AGK_HUMAN
Evidence for PS localization
Functions
Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively (PubMed). Does not phosphorylate sphingosine (PubMed). Phosphorylates ceramide . Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol . Independently of its lipid kinase activity, acts as a component of the TIM22 complex (PubMed, PubMed). The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force (PubMed, PubMed). In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23 (PubMed). Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AGK_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 35.1351 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 35.1351 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 35.1351 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 35.1351 | 4 | yes |
| GO:0043168 | anion binding | 35.1351 | 4 | yes |
| GO:0043169 | cation binding | 29.7297 | 4 | no |
| GO:0046872 | metal ion binding | 29.7297 | 5 | no |
| GO:0005524 | ATP binding | 27.0270 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 27.0270 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 27.0270 | 5 | yes |
| GO:0016301 | kinase activity | 18.9189 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 18.9189 | 4 | yes |
| GO:0001727 | lipid kinase activity | 5.4054 | 5 | yes |
| GO:0001729 | ceramide kinase activity | 5.4054 | 6 | yes |
| GO:0004143 | ATP-dependent diacylglycerol kinase activity | 5.4054 | 5 | yes |
| GO:0047620 | acylglycerol kinase activity | 5.4054 | 5 | yes |
| GO:0102773 | dihydroceramide kinase activity | 5.4054 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AGK_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 54.0541 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 48.6486 | 4 | no |
| GO:0071702 | organic substance transport | 45.9459 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 43.2432 | 4 | no |
| GO:0008104 | protein localization | 40.5405 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 40.5405 | 4 | yes |
| GO:0010646 | regulation of cell communication | 40.5405 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.5405 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.5405 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 32.4324 | 4 | no |
| GO:0022607 | cellular component assembly | 32.4324 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 32.4324 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 32.4324 | 4 | no |
| GO:0015031 | protein transport | 29.7297 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 29.7297 | 5 | no |
| GO:0051049 | regulation of transport | 29.7297 | 4 | no |
| GO:0009966 | regulation of signal transduction | 29.7297 | 4 | no |
| GO:0009894 | regulation of catabolic process | 27.0270 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 27.0270 | 5 | no |
| GO:0023056 | positive regulation of signaling | 27.0270 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.0270 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 27.0270 | 4 | no |
| GO:0010468 | regulation of gene expression | 27.0270 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 27.0270 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 27.0270 | 5 | no |
| GO:0043933 | protein-containing complex organization | 27.0270 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 27.0270 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.0270 | 5 | no |
| GO:0033043 | regulation of organelle organization | 24.3243 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.3243 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 24.3243 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.6216 | 4 | yes |
| GO:0006886 | intracellular protein transport | 21.6216 | 4 | yes |
| GO:0051050 | positive regulation of transport | 21.6216 | 4 | no |
| GO:0007010 | cytoskeleton organization | 21.6216 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 21.6216 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 21.6216 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.6216 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 21.6216 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.6216 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.6216 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 21.6216 | 4 | no |
| GO:0071310 | cellular response to organic substance | 21.6216 | 4 | no |
| GO:0016310 | phosphorylation | 18.9189 | 5 | yes |
| GO:0033365 | protein localization to organelle | 18.9189 | 5 | yes |
| GO:0061024 | membrane organization | 16.2162 | 4 | yes |
| GO:0006839 | mitochondrial transport | 13.5135 | 4 | yes |
| GO:0007005 | mitochondrion organization | 13.5135 | 5 | yes |
| GO:0007006 | mitochondrial membrane organization | 8.1081 | 5 | yes |
| GO:0070585 | protein localization to mitochondrion | 8.1081 | 6 | yes |
| GO:0072657 | protein localization to membrane | 8.1081 | 4 | yes |
| GO:0006643 | membrane lipid metabolic process | 5.4054 | 4 | yes |
| GO:0006665 | sphingolipid metabolic process | 5.4054 | 4 | yes |
| GO:0007007 | inner mitochondrial membrane organization | 5.4054 | 6 | yes |
