AT12A_HUMAN
The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellular compartment (PubMed, PubMed, PubMed, PubMed). Involved in the maintenance of electrolyte homeostasis through K(+) ion absorption in kidney and colon . In the airway epithelium, may play a primary role in mucus acidification regulating its viscosity and clearance (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in AT12A_HUMAN |
---|---|---|---|---|
GO:0008324 | cation transmembrane transporter activity | 35.0000 | 4 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 35.0000 | 4 | yes |
GO:0017076 | purine nucleotide binding | 30.0000 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 30.0000 | 4 | yes |
GO:0046872 | metal ion binding | 30.0000 | 4 | yes |
GO:0022853 | active ion transmembrane transporter activity | 25.0000 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | yes |
GO:0046873 | metal ion transmembrane transporter activity | 25.0000 | 5 | yes |
GO:0015399 | primary active transmembrane transporter activity | 20.0000 | 4 | yes |
GO:0030554 | adenyl nucleotide binding | 20.0000 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 20.0000 | 5 | yes |
GO:0005391 | P-type sodium:potassium-exchanging transporter activity | 15.0000 | 5 | yes |
GO:0005524 | ATP binding | 15.0000 | 5 | yes |
GO:0008554 | P-type sodium transporter activity | 15.0000 | 4 | yes |
GO:0008556 | P-type potassium transmembrane transporter activity | 15.0000 | 4 | yes |
GO:0015078 | proton transmembrane transporter activity | 15.0000 | 5 | yes |
GO:0015079 | potassium ion transmembrane transporter activity | 15.0000 | 6 | yes |
GO:0015081 | sodium ion transmembrane transporter activity | 15.0000 | 6 | yes |
GO:0015662 | P-type ion transporter activity | 15.0000 | 4 | yes |
GO:0008553 | P-type proton-exporting transporter activity | 10.0000 | 4 | yes |
GO:0008900 | P-type potassium:proton transporter activity | 10.0000 | 5 | yes |
GO:0009678 | pyrophosphate hydrolysis-driven proton transmembrane transporter activity | 10.0000 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in AT12A_HUMAN |
---|---|---|---|---|
GO:0006811 | ion transport | 50.0000 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 40.0000 | 4 | no |
GO:0051049 | regulation of transport | 40.0000 | 4 | no |
GO:0098660 | inorganic ion transmembrane transport | 35.0000 | 4 | yes |
GO:0006812 | cation transport | 30.0000 | 5 | yes |
GO:0030001 | metal ion transport | 30.0000 | 6 | yes |
GO:0098655 | cation transmembrane transport | 30.0000 | 4 | yes |
GO:0098662 | inorganic cation transmembrane transport | 30.0000 | 5 | yes |
GO:0010646 | regulation of cell communication | 30.0000 | 4 | no |
GO:0006873 | cellular ion homeostasis | 25.0000 | 4 | yes |
GO:0006875 | cellular metal ion homeostasis | 25.0000 | 6 | yes |
GO:0030003 | cellular cation homeostasis | 25.0000 | 5 | yes |
GO:0048878 | chemical homeostasis | 25.0000 | 4 | yes |
GO:0050801 | ion homeostasis | 25.0000 | 5 | yes |
GO:0055065 | metal ion homeostasis | 25.0000 | 7 | yes |
GO:0055080 | cation homeostasis | 25.0000 | 6 | yes |
GO:0098771 | inorganic ion homeostasis | 25.0000 | 6 | yes |
GO:0008104 | protein localization | 25.0000 | 4 | no |
GO:0071702 | organic substance transport | 25.0000 | 4 | no |
GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 25.0000 | 4 | no |
GO:0051050 | positive regulation of transport | 25.0000 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 25.0000 | 4 | no |
GO:0034762 | regulation of transmembrane transport | 25.0000 | 4 | no |
GO:0034765 | regulation of ion transmembrane transport | 25.0000 | 5 | no |
GO:0043269 | regulation of ion transport | 25.0000 | 5 | no |
GO:1904062 | regulation of cation transmembrane transport | 25.0000 | 6 | no |
GO:0006813 | potassium ion transport | 20.0000 | 7 | yes |
GO:0006814 | sodium ion transport | 20.0000 | 7 | yes |
GO:0006883 | cellular sodium ion homeostasis | 20.0000 | 7 | yes |
GO:0030004 | cellular monovalent inorganic cation homeostasis | 20.0000 | 6 | yes |
GO:0030007 | cellular potassium ion homeostasis | 20.0000 | 7 | yes |
GO:0035725 | sodium ion transmembrane transport | 20.0000 | 6 | yes |
GO:0036376 | sodium ion export across plasma membrane | 20.0000 | 4 | yes |
