AGK_HUMAN
Evidence for PS localization
Functions
Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively (PubMed). Does not phosphorylate sphingosine (PubMed). Phosphorylates ceramide . Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol . Independently of its lipid kinase activity, acts as a component of the TIM22 complex (PubMed, PubMed). The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force (PubMed, PubMed). In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23 (PubMed). Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AGK_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 30.0000 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 30.0000 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 23.3333 | 4 | no |
| GO:0005524 | ATP binding | 20.0000 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 20.0000 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 20.0000 | 5 | yes |
| GO:0016301 | kinase activity | 10.0000 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 10.0000 | 4 | yes |
| GO:0001727 | lipid kinase activity | 6.6667 | 5 | yes |
| GO:0001729 | ceramide kinase activity | 6.6667 | 6 | yes |
| GO:0003951 | NAD+ kinase activity | 6.6667 | 5 | yes |
| GO:0004143 | diacylglycerol kinase activity | 6.6667 | 5 | yes |
| GO:0047620 | acylglycerol kinase activity | 6.6667 | 5 | yes |
| GO:0102773 | dihydroceramide kinase activity | 6.6667 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AGK_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 50.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.6667 | 4 | no |
| GO:0071702 | organic substance transport | 43.3333 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 40.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
| GO:0008104 | protein localization | 36.6667 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 36.6667 | 4 | no |
| GO:0010646 | regulation of cell communication | 36.6667 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 36.6667 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.6667 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 33.3333 | 4 | no |
| GO:0009894 | regulation of catabolic process | 30.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.0000 | 5 | no |
| GO:0051049 | regulation of transport | 30.0000 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 30.0000 | 4 | no |
| GO:0015031 | protein transport | 26.6667 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 26.6667 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 26.6667 | 4 | no |
| GO:0006811 | ion transport | 23.3333 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 23.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 23.3333 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.3333 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.3333 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.3333 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 23.3333 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 23.3333 | 5 | no |
| GO:0071310 | cellular response to organic substance | 23.3333 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.3333 | 5 | no |
| GO:0031329 | regulation of cellular catabolic process | 23.3333 | 5 | no |
| GO:0033043 | regulation of organelle organization | 23.3333 | 5 | no |
| GO:0051050 | positive regulation of transport | 23.3333 | 4 | no |
| GO:0006886 | intracellular protein transport | 20.0000 | 4 | yes |
| GO:0007005 | mitochondrion organization | 16.6667 | 5 | yes |
| GO:0033365 | protein localization to organelle | 16.6667 | 5 | yes |
| GO:0061024 | membrane organization | 16.6667 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 13.3333 | 4 | yes |
| GO:0006839 | mitochondrial transport | 10.0000 | 4 | yes |
| GO:0007006 | mitochondrial membrane organization | 10.0000 | 5 | yes |
| GO:0016310 | phosphorylation | 10.0000 | 5 | yes |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 10.0000 | 4 | yes |
| GO:0070585 | protein localization to mitochondrion | 10.0000 | 6 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 10.0000 | 4 | yes |
| GO:0006643 | membrane lipid metabolic process | 6.6667 | 4 | yes |
| GO:0006665 | sphingolipid metabolic process | 6.6667 | 4 | yes |
| GO:0006672 | ceramide metabolic process | 6.6667 | 5 | yes |
| GO:0007007 | inner mitochondrial membrane organization | 6.6667 | 6 | yes |
| GO:0008610 | lipid biosynthetic process | 6.6667 | 4 | yes |
| GO:0030148 | sphingolipid biosynthetic process | 6.6667 | 5 | yes |
| GO:0043603 | cellular amide metabolic process | 6.6667 | 4 | yes |
| GO:0043604 | amide biosynthetic process | 6.6667 | 5 | yes |
| GO:0045039 | protein insertion into mitochondrial inner membrane | 6.6667 | 6 | yes |
| GO:0046467 | membrane lipid biosynthetic process | 6.6667 | 4 | yes |
