Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

S2512_HUMAN

Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed, PubMed, PubMed). Also mediates the uptake of L-cysteinesulfinate by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in S2512_HUMAN
GO:0043169 cation binding 28.2353 4 yes
GO:0046872 metal ion binding 28.2353 5 yes
GO:0008324 monoatomic cation transmembrane transporter activity 22.3529 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 22.3529 4 yes
GO:0043168 anion binding 22.3529 4 no
GO:0015078 proton transmembrane transporter activity 21.1765 5 yes
GO:0022853 active monoatomic ion transmembrane transporter activity 20.0000 4 yes
GO:0005509 calcium ion binding 5.8824 6 yes
GO:0015175 neutral L-amino acid transmembrane transporter activity 4.7059 4 yes
GO:0015179 L-amino acid transmembrane transporter activity 4.7059 4 yes
GO:0046943 carboxylic acid transmembrane transporter activity 4.7059 4 yes
GO:0000099 sulfur amino acid transmembrane transporter activity 3.5294 4 yes
GO:0000514 3-sulfino-L-alanine: proton, glutamate antiporter activity 3.5294 4 yes
GO:0000515 aspartate:glutamate, proton antiporter activity 3.5294 5 yes
GO:0005310 dicarboxylic acid transmembrane transporter activity 3.5294 5 yes
GO:0005313 L-glutamate transmembrane transporter activity 3.5294 5 yes
GO:0015172 acidic amino acid transmembrane transporter activity 3.5294 4 yes
GO:0015183 L-aspartate transmembrane transporter activity 3.5294 5 yes
GO:0015291 secondary active transmembrane transporter activity 3.5294 4 yes
GO:0015297 antiporter activity 3.5294 5 yes
GO:0015556 C4-dicarboxylate transmembrane transporter activity 3.5294 5 yes
GO:0140848 amino acid:monoatomic cation antiporter activity 3.5294 4 yes
GO:1901680 sulfur-containing amino acid secondary active transmembrane transporter activity 3.5294 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in S2512_HUMAN
GO:0006996 organelle organization 44.7059 4 no
GO:0048522 positive regulation of cellular process 41.1765 4 no
GO:0010646 regulation of cell communication 40.0000 4 no
GO:0022607 cellular component assembly 36.4706 4 no
GO:0009966 regulation of signal transduction 36.4706 4 no
GO:0048523 negative regulation of cellular process 36.4706 4 no
GO:0031323 regulation of cellular metabolic process 35.2941 4 no
GO:0060255 regulation of macromolecule metabolic process 34.1176 4 no
GO:0006796 phosphate-containing compound metabolic process 30.5882 4 no
GO:0080090 regulation of primary metabolic process 30.5882 4 no
GO:0051128 regulation of cellular component organization 30.5882 4 no
GO:0043933 protein-containing complex organization 28.2353 4 no
GO:0071702 organic substance transport 27.0588 4 yes
GO:0071705 nitrogen compound transport 25.8824 4 yes
GO:0007005 mitochondrion organization 24.7059 5 no
GO:0009889 regulation of biosynthetic process 24.7059 4 no
GO:0010468 regulation of gene expression 24.7059 6 no
GO:0010556 regulation of macromolecule biosynthetic process 24.7059 5 no
GO:0031326 regulation of cellular biosynthetic process 24.7059 5 no
GO:1902531 regulation of intracellular signal transduction 24.7059 5 no
GO:0008104 protein localization 23.5294 4 no
GO:0065003 protein-containing complex assembly 23.5294 5 no
GO:0010648 negative regulation of cell communication 23.5294 5 no
GO:0023057 negative regulation of signaling 23.5294 4 no
GO:0009893 positive regulation of metabolic process 23.5294 4 no
GO:0051246 regulation of protein metabolic process 23.5294 5 no
GO:0009968 negative regulation of signal transduction 22.3529 5 no
GO:0048585 negative regulation of response to stimulus 22.3529 4 no
GO:0042981 regulation of apoptotic process 22.3529 5 no
GO:0043067 regulation of programmed cell death 22.3529 4 no
GO:0061024 membrane organization 21.1765 4 no
GO:0015980 energy derivation by oxidation of organic compounds 21.1765 4 no
GO:0006839 mitochondrial transport 16.4706 4 yes
GO:0010038 response to metal ion 10.5882 4 yes
GO:0019752 carboxylic acid metabolic process 10.5882 5 yes
GO:0043436 oxoacid metabolic process 10.5882 4 yes
GO:0006865 amino acid transport 7.0588 5 yes
GO:0015711 organic anion transport 7.0588 5 yes
GO:0015849 organic acid transport 7.0588 5 yes
GO:0046942 carboxylic acid transport 7.0588 6 yes
GO:0170033 L-amino acid metabolic process 7.0588 5 yes
GO:0170039 proteinogenic amino acid metabolic process 7.0588 4 yes
GO:1901605 alpha-amino acid metabolic process 7.0588 4 yes
GO:0006006 glucose metabolic process 5.8824 5 yes
GO:0006835 dicarboxylic acid transport 5.8824 7 yes
GO:0009066 aspartate family amino acid metabolic process 5.8824 5 yes
GO:0015800 acidic amino acid transport 5.8824 6 yes