GO:0055067 | monovalent inorganic cation homeostasis | 20.0000 | 7 | yes |
GO:0055075 | potassium ion homeostasis | 20.0000 | 8 | yes |
GO:0055078 | sodium ion homeostasis | 20.0000 | 8 | yes |
GO:0071805 | potassium ion transmembrane transport | 20.0000 | 6 | yes |
GO:0098657 | import into cell | 20.0000 | 4 | yes |
GO:0098659 | inorganic cation import across plasma membrane | 20.0000 | 5 | yes |
GO:0099587 | inorganic ion import across plasma membrane | 20.0000 | 4 | yes |
GO:1990573 | potassium ion import across plasma membrane | 20.0000 | 6 | yes |
GO:1902600 | proton transmembrane transport | 10.0000 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
CD63_HUMAN | [view interactions] | Low throughput | no | no |
TLN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KS6A1_HUMAN | [view interactions] | High throughput | no | yes |
NEP_HUMAN | [view interactions] | High throughput | no | no |
CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAV3_HUMAN | [view interactions] | High throughput | no | no |
GNAI3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NPY_HUMAN | [view interactions] | High throughput | no | yes |
RAB38_HUMAN | [view interactions] | High throughput | no | no |
TMIG3_HUMAN | [view interactions] | High throughput | no | no |
AA3R_HUMAN | [view interactions] | High throughput | no | no |
CLM6_HUMAN | [view interactions] | High throughput | no | no |
FCG3B_HUMAN | [view interactions] | High throughput | no | no |
HS2ST_HUMAN | [view interactions] | High throughput | no | yes |
SPIT2_HUMAN | [view interactions] | High throughput | no | yes |
TNR9_HUMAN | [view interactions] | High throughput | no | no |
C1QB_HUMAN | [view interactions] | High throughput | no | no |
CTDS2_HUMAN | [view interactions] | High throughput | no | yes |
SRPRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
SUSD4_HUMAN | [view interactions] | High throughput | no | yes |
H17B6_HUMAN | [view interactions] | High throughput | no | yes |
TRABD_HUMAN | [view interactions] | High throughput | no | yes |
P2Y14_HUMAN | [view interactions] | High throughput | no | yes |
PTH1R_HUMAN | [view interactions] | High throughput | no | no |
AGTR1_HUMAN | [view interactions] | High throughput | no | no |
PF2R_HUMAN | [view interactions] | High throughput | no | no |
HLAB_HUMAN | [view interactions] | High throughput | no | yes |
SLAF1_HUMAN | [view interactions] | High throughput | no | no |
SYRM_HUMAN | [view interactions] | High throughput | no | yes |
DLK1_HUMAN | [view interactions] | High throughput | no | no |
NAR3_HUMAN | [view interactions] | High throughput | no | no |
WBP1_HUMAN | [view interactions] | High throughput | no | yes |
RETR3_HUMAN | [view interactions] | High throughput | no | yes |
DHC24_HUMAN | [view interactions] | High throughput | no | yes |
TARG1_HUMAN | [view interactions] | High throughput | no | no |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
LNX1_HUMAN | [view interactions] | High throughput | no | yes |
TIM23_HUMAN | [view interactions] | High throughput | no | yes |
GTR5_HUMAN | [view interactions] | High throughput | no | yes |
S1PR1_HUMAN | [view interactions] | High throughput | no | no |
NK1R_HUMAN | [view interactions] | High throughput | no | no |
C5AR2_HUMAN | [view interactions] | High throughput | no | yes |
ODFP4_HUMAN | [view interactions] | High throughput | no | no |
PRG3_HUMAN | [view interactions] | High throughput | no | no |
ITM2A_HUMAN | [view interactions] | High throughput | no | no |
FPR2_HUMAN | [view interactions] | High throughput | no | yes |
AGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
S15A1_HUMAN | [view interactions] | High throughput | no | no |
TMED2_HUMAN | [view interactions] | High throughput | no | yes |
CLC2D_HUMAN | [view interactions] | High throughput | no | yes |
IIGP5_HUMAN | [view interactions] | High throughput | no | no |
SPX3_HUMAN | [view interactions] | High throughput | no | no |
ENSA_HUMAN | [view interactions] | High throughput | no | yes |
FEZ1_HUMAN | [view interactions] | High throughput | no | no |
GLMP_HUMAN | [view interactions] | High throughput | no | no |
GRPR_HUMAN | [view interactions] | High throughput | no | no |
F174A_HUMAN | [view interactions] | High throughput | no | yes |
TM223_HUMAN | [view interactions] | High throughput | no | yes |
MRAP2_HUMAN | [view interactions] | High throughput | no | no |
RAB2B_HUMAN | [view interactions] | High throughput | no | no |
CTDS1_HUMAN | [view interactions] | High throughput | no | no |
I13R2_HUMAN | [view interactions] | High throughput | no | no |
PACC1_HUMAN | [view interactions] | High throughput | no | no |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
FAXC_HUMAN | [view interactions] | High throughput | no | no |
FXYD6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTLR_HUMAN | [view interactions] | High throughput | no | no |
HCST_HUMAN | [view interactions] | High throughput | no | no |
NAT8B_HUMAN | [view interactions] | High throughput | no | no |
GPR17_HUMAN | [view interactions] | High throughput | no | no |
FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NK3R_HUMAN | [view interactions] | High throughput | no | no |
NIPA3_HUMAN | [view interactions] | High throughput | no | no |
BRID5_HUMAN | [view interactions] | High throughput | no | no |
CLRN2_HUMAN | [view interactions] | High throughput | no | no |
CCR6_HUMAN | [view interactions] | High throughput | no | no |
MPCP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
B3GN7_HUMAN | [view interactions] | High throughput | no | no |
SPCS1_HUMAN | [view interactions] | High throughput | no | yes |
NUD16_HUMAN | [view interactions] | High throughput | no | yes |
NPHN_HUMAN | [view interactions] | High throughput | no | no |
GLR_HUMAN | [view interactions] | High throughput | no | no |
PCAT2_HUMAN | [view interactions] | High throughput | no | yes |
KLH11_HUMAN | [view interactions] | High throughput | no | yes |
X3CL1_HUMAN | [view interactions] | High throughput | no | yes |
LCFC1_HUMAN | [view interactions] | High throughput | no | no |
GPR88_HUMAN | [view interactions] | High throughput | no | no |
NKAI1_HUMAN | [view interactions] | High throughput | no | no |
KLRB1_HUMAN | [view interactions] | High throughput | no | yes |
ACHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LAGE3_HUMAN | [view interactions] | High throughput | no | yes |
KI2L4_HUMAN | [view interactions] | High throughput | no | no |
EFNA5_HUMAN | [view interactions] | High throughput | no | yes |
KCMB3_HUMAN | [view interactions] | High throughput | no | no |
OPRX_HUMAN | [view interactions] | High throughput | no | no |
C5AR1_HUMAN | [view interactions] | High throughput | no | yes |
S22AF_HUMAN | [view interactions] | High throughput | no | yes |
MR1L1_HUMAN | [view interactions] | High throughput | no | no |
UPK2_HUMAN | [view interactions] | High throughput | no | no |
INLR1_HUMAN | [view interactions] | High throughput | no | no |
NKG2C_HUMAN | [view interactions] | High throughput | no | no |
CD3D_HUMAN | [view interactions] | High throughput | no | no |
KC1AL_HUMAN | [view interactions] | High throughput | no | no |
CEP41_HUMAN | [view interactions] | High throughput | no | yes |
AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
G3ST2_HUMAN | [view interactions] | High throughput | no | no |
KTAP2_HUMAN | [view interactions] | High throughput | no | no |
CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCP3_HUMAN | [view interactions] | High throughput | no | yes |
OX2R_HUMAN | [view interactions] | High throughput | no | no |
IL2RA_HUMAN | [view interactions] | High throughput | no | no |
TREM1_HUMAN | [view interactions] | High throughput | no | yes |
TSN10_HUMAN | [view interactions] | High throughput | no | no |
CD226_HUMAN | [view interactions] | High throughput | no | yes |
GPR12_HUMAN | [view interactions] | High throughput | no | no |
CXL16_HUMAN | [view interactions] | High throughput | no | no |
TR10C_HUMAN | [view interactions] | High throughput | no | no |
SO4C1_HUMAN | [view interactions] | High throughput | no | no |
PLD6_HUMAN | [view interactions] | High throughput | no | yes |
WFD11_HUMAN | [view interactions] | High throughput | no | no |
PCDG7_HUMAN | [view interactions] | High throughput | no | no |
SEC62_HUMAN | [view interactions] | High throughput | no | yes |
FPR1_HUMAN | [view interactions] | High throughput | no | no |
NMDE3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NTR1_HUMAN | [view interactions] | High throughput | no | no |
IDD_HUMAN | [view interactions] | High throughput | no | no |
NAA30_HUMAN | [view interactions] | High throughput | no | no |
NKG2F_HUMAN | [view interactions] | High throughput | no | no |
RN149_HUMAN | [view interactions] | High throughput | no | no |
UD14_HUMAN | [view interactions] | High throughput | no | no |
HS3S4_HUMAN | [view interactions] | High throughput | no | no |
RTP2_HUMAN | [view interactions] | High throughput | no | no |
CHODL_HUMAN | [view interactions] | High throughput | no | no |
GPV_HUMAN | [view interactions] | High throughput | no | no |
LYZL6_HUMAN | [view interactions] | High throughput | no | no |
S26A4_HUMAN | [view interactions] | High throughput | no | no |
JTB_HUMAN | [view interactions] | High throughput | no | yes |
NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VIPR2_HUMAN | [view interactions] | High throughput | no | no |
PCP4_HUMAN | [view interactions] | High throughput | no | yes |
HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
AUP1_HUMAN | [view interactions] | High throughput | no | yes |
FFAR1_HUMAN | [view interactions] | High throughput | no | no |
5NT1A_HUMAN | [view interactions] | High throughput | no | yes |
ACKR2_HUMAN | [view interactions] | High throughput | no | no |
VIPR1_HUMAN | [view interactions] | High throughput | no | yes |
TPST2_HUMAN | [view interactions] | High throughput | no | yes |
PLCA_HUMAN | [view interactions] | High throughput | no | yes |
PAR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PINK1_HUMAN | [view interactions] | High throughput | no | yes |
G6PT1_HUMAN | [view interactions] | High throughput | no | no |
ACKR4_HUMAN | [view interactions] | High throughput | no | no |
TYOBP_HUMAN | [view interactions] | High throughput | no | no |
P2RY2_HUMAN | [view interactions] | High throughput | no | no |
PRND_HUMAN | [view interactions] | High throughput | no | no |
GP182_HUMAN | [view interactions] | High throughput | no | no |
VSIG4_HUMAN | [view interactions] | High throughput | no | no |
DKKL1_HUMAN | [view interactions] | High throughput | no | no |
SIA4A_HUMAN | [view interactions] | High throughput | no | yes |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
SPP2B_HUMAN | [view interactions] | High throughput | no | yes |
PTAFR_HUMAN | [view interactions] | High throughput | no | yes |
P2RY8_HUMAN | [view interactions] | High throughput | no | no |
ADT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RN115_HUMAN | [view interactions] | High throughput | no | yes |
APJ_HUMAN | [view interactions] | High throughput | no | yes |
LRN4L_HUMAN | [view interactions] | High throughput | no | yes |
S1PR4_HUMAN | [view interactions] | High throughput | no | no |
GPR84_HUMAN | [view interactions] | High throughput | no | no |
DRB1_HUMAN | [view interactions] | High throughput | no | no |
SARAF_HUMAN | [view interactions] | High throughput | no | no |
GRAH_HUMAN | [view interactions] | High throughput | no | no |
EMRE_HUMAN | [view interactions] | High throughput | no | yes |
PLCB_HUMAN | [view interactions] | High throughput | no | yes |
CCR1_HUMAN | [view interactions] | High throughput | no | no |
UPK1A_HUMAN | [view interactions] | High throughput | no | no |
PILRB_HUMAN | [view interactions] | High throughput | no | yes |
PDE2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VPP3_HUMAN | [view interactions] | Computational | no | no |
LHPP_HUMAN | [view interactions] | Computational | no | yes |
CP2CJ_HUMAN | [view interactions] | Computational | no | no |
IPYR_HUMAN | [view interactions] | Computational | no | yes |
ATP4A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
VATB1_HUMAN | [view interactions] | Computational | no | no |
ATNG_HUMAN | [view interactions] | Computational | no | no |
IPYR2_HUMAN | [view interactions] | Computational | no | yes |
ATP4B_HUMAN | [view interactions] | Computational | no | no |
HRH2_HUMAN | [view interactions] | Computational | no | no |
AT1B2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SL9A1_HUMAN | [view interactions] | Computational | no | no |
GAST_HUMAN | [view interactions] | Computational | no | no |