Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NMDE3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NMDE3_HUMAN
GO:0008324 cation transmembrane transporter activity 42.5000 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 42.5000 4 yes
GO:0005216 ion channel activity 40.0000 4 yes
GO:0005261 cation channel activity 40.0000 5 yes
GO:0015267 channel activity 40.0000 4 yes
GO:0022836 gated channel activity 40.0000 5 yes
GO:0005230 extracellular ligand-gated ion channel activity 35.0000 6 yes
GO:0015276 ligand-gated ion channel activity 35.0000 5 yes
GO:0022834 ligand-gated channel activity 35.0000 6 yes
GO:0099094 ligand-gated cation channel activity 32.5000 6 yes
GO:0017076 purine nucleotide binding 30.0000 4 no
GO:0032555 purine ribonucleotide binding 30.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.0000 4 no
GO:0004970 ionotropic glutamate receptor activity 27.5000 5 yes
GO:0008066 glutamate receptor activity 27.5000 4 yes
GO:0022824 transmitter-gated ion channel activity 27.5000 5 yes
GO:0022835 transmitter-gated channel activity 27.5000 4 yes
GO:0046873 metal ion transmembrane transporter activity 27.5000 5 yes
GO:0005262 calcium channel activity 25.0000 6 yes
GO:0015085 calcium ion transmembrane transporter activity 25.0000 6 yes
GO:0046872 metal ion binding 25.0000 4 no
GO:0019900 kinase binding 25.0000 4 no
GO:0005524 ATP binding 25.0000 5 no
GO:0030554 adenyl nucleotide binding 25.0000 5 no
GO:0032559 adenyl ribonucleotide binding 25.0000 5 no
GO:0005244 voltage-gated ion channel activity 20.0000 4 yes
GO:0022832 voltage-gated channel activity 20.0000 6 yes
GO:0022843 voltage-gated cation channel activity 20.0000 5 yes
GO:0004972 NMDA glutamate receptor activity 15.0000 6 yes
GO:0099604 ligand-gated calcium channel activity 15.0000 7 yes
GO:0022849 glutamate-gated calcium ion channel activity 12.5000 6 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 12.5000 4 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 12.5000 5 yes
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 12.5000 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NMDE3_HUMAN
GO:0048522 positive regulation of cellular process 72.5000 4 yes
GO:0010646 regulation of cell communication 62.5000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 57.5000 4 yes
GO:0060255 regulation of macromolecule metabolic process 55.0000 4 yes
GO:0080090 regulation of primary metabolic process 55.0000 4 yes
GO:0051246 regulation of protein metabolic process 50.0000 5 yes
GO:0009966 regulation of signal transduction 47.5000 4 no
GO:0031323 regulation of cellular metabolic process 47.5000 4 no
GO:0048523 negative regulation of cellular process 47.5000 4 no
GO:0009893 positive regulation of metabolic process 42.5000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 42.5000 5 no
GO:0010647 positive regulation of cell communication 40.0000 5 yes
GO:0023056 positive regulation of signaling 40.0000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 40.0000 5 no
GO:0051049 regulation of transport 40.0000 4 no
GO:0051247 positive regulation of protein metabolic process 40.0000 6 no
GO:0008104 protein localization 37.5000 4 yes
GO:0050804 modulation of chemical synaptic transmission 32.5000 5 yes
GO:0099177 regulation of trans-synaptic signaling 32.5000 4 yes
GO:0010468 regulation of gene expression 32.5000 5 no
GO:0031325 positive regulation of cellular metabolic process 32.5000 5 no
GO:0043085 positive regulation of catalytic activity 32.5000 4 no
GO:0099537 trans-synaptic signaling 30.0000 4 yes
GO:0022607 cellular component assembly 30.0000 4 no
GO:0043269 regulation of ion transport 30.0000 5 no
GO:0048584 positive regulation of response to stimulus 30.0000 4 no
GO:0031399 regulation of protein modification process 30.0000 6 no
GO:1902531 regulation of intracellular signal transduction 30.0000 5 no
GO:0007268 chemical synaptic transmission 27.5000 6 yes
GO:0098916 anterograde trans-synaptic signaling 27.5000 5 yes
GO:0009889 regulation of biosynthetic process 27.5000 4 no
GO:0009967 positive regulation of signal transduction 27.5000 5 no
GO:0031326 regulation of cellular biosynthetic process 27.5000 5 no
GO:0034762 regulation of transmembrane transport 27.5000 4 no
GO:0034765 regulation of ion transmembrane transport 27.5000 5 no