| GO:0046486 | glycerolipid metabolic process | 6.6667 | 4 | yes |
| GO:0046513 | ceramide biosynthetic process | 6.6667 | 6 | yes |
| GO:0051204 | protein insertion into mitochondrial membrane | 6.6667 | 5 | yes |
| GO:0051205 | protein insertion into membrane | 6.6667 | 5 | yes |
| GO:0072594 | establishment of protein localization to organelle | 6.6667 | 4 | yes |
| GO:0072655 | establishment of protein localization to mitochondrion | 6.6667 | 5 | yes |
| GO:0072657 | protein localization to membrane | 6.6667 | 4 | yes |
| GO:0090150 | establishment of protein localization to membrane | 6.6667 | 4 | yes |
| GO:0090151 | establishment of protein localization to mitochondrial membrane | 6.6667 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in AGK_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 10.0000 | 3 | no |
| DOID:1289 | neurodegenerative disease | 6.6667 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TIM22_HUMAN | [view interactions] | Low throughput | no | no |
| TIM9_HUMAN | [view interactions] | Low throughput | no | yes |
| T10B_HUMAN | [view interactions] | Low throughput | no | yes |
| TIM29_HUMAN | [view interactions] | Low throughput | no | no |
| TIM10_HUMAN | [view interactions] | Low throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| AT12A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHC24_HUMAN | [view interactions] | High throughput | no | yes |
| ASM3B_HUMAN | [view interactions] | High throughput | no | no |
| GTPB6_HUMAN | [view interactions] | High throughput | no | no |
| SNX4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLCM_HUMAN | [view interactions] | High throughput | no | yes |
| GTR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HEM1_HUMAN | [view interactions] | High throughput | no | yes |
| PPIC_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD3_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| S39AE_HUMAN | [view interactions] | High throughput | no | yes |
| AT2B3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCMC1_HUMAN | [view interactions] | High throughput | no | no |
| CNNM4_HUMAN | [view interactions] | High throughput | no | yes |
| SFXN2_HUMAN | [view interactions] | High throughput | no | no |
| CYTM1_HUMAN | [view interactions] | High throughput | no | no |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FARP2_HUMAN | [view interactions] | High throughput | no | yes |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| COX11_HUMAN | [view interactions] | High throughput | no | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| C2CD2_HUMAN | [view interactions] | High throughput | no | yes |
| TTI1_HUMAN | [view interactions] | High throughput | no | yes |
| GP107_HUMAN | [view interactions] | High throughput | no | yes |
| EFNMT_HUMAN | [view interactions] | High throughput | no | yes |
| PRSS8_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYM_HUMAN | [view interactions] | High throughput | no | yes |
| INT4_HUMAN | [view interactions] | High throughput | no | yes |
| AT2C1_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEUR1_HUMAN | [view interactions] | High throughput | no | yes |
| AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNR6_HUMAN | [view interactions] | High throughput | no | no |
| RAB7L_HUMAN | [view interactions] | High throughput | no | yes |
| TNAP2_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| LMNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| CMC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| AGO4_HUMAN | [view interactions] | High throughput | no | no |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| AP3S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCHL_HUMAN | [view interactions] | High throughput | no | yes |
| RSPRY_HUMAN | [view interactions] | High throughput | no | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| BAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MED23_HUMAN | [view interactions] | High throughput | no | no |
| PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
| LIMK1_HUMAN | [view interactions] | High throughput | no | yes |
| PAK6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDM1_HUMAN | [view interactions] | High throughput | no | yes |
| KLF16_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPHP1_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBF1_HUMAN | [view interactions] | High throughput | no | no |
| POC5_HUMAN | [view interactions] | High throughput | no | yes |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| RYK_HUMAN | [view interactions] | High throughput | no | no |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCSK9_HUMAN | [view interactions] | High throughput | no | no |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |