AT12A_HUMAN
Evidence for PS localization
Functions
The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellular compartment (PubMed, PubMed, PubMed, PubMed). Involved in the maintenance of electrolyte homeostasis through K(+) ion absorption in kidney and colon . In the airway epithelium, may play a primary role in mucus acidification regulating its viscosity and clearance (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AT12A_HUMAN |
|---|---|---|---|---|
| GO:0008324 | monoatomic cation transmembrane transporter activity | 30.4348 | 4 | yes |
| GO:0043169 | cation binding | 30.4348 | 4 | yes |
| GO:0046872 | metal ion binding | 30.4348 | 5 | yes |
| GO:0000166 | nucleotide binding | 26.0870 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 26.0870 | 5 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 26.0870 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 26.0870 | 4 | yes |
| GO:0043168 | anion binding | 26.0870 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.7391 | 4 | yes |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 17.3913 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 17.3913 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 17.3913 | 5 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 17.3913 | 5 | yes |
| GO:0005524 | ATP binding | 13.0435 | 5 | yes |
| GO:0015078 | proton transmembrane transporter activity | 13.0435 | 5 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 13.0435 | 4 | yes |
| GO:0005391 | P-type sodium:potassium-exchanging transporter activity | 8.6957 | 5 | yes |
| GO:0008554 | P-type sodium transporter activity | 8.6957 | 4 | yes |
| GO:0008556 | P-type potassium transmembrane transporter activity | 8.6957 | 4 | yes |
| GO:0015079 | potassium ion transmembrane transporter activity | 8.6957 | 6 | yes |
| GO:0015081 | sodium ion transmembrane transporter activity | 8.6957 | 6 | yes |
| GO:0015662 | P-type ion transporter activity | 8.6957 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 8.6957 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 8.6957 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 8.6957 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AT12A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 43.4783 | 4 | no |
| GO:0051049 | regulation of transport | 43.4783 | 4 | no |
| GO:0010646 | regulation of cell communication | 34.7826 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 34.7826 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.4348 | 4 | no |
| GO:0006811 | monoatomic ion transport | 26.0870 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 26.0870 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 26.0870 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.0870 | 4 | no |
| GO:0044057 | regulation of system process | 26.0870 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.7391 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 21.7391 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 21.7391 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 21.7391 | 4 | no |
| GO:0010468 | regulation of gene expression | 21.7391 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.7391 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.7391 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 21.7391 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 21.7391 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.7391 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 21.7391 | 4 | no |
| GO:0008104 | protein localization | 21.7391 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 21.7391 | 5 | no |
| GO:0033043 | regulation of organelle organization | 21.7391 | 5 | no |
| GO:0043269 | regulation of monoatomic ion transport | 21.7391 | 5 | no |
| GO:0006812 | monoatomic cation transport | 17.3913 | 5 | yes |
| GO:0030001 | metal ion transport | 17.3913 | 6 | yes |
| GO:0098655 | monoatomic cation transmembrane transport | 17.3913 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 17.3913 | 4 | yes |
| GO:0006873 | intracellular monoatomic ion homeostasis | 13.0435 | 4 | yes |
| GO:0030003 | intracellular monoatomic cation homeostasis | 13.0435 | 5 | yes |
| GO:0055080 | monoatomic cation homeostasis | 13.0435 | 4 | yes |
| GO:0098657 | import into cell | 13.0435 | 4 | yes |
| GO:0098659 | inorganic cation import across plasma membrane | 13.0435 | 5 | yes |
| GO:0099587 | inorganic ion import across plasma membrane | 13.0435 | 4 | yes |
| GO:0006813 | potassium ion transport | 8.6957 | 7 | yes |
| GO:0006814 | sodium ion transport | 8.6957 | 7 | yes |
| GO:0006883 | intracellular sodium ion homeostasis | 8.6957 | 5 | yes |
| GO:0030007 | intracellular potassium ion homeostasis | 8.6957 | 5 | yes |
| GO:0035725 | sodium ion transmembrane transport | 8.6957 | 5 | yes |
| GO:0036376 | sodium ion export across plasma membrane | 8.6957 | 4 | yes |
| GO:0055075 | potassium ion homeostasis | 8.6957 | 4 | yes |
| GO:0055078 | sodium ion homeostasis | 8.6957 | 4 | yes |
| GO:0071805 | potassium ion transmembrane transport | 8.6957 | 5 | yes |
| GO:1902600 | proton transmembrane transport | 8.6957 | 5 | yes |
| GO:1990573 | potassium ion import across plasma membrane | 8.6957 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CD63_HUMAN | [view interactions] | Low throughput | no | no |
| AT1B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PLCB_HUMAN | [view interactions] | High throughput | no | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| UPK1A_HUMAN | [view interactions] | High throughput | no | no |
| PILRB_HUMAN | [view interactions] | High throughput | no | yes |
| PDE2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| PLD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI33_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEP_HUMAN | [view interactions] | High throughput | no | no |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| GNAI3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPY_HUMAN | [view interactions] | High throughput | no | yes |
| RAB38_HUMAN | [view interactions] | High throughput | no | no |
| TMIG3_HUMAN | [view interactions] | High throughput | no | no |
| AA3R_HUMAN | [view interactions] | High throughput | no | no |
| CLM6_HUMAN | [view interactions] | High throughput | no | no |
| FCG3B_HUMAN | [view interactions] | High throughput | no | no |
| HS2ST_HUMAN | [view interactions] | High throughput | no | yes |
| SPIT2_HUMAN | [view interactions] | High throughput | no | yes |
| TNR9_HUMAN | [view interactions] | High throughput | no | no |
| C1QB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTDS2_HUMAN | [view interactions] | High throughput | no | yes |
| SRPRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
| SUSD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H17B6_HUMAN | [view interactions] | High throughput | no | yes |
| TRABD_HUMAN | [view interactions] | High throughput | no | yes |
| P2Y14_HUMAN | [view interactions] | High throughput | no | yes |
| PTH1R_HUMAN | [view interactions] | High throughput | no | no |
| AGTR1_HUMAN | [view interactions] | High throughput | no | no |
| PF2R_HUMAN | [view interactions] | High throughput | no | no |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| SLAF1_HUMAN | [view interactions] | High throughput | no | no |
| SYRM_HUMAN | [view interactions] | High throughput | no | yes |
| DLK1_HUMAN | [view interactions] | High throughput | no | no |
| NAR3_HUMAN | [view interactions] | High throughput | no | no |
| WBP1_HUMAN | [view interactions] | High throughput | no | yes |
| RETR3_HUMAN | [view interactions] | High throughput | no | yes |
| DHC24_HUMAN | [view interactions] | High throughput | no | yes |
| TARG1_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM23_HUMAN | [view interactions] | High throughput | no | yes |
| GTR5_HUMAN | [view interactions] | High throughput | no | yes |
| S1PR1_HUMAN | [view interactions] | High throughput | no | no |
| NK1R_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| C5AR2_HUMAN | [view interactions] | High throughput | no | yes |
| ODFP4_HUMAN | [view interactions] | High throughput | no | no |
| PRG3_HUMAN | [view interactions] | High throughput | no | no |
| ITM2A_HUMAN | [view interactions] | High throughput | no | no |
| FPR2_HUMAN | [view interactions] | High throughput | no | yes |
| AGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S15A1_HUMAN | [view interactions] | High throughput | no | no |
| TMED2_HUMAN | [view interactions] | High throughput | no | yes |
| CLC2D_HUMAN | [view interactions] | High throughput | no | yes |
| IIGP5_HUMAN | [view interactions] | High throughput | no | no |
| SPX3_HUMAN | [view interactions] | High throughput | no | no |
| ENSA_HUMAN | [view interactions] | High throughput | no | yes |
| FEZ1_HUMAN | [view interactions] | High throughput | no | no |
| GLMP_HUMAN | [view interactions] | High throughput | no | no |
| GRPR_HUMAN | [view interactions] | High throughput | no | no |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| TM223_HUMAN | [view interactions] | High throughput | no | yes |
| MRAP2_HUMAN | [view interactions] | High throughput | no | no |
| RAB2B_HUMAN | [view interactions] | High throughput | no | no |
| CTDS1_HUMAN | [view interactions] | High throughput | no | no |
| I13R2_HUMAN | [view interactions] | High throughput | no | no |
| PACC1_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| FAXC_HUMAN | [view interactions] | High throughput | no | no |
| FXYD6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTLR_HUMAN | [view interactions] | High throughput | no | no |
| HCST_HUMAN | [view interactions] | High throughput | no | no |
| NAT8B_HUMAN | [view interactions] | High throughput | no | no |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NK3R_HUMAN | [view interactions] | High throughput | no | no |
| NIPA3_HUMAN | [view interactions] | High throughput | no | no |
| BRID5_HUMAN | [view interactions] | High throughput | no | no |
| CLRN2_HUMAN | [view interactions] | High throughput | no | no |
| CCR6_HUMAN | [view interactions] | High throughput | no | no |
| S25A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B3GN7_HUMAN | [view interactions] | High throughput | no | no |
| SPCS1_HUMAN | [view interactions] | High throughput | no | yes |
| NUD16_HUMAN | [view interactions] | High throughput | no | yes |
| NPHN_HUMAN | [view interactions] | High throughput | no | no |
| GLR_HUMAN | [view interactions] | High throughput | no | no |
| PCAT2_HUMAN | [view interactions] | High throughput | no | yes |
| KLH11_HUMAN | [view interactions] | High throughput | no | yes |
| X3CL1_HUMAN | [view interactions] | High throughput | no | yes |