GO:0015807 L-amino acid transport 5.8824 5 yes
GO:0019318 hexose metabolic process 5.8824 4 yes
GO:1905039 carboxylic acid transmembrane transport 5.8824 4 yes
GO:0006094 gluconeogenesis 4.7059 6 yes
GO:0015813 L-glutamate transmembrane transport 4.7059 5 yes
GO:0016051 carbohydrate biosynthetic process 4.7059 4 yes
GO:0019319 hexose biosynthetic process 4.7059 5 yes
GO:0046364 monosaccharide biosynthetic process 4.7059 4 yes
GO:0051938 L-glutamate import 4.7059 6 yes
GO:1902475 L-alpha-amino acid transmembrane transport 4.7059 4 yes
GO:0015740 C4-dicarboxylate transport 3.5294 8 yes
GO:0015810 aspartate transmembrane transport 3.5294 4 yes
GO:0043490 malate-aspartate shuttle 3.5294 4 yes
GO:0051592 response to calcium ion 3.5294 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PHB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PHB2_HUMAN [view entry] [view interactions] Low throughput yes yes
MAVS_HUMAN [view interactions] Low throughput no yes
S2512_HUMAN [view entry] [view interactions] Low throughput yes yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
TM9S4_HUMAN [view interactions] High throughput no yes
S2513_HUMAN [view entry] [view interactions] High throughput yes yes
ECH1_HUMAN [view interactions] High throughput no yes
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
DICER_HUMAN [view entry] [view interactions] High throughput yes yes
CDC73_HUMAN [view interactions] High throughput no yes
SH2D3_HUMAN [view interactions] High throughput no no
RHG06_HUMAN [view interactions] High throughput no yes
STA13_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
MOT11_HUMAN [view interactions] High throughput no no
RA51D_HUMAN [view interactions] High throughput no no
SIM26_HUMAN [view interactions] High throughput no no
FBX43_HUMAN [view interactions] High throughput no no
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
APBB1_HUMAN [view entry] [view interactions] High throughput yes yes
SPTCS_HUMAN [view interactions] High throughput no yes
LAT_HUMAN [view interactions] High throughput no no
PHAG1_HUMAN [view interactions] High throughput no yes
PHLA3_HUMAN [view interactions] High throughput no yes
PELO_HUMAN [view interactions] High throughput no yes
RCAF1_HUMAN [view interactions] High throughput no yes
PNKP_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
HSPB2_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
RD3_HUMAN [view interactions] High throughput no no
RYBP_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
SMAD3_HUMAN [view interactions] High throughput no yes
NFKB1_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
JUND_HUMAN [view interactions] High throughput no yes
CE128_HUMAN [view interactions] High throughput no yes
CEP89_HUMAN [view interactions] High throughput no no
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
COX14_HUMAN [view interactions] High throughput no yes
SCO1_HUMAN [view interactions] High throughput no yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
IMP2L_HUMAN [view interactions] High throughput no yes
HTRA2_HUMAN [view interactions] High throughput no yes
IMP1L_HUMAN [view interactions] High throughput no yes
LACTB_HUMAN [view interactions] High throughput no yes
OMA1_HUMAN [view interactions] High throughput no no
PARL_HUMAN [view interactions] High throughput no yes
YMEL1_HUMAN [view interactions] High throughput no yes
SRGP2_HUMAN [view entry] [view interactions] High throughput yes no
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
FBX6_HUMAN [view interactions] High throughput no yes
PCSK9_HUMAN [view interactions] High throughput no no
EED_HUMAN [view interactions] High throughput no yes
PODO_HUMAN [view interactions] High throughput no no
MERL_HUMAN [view interactions] High throughput no yes
LNX2_HUMAN [view interactions] High throughput no yes
ZN746_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
HIF1N_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
LAP2A_HUMAN [view interactions] High throughput no yes
UB2R1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
WWOX_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
GRWD1_HUMAN [view interactions] High throughput no no
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
NR2C2_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
LMBRL_HUMAN [view interactions] High throughput no no
BRD7_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
EMC1_HUMAN [view interactions] High throughput no yes
ANR55_HUMAN [view interactions] High throughput no yes
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
PRC1_HUMAN [view interactions] High throughput no yes
BRD9_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
ASXL1_HUMAN [view interactions] High throughput no no
UFL1_HUMAN [view interactions] High throughput no yes
NBR1_HUMAN [view interactions] High throughput no yes
EPN1_HUMAN [view entry] [view interactions] High throughput yes yes
YTHD1_HUMAN [view interactions] High throughput no no
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
CST9L_HUMAN [view interactions] High throughput no no
NAAA_HUMAN [view interactions] High throughput no yes
SPRY7_HUMAN [view interactions] High throughput no yes
SFPA2_HUMAN [view interactions] High throughput no no
HUMMR_HUMAN [view interactions] High throughput no yes
LRC25_HUMAN [view interactions] High throughput no yes
FMOD_HUMAN [view interactions] High throughput no no
SPRTN_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
DVL2_HUMAN [view interactions] High throughput no yes
SOX2_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
E2F4_HUMAN [view interactions] High throughput no no
ARMC5_HUMAN [view interactions] High throughput no yes
MAP1B_HUMAN [view entry] [view interactions] High throughput yes yes
LOXL2_HUMAN [view interactions] High throughput no yes
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
UBP48_HUMAN [view interactions] High throughput no yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
TNIP1_HUMAN [view interactions] High throughput no yes
MET14_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
CL16A_HUMAN [view interactions] High throughput no yes
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
CSK_HUMAN [view interactions] High throughput no yes
MIC25_HUMAN [view entry] [view interactions] High throughput yes yes
MIC60_HUMAN [view entry] [view interactions] High throughput yes yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
HXK1_HUMAN [view entry] [view interactions] High throughput yes yes
NNTM_HUMAN [view entry] [view interactions] High throughput yes yes
SYJ2B_HUMAN [view interactions] High throughput no no
TRXR1_HUMAN [view interactions] High throughput no yes
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
LAT1_HUMAN [view interactions] High throughput no yes
NHLC2_HUMAN [view interactions] High throughput no yes
DBLOH_HUMAN [view interactions] High throughput no no
MIC26_HUMAN [view entry] [view interactions] High throughput yes yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
ACAD9_HUMAN [view interactions] High throughput no yes
ACOT2_HUMAN [view interactions] High throughput no yes
AFG32_HUMAN [view entry] [view interactions] High throughput yes yes
AGK_HUMAN [view entry] [view interactions] High throughput yes yes
KAD2_HUMAN [view interactions] High throughput no no
MIC27_HUMAN [view entry] [view interactions] High throughput yes yes
PRAF3_HUMAN [view interactions] High throughput no yes
ATD3A_HUMAN [view entry] [view interactions] High throughput yes yes
ATD3B_HUMAN [view interactions] High throughput no yes
ATIF1_HUMAN [view interactions] High throughput no yes
AT5F1_HUMAN [view interactions] High throughput no yes
UQCC6_HUMAN [view interactions] High throughput no yes
CYBP_HUMAN [view entry] [view interactions] High throughput yes yes
SYCM_HUMAN [view interactions] High throughput no yes
MITOK_HUMAN [view interactions] High throughput no yes
MIX23_HUMAN [view interactions] High throughput no yes
CDCA3_HUMAN [view interactions] High throughput no no
MIC19_HUMAN [view entry] [view interactions] High throughput yes yes
MIA40_HUMAN [view interactions] High throughput no yes
KCRU_HUMAN [view entry] [view interactions] High throughput yes yes
CLPB_HUMAN [view interactions] High throughput no yes
CNIH4_HUMAN [view interactions] High throughput no yes
COA7_HUMAN [view interactions] High throughput no yes
COX11_HUMAN [view interactions] High throughput no yes
COX15_HUMAN [view interactions] High throughput no yes
COX2_HUMAN [view entry] [view interactions] High throughput yes yes
COX5A_HUMAN [view entry] [view interactions] High throughput yes yes
COX5B_HUMAN [view entry] [view interactions] High throughput yes yes
CX6A1_HUMAN [view interactions] High throughput no yes
CX6B1_HUMAN [view entry] [view interactions] High throughput yes yes
COX6C_HUMAN [view entry] [view interactions] High throughput yes yes
CX7A2_HUMAN [view interactions] High throughput no no
HEM6_HUMAN [view interactions] High throughput no no
CY1_HUMAN [view entry] [view interactions] High throughput yes yes
DYR_HUMAN [view interactions] High throughput no yes
DHX30_HUMAN [view entry] [view interactions] High throughput yes yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
NUCG_HUMAN [view entry] [view interactions] High throughput yes yes
