |
| AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPIX_HUMAN | [view interactions] | High throughput | no | no |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| GPN3_HUMAN | [view interactions] | High throughput | no | yes |
| OGFD3_HUMAN | [view interactions] | High throughput | no | no |
| LRAD1_HUMAN | [view interactions] | High throughput | no | no |
| CIB3_HUMAN | [view interactions] | High throughput | no | no |
| CD79A_HUMAN | [view interactions] | High throughput | no | no |
| PBIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AMHR2_HUMAN | [view interactions] | High throughput | no | no |
| OTUL_HUMAN | [view interactions] | High throughput | no | yes |
| KI2L1_HUMAN | [view interactions] | High throughput | no | no |
| NUBP2_HUMAN | [view interactions] | High throughput | no | yes |
| LPAR2_HUMAN | [view interactions] | High throughput | no | yes |
| INSRR_HUMAN | [view interactions] | High throughput | no | no |
| TTMP_HUMAN | [view interactions] | High throughput | no | no |
| TBB4A_HUMAN | [view interactions] | High throughput | no | yes |
| SYPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACHA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PIGH_HUMAN | [view interactions] | High throughput | no | yes |
| HIPL1_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| BBLN_HUMAN | [view interactions] | High throughput | no | yes |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| CAH9_HUMAN | [view interactions] | High throughput | no | no |
| S27A1_HUMAN | [view entry] [view interactions] | Computational | yes | no |