GO:0044057 regulation of system process 27.5000 4 no
GO:0051050 positive regulation of transport 27.5000 4 no
GO:1904062 regulation of cation transmembrane transport 27.5000 6 no
GO:0006811 ion transport 25.0000 4 yes
GO:0006812 cation transport 25.0000 5 yes
GO:0072657 protein localization to membrane 25.0000 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0051128 regulation of cellular component organization 25.0000 4 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0007215 glutamate receptor signaling pathway 22.5000 4 yes
GO:0009892 negative regulation of metabolic process 22.5000 4 yes
GO:0030001 metal ion transport 22.5000 6 yes
GO:0006355 regulation of DNA-templated transcription 22.5000 6 no
GO:0010243 response to organonitrogen compound 22.5000 4 no
GO:1903506 regulation of nucleic acid-templated transcription 22.5000 7 no
GO:2001141 regulation of RNA biosynthetic process 22.5000 6 no
GO:0010941 regulation of cell death 22.5000 4 no
GO:0010648 negative regulation of cell communication 22.5000 5 no
GO:0023057 negative regulation of signaling 22.5000 4 no
GO:0048585 negative regulation of response to stimulus 22.5000 4 no
GO:0006996 organelle organization 22.5000 4 no
GO:0006816 calcium ion transport 20.0000 7 yes
GO:0010605 negative regulation of macromolecule metabolic process 20.0000 5 yes
GO:0035418 protein localization to synapse 17.5000 6 yes
GO:0050806 positive regulation of synaptic transmission 17.5000 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 17.5000 5 yes
GO:0098655 cation transmembrane transport 17.5000 4 yes
GO:0098660 inorganic ion transmembrane transport 17.5000 4 yes
GO:0098662 inorganic cation transmembrane transport 17.5000 5 yes
GO:1902414 protein localization to cell junction 17.5000 5 yes
GO:0009894 regulation of catabolic process 15.0000 4 yes
GO:0051248 negative regulation of protein metabolic process 15.0000 6 yes
GO:0062237 protein localization to postsynapse 15.0000 7 yes
GO:0070588 calcium ion transmembrane transport 15.0000 6 yes
GO:1903539 protein localization to postsynaptic membrane 15.0000 5 yes
GO:1990778 protein localization to cell periphery 15.0000 5 yes
GO:0007420 brain development 12.5000 4 yes
GO:0060078 regulation of postsynaptic membrane potential 12.5000 4 yes
GO:0060079 excitatory postsynaptic potential 12.5000 5 yes
GO:0097553 calcium ion transmembrane import into cytosol 12.5000 7 yes
GO:0098976 excitatory chemical synaptic transmission 12.5000 7 yes
GO:0042176 regulation of protein catabolic process 10.0000 5 yes
GO:0050905 neuromuscular process 10.0000 4 yes
GO:0060291 long-term synaptic potentiation 10.0000 4 yes
GO:0009895 negative regulation of catabolic process 7.5000 5 yes
GO:0042177 negative regulation of protein catabolic process 7.5000 6 yes
GO:0050885 neuromuscular process controlling balance 5.0000 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
INADL_HUMAN [view interactions] Low throughput no no
1433E_HUMAN [view entry] [view interactions] Low throughput yes yes
IL16_HUMAN [view interactions] Low throughput no no
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
EPS8_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
ERBIN_HUMAN [view entry] [view interactions] Low throughput yes yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
DPYS_HUMAN [view interactions] High throughput no no
CO2A1_HUMAN [view interactions] High throughput no no
TEN1L_HUMAN [view interactions] High throughput no no
CDK2_HUMAN [view interactions] High throughput no yes
TRI23_HUMAN [view interactions] High throughput no yes
RPAB1_HUMAN [view interactions] High throughput no yes
PER1_HUMAN [view interactions] High throughput no no
NPAS2_HUMAN [view interactions] High throughput no yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
IL37_HUMAN [view interactions] High throughput no no
SNW1_HUMAN [view interactions] High throughput no yes
ELL2_HUMAN [view interactions] High throughput no no
MS18B_HUMAN [view interactions] High throughput no no
DUS10_HUMAN [view entry] [view interactions] High throughput yes yes
TI17B_HUMAN [view interactions] High throughput no no
CDS2_HUMAN [view interactions] High throughput no yes
TELT_HUMAN [view interactions] High throughput no no
GO45_HUMAN [view interactions] High throughput no yes
FOSL1_HUMAN [view interactions] High throughput no yes
ZBT14_HUMAN [view interactions] High throughput no yes
UB2V1_HUMAN [view entry] [view interactions] High throughput yes no
UBE2A_HUMAN [view interactions] High throughput no no
STIM1_HUMAN [view interactions] High throughput no yes
RS4X_HUMAN [view entry] [view interactions] High throughput yes yes
RHEB_HUMAN [view entry] [view interactions] High throughput yes yes
PSME1_HUMAN [view interactions] High throughput no yes
PRS10_HUMAN [view interactions] High throughput no yes
AAKB2_HUMAN [view interactions] High throughput no yes
PPARA_HUMAN [view interactions] High throughput no yes
LHX5_HUMAN [view interactions] High throughput no no
DPYL5_HUMAN [view entry] [view interactions] High throughput yes yes
TEX12_HUMAN [view interactions] High throughput no no
LURA1_HUMAN [view interactions] High throughput no yes
WBP1L_HUMAN [view interactions] High throughput no yes
MYOZ2_HUMAN [view interactions] High throughput no no
CIA2B_HUMAN [view interactions] High throughput no yes
NO40_HUMAN [view interactions] High throughput no yes
RN138_HUMAN [view interactions] High throughput no no
DBNL_HUMAN [view entry] [view interactions] High throughput yes yes
RN208_HUMAN [view interactions] High throughput no no
CC036_HUMAN [view interactions] High throughput no no
PKHS1_HUMAN [view interactions] High throughput no no
E2F8_HUMAN [view interactions] High throughput no yes
DPPA2_HUMAN [view interactions] High throughput no no
F163A_HUMAN [view interactions] High throughput no no
HAUS1_HUMAN [view interactions] High throughput no yes
HAUS8_HUMAN [view interactions] High throughput no yes
CHMP7_HUMAN [view interactions] High throughput no yes
MSD3_HUMAN [view interactions] High throughput no no
THAP3_HUMAN [view interactions] High throughput no yes
BRM1L_HUMAN [view interactions] High throughput no no
LOXL4_HUMAN [view interactions] High throughput no no
EF1DL_HUMAN [view interactions] High throughput no no
LONF2_HUMAN [view interactions] High throughput no yes
CH048_HUMAN [view interactions] High throughput no no
TT23L_HUMAN [view interactions] High throughput no no
LHX8_HUMAN [view interactions] High throughput no no
PKHG7_HUMAN [view interactions] High throughput no no
CF218_HUMAN [view interactions] High throughput no no
SPAS1_HUMAN [view interactions] High throughput no no
TMM61_HUMAN [view interactions] High throughput no no
KAT1_HUMAN [view interactions] High throughput no yes
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRK_HUMAN [view interactions] High throughput no no
OAF_HUMAN [view interactions] High throughput no no
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
CHLE_HUMAN [view interactions] High throughput no no
AT12A_HUMAN [view entry] [view interactions] High throughput yes no
SEN2_HUMAN [view interactions] High throughput no yes
DD19B_HUMAN [view interactions] High throughput no yes
MANBA_HUMAN [view interactions] High throughput no yes
NMDE2_HUMAN [view entry] [view interactions] Computational yes no
P2RX3_HUMAN [view interactions] Computational no no
P2RX7_HUMAN [view interactions] Computational no yes
NOS1_HUMAN [view entry] [view interactions] Computational yes yes
ERBB4_HUMAN [view entry] [view interactions] Computational yes yes
P2RX5_HUMAN [view interactions] Computational no no
P2RX6_HUMAN [view entry] [view interactions] Computational yes no
NMD3B_HUMAN [view entry] [view interactions] Computational yes no
P2RX4_HUMAN [view entry] [view interactions] Computational yes yes
PDYN_HUMAN [view interactions] Computational no yes
NMD3A_HUMAN [view entry] [view interactions] Computational yes no
P2RX1_HUMAN [view entry] [view interactions] Computational yes no
NRG1_HUMAN [view entry] [view interactions] Computational yes no
SRC_HUMAN [view entry] [view interactions] Computational yes no
GRIA3_HUMAN [view entry] [view interactions] Computational yes yes
CCG2_HUMAN [view entry] [view interactions] Computational yes no
NMDE4_HUMAN [view entry] [view interactions] Computational yes yes
CCG3_HUMAN [view entry] [view interactions] Computational yes no
DLG2_HUMAN [view entry] [view interactions] Computational yes yes
GRIA4_HUMAN [view entry] [view interactions] Computational yes no
GRIA2_HUMAN [view entry] [view interactions] Computational yes yes