| LCFC1_HUMAN | [view interactions] | High throughput | no | no |
| GPR88_HUMAN | [view interactions] | High throughput | no | no |
| NKAI1_HUMAN | [view interactions] | High throughput | no | no |
| KLRB1_HUMAN | [view interactions] | High throughput | no | yes |
| ACHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAGE3_HUMAN | [view interactions] | High throughput | no | yes |
| KI2L4_HUMAN | [view interactions] | High throughput | no | no |
| EFNA5_HUMAN | [view interactions] | High throughput | no | yes |
| KCMB3_HUMAN | [view interactions] | High throughput | no | no |
| OPRX_HUMAN | [view interactions] | High throughput | no | no |
| C5AR1_HUMAN | [view interactions] | High throughput | no | yes |
| S22AF_HUMAN | [view interactions] | High throughput | no | yes |
| MR1L1_HUMAN | [view interactions] | High throughput | no | no |
| UPK2_HUMAN | [view interactions] | High throughput | no | no |
| INLR1_HUMAN | [view interactions] | High throughput | no | no |
| NKG2C_HUMAN | [view interactions] | High throughput | no | no |
| CD3D_HUMAN | [view interactions] | High throughput | no | no |
| KC1AL_HUMAN | [view interactions] | High throughput | no | no |
| CEP41_HUMAN | [view interactions] | High throughput | no | yes |
| G3ST2_HUMAN | [view interactions] | High throughput | no | no |
| KTAP2_HUMAN | [view interactions] | High throughput | no | no |
| CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCP3_HUMAN | [view interactions] | High throughput | no | yes |
| OX2R_HUMAN | [view interactions] | High throughput | no | no |
| IL2RA_HUMAN | [view interactions] | High throughput | no | no |
| TREM1_HUMAN | [view interactions] | High throughput | no | yes |
| TSN10_HUMAN | [view interactions] | High throughput | no | no |
| CD226_HUMAN | [view interactions] | High throughput | no | yes |
| GPR12_HUMAN | [view interactions] | High throughput | no | no |
| CXL16_HUMAN | [view interactions] | High throughput | no | no |
| TR10C_HUMAN | [view interactions] | High throughput | no | no |
| SO4C1_HUMAN | [view interactions] | High throughput | no | no |
| PLD6_HUMAN | [view interactions] | High throughput | no | yes |
| WFD11_HUMAN | [view interactions] | High throughput | no | no |
| PCDG7_HUMAN | [view interactions] | High throughput | no | no |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| FPR1_HUMAN | [view interactions] | High throughput | no | no |
| NMDE3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTR1_HUMAN | [view interactions] | High throughput | no | no |
| IDD_HUMAN | [view interactions] | High throughput | no | no |
| NAA30_HUMAN | [view interactions] | High throughput | no | no |
| NKG2F_HUMAN | [view interactions] | High throughput | no | no |
| RN149_HUMAN | [view interactions] | High throughput | no | no |
| UD14_HUMAN | [view interactions] | High throughput | no | no |
| HS3S4_HUMAN | [view interactions] | High throughput | no | no |
| RTP2_HUMAN | [view interactions] | High throughput | no | no |
| CHODL_HUMAN | [view interactions] | High throughput | no | no |
| GPV_HUMAN | [view interactions] | High throughput | no | no |
| LYZL6_HUMAN | [view interactions] | High throughput | no | no |
| S26A4_HUMAN | [view interactions] | High throughput | no | no |
| JTB_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIPR2_HUMAN | [view interactions] | High throughput | no | no |
| PCP4_HUMAN | [view interactions] | High throughput | no | yes |
| HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
| AUP1_HUMAN | [view interactions] | High throughput | no | yes |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| 5NT1A_HUMAN | [view interactions] | High throughput | no | yes |
| ACKR2_HUMAN | [view interactions] | High throughput | no | no |
| VIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| TPST2_HUMAN | [view interactions] | High throughput | no | yes |
| PLCA_HUMAN | [view interactions] | High throughput | no | yes |
| PAR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| G6PT1_HUMAN | [view interactions] | High throughput | no | no |
| ACKR4_HUMAN | [view interactions] | High throughput | no | no |
| TYOBP_HUMAN | [view interactions] | High throughput | no | no |
| P2RY2_HUMAN | [view interactions] | High throughput | no | no |
| PRND_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| DKKL1_HUMAN | [view interactions] | High throughput | no | no |
| SIA4A_HUMAN | [view interactions] | High throughput | no | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| SPP2B_HUMAN | [view interactions] | High throughput | no | yes |
| PTAFR_HUMAN | [view interactions] | High throughput | no | yes |
| P2RY8_HUMAN | [view interactions] | High throughput | no | no |
| ADT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN115_HUMAN | [view interactions] | High throughput | no | yes |
| APJ_HUMAN | [view interactions] | High throughput | no | yes |
| LRN4L_HUMAN | [view interactions] | High throughput | no | yes |
| S1PR4_HUMAN | [view interactions] | High throughput | no | no |
| GPR84_HUMAN | [view interactions] | High throughput | no | no |
| DRB1_HUMAN | [view interactions] | High throughput | no | no |
| SARAF_HUMAN | [view interactions] | High throughput | no | no |
| GRAH_HUMAN | [view interactions] | High throughput | no | no |
| EMRE_HUMAN | [view interactions] | High throughput | no | yes |