| GO:0008610 | lipid biosynthetic process | 5.4054 | 4 | yes |
| GO:0030148 | sphingolipid biosynthetic process | 5.4054 | 5 | yes |
| GO:0030258 | lipid modification | 5.4054 | 4 | yes |
| GO:0045039 | protein insertion into mitochondrial inner membrane | 5.4054 | 5 | yes |
| GO:0046467 | membrane lipid biosynthetic process | 5.4054 | 4 | yes |
| GO:0046486 | glycerolipid metabolic process | 5.4054 | 4 | yes |
| GO:0046513 | ceramide biosynthetic process | 5.4054 | 4 | yes |
| GO:0046834 | lipid phosphorylation | 5.4054 | 5 | yes |
| GO:0072594 | establishment of protein localization to organelle | 5.4054 | 4 | yes |
| GO:0072655 | establishment of protein localization to mitochondrion | 5.4054 | 5 | yes |
| GO:0090150 | establishment of protein localization to membrane | 5.4054 | 4 | yes |
| GO:0090151 | establishment of protein localization to mitochondrial membrane | 5.4054 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 5.4054 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| M2OM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TIM22_HUMAN | [view interactions] | Low throughput | no | no |
| TIM9_HUMAN | [view interactions] | Low throughput | no | yes |
| TIM10_HUMAN | [view interactions] | Low throughput | no | yes |
| TIM29_HUMAN | [view interactions] | Low throughput | no | no |
| T10B_HUMAN | [view interactions] | Low throughput | no | yes |
| SIM26_HUMAN | [view interactions] | Low throughput | no | no |
| KLF16_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPHP1_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBF1_HUMAN | [view interactions] | High throughput | no | no |
| POC5_HUMAN | [view interactions] | High throughput | no | yes |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| RYK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCSK9_HUMAN | [view interactions] | High throughput | no | no |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| AT12A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHC24_HUMAN | [view interactions] | High throughput | no | yes |
| ASM3B_HUMAN | [view interactions] | High throughput | no | no |
| GTPB6_HUMAN | [view interactions] | High throughput | no | no |
| SNX4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBA1_HUMAN | [view interactions] | High throughput | no | yes |
| GTR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HEM1_HUMAN | [view interactions] | High throughput | no | yes |
| PPIC_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD3_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| S39AE_HUMAN | [view interactions] | High throughput | no | yes |
| AT2B3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCMC1_HUMAN | [view interactions] | High throughput | no | no |
| CNNM4_HUMAN | [view interactions] | High throughput | no | yes |
| SFXN2_HUMAN | [view interactions] | High throughput | no | no |
| CYTM1_HUMAN | [view interactions] | High throughput | no | no |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FARP2_HUMAN | [view interactions] | High throughput | no | yes |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| COX11_HUMAN | [view interactions] | High throughput | no | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| C2CD2_HUMAN | [view interactions] | High throughput | no | yes |
| TTI1_HUMAN | [view interactions] | High throughput | no | yes |
| GP107_HUMAN | [view interactions] | High throughput | no | yes |
| EFNMT_HUMAN | [view interactions] | High throughput | no | yes |
| PRSS8_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYM_HUMAN | [view interactions] | High throughput | no | yes |
| INT4_HUMAN | [view interactions] | High throughput | no | yes |
| AT2C1_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEUR1_HUMAN | [view interactions] | High throughput | no | yes |
| AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNR6_HUMAN | [view interactions] | High throughput | no | no |
| RAB7L_HUMAN | [view interactions] | High throughput | no | yes |
| TNAP2_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| LMNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| DOT1L_HUMAN | [view interactions] | High throughput | no | yes |
| MEN1_HUMAN | [view interactions] | High throughput | no | yes |
| R113A_HUMAN | [view interactions] | High throughput | no | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| S2512_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| AGO4_HUMAN | [view interactions] | High throughput | no | no |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| AP3S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCHL_HUMAN | [view interactions] | High throughput | no | yes |
| RSPRY_HUMAN | [view interactions] | High throughput | no | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| BAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MED23_HUMAN | [view interactions] | High throughput | no | no |
| PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
| LIMK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAK6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDM1_HUMAN | [view interactions] | High throughput | no | yes |