ETFA_HUMAN [view interactions] High throughput no yes
EXOG_HUMAN [view interactions] High throughput no yes
F162A_HUMAN [view interactions] High throughput no yes
GHITM_HUMAN [view interactions] High throughput no yes
LGUL_HUMAN [view interactions] High throughput no yes
GPDM_HUMAN [view entry] [view interactions] High throughput yes yes
HAX1_HUMAN [view interactions] High throughput no no
CCHL_HUMAN [view interactions] High throughput no yes
HIG2A_HUMAN [view interactions] High throughput no yes
P33MX_HUMAN [view interactions] High throughput no yes
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
LPPRC_HUMAN [view entry] [view interactions] High throughput yes yes
MICU1_HUMAN [view interactions] High throughput no yes
MICU2_HUMAN [view interactions] High throughput no yes
MLF1_HUMAN [view entry] [view interactions] High throughput yes yes
MLF2_HUMAN [view entry] [view interactions] High throughput yes yes
MPC2_HUMAN [view interactions] High throughput no yes
RM18_HUMAN [view interactions] High throughput no yes
RM24_HUMAN [view interactions] High throughput no yes
RM04_HUMAN [view interactions] High throughput no yes
RT14_HUMAN [view interactions] High throughput no yes
RT02_HUMAN [view interactions] High throughput no no
RT22_HUMAN [view interactions] High throughput no yes
RT31_HUMAN [view interactions] High throughput no yes
RT09_HUMAN [view interactions] High throughput no yes
MTX2_HUMAN [view entry] [view interactions] High throughput yes yes
NDUAB_HUMAN [view interactions] High throughput no no
NDUAD_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA5_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA8_HUMAN [view entry] [view interactions] High throughput yes yes
CIA30_HUMAN [view interactions] High throughput no yes
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
NDUBB_HUMAN [view interactions] High throughput no yes
NDUB7_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUV3_HUMAN [view interactions] High throughput no yes
NUDC2_HUMAN [view entry] [view interactions] High throughput yes yes
NUDC3_HUMAN [view interactions] High throughput no yes
TIRR_HUMAN [view interactions] High throughput no no
OCAD1_HUMAN [view interactions] High throughput no yes
ODO1_HUMAN [view entry] [view interactions] High throughput yes yes
OPA1_HUMAN [view entry] [view interactions] High throughput yes yes
MPPA_HUMAN [view interactions] High throughput no yes
PGES2_HUMAN [view interactions] High throughput no yes
PUSL1_HUMAN [view interactions] High throughput no yes
RDH13_HUMAN [view interactions] High throughput no no
SAM50_HUMAN [view entry] [view interactions] High throughput yes yes
SCO2_HUMAN [view interactions] High throughput no no
SFXN4_HUMAN [view interactions] High throughput no yes
SHSA8_HUMAN [view entry] [view interactions] High throughput yes no
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
SCMC1_HUMAN [view interactions] High throughput no no
SCMC2_HUMAN [view interactions] High throughput no yes
SIM12_HUMAN [view interactions] High throughput no yes
TIM13_HUMAN [view interactions] High throughput no yes
TIM23_HUMAN [view interactions] High throughput no yes
TIM29_HUMAN [view interactions] High throughput no no
TIM50_HUMAN [view entry] [view interactions] High throughput yes yes
TIM8A_HUMAN [view interactions] High throughput no yes
TIM8B_HUMAN [view interactions] High throughput no yes
TIDC1_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
TOM40_HUMAN [view interactions] High throughput no yes
ICT1_HUMAN [view interactions] High throughput no yes
TOM70_HUMAN [view interactions] High throughput no yes
NPHP4_HUMAN [view interactions] High throughput no yes
TRABD_HUMAN [view interactions] High throughput no yes
ATF2_HUMAN [view interactions] High throughput no yes
TRIA1_HUMAN [view interactions] High throughput no yes
COA3_HUMAN [view interactions] High throughput no yes
TTC19_HUMAN [view interactions] High throughput no yes
RIPK4_HUMAN [view interactions] High throughput no no
S2551_HUMAN [view interactions] High throughput no no
LMTK1_HUMAN [view interactions] High throughput no yes
CLPP_HUMAN [view interactions] High throughput no yes
PAEP_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
AKAP5_HUMAN [view entry] [view interactions] High throughput yes yes
RFA2_HUMAN [view interactions] High throughput no yes
LIS1_HUMAN [view entry] [view interactions] High throughput yes yes
RFA3_HUMAN [view interactions] High throughput no yes
NICA_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
TBCK_HUMAN [view interactions] High throughput no yes
TPX2_HUMAN [view interactions] High throughput no yes